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A comparative study of automotive trip characteristics between older drivers and others among densely inhabited district and other areas

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Journal of Modern Transportation 2016年第3期24卷 177-186页

作者： Yanning Zhao toshiyuki yamamoto Takayuki Morikawa Department of Civil Engineering Nagoya University Institute of Materials and Systems for Sustainability Nagoya University Institute of Innovation for Future Society Nagoya University

This paper examines older driver＇s automotive trip （abbreviation： trip） characteristics which include trip frequency, trip length, destination distribution, and non- home-based （NHB） trips. A two-month experiment of 108 participants was carried out to collect GPS tracking data in Aichi Prefecture, Japan. To identify the effect of living area, a comparative analysis between older drivers and others is conducted in densely inhabited district （DID, i.e., urban） and other areas （non-DID, i.e., suburban, rural, etc）, separately. The present study found that there was no sig- nificant difference between the trip characteristics of older drivers and others who were living in DID. Thus, we suggest that the education of safety driving and the rec- ommendation of public transportation should be given to DID-living older drivers. However, the results of non-DID reflected that older drivers＇ trip frequency, trip length, destination, and NHB trips rate were shorter and lower than others＇. This implies that electric vehicles may be suit- able for promotion among older drivers in suburban and rural area. Furthermore, the regression analysis confirmed that ＂older driver＂ was a significant independent variable on trip frequency, trip length, and NHB trips, and there were interaction effects between ＂older driver＂ and ＂living areas＂ on all trip characteristics.

关键词： Older driver Travel behavior Living areaTrip frequency - Trip length Destination distribution Non-home-based (NHB) trips

An analysis on older driver＇s driving behavior by GPS tracking data： Road selection, left/right turn, and driving speed

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第1期5卷 56-65页

作者： Yanning Zhao toshiyuki yamamoto Takayuki Morikawa Department of Civil Engineering Nagoya University Nagoya 464-8603 Japan Institute of Materials and Systems for Sustainability Nagoya University Nagoya 464-8603Japan Institute of Innovation for Future Society Nagoya University Nagoya 464-8603Japan

With the high older-related accident ratio and increasing population aging problem, understanding older drivers＇ driving behaviors has become more and more important for building and improving transportation system. This paper examines older driver＇s driving behavior which includes road selection, left/right turn and driving speed. A two-month experiment of 108 participants was carried out in Aichi Prefecture, Japan. Since apparently contradictory statements were often drawn in survey-based or simulators-based studies, this study collected not only drivers＇ basic information but also GPS data. Analysis of road selection demonstrates that older drivers are reluctant to drive on expressway not only in short trips but also in long trips. The present study did not find significant difference be- tween older drivers and others while turning at the intersections. To investigate the impact factors on driving speed, a random-effects regression model is constructed with explan- atory variables including age, gender, road types and the interaction terms between age and road types. Compared with other variables, it fails to find that age （60 years old or over） has significant impact on driving speed. Moreover, the results reflect that older drivers drive even faster than others at particular road types： national road and ordinary municipal road. The results in this study are expected to help improve transportation planning and develop driving assistance systems for older drivers.

关键词： Older driver Driving behavior Road selection Left/right turn Driving speed

Pyoderma gangrenosum:An important dermatologic condition occasionally associated with rheumatic diseases

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World Journal of Rheumatology 2015年第2期5卷 101-107页

作者： toshiyuki yamamoto Department of Dermatology Fukushima Medical University

Pyoderma gangrenosum(PG) presents with refractory,sterile,deep ulcers most often on the lower ***,PG exhibits four types,i.e.,ulcerative,bullous,pustular,and vegetative *** may be triggered by surgical operation or even by minor iatrogenic procedures such as needle prick or catheter insertion,which is wellknown as *** is sometimes seen in association with several systemic diseases including rheumatoid arthritis(RA),inflammatory bowel disease,hematologic malignancy,and Takayasu's *** particular,various cutaneous manifestations are induced in association with RA by virtue of the activation of inflammatory cells(neutrophils,lymphocytes,macrophages),vasculopathy,vasculitis,drugs,and so *** appearances of ulcerative PG mimic rheumatoid vasculitis or leg ulcers due to impaired circulation in patients with *** addition,patients with PG sometimes develop joint manifestations as ***,it is necessary for not only dermatologists but also rheumatologists to understand PG.

关键词： Neutrophilic dermatosis Pathergy Kebner phenomenon Autoinflammatory disorder

Identification of activity stop locations in GPS trajectories by density-based clustering method combined with support vector machines

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Journal of Modern Transportation 2015年第3期23卷 202-213页

作者： Lei Gong Hitomi Sato toshiyuki yamamoto Tomio Miwa Takayuki Morikawa Department of Civil Engineering Nagoya University Institute of Innovation for Future Society Nagoya University EcoTopia Science Institute Nagoya University

The identification of activity locations in con- tinuous GPS trajectories is an essential preliminary step in obtaining person trip data and for activity-based trans- portation demand forecasting. In this research, a two-step methodology for identifying activity stop locations is pro- posed. In the first step, an improved density-based spatial clustering of applications with noise （DBSCAN） algorithm identifies stop points and moving points; then in the second step, the support vector machines （SVMs） method distin- guishes activity stops from non-activity stops among the identified stop points. A time sequence constraint and a direction change constraint are applied as improvements to DBSCAN （yielding an improved algorithm known as C-DBSCAN）. Then three major features are extracted for use in the SVMs method： stop duration, mean distance to the centroid of a cluster of points at a stop location, and the shorter of distances from current location to home and to the workplace. The proposed methodology was tested using GPS data collected from mobile phones in the Nagoya area of Japan. The C-DBSCAN algorithm achieves an accuracy of 90 % in identifying stop points in the first step, while the SVMs method is 96 % accurate in distin- guishing the locations of activity stops from non-activity stops in the second step. Compared to other variants of DBSCAN used to identify activity locations from GPS trajectories, this two-step method is generally superior.

关键词： Activity Stop · Non-activity stop · Stopidentification · DBSCAN· Support vector machines

Prenatal diagnosis of Werdnig-Hoffmann disease in China

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Chinese Medical Journal 2003年第5期116卷 673-675页

作者：冯建华 toshiyuki yamamoto Department of Neurology Children’s Hospital Zhejiang University Hangzhou 310027 China Gene Research Center Tottori University Yonago 683-8503 Japan

Objective To establish a means for prenatal prediction of spinal muscular atrophy (SMA) through survival motor neuron (SMN) gene deletion analysis and genetic counseling in families with a child affected with SMA. Methods Genetic analysis for prenatal prediction of Werdnig-Hoffmann disease was performed in a at risk Chinese family by polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) in SMN gene exons 7 and *** The pregnancy was positive for the homozygous deletion of the SMN gene, thus the fetus was diagnosed as being affected and the pregnancy was *** This approach is fast and reliable for DNA-based prenatal diagnosis of Werdnig-Hoffmann disease.

关键词： spinal muscular atrophies of childhood prenatal diagnosis SSCP

Impact of Electric Vehicles on Travel and Electricity Demand in Metropolitan Area： A Case Study in Nagoya

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Journal of Civil Engineering and Architecture 2015年第3期9卷 341-349页

作者： Ryo Kanamori Takayuki Morikawa Masaya Okumiya toshiyuki yamamoto Takayuki Ito Institute of Innovation for Future Society Nagoya University Nagoya 464-8603 Japan Department of Environmental Engineering and Architecture Nagoya University Nagoya 464-8603 Japan Eco Topia Science Institute Nagoya University Nagoya 464-8603 Japan Department of Computer Science and Engineering Nagoya Institute of Technology Nagoya 466-8555 Japan

In this study, we examine the impacts that EVs （electric vehicles） have on vehicle usage patterns and environmental improvements, using our integrated travel demand forecasting model, which can simulate an individual activity-travel behavior in each time period, as well as consider an induced demand by decreasing travel cost. In order to examine the effects that charging/discharging have on the demand in electricity, we analyze scenarios based on the simulation results of the EVs＇ parking location, parking duration and the battery state of charge. From the simulation, result under the ownership rate of EVs in the Nagoya metropolitan area in 2020 is about 6%, which turns out that the total CO2 emissions have decreased by 4% although the situation of urban transport is not changed. After calculating the electricity demand in each zone using architectural area and basic units of hourly power consumption, we evaluate the effect to decrease the peak load by V2G （vehicle-to-grid）. According to the results, if EV drivers charge at home during the night and discharge at work during the day, the electricity demand in Nagoya city increases by approximately 1%, although changes in each individual zone range from -7% to ＋8%, depending on its characteristics.

关键词： Electric vehicle integrated travel demand forecasting model electricity demand V2G.

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微型车对城市交通小区影响仿真分析

交通运输系统工程与信息 2013年第6期13卷 44-51页

作者：穆蕊山本俊行名古屋大学工学研究科名古屋大学EcoTopia科学研究所

通过VISSIM进行微观仿真,研究微型车的加入对环境和城市交通小区网络的影响.首先根据实际路网在VISSIM中创建对象,建立基础仿真模型并完成校对.然后针对微型车期望速度作三种假设,并设定不同微型车比率.最后仿真计算网络交通功率总输出... 详细信息

通过VISSIM进行微观仿真,研究微型车的加入对环境和城市交通小区网络的影响.首先根据实际路网在VISSIM中创建对象,建立基础仿真模型并完成校对.然后针对微型车期望速度作三种假设,并设定不同微型车比率.最后仿真计算网络交通功率总输出作为车辆尾气排放计算参考,网络总旅行时间、平均速度、延误时间作为网络表现参数.结果表明,低微型车期望车速和高比率导致更少尾气排放.当微型车期望车速等于或微小于普通小汽车期望速度时,高微型车比率更加缓解交通;但当其期望车速接近网络平均车速时,高微型车比率对交通网络有更消极影响.

关键词：城市交通微型车微观仿真环境负担交通网络 VISSIM

Higher levels of the lipophilic antioxidants coenzyme Q_(10) and vitamin E in long-lived termite queens than in short-lived workers

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Insect Science 2024年第1期31卷 201-210页

作者： Eisuke Tasaki Yorihiro yamamoto Yoshihito Iuchi Department of Biological Chemistry Graduate School of Sciences and Technology for InnovationYamaguchi UniversityYamaguchiJapan School of Bioscience and Biotechnology Tokyo University of TechnologyHachiojiTokyoJapan

Termite queens and kings live longer than nonreproductive *** molecular mechanisms contributing to their long lifespan have been investigated;however,the underlying biochemical explanation remains *** Q(CoQ),a component of the mitochondrial electron transport chain,plays an essential role in the lipophilic antioxidant defense *** beneficial effects on health and longevity have been well studied in several ***,we demonstrated that long-lived termite queens have significantly higher levels of the lipophilic antioxidant CoQ_(10) than *** chromatography analysis revealed that the levels of the reduced form of CoQ_(10) were 4 fold higher in the queen's body than in the worker's *** addition,queens showed 7 fold higher levels of vitamin E,which plays a role in antilipid peroxidation along with CoQ,than ***,the oral administration of CoQ_(10) to termites increased the CoQ_(10) redox state in the body and their survival rate under oxidative *** findings suggest that CoQ_(10) acts as an efficient lipophilic antioxidant along with vitamin E in long-lived termite *** study provides essential biochemical and evolutionary insights into the relationship between CoQ_(10) concentrations and termite lifespan extension.

关键词： antioxidant defense system coenzyme Q termite queens vitamin E

Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 1-3页

作者： Kazuaki Shimada Kenichi Nakamura Noboru yamamoto Department of Hepatobiliary and Pancreatic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a growing field *** its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical *** main obstacles are associated... 详细信息

关键词： clinical Cancer overcome