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Proteomic Profile Modification of Anaplastic Medulloblastoma after in-Vivo Radiotherapy: A Case Study

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Journal of Cancer Therapy 2010年第2期1卷 97-103页

作者： C. Zanini G. Mandili D. baci M. Leone I. Morra M. Forni Department of Genetics Biology and Biochemistry (CERMS) University of Turin Italy Department of Genetics Biology and Biochemistry (MBC) University of Turin Turin Italy Division of Pediatric Pathology Ospedale Infantile Regina Margherita Turin Italy

Medulloblastoma (MDB) is an aggressive tumor of Central Nervous System (CNS). Radiotherapy after radical surgery has an important role in treatment of standard and high risk patients and is followed by intensive chemotherapy. To explore modifications of protein expression induced by in vivo radiotherapy proteomic analysis was performed on a case of Anaplastic MDB. 2D-gel electrophoresis and MALDI-TOF mass spectrometry detected qualitative differences of protein expression in Anaplastic MDB at diagnosis and in relapse after radiotherapy. Relevant proteomic data were confirmed by western blot and Real-Time PCR analysis, validating the presence of Sthatmin 1 (STMN1), Heat shock protein 60 (HSP60), HSP27 and Disulfide Isomerase (ER60) among the six proteins present in both samples. The most relevant modification induced by radiotherapy was a drastic reduction of the total number of proteins (60.6%) and the appearance of few new proteins. The modifications and the striking simplification of proteins expressed by the tumor after radiotherapy may allow to tailor subsequent chemotherapy on a rational basis. A proteomic guided chemotherapy may be of great benefit to patients.

关键词： Proteomics Anaplastic Medulloblastoma Radiotherapy

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西米替丁及雷尼替丁与心血管药物的相互作用

工企医刊 1990年第3期3卷 54-57页

作者： baci.,AM 苏代泉

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Protein Biosynthesis

A substantial incidence of silent short segment endoscopically suspected esophageal metaplasia in an adult Japanese primary care practice

丛书名： Cell Biology Research Progress Ser.

2009年

作者： toma E. Esterhouse and Lado B. Petrinos

ISBN: (数字)9781614707042

ISBN: (纸本)9781606921562

Protein biosynthesis (synthesis) is the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and transcription which are then used for translation. Protein biosynthesis, although very similar, differs between prokaryotes and eukaryotes. This new book presents important research in the field from around the globe.

关键词： Proteins -- Synthesis

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastrointestinal Endoscopy 2012年第2期4卷 38-44页

作者： Shouji Shimoyama Toshihisa Ogawa Toshiyuki toma Kousuke Hirano Shuichi Noji Gastrointestinal Unit Settlement Clinic 4-20-7 Towa Adachi-ku Tokyo 120-0003 Japan

AIM: To determine the incidence and characteristics of endoscopically suspected esophageal metaplasia (ESEM) in a primary adult care institution. METHODS: Eight hundred and thirty two consecutive individuals (mean age, 67.6 years) undergoing upper gastrointestinal endoscopy between January 2009 and December 2010 were included in this study. The diagnosis of ESEM was based on the criteria proposed by the Japan Esophageal Society, and was classified as long segment ESEM (3 cm or more) or short segment ESEM (< 3cm). Short segment ESEM was further divided into circumferential and partial types. Age, gender, hiatus hernia, esophagitis, gastroesophageal reflux disease (GERD)-suggested symptoms, and antacid medications were recorded as background factors. Esophagitis was graded according to the Los Angeles classification. Hiatus hernia was divided into absent and at least partially present. RESULTS: Long and short segment ESEM were found in 0 and 184 (22.1%) patients, respectively (mean age of short segment ESEM patients, 68.3 years). Male gender and hiatus hernia were shown to be significant factors affecting short segment ESEM by both univariate (P = 0.03 and P = 9.9x10-18) and multivariate [Odds ratio (OR) = 1.45; P = 0.04, and OR = 43.3; P = 1.5x10-7)] analyses. Two thirds of patients with short segment ESEM did not have GERD-suggested symptoms. There was no correlation between short segment ESEM and GERD-suggested symptoms. CONCLUSION: The incidence of short segment ESEM in our community practice seems higher than assumed in Asian countries. As GERD-suggested symptoms are a poor predictor of ESEM, endoscopists should bear in mind that silent short segment ESEM does exist and, in fact, was found in the majority of our patients.

关键词： Endoscopically suspected esophageal metaplasia Esophagitis Gastroesophageal reflux disease Hiatus hernia Longitudinal vessel

Diabetic retinopathy:an inflammatory disease

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Annals of Eye Science 2018年第1期3卷 355-364页

作者： Stela Vujosevic Caterina toma Eye Unit University Hospital Maggiore della CaritàNovaraItaly

Diabetic retinopathy (DR) is a complex multifactorial disease and one of the leading causes of visual impairment worldwide. DR pathogenesis is still not completely understood and, even if studies performed in the past focused on microvascular dysfunction as the main event, growing body of scientific evidence has demonstrated an important role of inflammation and neurodegeneration in the onset and progression of DR. This review summarizes current literature on the role of inflammation in the pathogenesis and progression of DR. In particular, it focuses on clinical inflammatory biomarkers detectable with non-invasive retinal imaging, suggestive of a local inflammatory condition. Current available treatments are applicable only at advanced stages of disease, therefore, there is the need to detect biomarkers of subclinical or early DR that can help in DR management before irreversible damage occurs. A better understanding of inflammatory pathways involved in DR may permit to implement more specific and personalized therapeutic strategies and clinical biomarkers may be a helpful tool in the everyday clinical practice to direct the patient to the most appropriate treatment option.

关键词： Diabetes mellitus diabetic retinopathy(DR) diabetic macular edema inflammation biomarker

Predictive value of preoperative albumin-bilirubin score and other risk factors for short-term outcomes after open pancreatoduodenectomy

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世界临床病例杂志 2023年第26期11卷 6051-6065页

作者： Hana Zavrtanik Davide Cosola David Badovinac Benjamin Hadžialjević Gašper Horvat Danaja Plevel Selene Bogoni Paola Tarchi Nicolòde Manzini Aleštomažič Department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Clinica Chirurgica Azienda Sanitaria Universitaria Giuliano IsontinaCattinara HospitalTrieste 34149Italy Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34149Italy Faculty of Medicine University of LjubljanaLjubljana 1000Slovenia

BACKGROUND Pancreatoduodenectomy represents a complex procedure involving extensive organ resection and multiple alimentary *** is still associated with high morbidity,even in high-volume *** tools including preoperative patient-related factors to preoperatively identify patients at high risk for postoperative complications could enable tailored perioperative management and improve patient *** To evaluate the clinical significance of preoperative albumin-bilirubin score and other risk factors in relation to short-term postoperative outcomes in patients after open *** This retrospective study included all patients who underwent open pancreatic head resection(pylorus-preserving pancreatoduodenectomy or Whipple resection)for various pathologies during a five-year period(2017-2021)in a tertiary care setting at University Medical Centre Ljubljana,Slovenia and Cattinara Hospital,Trieste,***-term postoperative outcomes,namely,postoperative complications,postoperative pancreatic fistula,reoperation,and mortality,were evaluated in association with albumin-bilirubin score and other risk *** logistic regression models were built to identify risk factors associated with these short-term postoperative *** Data from 347 patients were *** complications,major postoperative complications,postoperative pancreatic fistula,reoperation,and mortality were observed in 52.7%,22.2%,23.9%,21.3%,and 5.2%of patients,*** was no statistically significant association between the albumin-bilirubin score and any of these short-term postoperative complications based on univariate *** controlling for other predictor variables in a logistic regression model,soft pancreatic texture was statistically significantly associated with postoperative complications[odds ratio(OR):2.09;95%confidence interval(95%CI):1.19-3.67];male gender(OR:2.12;95%CI:1.15-3.93),soft pan

关键词： Pancreatoduodenectomy Albumin Bilirubin Postoperative complications Pancreatic fistula Perioperative care

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堆叠封装技术:提前实现下一代存储器的密度

电子产品世界 2004年第2期11卷 85-85,88页

作者： Jeanclaude toma SimpleTech公司

随着微型化以及性能提升趋势的不断发展,设计人员不断寻求在尽可能小的空间内获得尽可能高的电气功能和性能.在这一过程中存在的两个关键限制因素通常是集成度和I/O引脚限制.

关键词：堆叠封装存储器集成度 I/O引脚密度

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蔗糖聚酯代谢作用及其应用前景

粮食与油脂 1989年第3期2卷 60-61,58页

作者： toma 王虹安徽粮食科研所

尽管科学技术和医学领域取得进展,但心脏病仍是美国死亡率和发病率居高不下的主要疾病之一,特别是高脂肪高胆固醇膳食认为是增加心脏患病率一种因素。一种简单的解决办法是希望能出现低脂肪和胆固醇的膳食。可惜,象这样的膳食很难获得,... 详细信息

尽管科学技术和医学领域取得进展,但心脏病仍是美国死亡率和发病率居高不下的主要疾病之一,特别是高脂肪高胆固醇膳食认为是增加心脏患病率一种因素。一种简单的解决办法是希望能出现低脂肪和胆固醇的膳食。可惜,象这样的膳食很难获得,特别是对那些久已形成不良饮食习惯的人。蔗糖聚酯(SPE)也许可通过取代食品配方中传统脂肪来解决这个难题,美国国立健康研究所已支持将SPE作为人体不吸收的合成脂肪进行试验研究。 Mattson等(1976)曾描述,SPE酷似脂肪,混溶于甘油三酯,不溶于水。

关键词：营养生物化学蔗糖聚酯代谢作用

Family medicine residency training in Ghana after 20 years:resident attitudes about their education

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Family Medicine and Community Health 2020年第4期8卷 31-39页

作者： Ghazwan toma Akye Essuman Michael D Fetters Department of Family Medicine University of MichiganAnn ArborMichiganUSA Family Medicine Unit Department of Community HealthUniversity of GhanaAccraGhana Mixed Methods Program University of MichiganAnn ArborMichiganUSA

Objective In addition to assessing educational needs of family medicine trainees in Ghana,we sought to assess whether those entering the training programme aimed to pursue an academic *** A case study using an anonymous cross-sectional survey through collaboration between faculty members from the family medicine departments of Ghana and the University of *** The family medicine postgraduate trainees and the most recent graduates in the three training sites,Accra,Kumasi and Mampong,as well as modular residents in Ghana served as the targeted participants during data collection between October and November of *** Second and third year family medicine residents,fellows(known as senior residents in Ghana)and recent graduates were invited to participate in this ***-five of 77 eligible subjects provided responses(46%response rate),but five records were eliminated due to incomplete data to yield a survey completion rate of 39%(30/77).Result Participants were mostly men(n=19),and the average age of respondents was 37 years *** participants indicated the residency programmes needed more faculty 97%(n=29),supervision during outpatient care 87%(n=26)and lectures 83%(n=25).The main reason provided by respondents for entering residency programme in family medicine,which is currently not required for practising primary care in Ghana,was to obtain more education 93%(n=28).Participants who had completed the residency programme were much more likely to be interested in becoming faculty compared with those still in residency(p<0.001).Conclusion The research confirms the need for more faculty and the importance of investing in faculty development resources for ensuring a robust *** findings provide constructive feedback that could improve residency curricula of the local and regional family medicine training programmes and supports investing in trainees and new graduates as future faculty candidates.

关键词： education faculty graduate