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World Journal of Clinical Cases 2021年第27期9卷 7963-7972页

作者： Daisuke Usuda toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Department of Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

Exophiala is a genus comprising several species of opportunistic black yeasts,which belongs to *** is a rare cause of fungal ***,infections are often chronic and recalcitrant,and while the number of cases is steadily increasing in both immunocompromised and immunocompetent people,detailed knowledge remains scarce regarding infection mechanisms,virulence factors,specific predisposing factors,risk factors,and host *** most common manifestations of Exophiala infection are skin infections,and the most frequent type of deep infection is pulmonary infection due to *** invasive disease ranges from cutaneous or subcutaneous infection to systemic dissemination to internal *** final identification of the causative organism should be achieved through a combination of several methods,including the newly introduced diagnostic analysis,matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry,together with sequencing of the ribosomal ribonucleic acid internal transcribed spacer region of the fungi,and histological and culture *** treatment,because anti-infective agents and natural compounds exhibited poor antibiofilm activity,few treatments have ultimately been found to be effective for specific antifungal therapy,so the optimal antifungal therapy and duration of therapy for these infections remain ***,most forms of disease caused by Exophiala dermatitidis require aggressive combination therapies:Both surgical intervention and aggressive antifungal therapy with novel compounds and azoles are necessary for effective treatment.

关键词： Exophiala dermatitidis Black yeast Immunocompromised host Matrixassisted laser desorption/ionization-time-of-flight mass spectrometry Ribosomal ribonucleic acid Antifungal drugs

Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction

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World Journal of Gastroenterology 2012年第21期18卷 2735-2738页

作者： toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi Division of Gastroenterology National Hospital Organization Tokyo Medical CenterTokyo 1528902 Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of MedicineTokyo 1608582 Japan Division of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555 Japan Division of Gastroenterology National Kyushu Medical CenterFukuoka 8108563 Japan Division of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 7208520 Japan Division of Gastroenterology National Hospital Organization Kure Medical CenterKure 7370023 Japan Division of Gastroenterology National Hospital Organization Hakodate Medical CenterHakodate 0418512 Japan Division of Gastroenterology National Hospital Organization Maizuru Medical CenterMaizuru 6258502 Japan Division of Gastroenterology National Hospital Organization Higashihiroshima Medical CenterHigashihiroshima 7390041 Japan Division of Gastroenterology National Hospital Organization Sendai Medical CenterSendai 9838520 Japan Division of Gastroenterology National Hospital Organization Osaka Medical CenterOsaka 5400006 Japan Division of Gastroenterology National Hospital Organization Ureshino Medical CenterUreshino 8430393 Japan Division of Gastroenterology National Hospital Organization Osaka Minami Medical CenterKawachinagano 5868521 Japan Division of Gastroenterology National Hospital Organization Fukuoka Higashi Medical CenterKoga 8113195 Japan Division of Gastroenterology National Hospital Organization Yonago Medical CenterYonago 6838518 Japan Division of Gastroenterology National Hospital Organization Disaster Medical CenterTachikawa 1900014 Japan Pharmaceutical Department National Center for Global Health and MedicineTokyo 1658655 Japan

We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.

关键词： Helicobacter pylori Amoxicillin Dual therapy Eradication Urea breath test

二垩英与资源回收-Ⅱ燃烧过程二垩英抑制和生成基础研究

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钢铁 2003年第Z1期38卷 76-78页

作者： Hirotoshi KAWABATA Tateo USUI Shigeta HARA toshihiro TANAKA Hideki ONO-NAKAZATO Mashayuki TANABE Katsukiyo MARUKAWA Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Baoshan Iron & Steel Co. LTD China and Collaborative Research Center for Advanced Science and Technology Osaka University Japan

氯来源、种类和燃烧物中氯浓度对燃烧过程中二垩英生成有重要影响.在实验燃烧炉中研究1 073K温度下上述三种因素对燃烧过程二垩英生成的影响.二垩英生成浓度在相同氯源和种类条件下与燃烧物中氯含量几乎成正比,且受氯源明显影响.如有机... 详细信息

氯来源、种类和燃烧物中氯浓度对燃烧过程中二垩英生成有重要影响.在实验燃烧炉中研究1 073K温度下上述三种因素对燃烧过程二垩英生成的影响.二垩英生成浓度在相同氯源和种类条件下与燃烧物中氯含量几乎成正比,且受氯源明显影响.如有机氯化合物或无机氯化物.即使对无机氯化物,在有活性氯存在时也会生成高浓度二垩英,如由盐和面粉形成的水化物中的活性氯.

关键词：氯源氯种类燃烧过程二垩英/呋喃水化物 PVC

二垩英与资源回收-Ⅰ考虑到二垩英生成的资源与能量回收基础研究

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钢铁 2003年第Z1期38卷 73-75页

作者： Katsukiyo MARUKAWA Shigeta HARA Hirotoshi KAWABATA Hideki ONO-NAKAZATO Tateo USUI toshihiro TANAKA Hongzhi SHI Baoshan Iron & Steel Co. LTD China and Collaborative Research Center for Advanced Science and Technology Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan （Graduate School of Engineering Osaka University Japan） Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Baoshan Iron & Steel Co. LTD China

目前在日本,存在大量工业垃圾,包括各种塑料制品,ASR(汽车破碎垃圾),含有毒PCB(多氯联苯)的110变压器和PVC(聚氯乙稀)制品等.而来自城市垃圾焚烧炉的废气含有大量能量.因此,在充分考虑环境、避免二垩英生成的同时,安全回收来自工业垃圾... 详细信息

目前在日本,存在大量工业垃圾,包括各种塑料制品,ASR(汽车破碎垃圾),含有毒PCB(多氯联苯)的110变压器和PVC(聚氯乙稀)制品等.而来自城市垃圾焚烧炉的废气含有大量能量.因此,在充分考虑环境、避免二垩英生成的同时,安全回收来自工业垃圾、城市和/或工业垃圾焚烧炉的资源和能量是个非常重要的课题,这也将对抑制CO2排放作出贡献.正确地阐明焚烧过程中二垩英的生成机理及详细研究含少量二垩英的焚烧废气在冷却过程中大量形成二垩英的临界温度是项很重要的工作.解决这个问题可有效实现资源和能量的回收.本报告介绍日本在二垩英排放方面目前采取的对策和存在的问题以及大阪大学为阻止二垩英生成所做的基础研究工作.

关键词：焚烧过程工业垃圾和废钢二垩英生成机理资助和能量回收抑制二垩英生成

二垩英与资源回收-Ⅲ燃烧过程二垩英生成热力学计算

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钢铁 2003年第Z1期38卷 79-81页

作者： Hideki Ono-Nakazato Hirotoshi Kawabata Tateo Usui Shigeta Hara toshihiro Tanaka Mashayuki Tanabe Katsukiyo Marukawa Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Baoshan Iron & Steel Co. LTD China and Collaborative Research Center for Advanced Science and Technology Osaka University Japan

进行相关热力学计算以研究高温燃烧过程二垩英生成的条件.计算得到:①在体系存在过剩氧即完全燃烧时不会产生二垩英;②当有固体碳沉积时也不会生成二垩英,因固体碳在热力学上比含二垩英的含碳物更稳定.另一方面,实际上即使在1 073 K完... 详细信息

进行相关热力学计算以研究高温燃烧过程二垩英生成的条件.计算得到:①在体系存在过剩氧即完全燃烧时不会产生二垩英;②当有固体碳沉积时也不会生成二垩英,因固体碳在热力学上比含二垩英的含碳物更稳定.另一方面,实际上即使在1 073 K完全燃烧条件下(即体系显著过剩氧)也有二垩英生成,原因是在实际燃烧炉中含碳微粒不可能完全烧尽.从热力学角度假设不发生碳沉积,计算得出二垩英在1 073 K高温和高CO/CO2比范围内会生成.实际考虑的条件放在燃烧炉内含碳微粒的周围.在有含碳微粒存在条件下,即使反应2CO→C+CO2(碳沉积)发生,C+CO2→2CO反应(CO生成;含碳微粒被CO2氧化)也会同时发生,导致在含碳微粒周围保持一个高的CO/CO2比,由此产生二垩英.假设在含碳微粒周围存在高CO/CO2比的异质位置,则认为二垩英会形成.

关键词：燃烧过程二垩英生成含碳微粒热力学

PCR技术对Wilson病基因进行定点突变的研究

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中山医科大学学报 2002年第2期23卷 94-96,F002页

作者：闫振文梁秀龄杨春水侯国庆王莹 toshihiro Sugiyama 中山医科大学附属第一医院神经内科广东广州510080

【目的】利用聚合酶链反应 (PCR)技术对Wilson病 (WD)基因进行体外定点突变的研究。【方法】采用PCR定点突变技术 ,首先设计两对引物 ,将突变位点设计在引物上 ,通过重叠延伸法两次PCR扩增 ,扩增片段上含有所需要的突变位点 ,最后将扩... 详细信息

【目的】利用聚合酶链反应 (PCR)技术对Wilson病 (WD)基因进行体外定点突变的研究。【方法】采用PCR定点突变技术 ,首先设计两对引物 ,将突变位点设计在引物上 ,通过重叠延伸法两次PCR扩增 ,扩增片段上含有所需要的突变位点 ,最后将扩增片段克隆入pRc/CMV载体中。【结果】DNA测序表明在预期位点已经发生突变 ,WD基因第 778位密码子由精氨酸 (Arg)残基突变为亮氨酸残基 (Leu) ,用PCR定点突变技术成功构建Wilson病基因突变体。【结论】PCR技术诱导定点突变准确、高效。Wilson病基因突变体的构建成功 ,为进一步研究该突变位点导致Wilson病的发病机制和Wilson病蛋白的结构和功能的关系奠定了基础。

关键词：肝豆状核变性遗传学聚合酶链反应定点诱变基因突变研究

DIOXINS AND RECYCLING OF RESOURCES-Ⅰ FUNDAMENTAL STUDIES ON RECOVERY OF RESOURCES AND ENERGY IN CONSIDERATION OF DIOXINS FORMATION

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DIOXINS AND RECYCLING OF RESOURCES-Ⅰ FUNDAMENTAL STUDIES ON...

Solar power sail mission of OKEANOS

International Symposium on Global Environment and Steel Industry(ISES’03)

作者： Katsukiyo MARUKAWA Shigeta HARA Hirotoshi KAWABATA Hideki ONO-NAKAZATO Tateo USUI toshihiro TANAKA Baoshan Iron ＆ Steel Co. LTD China and Collaborative Research Center for Advanced Science and Technology Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan Graduate School of Engineering Osaka University Japan

＜正＞At present in Japan, there are a large amount of industrial wastes which include many kind of plastic products, a great amount of ASR （Automobile Shredder Rubbish）, many used transformers containing toxic polychlorinated biphenyl （PCB）, and a large amount of poly vinyl chloride （PVC） products and so on. Furthermore, the exhaust gas from municipal waste incinerator has a great quantity of energy. Therefore, the safe recovery of resources and energy from industrial wastes and municipal and/or industrial waste incinerators is very important subjects with no dioxins/furans （Dioxins） formation in sufficient consideration of the environment and also will be able to contribute to the suppression of CO2 *** is very important assignments to exactly elucidate the mechanism of Dioxins formation in incineration processes and to more investigate the critical temperature at which Dioxins formation becomes remarkable in cooling processes of an exhaust gas having little Dioxin’s concentration. The recovery of resources and energy can be effectively realized when those assignments are solved This report introduces the present countermeasures and the remaining subjects in Japan for Dioxins emission and fundamental studies in Osaka University with the aim of no Dioxins formation.

关键词： Incineration process Industrial waste and scrap Mechanism of Dioxins formation Recovery of resource and energy Suppression of Dioxins formation

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu Mori Jun Matsumoto toshihiro Chujo Masanori Matsushita Hideki Kato Takanao Saiki Yuichi Tsuda Jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS

Preliminary Clinical Study Using a Novel Wound Dressing Composed of Hyaluronic Acid and Collagen Containing EGF

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Open Journal of Regenerative Medicine 2015年第1期4卷 6-13页

作者： Akane Yu Akira Takeda Kenichi Kumazawa Hiroshi Miyoshi Misato Kuroyanagi toshihiro Yoshitake Eiju Uchinuma Ryusuke Suzuki Yoshimitsu Kuroyanagi R&D Center for Artificial Skin Kitasato University Kanagawa Japan Department of Plastic and Aesthetic Surgery Kitasato University Kanagawa Japan Kitasato University Hospital Emergency Center Kanagawa Japan Sagamihara Kyodo Hospital Kanagawa Japan

This clinical trial aimed to evaluate the efficacy and safety of a novel wound dressing composed of hyaluronic acid (HA) and collagen (Col) containing epidermal growth factor (EGF), referred to as EGF-wound dressing. EGF-wound dressing was prepared by freeze-drying a mixed aqueous solution of high-molecular-weight HA, low-molecular-weight HA and heat-denatured Col containing EGF. EGF-wound dressing was applied to skin defects, such as intractable skin ulcers, burn ulcers, traumatic skin defects and skin donor-site wounds. The dressing was changed twice a week for a period of 6 weeks or longer, if necessary. The primary endpoints were size of wound area, formation of granulation tissue, extent of epithelialization, infection control and macroscopic appearance. Effectiveness, safety and overall clinical evaluation were scored by plastic surgeons, as authorized by the Japanese Society of Plastic and Reconstructive Surgery. This study was registered with the University Hospital Medical Information Network (UMIN0000005264). Healthy granulation tissue and rapid epithelialization were observed for a given period after application of EGF-wound dressing onto the wounds. Most cases were assessed as having achieved good or excellent results. This clinical study demonstrated that EGF-wound dressing was beneficial in the treatment of various skin defects.

关键词： Hyaluronic Acid Collagen Epidermal Growth Factor Wound Dressing