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The timing behavior of magnetar Swift J1822.3—1606: timing noise or a decreasing period derivative?

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Research in Astronomy and Astrophysics 2013年第10期13卷 1207-1212页

作者： Hao tong Ren-Xin xu Xinjiang Astronomical Observatory Chinese Academy of Sciences KIAA and School of Physics Peking University

The different timing results of the magnetar Swift J1822.3—1606 are analyzed and understood *** is noted that different timing solutions are caused not only by timing noise,but also because the period derivative is decreasing after the *** the decreasing period derivative and the large timing noise may originate from wind braking associated with the *** timing of Swift J1822.3—1606 will help clarify whether or not its period derivative is decreasing with time.

关键词： pulsars:individual(Swift J1822.3—1606) stars:magnetar stars:neutron

Causality Analysis of Futures Sugar Prices in Zhengzhou Based on Graphical Models for Multivariate Time Series

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 129-136页

作者： Jing xu Xing-wei tong School of Statistics University of International Business and Economics School of Statistics Beijing Normal University

This paper presents a method of constructing a mixed graph which can be used to analyze the causality for multivariate time *** construct a partial correlation graph at first which is an undirected *** every undirected edge in the partial correlation graph,the measures of linear feedback between two time series can help us decide its direction,then we obtain the mixed *** this method,we construct a mixed graph for futures sugar prices in Zhengzhou（ZF）,spot sugar prices in Zhengzhou（ZS） and futures sugar prices in New York（NF）.The result shows that there is a bi-directional causality between ZF and ZS,an unidirectional causality from NF to ZF,but no causality between NF and ZS.

关键词： causality partial spectral coherence partial correlation graph linear feedback mixed graph

DYNAMICS OF FREE STRAIGHT SWIMMING OF ANGULLA ANGULLA INCLUDING FORWARD,BRAKING AND BACKWARD LOCOMOTION

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Journal of Hydrodynamics 2007年第4期19卷 395-402页

作者： HU wen-rong tong Bing-gang LIU Hao Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China Laboratory for Biomechanics of Animal Locomotion Graduate University of the Chinese Academy of Sciences Beijing 100039 China Department of Electronics and Mechanical Engineering Chiba University Japan

Eels can swim backward by reversing the direction of the traveling wave along the body. The propulsive mechanism of an eel, angulla angulla, during its self-propelled straight swimming, including forward swimming, braking and switching direction to backward swimming was numerically studied. The problem was reasonably simplified to a loose-coupling problem of fish swimming dynamics and hydrodynamics only in the swimming direction. The approach involved the simulation of the flow by solving the two-dimensional unsteady incompressible N-S equations and the fish motion dynamic problem with Newton＇s second law. Visualizations of flow fields and vortex structures were performed. The propulsive mechanism and dynamics during each process were investigated and the effects of controllable factors on forward free swimming were discussed.

关键词： self-propelled propulsive mechanism Navier-Stokes equations coupling problem

3D-QSAR Studies on the Imidazopyrimidine Derivatives

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Chinese Journal of Structural Chemistry 2020年第11期39卷 1985-1989页

作者： tong Jian-Bo CAO xu Shaanxi Key Laboratory of Chemical Additives for Industry Shaanxi University of Science and TechnologyXi'an 710021China

Comparative molecular field analysis(CoMFA) and comparative molecular similarity indices analysis(CoMSIA) for imidazopyrimidine derivatives were performed to get the molecular active conformation selection, molecular alignment, as well as the establishment of corresponding 3 D-QSAR model. The model established by this method has good ability to predict such compounds. For CoMFA model, the cross-validated q2 and non-cross-validated r2 values are 0.665 and 0.872, respectively. The best q2 value for CoMSIA model is 0.632 and r2 value is 0.923. Using this information and the three-dimensional equipotential map for molecular design can theoretically obtain some new antibacterial drugs with higher activity. There are two newly designed molecules with activity values of 7.921 and 7.872, which are higher than that of the template molecule No. 12 with an activity value of 7.850, and the QSAR research results can provide a theoretical reference for the synthesis of new drugs.

关键词： 3D-QSAR comparative molecular force field analysis molecular design

ITO thin films prepared by electron beam evaporation with End-Hall ion source assisted without heating to the substrate

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光学精密工程 2005年第4期13卷 397-402页

作者： GAO Jin-song xu Ying WANG Xiao-yi WANG tong-tong Optical Technology and Research Center Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130022 China

ITO （indium oxide doped with tin） thin films were deposited on glass substrates by using ITO pellet with a composition of w（In2O3）=90% and w（SnO2）=10% by electron beam evaporated with End-Hall ion source assisted without extra heating. The rate of deposition and flow rate of oxygen were measured and changed to obtain the best properties of ITO thin films. Furthermore, the post annealing process was done in vacuum at different annealing temperatures for 2 h and at 400℃ for different keeping time, respectively. The relation between optical, electrical properties and structure was discussed in detail.

关键词： ITO 薄膜电子束离子源

TiO_2 photocatalytic antifungal technique for crops diseases control

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Journal of Environmental Sciences 2006年第2期18卷 397-401页

作者： LU Jian-wei LI Fang-bai GUO Ting LIN Lan-wen HOU Mei-fang LIU tong-xu Faculty of Resource and Environment Center China Agricultural University Wuhan 430070 China Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control Guangdong Institute of Eco-Environment and Soil Sciences Guangzhou 510650 China South China Institute of Botany Chinese Academy of Sciences Guangzhou 510650 China

TiO2 and 1% Ce^3＋-TiO2 prepared by hydrothermal method were characterized by means of XRD and UV-visible diffusive reflectance spectra（DRS）. The results of DRS analysis indicated that the 1% Ce^3＋-TiO2 catalyst had significant optical absorption in the visible region between 400-450 nm because electrons could be excited from the valence band of TiO2 or cerium oxides to Ce 4f level. To investigate the photocatalytic activity of different catalysts for crop fungal disease control, a series of Quine tests were carried out for cucumber powdery mildew and litchi downy blight control in home-made photocatalytic reactor. The results showed that TiO2 photocatalysis technique should be effective to inhibit the growth of fungal diseases to some extent and P-25 had a higher activity for antifungal control than home-made TiO2 catalysts. TiO2-A prepared with Ti（SO4）2 is more active to contro 1 antifungal disease than TiO2-B prepared with TiOSO4 as precursor because the crystalline of TiO2-A was higher than that of TiO2-B. The antifungal index litchi downy blight control was greatly enhanced by doping 1% cerium ion. The antifungal index of 1.0%Ce3^＋-TiO2 was（47.0 ± 4.7）%, （82.2 ± 3.5）%, （100 ±0.0）% under indoor weaker light, solar light and black light, respectively. The results of field experiments showed that the antifungal index of 1.0%Ce^3＋-TiO2 was more than that of P-25. The antifungal index of 1.0%Ce^3＋-TiO2 was （81.7 ± 6.5）%, （67.5 ±4.7）%, （38.6±1.9）% for litchi downy blight, maize southern leaf spot, and rice blast, respectively. It was concluded that TiO2 photocatalysis technique should be an effective way for litchi fungal disease control in practice.

关键词： titanium dioxide photocatalytic fungal disease solar light litchi downy blight

Chinese Medicine Treatment Prolonged Survival in Small Cell Lung Cancer Patients:A Clinical Observation

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Chinese Journal of Integrative Medicine 2021年第7期27卷 496-501页

作者： xu Xiao-qing DENG wen-qi WANG Da-yang LI Meng KOU Dong-lei ZHANG Pei-tong Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Beijing University of Chinese Medicine Beijing100029China

Objective To evaluate the effect of Chinese medicine(CM)treatment on survival time and quality of life(QOL)in patients with small cell lung cancer(SCLC).Methods This was an exploratory and prospective clinical *** diagnosed with SCLC receiving CM treatment were included and followed up every 3 *** primary outcome was overall survival(OS),and the secondary outcomes were progression-free survival(PFS)and *** A total of 136 patients including 65 limited-stage SCLC(LS-SCLC)patients and 71 extensive-stage SCLC(ES-SCLC)patients were *** median OS of ES-SCLC patients was 17.27 months,and the median OS of LS-SCLC was 40.07 *** survival time was 16.27 months for SCLC patients with brain metastasis,9.83 months for liver metastasis,13.43 months for bone metastasis,and 18.13 months for lung *** age,pleural fluid,liver and brain metastasis were risk factors,while longer CM treatment duration was a protective *** assessment indicated that after 6 months of CM treatment,scores increased in function domains and decreased in symptom *** CM treatment might help prolong OS of SCLC ***,CM treatment brought the trend of symptom amelioration and QOL *** results provide preliminary evidence for applying CM in SCLC multi-disciplinary treatment.

关键词： small cell lung cancer Chinese medicine survival time follow-up quality of life

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan xu Jia-Bao Liao Wei-Bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Chemical ecology-driven discovery of bioactive marine natural products as potential drug leads

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Chinese Journal of Natural Medicines 2020年第11期18卷 837-838页

作者： LI xu-wen State Key Laboratory of Dmg Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Over the past decades, more and more bioactive marine natural products(MNPs) have attracted numerous chemists and pharmacologists for their medicinal application. Up until now, nearly twenty MNPs-derived drugs have been successfully developed and are available on market. In this special issue, we are please to publish four original articles on MNPs, which represent the currently most studied marine living organisms, soft corals,sponges, and marine derived fungi, from far sea, deep sea or special mangrove living conditions.

关键词： drugs please sponge