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Efficacy of transvaginal ultrasound-guided local injections of absolute ethanol for ectopic pregnancies with intrauterine implantation sites

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World Journal of Clinical Cases 2023年第4期11卷 788-796页

作者： toshiyuki Kakinuma Kaoru Kakinuma Yoshio Matsuda Kaoru Yanagida Michitaka Ohwada HirotsuneKaijima Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan Minatomirai Yume Clinic Yokohama 2200012Japan

BACKGROUND Cervical pregnancies,interstitial tubal pregnancies,and cesarean scar pregnancies,which are ectopic pregnancies with intrauterine implantation sites exhibit increasing trends with the recent widespread use of assisted reproductive technologies and increased rate of cesarean *** development of highsensitivity human chorionic gonadotropin testing reagents and the increased precision of transvaginal ultrasonic tomography have made early diagnosis possible and have enabled *** of ectopic pregnancies using methotrexate therapy and/or uterine artery embolization has been ***,delayed resumption of infertility treatments after methotrexate therapy is indicated,and negative effects on the next pregnancy after uterine artery embolization have been *** To examine the efficacy and safety of ultrasound-guided topical absolute ethanol injection in ectopic pregnancies with an intrauterine implantation *** In this study,we retrospectively examined the medical records of 21 patients who were diagnosed with an ectopic pregnancy with an intrauterine implantation site at our hospital,between April 2010 and December 2018,and underwent transvaginal ultrasound-guided local injections of absolute ethanol to determine the treatment *** evaluated the treatment methods,treatment outcomes,presence of bleeding requiring hemostasis measures and blood transfusion,complications,and treatment *** treatment was defined as the completion of treatment using transvaginal ultrasound-guided local injections of absolute ethanol *** There were 21 total cases comprising 10 cervical pregnancies,10 interstitial tubal pregnancies,and 1 cesarean scar *** patients completed treatment with this *** massive hemorrhaging or serious adverse reactions were observed during *** mean gestation ages at the time of diagnosis were 5.9 wk(SD,±0.9 wk)for cervical and 6.9 wk(SD,±2.1 wk)for interstitial

关键词： Embryo transfer Fertility Fertilization in vitro Pregnancy complications Prenatal care Ectopic pregnancy

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Reactive lymphoid hyperplasia of the liver:A case report and review of literature

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World Journal of Gastroenterology 2007年第40期13卷 5403-5407页

作者： Takuro Machida toshiyuki Takahashi Tomoo Itoh Michiaki Hirayama Takayuki Morita Shoichi Horita Department of Internal Medicine Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido University HospitalSapporoHokkaido060-8648Japan Department of Surgery Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan

A case of a 53-year-old female patient with reactive lymphoid hyperplasia （RLH）, clinically designated as pseudolymphoma of the liver is described in this article. The patient was admitted to our hospital for further evaluation of hepatic tumors incidentally discovered at another hospital. Various diagnostic methods, including ultrasonography （US）, computerized tomography （CT）, magnetic resonance imaging （MRI） and hepatic angiography displayed three small lesions in the liver with outstanding findings consistent with hepatocellular carcinoma （HCC）. Surgical resection was performed and the three lesions were microscopically diagnosed as RLH of the liver. The lesions comprised a massive infiltration of lymphoid cells with follicles and hyalinized inter- follicular spaces. Immunohistochemical examination revealed that infiltrating lymphocytes had no prominent nuclear atypia and polyclonality. RLH of the liver is a very rare condition and only twelve cases have been reported in the English literature. Majority of the reported cases were middle-aged women and about half of them had some immunologic abnormalities such as autoimmune thyroiditis, Sjogren＇s syndrome, primary immunodeficiency, primary biliary cirrhosis. Since they are olden clinically misdiagnosed as HCC, surgery is the choice of treatment for these patients. Although their pathology resembles malignant lymphoma, the clinical course is completely benign. The authors propose that RLH of the liver can be discriminated from HCC by its clinical features.

关键词： Reactive lymphoid hyperplasia Pseudo lymphoma Hepatocellular carcinoma Autoimmunethyroiditis Immunohistochemistry

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Enzymatic treatment of estrogens and estrogen glucuronide

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Journal of Environmental Sciences 2009年第6期21卷 731-735页

作者： Takaaki Tanaka toshiyuki Tamura Yuuichi Ishizaki Akito Kawasaki Tomokazu Kawase Masahiro Teraguchi Masayuki Taniguchi Department of Materials Science and Technology Niigata University Venture Business Laboratory Niigata University Department of Chemistry and Chemical Engineering Niigata University

Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens （estrone, 17β-estradiol, and 17α-ethynyletstradiol） by a fungal laccase which oxidize phenolic compounds with dissolved oxygen. The elimination of the estrogenic activities by enzymatic oxidation was demonstrated by medaka vitellogenin assay. In addition, we developed an enzymatic treatment system comprised of β-D-glucuronidase and the laccase for 17β-estradiol 3-（β-D-glucuronide） degradation. The two enzymes eliminated 17β-estradiol 3-（β- D-glucuronide） and the intermediate, 17β-estradiol, efficiently.

关键词： enzymatic treatment laccase estrone estradiol ethynylestradiol glucuronidase glucuronide

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Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138

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World Journal of Gastroenterology 2009年第44期15卷 5533-5540页

作者： Tatsuhiro Tsujimoto Hideto Kawaratani toshiyuki Kitazawa Hitoshi Yoshiji Masao Fujimoto Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan

AIM:To investigate the possible use of the multiple cytokine production modulator,Y-40138,as a novel immunotherapy in the rat nonalcoholic steatohepatitis (NASH) model. METHODS:We allocated 6-wk-old male F344 rats to choline-supplemented,L-amino acid-defined (CSAA) diet (control group),CSAA diet + Y-40138 (control + Y-40138 group),choline-def icient,L-amino acid-def ined (CDAA) diet (NASH group),or CDAA diet + Y-40138 (NASH + Y-40138 group). In each group,we measured the plasma alanine aminotransferase (ALT) levels,and the plasma and liver levels of tumor necrosis factor-α (TNF-α),interferon-γ (IFN-γ),and interleukin-10 (IL-10). Tissue specimens of phosphate buffered saline-perfused liver were subjected to hematoxylin and eosin staining,Azan staining,Sirius red staining,and immunohistochemical staining (for Kupffer cells and TNF-α). We then extracted Kupffer cells from the collagenase-perfused livers using the Percoll gradient centrifugation method,and measured the TNF-α levels in the supernatant (in vitro TNF-α production by Kupffer cells) using an enzyme-linked immunosorbent assay ***:In comparison to the NASH group,serumALT elevation was mild,production of serum and liver TNF-α and IFN-γ was inhibited,and IL-10 production was increased in the NASH + Y-40138 group. Amelioration of liver histology was also noted in the NASH + Y-40138 group. Kupffer cell immunohistochemical staining revealed no differences between groups,whereas TNF-α immunohistochemical staining showed fewer stained cells in the NASH + Y-40138 group than in the NASH group. The TNF-α levels in the in-vitro Kupffer cell culture supernatant were lower in the NASH + Y-40138 group than in the NASH ***:Administration of Y-40138 to NASH model rats reduced hepatic inflammation and suppressed fibrosis. These results indicate that the multiple cytokine production modulator,Y-40138,is promising as a novel treatment for NASH.

关键词： Nonalcoholic steatohepatitis Y-40138 Tumor necrosis factor α Interferon γ Interleukin-10 Kupffer cell Innate immunity

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Orthodontic Ttreatments of Class Ⅲ Mandibular Rotated Cases

Orthodontic Ttreatments of Class Ⅲ Mandibular Rotated Cases

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Beijing International Conference on Orthodontics

作者： Shuichiro sawa

＜正＞Mandibular clockwise rotated eases are foten treated in Japanese orthodontic *** cases were maxillary protrusion or bimaxillary *** some cases don’t have the maxillary pro- trusion or labial inclined upper *** ...

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Factors associated with the overall survival of elderly patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第16期18卷 1926-1932页

作者： Hideki Fujii Yoshito Itoh Naoki Ohnishi Masafumi Sakamoto Tohru Ohkawara Yoshihiko sawa Koichi Nishida Yasuo Ohkawara Kanji Yamaguchi Masahito Minami Takeshi Okanoue Department of Internal Medicine Aiseikai Yamashina HospitalKyoto 602-8566Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan Hepatology Center Saiseikai Suita HospitalOsaka 564-0013Japan

AIM:To identify the factors associated with overall survival of elderly patients with hepatocellular carcinoma(HCC).METHODS:A total of 286 patients with HCC(male/female:178/108,age:46-100 years),who were diagnosed and treated by appropriate therapeutic procedures between January 2000 and December 2010,were enrolled in this *** were stratified into two groups on the basis of age:Elderly(≥ 75 years old) and non-elderly(< 75 years old).Baseline clinical characteristics as well as cumulative survival rates were then compared between the two *** and multivariate analyses were used to identify the factors associated with prolonged overall survival of patients in each *** survival rates in the two groups were calculated separately for each modified Japan Integrated Stage score(mJIS score) category by the Kaplan-Meier *** addition,we compared the cumulative survival rates of elderly and non-elderly patients with good hepatic reserve capacity(≤ 2 points as per mJIS).RESULTS:In the elderly group,the proportion of female patients,patients with absence of hepatitis B or hepatitis C viral infection,and patients with coexisting extrahepatic comorbid illness was higher(56.8% vs 31.1%,P < 0.001;27.0% vs 16.0%,P = 0.038;33.8% vs 22.2%,P = 0.047;respectively) than that in the nonelderly *** the non-elderly group,the proportion of hepatitis B virus(HBV)-infected patients was higher than that in the elderly group(9.4% vs 0%,P = 0.006).The cumulative survival rates in the elderly group were 53.7% at 3 years and 32.9% at 5 years,which were equivalent to those in the non-elderly group(55.9% and 39.4%,respectively),as shown by a log-rank test(P = 0.601).In multivariate analysis,prolonged survival was significantly associated with the extent of liver damage and stage(P < 0.001 and P < 0.001,respectively),but was not associated with patient ***,on individual evaluation of factors in both groups,stage was significantly(P < 0.001) associ

关键词： Age Hepatocellular carcinoma Liver damage Stage Survival

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Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet

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World Journal of Gastroenterology 2008年第43期14卷 6655-6661页

作者： Hideto Kawaratani Tatsuhiro Tsujimoto toshiyuki Kitazawa Mitsuteru Kitade Hitoshi Yoshiji Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical University840 Shijo-choKashiharaNara 634-8522Japan

AIM： To investigate the innate immune reactivity of tumor necrosis factor-alpha （TNF-α）, Toll-like receptor 4 （TLR4）, and CD14 in the liver of non-alcoholic steatohepatitis （NASH） model rats. METHODS： Male F344 rats were fed a cholinedeficient L-amino-acid-defined （CDAA） diet. The rats were killed after 4 or 8 wk of the diet, and their livers were removed for immunohistochemical investigation and RNA extraction. The liver specimens were immunostained for TNF-α, TLR4, and CD14. The gene expressions of TNF-α, TLR4, and CD14 were determined by reverse-transcriptase polymerase chain reaction （RT-PCR）. Kupffer cells were isolated from the liver by Percoll gradient centrifugation, and were then cultured to measure TNF-α production. RESULTS： The serum and liver levels of TNF-~ in the CDAA-fed rats increased significantly as compared with the control group, as did the immunohistochemical values and gene expressions of TNF-α, TLR4, and CD14 with the progression of steatohepatitis. TNF-α production from the isolated Kupffer cells of the CDAAfed rats was elevated by lipopolysaccharide stimulation. CONCLUSION： The expressions of TNF-α, TLR4, and CD14 increased in the NASH model, suggesting that

关键词： Nonalcoholic steatohepatitis Kupffer cells Toll-like receptor 4 CD14 Endotoxins Tumor necrosisfactor-alpha

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Identifying key traits in high-yielding rice cultivars for adaptability to both temperate and tropical environments

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The Crop Journal 2019年第5期7卷 685-693页

作者： toshiyuki Takai Patrick Lumanglas Eliza Vie Simon Yumiko Arai-Sanoh Hidetoshi Asai Nobuya Kobayashi Japan International Research Center for Agricultural Sciences TsukubaIbaraki 305-8686Japan International Rice Research Institute DAPO Box 7777Metro ManilaPhilippines Institute of Crop Science National Agriculture and Food Research Organization(NARO)TsukubaIbaraki 305-8518Japan

Increasing rice yield potential is a continuous challenge posed by world population *** increase yield potential,favorable alleles of valuable genes need to be accumulated in promising *** conducted comparative yield trials for two years in Tsukuba,Japan,in a temperate region and at the International Rice Research Institute(IRRI),Philippines,in a tropical region using five high-yielding rice cultivars:Takanari and Hokuriku193,developed in Japan,and IR64,NSIC Rc158,and YTH183,developed in the *** plus genotype×environment interaction(GGE)biplot analysis across four environments(two regions×two seasons)classified the five cultivars into four categories:Takanari and YTH183 showed high adaptability to both tropical and temperate regions,Hokuriku193 was suitable for temperate regions,NSIC Rc158 was suitable for the tropics,and IR64 was inferior to the other cultivars in both *** high yield and adaptability in Takanari and YTH183 were attributed to their large sink capacity with good grain *** plant type for high yield was different,however,between the two cultivars;Takanari was a panicle-weight type,whereas YTH183 was a panicle-number *** of F2 progeny of a cross between Takanari and YTH183 showed transgressive segregation for number of panicles per plant as well as number of spikelets per panicle,leading some F2 plants to produce more spikelets per plant(corresponding to larger sink size)than the parental cultivars in both *** results suggest the possibility of developing rice cultivars with high yield potential in both temperate and tropical regions by crossing temperate with tropical high-yielding cultivars.

关键词： Adaptability Genotype×environment interaction Rice Sink capacity Yield potential

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Ultrasound-guided local ethanol injection for fertility-preserving cervical pregnancy accompanied by fetal heartbeat: Two case reports

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World Journal of Clinical Cases 2022年第11期10卷 3587-3592页

作者： toshiyuki Kakinuma Kaoru Kakinuma Yoshio Matsuda Michitaka Ohwada Kaoru Yanagida Hirotsune Kaijima Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan Minatomirai Yume Clinic Yokohama 220-0012Japan

BACKGROUND The incidence of cervical pregnancy is increasing due to the recent widespread application of assisted reproductive *** hysterectomy has been a treatment option,high-sensitivity human chorionic gonadotropin testing and improved accuracy of transvaginal ultrasound imaging have increased possibility of uterine *** and curettage with methotrexate therapy and uterine artery embolization have been reported as treatments with fertility preservation;however,certain disadvantages limit their *** SUMMARY In our two reported cases,we avoided massive bleeding and immediately resumed infertility treatment using ultrasound-guided local ethanol injection for cervical pregnancies with fetal *** This treatment may be a new fertility-preserving option for cervical pregnancy.

关键词： Ultrasonography Ethanol Infertility Fertility preservation Methotrexate Case report

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Patterns of plant diversity at high altitudes on the Qinghai-Tibetan Plateau

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Journal of Plant Ecology 2010年第1期3卷 1-7页

作者： Ayako Shimono Huakun Zhou Haihua Shen Mitsuru Hirota toshiyuki Ohtsuka Yanhong Tang Environmental Biology Division National Institute for Environmental StudiesTsukubaIbaraki 305-8506Japan Present address:Department of Ecology and Environmental Science Umea°UniversityUmea°901-87Sweden Northwest Plateau Institute of Biology Chinese Academy of SciencesXining 810001QinghaiChina Graduate School of Life and Environmental Sciences University of TsukubaTsukubaIbaraki 305-8572Japan Institute for Basin Ecosystem Study Gifu University1-1 YanagitoGifuGifu 501-1193Japan

To describe the biodiversity patterns of plants along an altitudinal gradient on the Qinghai-Tibetan Plateau and to clarify the bias in plant specimen records at high *** We conducted a large-scale investigation of vegetation at a wide range of altitudes,focusing on a high-altitudinal range(3200-5200 m)at different locations on the Qinghai-Tibetan *** then compared the altitudinal distribution of plant species obtained from our field investigation with that in plant specimen records from published sources and an online *** Findings Our data provide evidence that altitude plays a large role in regulating species composition on the Qinghai-Tibetan *** could not,however,detect a clear relationship between altitude and species richness,although a weak monotonically increasing trend of richness was detected with increasing *** to specimen records,most species have been sampled at a wide range of altitudes,and the average range of 145 species is>2000 *** this wide range,more than half of the species we observed were at higher altitudes than the specimen records ***-altitude areas have probably been so poorly sampled that only a small fraction of the resident species has been *** study clearly shows the regional bias of specimen records in the Qinghai-Tibetan Plateau.

关键词： altitudinal gradient alpine plant species composition species richness specimen bias

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