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The roles of tubulin-folding cofactors in neuronal morphogenesis and disease

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Neural Regeneration Research 2015年第9期10卷 1388-1389页

作者： Misako Okumura Masayuki miura Takahiro Chihara Department of Genetics Graduate School of Pharmaceutical Sciences The University of Tokyo Core Research for Evolutional Science and Technology Japan Science and Technology Agency

Microtubules play important roles in neuronal morphogenesis, including cellular polarization, neurite growth, and branching. A microtubule is a polymer of a- and β-tubulin heterodimers that are formed by a multistep process assisted by at least five tubulin-fold- ing cofactors （TBCA-E）（Lopez-Fanarraga et al., 2001）. Newly syn- thesized α- and β-tubulins associate with the cytosolic chaperonin complex （CCT）, and then the quasi-native tubulins interact with five tubulin-folding cofactors. The α- and β-tubulins first interact with TBCB and TBCA, which are further transferred to TBCE and TBCD, respectively. The α- and β-tubulins, TBCC, TBCD, and TBCE form a supercomplex, and guanosine triphosphate （GTP） hydrolysis occurs within the supercomplex, releasing a tubulin heterodimer. In addition to their functions in tubulin folding and tubulin heterodimer formation, excess amounts of TBCD or TBCE may interact with tubulin heterodimers, leading to their degrada- tion. Thus, tubulin-folding cofactors may play a role in both the synthesis and degradation of tubulin heterodimers.

关键词： The roles of tubulin-folding cofactors in neuronal morphogenesis and disease Figure

Complex Formation of 1,6-Anhydro-<i>β</i>-Maltose and Sodium Ions Using Single-Crystal X-Ray Crystallography and NMR Spectroscopy

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American Journal of Analytical Chemistry 2013年第8期4卷 361-367页

作者： Takashi Fujimoto Daisuke miura Takayuki Kato Osamu Kamo Yuichi Shimoikeda tomoya Machinami Mitsuru Tashiro Department of Chemistry School of Sciences and Engineering Meisei University Hino Japan Solution & Marketing Division JEOL RESONANCE Inc. Akishima Japan

Complex formation of 1,6-anhydro-β-maltose and sodium ions was characterized using single-crystal X-ray crystallography and solution- and solid-state NMR spectroscopy. The 7-coordination structure, comprising two 1,6-anhydro-β-maltoses, a thiocyanate ion and a sodium ion, was identified in the crystal of the complex, where a sodium ion was positioned in the center of the pentagon. In the NMR study, the line broadening of 23Na signals and the decrease of the spin-lattice relaxation times (T1) of 23Na were observed in CD3OD in the presence of 1,6-anhydro-β-maltose, indicating complex formation.

关键词： 1 6-Anhydro-β-Maltose Complex Formation Single-Crystal X-Ray Crystallography Solid-State NMR Spectroscopy

Aero-Thermal Performances of Leakage Flows Injection from the Endwall Slot in Linear Cascade of High-Pressure Turbine

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Journal of Thermal Science 2015年第1期24卷 49-57页

作者： Wan Aizon W Ghopa Zambri Harun Ken-ichi Funazaki Takemitsu miura Department of Mechanical and Materials Engineering Universiti Kebangsaan Malaysia Department of Mechanical Engineering Iwate University

The existence of a gap between combustor and turbine endwall in the real gas turbine induces to the leakages phenomenon. However, the leakages could be used as a coolant to protect the endwaU surfaces from the hot gas since it could not be completely prevented. Thus, present study investigated the potential of leakage flows as a function of film cooling. In present study, the flow field at the downstream of high-pressure turbine blade has been investigated by 5-holes pitot tube. This is to reveal the aerodynamic performances under the influenced of leakage flows while the temperature measurement was conducted by thermoehromic liquid crystal （TLC）. Expe- rimental has significantly captured theaerodynamics effect of leakage flows near the blade downstream. Further- more, TLC measurement illustrated that the film cooling effectiveness contours were strongly influenced by the secondary flows behavior on the endwall region. Aero-thermal results were validated by the numerical simulation adopted by commercial sottware, ANSYS CFX 13. Both experimental and numerical simulation indicated almost similar trendinaero and also thermal behavior as the amount of leakage flows increases.

关键词： endwall fllmcooling leakage flows secondary flows aerodynamic loss film cooling effectiveness

Rayleigh scattering studies on inter-layer interactions in structure-defined individual double-wall carbon nanotubes

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Nano Research 2014年第10期7卷 1548-1555页

作者： Sihan Zhao tomoya Kitagawa Yuhei Miyauchi Kazunari Matsuda Hisanori Shinohara Ryo Kitaura Department of Chemistry & Institute forAdvanced Research Nagoya University Nagoya 464-8502 Japan Institute of Advanced Energy Kyoto University Uji Kyoto 511-0011 Japan Japan Science and Technology Agency PRESTO Saitama 332-0012 Japan

Although the inter-layer coupling in layered materials has attracted considerable interest due to its importance in determining physical properties of two- dimensional systems, studies on the inter-layer coupling in one-dimensional systems have so far been limited. Double-wall carbon nanotubes （DWCNTs） are one of the most fundamental and ideal model systems to study the interqayer coupling in one-dimensional systems. In this work, Rayleigh scattering spectroscopy and transmission electron microscopy are used to characterize the electronic transition between inner-and outer-nanotubes of the exactly same individual DWCNT. We find that the interqayer coupling is strong, leading to downshifts in most of the optical transition energies （up to -0.2 eV） compared to isolated CNTs. We also find that the presence of metallic tubes lead to stronger shifts. The inter-layer screening of Coulomb interactions is one of the key factors in explaining the observed results.

关键词： inter-layer coupling one-dimensional system electronic properties double-wall carbonnanotubes (DWCNTs) dielectric screening

Sensing Characteristics of Mixed-Potential-Type YSZ-Based NO_x Sensor Using Au-Doped NiO Sensing Electrode

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稀有金属材料与工程 2006年第A3期35卷 36-39页

作者： Vladimir V.Plashnitsa Taro Ueda Norio miura Art Science and Technology Center for Cooperative ResearchKyushu UniversityKasuga-ShiFukuoka 816-8580Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityKasuga-shiFukuoka 816-8580Japan

The nano-structured NiO powder obtained by sol-gel method was doped with 10 wt% gold in order to modify its morphology as well as its electrochemical catalytic *** NO_x sensing characteristics of mixed-potential-type YSZ-based planar sensors attached with each of the nano-NiO and the Au-doped nano-NiO materials as a sensing electrode SE) were examined at temperatures of 700℃～800℃.The Au-doped NiO-SE was found to give a large enhancement in the NO_2 sensitivity as well as the NO_2 selectivity at 800℃under wet condition,in comparison with the pure *** reason for the improvement in the NO_2 sensitivity was examined based on the data of polarization curves,impedance spectra and catalytic activity for the gas-phase NO_2 decomposition.

关键词： NO_x sensor mixed potential NiO nanostructure YSZ Au

MORPHOLOGICAL VARIATIONS OF INITIAL DEPRESSION ARISEN FROM CRUSTAL MOVEMENT DURING QUATERNARY ON SEVERAL ISLANDS IN THE RYUKYUS, JAPAN

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中国岩溶 1992年第S1期11卷 60-64页

作者： Hajime miura Yamaguchi University Japan

interest is to make clear the occurring mechanism of the init(?) (?)ion on the limestone terrain I have been investigating (?) (?)ssions on several islands over the Ryukyu islands under the hum(?) (?) *** Ryukyus are composod of more than 70 isiands with (?) (?) reef limestone There are geomor(?)hological feature of var karstic initial depressions on each isiand affeeted by diff(?) crustal movement with (?)eated aplifted dro(?)ed

关键词： limestone crustal terrain karst north sections island rock directions linen

ASimplified Neuronal Model for the Instigation and Propagation of Cortical Spreading Depression

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Advances in Applied Mathematics and Mechanics 2011年第6期3卷 759-773页

作者： Huaxiong Huang Robert M.miura Wei Yao Department of Mathematics and Statistics York UniversityTorontoOntario M3J1P3Canada Center for Applied Mathematics and Statistics New Jersey Institute of TechnologyNewarkNJ 07102USA Department of Mathematical Sciences New Jersey Institute of TechnologyNewarkNJ 07102USA Department of Mechanics and Engineering Science Fudan UniversityShanghai 200433China

In this paper,we construct a simplified neuronal model that is capable of simulating the instigation of cortical spreading depression(CSD)and propagation of a CSD *** model is a simplification and extension of a single neuron model proposed in the literature for studying the instigation of *** the simplified neuronal model,we construct a network of these simplified *** network model shows that the propagation of a CSD wave occurs naturally after it is instigated electrically or *** the model is simple,the speed of the CSD wave predicted by our model is consistent with experimentally observed ***,our model allows us to investigate the effects of specific ion channels on the spread of a CSD wave.

关键词： Cortical spreading depression neuronal model network numerical simulation

Water-saving irrigation of paddy field to reduce nutrient runoff

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Journal of Environmental Sciences 2010年第6期22卷 885-891页

作者： Tadayoshi Hitomi Yusaku Iwamoto Asa miura Koji Hamada Kyoji Takaki Eisaku Shiratani National Institute for Rural Engineering Kyusyu Regional Agricultural Administration Office

The purpose of this work is to study the effect of a type of water-saving irrigation （WSI） on nutrient runoff of paddy field. The volume of surface drainage was maintained low by WSI. In particular, WSI effectively reduced surface drainage in rain events. Model simulation indicated that net runoff load of total nitrogen （TN） from the paddy field was increased by WSI. Meanwhile, net runoff loads of total phosphorus （TP） and total organic carbon （TOC） from the paddy field was decreased by WSI. Because ponding waters of the study fields were enriched with TP and TOC, WSI reduced runoff of these nutrients by controlling the volume of surface drainage. WSI could be considered an efficient method for reducing runoff loads and could conserve water quality in an agricultural watershed.

关键词： model simulation net runoff load storage capacity surface drainage tank model water management

Grain size and texture changes of magnesium alloy AZ31 during multi-directional forging

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中国有色金属学会会刊：英文版 2008年第A1期18卷 200-204页

作者：杨续跃孙争艳 XING 3Jie miura Hiromi SAKAI Taku School of Materials Science and Engineering Central South University Changsha 410083 China Key Laboratory of Nonferrous Metal Materials Science and Engineering Ministry of Education Central South University Changsha 410083 China Department of Mechanical Engineering and Intelligent Systems UEC Tokyo Tokyo 182-8585 Japan

Grain size and texture changes of magnesium alloy AZ31 were studied in multidirectional forging(MDF) under decreasing temperature *** was carried out up to large cumulative strains of 4.8 with changing the loading direction during decrease in temperature from pass to *** can accelerate the uniform development of fine-grained structures and increase the plastic workability at low *** a result,the MDFed alloy shows excellent higher strength as well as moderate ductility at room temperature even at the grain size below 1μ*** flow takes place at 423 K and depends on the anisotropy of MDFed *** mechanisms of strain-induced fine-grained structure development and of the plastic deformation were discussed in detail.

关键词：镁合金 AZ31镁合金常温金属功能材料