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世界建筑导报 2020年第3期35卷 54-54页

作者： tomasz Zakrzewski(摄影) archifolio(摄影) 无不详 OVO Grabczewscy Architekci

该建筑成为受舞者,艺术活动,各种展览,节日,婚礼摄影,广告等青睐的热门场所。它成为西里西亚小城Zory的象征,在这里当代的试验性建筑是其身份的一部分,也是自豪感的来源。

关键词：自豪感试验性消防博物馆婚礼摄影小城建筑

Parasites of Anisakidae Family--Geographical Distribution and Threat to Human Health

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Journal of Agricultural Science and Technology(A) 2015年第2期5卷 146-152页

作者： Ewa Bilska-Zajac Mirostaw Rozycki Ewa Chmurzynska Jacek Karamon Jacek Sroka Maciej Kochanowski Pawet Kusyk tomasz Cencek Department of Parasitology and Invasive Diseases National Veterinary Research Institute in Putawy Partyzant6w Avenue 57Putawy 24-100 Poland

Nematodes of the Anisakidae family are important parasites that can cause anisakiasis—-human parasitic infection of gastrointestinal tract. Allergic symptoms can arise as secondary immune response after infection by living parasite. In the life cycle of these parasites, intermediate, definitive and paratenic hosts (fish) might occur. In most cases, human anisakiasis is caused by consumption of fish which are infected with the larvae of the Anisakidae family. The purpose of the article was to assess the definitive host, the geographical spread of the parasites and the risk associated with consumption of raw fish and fishery products. Furthermore, this article describes symptoms and treatment of anisakiasis and kinds of preventive measures that can be taken to prevent anisakiasis.

关键词：寄生虫感染地理分布人类健康异尖线虫病威胁家族家庭消费原料鱼

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在定点DSP上的浮点仿真变得切实可行

电子设计技术 EDN CHINA 2005年第9期12卷 94-94页

作者： David Katz tomasz Lukasiak Rick Gentile ADI公司

数字信号处理器(DSP)分为两大类:定点DSP和浮点DSP.一般来讲,处于技术前沿的定点DSP系列往往趋向于注重快速、低功耗和低成本,而浮点DSP可以在大动态范围内提供高精度.动态范围是指可以用数字形式表示的最大数字量和最小数字量之间的比... 详细信息

数字信号处理器(DSP)分为两大类:定点DSP和浮点DSP.一般来讲,处于技术前沿的定点DSP系列往往趋向于注重快速、低功耗和低成本,而浮点DSP可以在大动态范围内提供高精度.动态范围是指可以用数字形式表示的最大数字量和最小数字量之间的比率,而精度是指可以用来定义化分最小度量的间隔.

关键词：定点DSP 浮点DSP 数字信号处理器(DSP) 大动态范围仿真 SP系列高精度数字量低功耗

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PNAS:维生素A和C如何擦除细胞记忆?

现代生物医学进展 2017年第4期17卷 I0003-I0003页

作者： Timothy Alexander Hore[a],[b], Ferdinand von Meyenn[a], Mirunalini Ravichandran[c], Martin Bachman[d],[e] Gabriella Ficz[f] David Oxley[g] Fátima Santos[a] Shankar Balasubramanian[d],[e] tomasz P. Jurkowski[c], Wolf Reik[a],[h], [a]Epigenetics Programme Babraham Institute Cambridge CB22 3AT United Kingdom [b]Department of Anatomy University of Otago Dunedin 9016 New Zealand [c]Institute of Biochemistry University of Stuttgart 70569 Stuttgart Germany [d]Department of Chemistry University of Cambridge Cambridge CB2 1EW United Kingdom [e]Cancer Research UK Cambridge Institute University of Cambridge Cambridge CB2 0RE United Kingdom [f]Barts Cancer Institute Queen Mary University of London London EC1M 6BQ United Kingdom [g]Mass Spectrometry Facility Babraham Institute Cambridge CB22 3AT United Kingdom [h]Wellcome Trust Sanger Institute Hinxton CB10 1SA United Kingdom

维生素A和C不只是对我们的健康有益，其还会影响到机体的DNA，日前一项刊登于国际杂志PNAS上的研究论文中，来自巴布拉汉研究所（Babraham Institute）等机构的研究人员通过研究揭示了维生素A和C如何修饰细胞的表观遗传记忆。相关研究... 详细信息

维生素A和C不只是对我们的健康有益，其还会影响到机体的DNA，日前一项刊登于国际杂志PNAS上的研究论文中，来自巴布拉汉研究所（Babraham Institute）等机构的研究人员通过研究揭示了维生素A和C如何修饰细胞的表观遗传记忆。相关研究或为后期研究者们开发新型再生医学疗法或者对细胞重编程提供一定的思路。

关键词：维生素A 细胞记忆擦除研究论文表观遗传研究人员再生医学

Changing the Moisture Content of the Spartina and Miscanthus and Willow Shoots during Storage in Natural Conditions

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Journal of Agricultural Science and Technology(B) 2013年第7期3卷 469-479页

作者： Aleksander Lisowski Artur Ciechacki Michal Sypula Jacek Klonowski Jaroslaw Chlebowski Krzysztof Kostyra tomasz Nowakowski Adam Struzyk Jan Kaminski Malgorzata Powalka Department of Agricultural and Forest Machinery Warsaw University of Life Sciences Warsaw 02-787 Poland Department of Production Management and Engineering Warsaw University of Life Sciences Warsaw 02-787 Poland

The aim of this study was to determine the characteristics of the distribution of energy plant moisture content along the height of their shoots and the dynamics of moisture during storage in natural conditions. The shoots of Spartina, Miscanthus and willow were used in the study. Entire shoots were cut into sections of 10 cm and for each set in monthly cycles for six months moisture content was evaluated. After a month"s storage of freshly cut shoots the biggest decrease of content moisture in the shoots of Spartina and Miscanthus was recorded, by 31% and 22%, respectively, and the lowest in willow shoots (12%). After sixth months of shoots storage the lowest moisture content (10%-12%) was reached in miscanthus. The most uneven moisture content along the height of shoots Spartina was characterized because on one third of the height from the bottom, the moisture content of shoots was 20%, and the top had moisture content in the range 5%-10%. Willow shoots were characterized by the smallest drop in moisture, and the final moisture content was about 23%, with the top part of moisture content of 10%-20%. The dynamics of moisture change during the six months of storage of grass shoots (Miscanthus and Spartina) in natural conditions under roofing was described by one power function regression, and willow by another one. Empirical models can be used to predict changes in moisture content of these plants in experiment conditions, since the coefficients of determination were 94.66% and 89.18%, respectively.

关键词：水分含量互花米草芒草贮藏过程自然树芽能源植物储存过程

Improving ITS sequence data for identification of plant pathogenic fungi

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Fungal Diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov Department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Systematics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland Department of Organismal Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia Microbial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Department of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environmental Microbiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic Department of Infectious Diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History Museum of Denmark Øster Voldgade 5-71350 København KDenmark Institute for Genomics and Bioinformatics Graz University of Technology8010 GrazAustria Core Facility Bioinformatics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochemistry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland Molecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human *** taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro *** a result,species identification is frequently ***(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular ***,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related *** present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi Molecular identification ITS Taxonomy Annotation

2022年欧洲血管外科学会(ESVS)下肢慢性静脉疾病管理临床实践指南(全译)

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中华血管外科杂志 2023年第1期8卷 76-158页

作者： Marianne G.De Maeseneer Stavros K.Kakkos Thomas Aherne Niels Baekgaard Stephen Black Lena Blomgren Athanasios Giannoukas Manjit Gohel Rick de Graaf Claudine Hamel-Desnos Arkadiusz Jawien Aleksandra Jaworucka-Kaczorowska Christopher R.Lattimer Giovanni Mosti Thomas Noppeney Marie JoseevanRijn Gerard Stansby 无 Philippe Kolh Frederico Bastos Gongalves Nabil Chakfé Raphael Coscas Gert J.deBorst Nuno V.Dias Robert J.Hinchliffe Igor B.Koncar Jes S.Lindholt Santi Trimarchi Rikka Tulamo Christopher P.Twine Frank Vermassen Anders Wanhainen Martin Bjorck Nicos Labropoulos Fedor Lurie Armando Mansilha Isaac K.Nyamekye Marta Ramirez Ortega Jorge H.Ulloa tomasz Urbanek Andre M.van Rij Marc E.Vuylsteke 荷兰鹿特丹伊拉斯谟医疗中心皮肤科希腊帕特雷帕特雷大学血管外科爱尔兰科尔克大学医院和爱尔兰国立大学戈尔韦分校血管外科丹麦哥本哈根大学根措夫特医院和国家教学研究医院血管外科英国伦敦盖伊和圣托马斯医院及国王学院瑞典厄勒布罗大学医学院心血管和胸外科希腊塞萨利大学健康科学学院医学院拉里萨大学医院血管外科英国伦敦剑桥大学医院和帝国理工学院德国弗里德里希沙芬诊所诊断和介入放射科法国巴黎圣约瑟夫医院集团法国卡昂圣马丁私立医院血管内科波兰托伦市路德维克·赖德吉耶医学院尼古拉·哥白尼大学血管外科和血管学系波兰戈佐市静脉和美容医学中心、外科和妇科中心伦敦西北大学医疗保健NHS信托基金会英国伦敦帝国学院意大利卢卡Maria Domenica Barbantini诊所血管科纽伦堡MarthaMaria医院血管和血管内外科德国雷根斯堡大学医院血管和内皮外科荷兰鹿特丹伊拉斯谟医疗中心血管外科英国泰恩河畔纽卡斯尔弗里曼医院纽卡斯尔大学 ESVS Guidelines Committee 比利时利日利日大学生物医学和临床前科学系葡萄牙里斯本诺瓦德里斯本大学圣玛尔塔医院里斯本中心医院和诺瓦医学院法国斯特拉斯堡大学血管外科和肾移植系巴黎援助公社(AP-HP)CHU AmbroiseParé 法国布洛涅比兰科特巴黎萨克莱大学凡尔赛大学圣昆廷分校血管外科荷兰乌得勒支大学医学中心血管外科瑞典马尔默隆德大学斯科纳大学医院血管中心和马尔默临床科学英国布里斯托尔布里斯托尔大学塞尔维亚贝尔格莱德大学医学院塞尔维亚临床中心血管和血管内外科诊所丹麦欧登塞大学医院心胸血管外科意大利米兰大学临床与社区科学系米兰IRCCS CaGranda Ospedae Maggiore Policlinico基金会芬兰赫尔辛基赫尔辛基大学医院和赫尔辛基大学英国布里斯托尔北布里斯托尔NHS信托基金会布里斯托尔大学比利特根特大学医院瑞典乌普萨拉大学外科学系瑞典乌梅奥大学外科和围手术期科学系爱沙尼亚塔尔图塔尔图大学临床医学研究所外科学系美国纽约州石溪市石溪大学医学中心美国俄亥俄州托莱多普惠约布斯特血管研究所密歇根大学葡萄牙波尔图大学医学院英国伍斯特伍斯特郡皇家医院伍斯特郡急症医院NHS信托西班牙马德里La Luz Quiron Salud医院哥伦比亚波哥大安第斯大学圣菲基金会波兰卡托维兹西里西亚医科大学普通外科、血管外科、血管和静脉科新西兰达尼丁奥塔哥大学外科学系比利时Tielt圣安德列齐肯胡斯血管外科

2022年指南与2015年指南相比的新内容是什么?与2015年版《慢性静脉疾病(chronic venous disease,CVD)管理指南》1相比,该指南的总体结构做了很大修改,使其更加实用和方便。在不同章节中增加了关于管理策略的相关内容,并附有流程图。

关键词：临床实践指南血管外科学慢性静脉疾病管理指南流程图总体结构管理策略

奥拉帕利维持治疗BRCA 1/2突变铂敏感复发性卵巢癌患者(SOLO2/ENGOT-Ov21):一项双盲随机对照Ⅲ期试验的最终分析

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肿瘤药学 2021年第3期11卷 275-279页

作者： Andrés Poveda Anne Floquet Jonathan A Ledermann Rebecca Asher Richard T Penson Amit M Oza Jacob Korach tomasz Huzarski Sandro Pignata Michael Friedlander Alessandra Baldoni Tjoung-Won Park-Simon Kenji Tamura Gabe S Sonke Alla Lisyanskaya Jae-Hoon Kim Elias Abdo Filho Tsveta Milenkova Elizabeth S Lowe Phil Rowe Ignace Vergote Eric Pujade-Lauraine the SOLO/ENGOT-Ovinvestigators 王娟(校) 李征(校) 不详

背景既往发表的SOLO2/ENGOT-Ov21试验的第一部分研究结果表明,作为BRCA1或BRCA2(BRCA1/2)突变铂敏感型的高级别浆液性或子宫内膜样卵巢癌复发患者使用奥拉帕利可延长无进展生存期。因此,本研究的最终分析目的是研究奥拉帕利对这类患者... 详细信息

背景既往发表的SOLO2/ENGOT-Ov21试验的第一部分研究结果表明,作为BRCA1或BRCA2(BRCA1/2)突变铂敏感型的高级别浆液性或子宫内膜样卵巢癌复发患者使用奥拉帕利可延长无进展生存期。因此,本研究的最终分析目的是研究奥拉帕利对这类患者总生存期的影响。方法本研究是一项在16个国家123个医疗中心进行的双盲、随机、安慰剂对照、Ⅲ期临床试验。纳入标准包括:年龄≥18岁;ECOG体能状态评分基线水平为0~1分;组织学检查确诊为复发性、高级别浆液性或高级别子宫内膜样卵巢癌,包括原发性腹膜癌或输卵管癌;以及既往接受过2种或2种以上铂类药物的治疗方案。入选患者按2∶1分配到奥拉帕利组(150 mg片剂,每日2次口服,共300 mg)或安慰剂组;根据既往化疗后是否缓解以及无铂治疗间隔时长进行分层;受试者、治疗提供者和数据分析人员在治疗分配时均设盲。主要终点是既往已报道过的无进展生存期;总生存期作为重要的次要终点之一,在所有随机分配的患者中进行分析;安全性评估在至少接受过1次给药的所有患者中进行。结果2013年9月3日—2014年11月21日,共295例患者参与了试验并被随机分到奥拉帕利组(196例,66%)或安慰剂组(99例,34%)治疗。奥拉帕利组患者中位随访时间为65.7个月(IQR:63.6~69.3),安慰剂组为64.5个月(IQR:63.4~68.7)。奥拉帕利组中位总生存期为51.7个月(95%CI:41.5~59.1),安慰剂组为38.8个月(95%CI:31.4~48.6)(HR=0.74,95%CI:0.54~1.00,P=0.054)。安慰剂组38%接受PARP抑制剂治疗的患者未作调整。治疗引发的最常见的Ⅲ级以上不良事件为贫血,奥拉帕利组发生率为21%(41/195),安慰剂组为2%(2/99)。

关键词：安慰剂 Ⅲ期临床试验输卵管癌铂类药物患者参与组织学检查 BRCA SOLO