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Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection

Bioactive Materials 2021年第11期6卷 1150-1162页

作者： Chaoqiang Fan Kaige Xu Yu Huang Shuang Liu tongchuan wang Wei wang Weichao Hu Lu Liu Malcolm Xing Shiming Yang Department of Gastroenterology Xinqiao HospitalArmy Medical UniversityNO.183Xinqiao StreetShapingba DistrictChongqing City400037People’s Republic of China Department of Mechanical Engineering Biochemistry and Medical GeneticsUniversity of ManitobaWinnipeg MBR3T 2N2ManitobaCanada

Endoscopic submucosal dissection(ESD)is a common procedure to treat early and precancerous gastrointestinal *** submucosal injection,a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic *** is a most common submucosal injection liquid,but the formed liquid pad lasts only a short time,and thus repeated injections increase the potential risk of adverse *** with high osmotic pressure and high viscosity are used as an alternate;however,with some drawbacks such as tissue damage,excessive injection resistance,and high ***,we reported a nature derived hydrogel of gelatin-oxidized alginate(G-OALG).Based on the rheological analysis and compare to commercial endoscopic mucosal resection(EMR)solution(0.25%hyaluronic acid,HA),a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability,higher viscosity and more stable *** G-OALG gel also showed lower propulsion resistance than 0.25%HA in the injection force assessment under standard endoscopic instruments,which eased the surgical *** addition,the G-OALG hydrogel showed good in vivo degradability *** comparing the results acquired via ESD to normal saline,the G-OALG shows great histocompatibility and excellent endoscopic injectability,and enables create a longer-lasting submucosal *** the features have been confirmed in the living both pig and rat *** G-OALG could be a promising submucosal injection agent for esophageal ESD.

关键词： Injectable hydrogel Controllable gelation and viscosity Esophageal submucosal liquid cushion Early esophageal cancer Pig model

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基于半监督学习的遥感影像变化检测研究综述

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现代计算机 2024年第1期30卷 61-65页

作者：唐天俊王铜川重庆开放大学城市建设工程学院重庆401520 重庆市地理信息和遥感应用中心重庆401121

近年来,在人工智能技术与遥感大数据的深度融合下,基于深度学习的全监督变化检测框架通过大量标注数据训练,表现出优异的性能。然而,变化检测数据标注需要逐像素比对两影像间差异,这将消耗大量的人力、时间成本。为解决数据标注的局限性... 详细信息

近年来,在人工智能技术与遥感大数据的深度融合下,基于深度学习的全监督变化检测框架通过大量标注数据训练,表现出优异的性能。然而,变化检测数据标注需要逐像素比对两影像间差异,这将消耗大量的人力、时间成本。为解决数据标注的局限性,基于半监督学习变化检测框架逐渐成为变化检测研究热点,该框架能充分利用大量的无标注数据提高变化检测方法的鲁棒性,减少模型对标注数据的依赖。

关键词：遥感影像深度学习半监督学习变化检测

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植被茂密地区点云双重滤波方法研究

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激光技术 2022年第2期46卷 233-238页

作者：王云云唐菲菲王章朋肖敏唐天俊王铜川重庆交通大学土木工程学院重庆400074 上海宝冶集团有限公司上海201908 杭州钱塘测绘有限公司杭州310000

为了解决目前机载激光雷达点云滤波算法中特征单一、运算效率低、植被覆盖区效果较差等问题,提出一种植被茂密地区的点云自适应双重滤波方法。首先利用回波分离方法,分别提取点云的单次回波和末次回波进行粗滤波处理;然后利用偏度平衡... 详细信息

为了解决目前机载激光雷达点云滤波算法中特征单一、运算效率低、植被覆盖区效果较差等问题,提出一种植被茂密地区的点云自适应双重滤波方法。首先利用回波分离方法,分别提取点云的单次回波和末次回波进行粗滤波处理;然后利用偏度平衡理论进行单次回波的强度阈值确定,同时利用最大类间方差法对首次回波和末次回波的高程差进行高差运算,实现末次回波高差阈值自动化,并融合粗滤波后单次回波和末次回波的点云数据;最后,利用不规则三角网渐进加密滤波算法对融合后的点云数据进行精滤波处理,并通过了实验验证。结果表明,3组数据集的Ⅱ类误差都相对较低,分别为1.06%,1.64%,1.34%。结合回波信息和高差信息的双重滤波方法不仅能较好地剔除植被,而且能较好地保留地形细节。

关键词：激光技术滤波偏度平衡点云最大类间方差法不规则三角网渐进加密滤波算法

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川东五百梯地区石炭系岩溶古地貌识别及储集意义

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岩性油气藏 2024年第4期36卷 109-121页

作者：王同川陈浩如温龙彬钱玉贵李玉琢文华国油气藏地质及开发工程全国重点实验室成都理工大学成都610059 成都理工大学沉积地质研究院成都610059 西华师范大学环境科学与工程学院四川南充637009 中石化西南油气分公司勘探开发研究院成都610041

综合利用钻井、测井、岩心及地震资料,通过建立地震正演模型模拟、RGB分频融合技术及波形分类分析等手段,对川东五百梯地区石炭系岩溶古地貌进行了识别与刻画。研究结果表明:(1)川东五百梯地区石炭系遭受的岩溶作用强度自西向东逐渐变小... 详细信息

综合利用钻井、测井、岩心及地震资料,通过建立地震正演模型模拟、RGB分频融合技术及波形分类分析等手段,对川东五百梯地区石炭系岩溶古地貌进行了识别与刻画。研究结果表明:(1)川东五百梯地区石炭系遭受的岩溶作用强度自西向东逐渐变小,东南部石炭系原始沉积厚度更大,但残余厚度分布不均匀,主要为10~30 m;西北部地层厚度较小,为0~15 m。(2)研究区石炭系自西向东可识别出岩溶高地和岩溶斜坡2个二级地貌单元,岩溶斜坡可划分为残丘和浅洼2个三级地貌单元,再依据其差异溶蚀特征,可进一步划分为陡斜坡浅洼和缓斜坡浅洼,浅洼内发育残丘、暗河及落水洞。反射同相轴的上提和下拉特征、岩溶角砾岩的发育、地震层拉平剖面、RGB分频融合及波形变化特征等均可识别出岩溶古地貌的发育。(3)研究区石炭系各地貌单元的分布受构造控制,浅洼和残丘多以椭圆状或不规则长条状呈北西—南东向展布,暗河的展布与浅洼长轴方向一致;岩溶古地貌控制着地层厚度以及溶蚀孔洞的发育,残丘残余厚度较大,岩溶作用强,充填作用较弱,溶蚀孔洞较发育,储层平均孔隙度为4.34%;缓斜坡浅洼残余厚度较小,充填作用较强,溶蚀孔洞不发育,储层平均孔隙度为2.68%,而陡斜坡浅洼虽然残余厚度小,但因潜水位低、泄水能力强,溶蚀作用强而充填作用弱,储集空间发育,储层平均孔隙度为5.05%;缓斜坡和陡斜坡储层平均孔隙度分别为3.67%和3.31%,岩溶高地孔隙度最小,平均为2.51%。

关键词：岩溶古地貌浅洼残丘岩溶斜坡带地震正演模拟 RGB分频融合岩溶角砾岩黄龙组石炭系川东五百梯地区

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Factors controlling deep-profile soil organic carbon and water storage following Robinia pseudoacacia afforestation of the Loess Plateau in China

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Forest Ecosystems 2022年第6期9卷 838-851页

作者： Xi Yang tongchuan Li Ming'an Shao State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling712100China College of Natural Resources and Environment Northwest A&F UniversityYangling712100China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing100190China

Background:Afforestation is a common and effective approach used for the restoration of degraded ecosystems *** China,Robinia pseudoacacia(RP)is among the main non-native tree species and has been widely planted in revegetation of the Loess ***,owing to uncertainties regarding soil water consumption and carbon sequestration,it is necessary to assess the suitability and sustainability of *** in *** this study,we aimed to analyse the dynamic effects of *** forest on soil carbon storage(SCS)and soil water storage(SWS).Specifically,we investigated the association between soil water content(SWC)and soil organic carbon(SOC)and underlying factors in the 0-500-cm profile of a 10-to 50-year-old ***:The results obtained indicated that the dynamics of SWS and SCS on this time scale could be divided into an initial reduction phase(the initial 20 years after afforestation)and subsequent recovery(20-50 years after afforestation).Compared with in the abandoned land(AL),the net accumulation of SCS in *** forest was 2.51 Mg·ha^(-1)at 50 years after afforestation,whereas there was a 398.76-mm deficit in ***,the natural succession of *** forest has contributed to the continuous change in stand structure(*** cover(VC),understory vegetation coverage(UVC),and litter biomass(LB)).Conclusions:These findings indicate that vegetation restoration increases carbon sequestration while causing soil water ***,stand density(SD)was established to make a predominant contribution to the dynamics of SWS and SCS via its effects in altering vegetation,soil,and litter ***,high-density plantation forests in the Loess Plateau area should be appropriately thinned to reduce the density of forest stands on the basis of soil erosion control and wind and sand fixation,so as to increase carbon sink with lower water consumption,thus realizing the synergistic

关键词： Afforestation Robinia pseudoacacia Soil organic carbon Soil water Coupling interaction

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Twenty years of Gendicine?rAd-p53 cancer gene therapy:The first-in-class human cancer gene therapy in the era of personalized oncology

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Genes & Diseases 2024年第4期11卷 234-245页

作者： Li Qi Guiqing Li Peipei Li Hongwei wang Xiaolong Fang tongchuan He Jingjing Li Affiliated Hospital of Weifang Medical University School of Clinical MedicineWeifang Medical UniversityWeifangShandong 262700China Jinming Yu Academician Workstation of Oncology Affiliated Hospital of Weifang Medical UniversityWeifangShandong 262700China Decording Therapeutics Corp Shangha 200000China Yangkun Biogroup Co. LtdNanjingJiangsu 210002China The University of Chicago ChicagoIL 60290USA

Genetic mutations in TP53 contribute to human malignancies through various *** date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other *** review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of *** human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene *** herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical ***,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy ***,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.

关键词： Gendicine Gene therapy p53 mutation Recombinant p53 adenovirus TP53

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基于DQN的智能农机路径跟踪控制研究

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农机化研究 2025年第3期47卷 28-34页

作者：杨琰张瑞瑞张林焕陈立平伊铜川吴明齐岳晓龙江苏大学农业工程学院江苏镇江212013 北京市农林科学院智能装备技术研究中心北京100097 农芯(南京)智慧农业研究院有限公司南京211800

针对复杂路面条件下无人化农业作业车辆路径跟踪控制精度低、控制器参数整定困难的问题,设计了一种基于深度强化学习的路径跟踪控制算法。基于五层BP神经网络构建了DQN(Deep Q-Network)路径跟踪控制器,实现了网络的轻量化和高度的可移... 详细信息

针对复杂路面条件下无人化农业作业车辆路径跟踪控制精度低、控制器参数整定困难的问题,设计了一种基于深度强化学习的路径跟踪控制算法。基于五层BP神经网络构建了DQN(Deep Q-Network)路径跟踪控制器,实现了网络的轻量化和高度的可移植性。控制器网络的输入状态在采用车辆当前舵角、车辆与目标路径上控制点间横向距离偏差的基础上,引入车辆前方设定距离内的平均路径曲率,实现了车辆转向性能的提高。分别开展了仿真和田间试验,验证了所设计深度强化学习网络算法的收敛性,并对比了有路径曲率输入和无路径曲率输入两种网络的路径跟踪控制性能。仿真试验中,基于正弦曲线对两种路径跟踪控制方法进行训练,两种路径跟踪控制网络收敛后的平均跟踪距离误差为0.008 4、0.017 7 m。在间隔6 m的U型路径上进行田间测试试验,结果显示:有路径曲率输入的模型性能显著优于无路径曲率输入的模型,两种路径跟踪控制方法在路径上平均跟踪距离误差为0.038 9、0.068 4 m。验证了该路径跟踪控制方法有效性,可满足农业作业车辆路径跟踪控制需求。

关键词：路径跟踪深度强化学习 DQN 路径曲率智能农机

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Droplets movement and deposition of an eight-rotor agricultural UAV in downwash flow field

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 47-56页

作者： Tang Qing Zhang Ruirui Chen Liping Xu Min Yi tongchuan Zhang Bin Beijing Research Center of Intelligent Equipment for Agriculture Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China National Research Center of Intelligent Equipment for Agriculture Beijing 100097China Beijing Key Laboratory of Intelligent Equipment Technology for Agriculture Beijing 100097China

The movement and deposition of the droplets sprayed by agricultural unmanned aerial vehicle(UAV)are influenced by the complex downwash flow field of the *** of conducting field experiment,a high speed particle image velocimetry(PIV)method was used to measure the movement and deposition of the droplets at different rotating speeds of rotors(1000-3000 r/min)or at different transverse injecting points(20-50 cm away from its nearby rotors)in the downwash flow field of an agricultural UAV with eight rotors and conical *** maximum speed and size of the high speed zone of the droplets were found greatly influenced by the downwash *** initial spray angle of the nozzle declined with the increase of downwash flow *** was found that the downwash velocity could not only change the deposition zone of the droplets,but also influence their *** increase of the downwash velocity would increase the deposition uniformity of the *** nozzle position in the downwash flow field could also influence the deposition of the *** the transverse distance between the nozzle and its nearby rotors increased,the relative deposition near the downwash flow of the rotors increased ***,the distance between the deposition peak and the nozzle stayed *** initial spray angle of the nozzle was not influenced by the transverse distance between the nozzle and its nearby *** research results could provide a theoretical basis and reference for the optimization of the spray application of multi-rotor UAV to minimize droplets deposition uncertainty.

关键词： chemical spray droplet deposition UAV flow field multi-rotor

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All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis

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Genes & Diseases 2022年第6期9卷 1742-1756页

作者： Yanting Sun Yun He Jishuang Tong Daijiang Liu Haodong Zhang tongchuan He Yang Bi Stem Cell Biology and Therapy Laboratory Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014PR China Department of Pediatric Surgery Children’s Hospital of Chongqing Medical UniversityChongqing 400014PR China Department of Gastroenterology Chongqing Emergency Medical CentreChongqing 400014PR China Molecular Oncology Laboratory Department of SurgeryThe University of Chicago Medical CentreChicagoIL 60637USA

All-trans retinoic acid(ATRA)can reverse the malignant behaviors of hepatocellular carcinoma(HCC)cells,thereby exerting anti-HCC effect;however,the underlying mechanism is yet to be *** study aimed to demonstrate that ATRA is vital to ferroptosis in ***-related genes exhibit different expression in patients with HCC compared to that in healthy individuals.A total of 20 amino acid products were detected in HepG2 cells,the expression level of 5 was decreased after ATRA *** improved the levels of lipid ROS,MDA,and NAPDt/NADPH,and reduced the mt-DNA copy number and changed the structure of mitochondria,in HepG2 and Hep3B *** found the expression of genes positively correlated with ferroptosis to increase and those negatively correlated to decrease with ATRA *** of ferroptosis by Ferrostatin-1 reversed ATRA-inhibited proliferation of HCC cells,along with cell migration and *** synthesis was blocked by ATRA,accompanied by decreased cystine content and increased glutamate content,and downregulation of the expression of GSH synthesis-related *** findings suggested that ATRA inhibited the malignancy of HCC cells by improving ferroptosis,and that inhibition of GSH synthesis contributed to ATRA-induced ferroptosis.

关键词： All-trans retinoic acid Ferroptosis Hepatocarcinoma Invasion Migration

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Self-consistent field theory and its applications in polymer systems

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Frontiers of Chemistry in China 2011年第4期6卷 310-331页

作者： Dadong YAN tongchuan SUO Xinghua ZHANG Xingkun MAN Bing MIAO Department of Physics Beijing Normal UniversityBeijing 100875China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

This review article addresses the widely used self-consistent field theory(SCFT)in interacting polymer *** theoretical framework and numerical method of solving the self-consistent equations are *** this paper,different structures of polymer can be considered,such as homopolymer,block copolymer,polydisperse polymer and charged *** systems,micro/macro phase separation,interface,self-assembly,are presented as examples to demonstrate its applications in ***,the fluctuation effects are *** first order is Gaussian fluctuation theory,which can be used to determine the stability of the mean-field solution and predict the kinetics of unstable *** derivation and applications of Gaussian fluctuation theory are presented as well.

关键词： self-consistent field theory(SCFT) Gaussian fluctuation theory self-assembly adsorption depletion polyelectrolyte confinement

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