Viscosity and degradation controlled injectable hydrogel for esophageal endoscopic submucosal dissection

作     者：Chaoqiang Fan Kaige Xu Yu Huang Shuang Liu Tongchuan Wang Wei Wang Weichao Hu Lu Liu Malcolm Xing Shiming Yang 

作者机构：Department of GastroenterologyXinqiao HospitalArmy Medical UniversityNO.183Xinqiao StreetShapingba DistrictChongqing City400037People’s Republic of China Department of Mechanical EngineeringBiochemistry and Medical GeneticsUniversity of ManitobaWinnipeg MBR3T 2N2ManitobaCanada 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第11期

页      面：1150-1162页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the the National Science Foundation of China(No.81802982) ChongQing Science&Technology Commission Fund(No.CSTC2018jcyjAX0102) 

主　　题：Injectable hydrogel Controllable gelation and viscosity Esophageal submucosal liquid cushion Early esophageal cancer Pig model 

摘      要：Endoscopic submucosal dissection(ESD)is a common procedure to treat early and precancerous gastrointestinal *** submucosal injection,a liquid cushion is created to lift and separate the lesion and malignant part from the muscular layer where the formed indispensable space is convenient for endoscopic *** is a most common submucosal injection liquid,but the formed liquid pad lasts only a short time,and thus repeated injections increase the potential risk of adverse *** with high osmotic pressure and high viscosity are used as an alternate;however,with some drawbacks such as tissue damage,excessive injection resistance,and high ***,we reported a nature derived hydrogel of gelatin-oxidized alginate(G-OALG).Based on the rheological analysis and compare to commercial endoscopic mucosal resection(EMR)solution(0.25%hyaluronic acid,HA),a designed G-OALG hydrogel of desired concentration and composition showed higher performances in controllable gelation and injectability,higher viscosity and more stable *** G-OALG gel also showed lower propulsion resistance than 0.25%HA in the injection force assessment under standard endoscopic instruments,which eased the surgical *** addition,the G-OALG hydrogel showed good in vivo degradability *** comparing the results acquired via ESD to normal saline,the G-OALG shows great histocompatibility and excellent endoscopic injectability,and enables create a longer-lasting submucosal *** the features have been confirmed in the living both pig and rat *** G-OALG could be a promising submucosal injection agent for esophageal ESD.