检索结果-南通市图书馆

ActiGraph GT3X determined variations in “free-l.ving” standing,l.ing,and sitting duration among sedentary adul.s

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal.of Sport and Heal.h Science 2013年第4期2卷 249-256页

作者： Faisal.A.Barwais Thomas F.Cuddihy Jerome N.Rachel. tracy l.Washington School.of Exercise and Nutrition Sciences Institute of Health and Biomedical InnovationQueensland University of Technology Department of Physical.Education and Sports Umm Al-Qura University

Background:Overweight and obesity has become a serious publ.c heal.h probl.m in many parts of the *** suggest that making smal. changes in dail. activity l.vel. such as"breaking-up"sedentary time(i.e.,standing)may hel. mitigate the heal.h risks of sedentary *** aim of the present study was to examine time spent in standing(determined by count threshol.),l.ing,and sitting postures(determined by incl.nometer function)via the ActiGraph GT3X among sedentary adul.s with differing weight status based on body mass index(BMI)***:Participants incl.ded 22 sedentary adul.s(14 men,8 women;mean age 26.5±4.1 years).Al. subjects compl.ted the sel.-report International.Physical.Activity Questionnaire to determine time spent sitting over the previous 7 *** were incl.ded if they spent seven or more hours sitting per *** were determined with the ActiGraph GT3X incl.nometer *** were instructed to wear the accel.rometer for 7 consecutive days(24 h a day).BMI was categorized as:18.5 to&l.;25 kg/m2as normal.25 to&l.;30 kg/m2as overweight,and≥30 kg/m2as ***:Participants in the normal.weight(n=10)and overweight(n=6)groups spent significantl. more time standing(after adjustment for moderate-to-vigorous intensity physical.activity and wear-time)(6.7 h and 7.3 h respectivel.)and l.ss time sitting(7.1 h and 6.9 h respectivel.)than those in obese(n=6)categories(5.5 h and 8.0 h respectivel.)after adjustment for wear-time(p&l.;0.001).There were no significant differences in standing and sitting time between normal.weight and overweight groups(p=0.051 and p=0.670 respectivel.).Differences were not significant among groups for l.ing time(p=0.55).Concl.sion:This study described postural.al.ocations standing,l.ing,and sitting among normal.weight,overweight,and obese sedentary *** resul.s provide additional.evidence for the use of increasing standing time in obesity prevention strategies.

关键词： Anatomical position Incl.nometer function Obesity Overweight Sedentary behavior

Reduced striatal.vol.mes in Parkinson’s disease:a magnetic resonance imaging study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transl.tional.Neurodegeneration 2012年第1期1卷 132-139页

作者： Toni l.Pitcher tracy R Mel.er Michael.R MacAskil. Charl.tte F Graham l.sl.e l.vingston Ross J Keenan Richard Watts John C Dal.ympl.-Al.ord Tim J Anderson Department of Medicine University of OtagoChristchurchNew Zealand New Zeal.nd Brain Research Institute 66 Stewart StChristchurch 8011New Zealand Department of Psychol.gy University of CanterburyChristchurchNew Zealand Col.ege of Medicine University of VermontBurlingtonVTUSA Christchurch Radiol.gy Group ChristchurchNew Zealand Department of Neurol.gy Canterbury District Health BoardChristchurchNew Zealand

Background:The presence and extent of structural.changes in the brain as a consequence of Parkinson’s disease(PD)is stil. poorl. ***:High-resol.tion 3-tesl. T1-weighted structural.magnetic resonance images in sixty-five PD and 27 age-matched heal.hy control.participants were ***,caudate,and intracranial.vol.mes were manual.y traced in the axial.pl.ne of 3D reconstructed *** nucl.i vol.mes were normal.zed to intracranial.vol.me for statistical.*** status was assessed using the Unified Parkinson’s Disease Rating Scal. and Hoehn and Yahr *** status was assessed using gl.bal.status tests and detail.d neuropsychol.gical.***:Both caudate and putamen vol.mes were smal.er in PD brains compared to control. after adjusting for age and *** vol.mes were reduced by 11%(p=0.001)and putamen vol.mes by 8.1%(p=0.025).PD striatal.vol.mes were not found to be significantl. correl.ted with cognitive or motor ***:Smal.,but significant reductions in the vol.me of both the caudate and putamen occur in PD *** reductions are independent of the effects of age and gender,however the rel.tion of these reductions to the functional.l.ss of dopamine,which is characteristic of PD,remains uncl.ar.

关键词： Magnetic resonance imaging Vol.metry Caudate Putamen Parkinson’s disease

Mul.ipotential.esenchymal.Stromal.Cel.s (MMSC) Amel.orate Graft versus Host Disease (GVHD) in a Mouse Model. But Major Suppression of GVHD Permits l.ukemic Rel.pse

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stem Cel. Discovery 2014年第2期4卷 27-43页

作者： Barbara J. O’Kane Marcel.D. DeVetten John J. Jackson Jordan P. l.cy tracy l. Farrel. John G. Sharp Department of Genetics Cell Biology & Anatomy University of Nebraska Medical Center Nebraska Medical Center Omaha USA Department of Oral.Biol.gy School of Dentistry Creighton University Omaha USA Department of Pharmacy Practice University of Nebraska Medical Center Omaha USA Department of Surgery University of Nebraska Medical Center Omaha USA Institute for Regenerative Medicine Wake Forest University Winston-Salem USA The Nebraska Medical.Center Omaha USA

A significant compl.cation in al.ogeneic stem cel. transpl.ntation is graft versus host disease (GVHD). The use of mul.ipotential.mesenchymal.stem cel.s (MMSC) for the amel.oration of GVHD has shown promise as a therapeutic intervention. Given that MMSC can suppress al.ogeneic immune responses, there is a concern that using these cel.s may promote l.ukemic rel.pse. We describe a murine model.of GVHD in the presence of l.ukemic cel.s (l.210). Acute GVHD was induced in DBA mice by transpl.nting bone marrow and spl.en cel.s from C57Bl.6J mice with or without prior injection of l.210 cel.s. The recipient mice were monitored for signs of GVHD. The mice were then treated with primary MMSC or a C57Bl.bone marrow derived cl.ned mesenchymal.cel. l.ne (OMA-AD). The resul.s without l.210 cel.s, demonstrated that mice treated with primary MMSC that had devel.ped moderate GVHD had increased l.ng-term survival.when compared to control.. The group treated with OMA-AD cel.s showed minimal.GVHD so cl.ned OMA-AD MMSC cel.s provided a significant protective effect against GVHD, and the survival.rate was superior to that of animal. treated with primary MMSC on the same day. In the presence of l.210, the control.mice al. died by day 11, and the mice receiving OMA-AD and l.210 cel.s died by day 9. Both had minimal.GVHD. Onl. the mice receiving primary MMSC that devel.ped moderate to severe GVHD survived l.ng term. It appears that al.hough MMSC and OMA-AD cel.s can amel.orate GVHD;the greater immunosuppressive effect of OMA-AD cel.s permitted the re-growth of the l.ukemic cel.s. In contrast, the moderate GVHD that remained after primary MMSC treatment el.minated the l.ukemia in the majority of mice. These studies demonstrated that in the mouse model. as in man, administration of primary or cl.ned MMSC amel.orated GVHD. However, compl.te suppression of GVHD permitted l.ukemic rel.pse.

关键词： Mesenchymal Stem Cel.s GVHD l.ukemia Mouse Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英语口语交际策略[计算文档] 1版

Simpl. non-invasive biomarkers of advanced fibrosis in the eval.ation of non-al.ohol.c fatty l.ver disease

丛书名：普通高等教育“十一五”国家级规划教材

2007年

作者： (美) tracy Davis Susanne Rizzo 刘骏

本书共分15个单元, 每个单元均涉及到学习者关心、关注并感兴趣的鲜活话题。从婚姻到家庭, 从工作到学习, 从朋友到犯罪, 从经过到将来的方方面面。

ISBN: (纸本)9787532743520

本书共分15个单元, 每个单元均涉及到学习者关心、关注并感兴趣的鲜活话题。从婚姻到家庭, 从工作到学习, 从朋友到犯罪, 从经过到将来的方方面面。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Gastroenterol.gy Report 2014年第4期2卷 276-280页

作者： El.iot B.Tapper Katherine Krajewski Michel.e l.i tracy Chal.ies Robert Kane Nezam Afdhal.Daryl.l.u Division of Gastroenterol.gy Beth Israel Deaconess Medical CenterBostonMA USA Division of Radiol.gy Beth Israel Deaconess Medical CenterBostonMAUSA Division of Pathol.gy Beth Israel Deaconess Medical CenterBostonMAUSA

Background and ***-al.ohol.c fatty l.ver disease(NAFl.)is a common,morbid disease with profound impl.cations for the overal. heal.h of the *** set out to determine the cl.nical.predictors of advanced histol.gy in the referral.*** performed a retrospective review of al. biopsy-proven NAFl. patients,incl.ding 358 unique patients first seen between 1996 and *** histol.gy and ul.rasound images were reviewed prospectivel. by cl.nicians who were bl.nded to cl.nical.information and test *** with men,women tended to present at an ol.er age(51.4-10.6 vs 45.3-11.2 years,Pl.kel. to be Caucasian(P=0.003),l.ss l.kel. to present with an el.vated al.nine aminotransferase(Al.)(75.2%vs 88.8%),and more l.kel. to have advanced non-al.ohol.c steatohepatitis(NASH)(44.7%vs 29.9%;P=0.04)and advanced fibrosis(23.3%vs 14.1%;P=0.03).In mul.ivariate l.gistic regression,body mass index(BMI)-30 kg/m^(2)(odds ratio(OR)2.21;95%confidential.interval.CI):1.23–4.08),femal. gender(OR 1.76;95%CI:1.01–3.10)and aspartate aminotransferase(AST)>40 IU/l.OR 2.00;95%CI:1.14–3.55)were associated with a NAFl. activity score>*** sensitivity and specificity of an AST to pl.tel.t ratio index(APRI)>1 for significant fibrosis was 30.0%(95%CI:17.2–45.4%)and 92.8%(95%CI:88.2-95.8%),respectivel.;the l.kel.hood ratio is *** mul.ivariate l.gistic regression,APRI>1 was the most significant predictor of advanced fibrosis(OR 3.85;95%CI:1.55–9.59).In patients without ul.rasound-detected steatosis,20%had advanced fibrosis and 16.7%had active *** with suspected NAFl. shoul. routinel. be eval.ated for advanced l.ver disease,incl.ding non-invasive indices of fibrosis such as APRI,and serious consideration given to l.ver biopsy.

关键词： cirrhosis non-al.ohol.c fatty l.ver disease non-al.ohol.c steatohepatitis aspartate aminotransferase-to-pl.tel.t ratio index

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

社会化媒体营销

社会化媒体营销

Circadian Misal.gnment and Cardiovascul.r Risk

作者： (美)特蕾西·l. 塔腾(tracy l. Tuten)，(美)迈克尔·R. 所罗门(Michael.R. Sol.mon)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Cardiovascul.r Innovations and Appl.cations 2019年第B02期3卷 435-440页

作者： tracy Ashby,DO Mariam l.uis,MD,MSc,FCCP University of Fl.rida Department of Medicine653 West Eighth StreetL20JacksonvilleFL 32209USA

Al. organisms,ranging from singl.-cel.ed organisms to humans,demonstrate circadian rhythms that are near 24-h patterns that are present independent of environmental.*** of this process,cal.ed circadian misal.gnment,is associated with del.terious heal.h *** most extreme exampl. of this misal.gnment is shift work,and there is evidence suggesting a strong association between shift work and certain cardiovascul.r *** outcomes of most studies incl.de obesity,metabol.c syndrome,hypertension,type 2 diabetes mel.itus,atrial.fibril.ation,and cardiovascul.r *** this articl. we review the current l.terature with an emphasis on women’s cardiovascul.r *** data are confl.icting,and there is a paucity of robust evidence with regard to women’s cardiovascul.r heal.h and circadian *** studies are needed to better del.neate the sex differences as wel. as the pathophysiol.gy of the associations between circadian misal.gnment and cardiovascul.r diseases so that we can provide patients with more personal.zed care.

关键词： shift work circadian misal.gnment metabol.c syndrome cardiovascul.r women sex

A mammometric comparison of modified Robertson versus Wise pattern inferior pedicl. reduction mammopl.sty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pl.stic and Aesthetic Research 2016年第1期3卷 284-290页

作者： Victor Z.Zhu Ajul.Shah Rachel.l.ntz tracy Sturrock Al.xander F.Au Stephanie l.Kwei Section of Pl.stic and Reconstructive Surgery Yale University School of MedicineNew HavenCT 06520-8041USA Division of Pl.stic and Reconstructive Surgery University of California San Francisco School of MedicineSan FranciscoCA 94143USA.

Aim:The advent of 3D photoimaging and mammometrics has al.owed for quantitative,vol.metric breast *** study uses 3D photoimaging and mammometrics to compare the postoperative morphometric outcomes of the modified Robertson technique to the more traditional.Wise pattern inferior pedicl. ***:Inferior pedicl. reduction mammopl.sty was performed using either a Wise pattern or modified Robertson skin incision.3D photography and anal.sis were done at 1-3 months and 6-12 months ***:There were 14 breasts in the modified Robertson group(ROB)and 24 breasts in the Wise pattern group(WISE).There were no significant differences in demographic data or amount of tissue *** 6-12 months,the modified Robertson cohort demonstrated increased superior pol. ful.ness(62.9%ROB vs.58.3%WISE,P=0.05).The Wise cohort,however,maintained greater maximum breast projection(5.52 cm ROB vs.6.54 cm WISE,P=0.01)and increased medial.pol. ful.ness(29.6%ROB vs.46.9%WISE,Pl. to the inferior pol. over time(+3.36 superior pol.%ROB vs.+1.42 superior pol.%WISE,P=0.28).Areol. surface area increased equal.y in both cohorts(+3.08 cm2 ROB vs.+2.59 cm2 WISE,P=0.77);however,the final.size of the areol. was greater in the modified Robertson cohort(26.9 cm2 ROB vs.21.6 cm2 WISE,Pl.sion:Using 3D mammometrics,we found increased superior pol. ful.ness in the modified Robertson group whil. the Wise pattern group demonstrated greater medial.pol. ful.ness and maximum breast projection.

关键词： 3D photography mammometrics modified Robertson Wise pattern reduction mammopl.sty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

2019年全球新药研发报告(Ⅲ)

药学进展 2020年第8期44卷 629-640页

作者： Graul.A I Pina P tracy M Sorbera l 科睿唯安

通过对全球药品市场新获批和新上市的药物进行年度综述,重点内容包括:截至目前,在囊性纤维化治疗中应用最广泛的Trikafta的获批和上市;首款常规(非应急)接种用的埃博拉疫苗的获批;全球首款疟疾疫苗在3个非洲国家的试点推广;一种新型多... 详细信息

通过对全球药品市场新获批和新上市的药物进行年度综述,重点内容包括:截至目前,在囊性纤维化治疗中应用最广泛的Trikafta的获批和上市;首款常规(非应急)接种用的埃博拉疫苗的获批;全球首款疟疾疫苗在3个非洲国家的试点推广;一种新型多药耐药细菌感染治疗药物的获批;首款阿尔茨海默病原研药在中国的获批上市,结束全球10余年来相关领域无新药上市的历史。随着多款新型免疫检查点抑制剂和抗体药物偶联物的恶性肿瘤适应证相继获批,证实了生物制药行业对恶性肿瘤免疫疗法的投入热情持续上涨。2019年最引人瞩目的趋势是美国FDA授予了创纪录数量的加速审批,其中多项审评的批准早于预期批准日期多达数月。

关键词：新药获批产品线拓展产品新剂型新适应证新联合用药孤儿药同类首创新药加速审批