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Evaluation of the margins of differentiated early gastric cancer by using conventional endoscopy

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World Journal of Gastrointestinal Endoscopy 2015年第6期7卷 659-664页

作者： Shigetaka yoshinaga Ichiro Oda Seiichiro Abe Satoru Nonaka Haruhisa Suzuki Hajime Takisawa Hirokazu Taniguchi Yutaka Saito Endoscopy Division National Cancer Center Hospital Pathology Division National Cancer Center Hospital

AIM: To evaluate the determination of the margin of differentiated-type early gastric cancers by using conventional ***: We retrospectively evaluated 364 differentiated early gastric cancers that were endoscopically resected as en-bloc specimens and diagnosed pathologically in detail between November 2007 and October 2008. All procedures were done with conventional endoscopes and all endoscopic samples, before and after indigo carmine dye, were re-evaluated using a digital filing system by one endoscopist. We analyzed the incidence of lesions with unclear margins and the relationship between unclear margins and relevant clinicopathological findings. RESULTS: The rate of lesions with unclear margins was 20.6%(75/364). Multivariate regression analysis suggested that the factors that make the determination of the margin difficult were normal color, presence of components of flat area(0-IIb), a diameter ≥ 21 mm, ulceration, and components of poorly differentiated adenocarcinoma in the mucosal ***: As many as 20% of differentiated early gastric cancers show unclear margins. Consideration of the factors associated with unclear margins may help endoscopists to accurately determine the margins of the lesion.

关键词： Early gastric cancer Conventional endoscopy Determination of the margin

90度攻角细长体在旋转时的气动系数近似计算方法

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导弹与航天运载技术(中英文) 1984年第12期 1-4页

作者： Takashi yoshinaga 刘志珩

引言近几年来,作用在大攻角细长旋成体上的侧向力受到很大的注意,因为该侧向力常常使火箭和飞机变为不可控制的。探空火箭头部模型空投试验表明,起初经过若干个翻滚运动以后,多数弹头边下降,边在平行于海平面的平面内,象螺旋桨一样旋转... 详细信息

引言近几年来,作用在大攻角细长旋成体上的侧向力受到很大的注意,因为该侧向力常常使火箭和飞机变为不可控制的。探空火箭头部模型空投试验表明,起初经过若干个翻滚运动以后,多数弹头边下降,边在平行于海平面的平面内,象螺旋桨一样旋转(平螺旋)。如果

关键词：临界雷诺数柱体气动系数自由流速度攻角迎角细长体

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东邦—光和球团氯化法的创立和发展

中国有色冶金 1987年第9期 23-31页

作者： M. yoshinaga ,蒋崇祐

利用黄铁矿精矿作为若干有价组分的一种资源,在日本有着悠久的历史。从黄铁矿烧渣中回收有色金属的球团氯化法是1965年由光和精矿有限公司所发展和工业化。将CaCl2之类的氯化剂加到黄铁矿烧渣中,然后将物料焙烧挥发有色金属。本文叙述... 详细信息

利用黄铁矿精矿作为若干有价组分的一种资源,在日本有着悠久的历史。从黄铁矿烧渣中回收有色金属的球团氯化法是1965年由光和精矿有限公司所发展和工业化。将CaCl2之类的氯化剂加到黄铁矿烧渣中,然后将物料焙烧挥发有色金属。本文叙述用氯化焙烧回收有色金属的最初工艺流程,以及后来的改进和其他的一些发展。介绍了世界和日本硫酸市场的最近动向和黄铁矿在作为硫酸和铁矿球团原料方面的贡献。并提到了该法用于处理炼铁高炉烟尘。

关键词：黄铁矿烧渣有色金属非铁金属黄铁矿精矿氯碱法氯化法造块球团氯化挥发硫化合物硫酸东邦

Beat-to-Beat Variability in Field Potential Duration in Human Embryonic Stem Cell-Derived Cardiomyocyte Clusters for Assessment of Arrhythmogenic Risk, and a Case Study of Its Application

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Pharmacology & Pharmacy 2014年第1期5卷 117-128页

作者： Kazuto Yamazaki Taro Hihara Hiroshi Kato Tatsuto Fukushima Kazuyuki Fukushima Tomohiko Taniguchi Takashi yoshinaga Norimasa Miyamoto Masashi Ito Kohei Sawada Biomarkers and Personalized Medicine CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Biopharmaceutical Assessment CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Global Discovery Research Neuroscience and General Medicine PCU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan Next Generation Systems CFU Eisai Product Creation Systems Eisai Co. Ltd. Tsukuba Japan

We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indicator of drug-induced QT interval prolongation. To investigate the applicability of the hES-CMC system to drug safety assessment, we investigated short-term variability in FPDc (STVFPDc) (beat rate rhythmicity) as a marker of torsadogenic risk. We investigated the FPDc and STVFPDc of hES-CMCs treated with hERG channel blockers (E-4031 or cisapride) or with our proprietary compounds X, Y, and Z. We also evaluated the electrocardiograms and hemodynamics of dogs treated with compound X, Y, or Z. The torsadogenic hERG channel blockers increased STVFPDc and prolonged FPDc. Compounds X, Y, and Z had hERG inhibitory activity. Compound X prolonged FPDc with increased STVFPDc, whereas compounds Y and Z tended to shorten FPDc in the hES-CMC system. In the in vivo canine study, compound X prolonged corrected QT (QTc), and compounds Y and Z tended to shorten QTc, showing a good correlation with the results in hES-CMCs. These findings suggest that combined assessment of FPDc and STVFPDc in the hES-CMC system increases the predictability of torsadogenic risk.

关键词： Human Embryonic Stem Cell-Derived Cardiomyocytes Field Potential Duration Short-Term Variability QT Interval Torsades de Pointes Risk Assessment

Structural study of receptor recognition mechanism of a mouse pheromone ESPl

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Structural study of receptor recognition mechanism of a mous...

Efficacy of 5-Fluorouracil and High-Concentration Cisplatin Suspended in Lipiodol by Short-Term Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Makoto Hirakane Sosuke yoshinaga Toru Sato Yumi Soejima Sachiko Haga Ichio Shimada Kazushige Touhara Hiroaki Terasawa Faculty of Life Sciences Kumamoto UniversityKumamotoJapan Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Graduate School of Pharmaceutical Sciences The University of TokyoTokyoJapan

Pheromones are species-specific chemical signals that regulate a wide range of social and sexual behaviours in many *** vomeronasal organ(VNO) detects the pheromonal information via vomeronasal sensory neurons(VSNs) in *** have identified a male-specific peptide ESPl(exocrine-gland-secreting peptide 1) secreted into tear fluids that stimulates female *** ESPl signal is received,the vomeronasal type 2

关键词： mouse pheromone ESP1 GPCR molecular recognition NMR

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Journal of Cancer Therapy 2015年第13期6卷 1151-1161页

作者： Yutaka Yata Masashi Namikawa Tatsuya Ohyama Takashi Ohsaki Daisuke Kanda Takeshi Hatanaka Kei Shibuya Jun Kubota Hitoshi Takagi Terumi Takahara Teruo yoshinaga Department of Gastroenterology Saiseikai Maebashi Hospital Maebashi-City Japan Department of Radiology Saiseikai Maebashi Hospital Maebashi-City Japan Third Department of Internal Medicine Toyama University Toyama-City Japan

Background: Since advanced hepatocellular carcinoma (HCC) is potentially fatal, and patients’ quality of life (QOL) often deteriorates during their treatment, improving the prognosis and QOL of patients given chemotherapy is very important. In addition, cost-effective treatments are highly desirable when chemotherapy must be given repeatedly. The aim of this study was to evaluate the efficacy and usefulness of 5-fluorouracil (5-FU) and high-concentration cisplatin by short-term hepatic arterial infusion chemotherapy (3-day FPL) in advanced HCC patients. Methods: Thirty patients with unresectable advanced HCC were enrolled. The patients underwent hepatic arterial infusion chemotherapy via the implanted port system with 5-FU on days 1 - 3 and a fine-powder formulation of cisplatin in suspended pre-warmed lipiodol on day 2 every 4 to 10 weeks. Tumor response was assessed one month later with CT. Results: All patients had evidence of portal vein invasion (Vp2-4). Four patients achieved a complete response (CR), 8 patients achieved a partial response (PR), and 7 patients had stable disease (SD). The median progression-free survival (PFS) and overall survival (OS) were 198 days and 452 days, respectively. The OS was significantly longer in the successful disease control group (CR, PR, and SD) than in the progressive disease group (P < 0.005). Conclusions: Three-day FPL was effective and tolerable in advanced HCC patients due to its shorter time of administration than conventional FP therapy. Therefore, repetitive 3-day FPL appears useful and contributes to improving the prognosis and QOL of patients with advanced HCC. In addition, this protocol is a cost-effective treatment.

关键词： Advanced Hepatocellular Carcinoma (HCC) Portal Vein Tumor Thrombosis (PVTT) Hepatic Arterial Infusion Chemotherapy (HAIC) 5-FU a Fine-Powder Formulation of Cisplatin Quality of Life (QOL) Cost-Effective Treatment

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矾土陶瓷制人工股骨头的实验研究

宁夏医学杂志 1988年第5期 319-320页

作者：贾刚田

已知人工股骨头置换术的主要合并症有髓臼关节软骨及骨质破坏或中心性脱位,其原因多认为是人工股骨头的机械性刺激或其所含金属成分导致关节软骨或其周围骨质的破坏。而陶瓷的生物相容性优于金属,化学稳定性高,耐磨性能强,对周围组织无... 详细信息

已知人工股骨头置换术的主要合并症有髓臼关节软骨及骨质破坏或中心性脱位,其原因多认为是人工股骨头的机械性刺激或其所含金属成分导致关节软骨或其周围骨质的破坏。而陶瓷的生物相容性优于金属,化学稳定性高,耐磨性能强,对周围组织无化学刺激性,故近年来陶瓷制人工股骨头应用较普遍。作者用金属和陶瓷制人工股骨头分别植入成年犬髋关节,比较观察了对关节软骨的组织学影响。

关键词：人工股骨头金属成年金属材料关节软骨

个旧市郊室内氡、钍射气浓度和地面γ辐射水平初步调查

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中国职业医学 2008年第3期35卷 211-213页

作者：雷淑洁 Shinji TOKONAMI 孙全富 Tetsuo ISHIKAWA Yosuke KOBAYASHI 李小娟闵向东武国亮 Shinji yoshinaga 尚兵中国疾病预防控制中心辐射防护与核安全医学所北京100088 National Institute of Radiological Sciences 4-9-1 AnagawaInage-kuChiba263-8555Japan 个旧市疾病预防控制中心 661400 云南省疾病预防控制中心昆明650022

目的调查个旧地区居室内氡（^222Rn）、钍射气（^220Rn）及其子体水平，明确钍射气的剂量贡献。方法考虑住宅类型和地理分布因素，从个旧市郊某村选取建筑结构有代表性的50户住宅的主卧室，采用氡-钍射气鉴别探测器测量氡、钍射气浓度... 详细信息

目的调查个旧地区居室内氡（^222Rn）、钍射气（^220Rn）及其子体水平，明确钍射气的剂量贡献。方法考虑住宅类型和地理分布因素，从个旧市郊某村选取建筑结构有代表性的50户住宅的主卧室，采用氡-钍射气鉴别探测器测量氡、钍射气浓度，用沉积率装置测量钍射气子体浓度。其中14间居室采用连续性氡测量探测器和α谱氡、钍射气鉴别探测器测量氡、钍射气浓度，空气采样滤膜结合CR-39探测器测量钍射气衰变产物浓度，碘化钠闪烁计数器测量地表γ剂量率。结果50间居室的氡浓度为32～498Bq／m^3，平均136Bq／m^3；钍射气浓度为39～7908Bq／m^3，平均3297Bq／m^3；钍射气子体浓度为2．0～23．9Bq／m^3，平均10．2Bq／m^3。钍射气子体衰变产物致居民年平均有效剂量大于氡子体衰变产物的平均年有效剂量（2．9mSv vs 1．6mSv）。结论个旧市郊部分居室室内钍射气及其子体浓度高，钍射气子体的剂量贡献要高于氡子体的剂量贡献。在个旧开展氡致肺癌危险评价研究应当考虑钍射气子体的剂量贡献。

关键词：氡钍射气钍射气子体 γ射线个旧市

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Brugada特征性心电图在青春期男性中的发生率和出现时间的3年随访研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 16-17页

作者： yoshinaga M. Anan R. Nomura Y. 宁宁

The prevalence of Brugada’s electrocardiographic(ECG) pattern in 7,022 male adolescents in the seventh grade was determined, and the same subjects were reexamined 3 years later, while in tenth grade. Two subjects(0.03%) and 7 subjects(0.10%) showed Brugada’s ECG pattern by the conventional criterion(J point or ST-segment ≥0.1 mV in leads V1 to V3), and no subjects(0%) and 2 subjects (0.03%) fulfilled the recent criterion(J point or ST-segment ≥0.2 mV) in the seventh and tenth grades, respectively, indicating that Brugada’s ECG pattern begins to appear during junior high school and increases until late adulthood.

关键词： Brugada 随访研究标准检查常规标准

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