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Mesenchymal stem cells as a therapeutic tool to treat sepsis

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World Journal of Stem Cells 2015年第2期7卷 368-379页

作者： Eleuterio Lombardo tom van der poll Olga Dela Rosa Wilfried Dalemans Tecnológico de Madrid Academic Medical Center Division of Infectious Diseases and The Center of Experimental and Molecular MedicineUniversity of Amsterdam Ti Genix NV

Sepsis is a clinical syndrome caused by a deregulated host response to an infection. Sepsis is the most frequent cause of death in hospitalized patients. Although knowledge of the pathogenesis of sepsis has increased substantially during the last decades, attempts to design effective and specific therapiestargeting components of the derailed host response have failed. Therefore, there is a dramatic need for new and mechanistically alternative therapies to treat this syndrome. Based on their immunomodulatory properties, adult mesenchymal stem or stromal cells(MSCs) can be a novel therapeutic tool to treat sepsis. Indeed, MSCs reduce mortality in experimental models of sepsis by modulating the deregulated inflammatory response against bacteria through the regulation of multiple inflammatory networks, the reprogramming of macrophages and neutrophils towards a more antiinflammatory phenotype and the release of antimicrobial peptides. This report will review the current knowledge on the effects of MSC treatment in preclinical experimental small animal models of sepsis.

关键词： Adult mesenchymal stem cells Therapy Sepsis

Inbreeding and genetic load in a pair of sibling grouse species:Tetrastes sewersowi and ***

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Avian Research 2024年第2期15卷 265-270页

作者： Kai Song tom van der Valk Bin Gao Peter Halvarsson Yun Fang Wendong Xie Siegfried Klaus Zhiming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Animal Ecology Department of Ecology and GeneticsUppsala UniversityNorbyvagen 18DUppsala75236Sweden Department of Cell and Molecular Biology Uppsala75273Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesPO Box 7036Uppsala75007Sweden Lindenhohe 5 JenaD-07749Germany The State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China

Genetic load and inbreeding are recognized as important factors to be considered in conservation *** levels of both can increase the risk of population extinction by negatively impacting fitness-related characters in many species of plants and animals,including humans(inbreeding depression).Genomic tech-niques are increasingly used in measuring and understanding genetic load and inbreeding and their importance in evolution and *** used whole genome resequencing data from two sibling grouse species in subarctic Eurasia to quantify *** found a large range of inbreeding measured as FROH(fraction of runs of homozygosity)in individuals from different populations of Chinese Grouse(Tetrastes sewerzowi)and Hazel Grouse(***).FROH estimated from genome-wide runs of homozygosity(ROH)ranged from 0.02 to 0.24 among Chinese Grouse populations and from 0.01 to 0.44 in Hazel *** from a population of Chinese Grouse residing in the Qilian mountains and from the European populations of Hazel Grouse(including samples from Sweden,Germany and Northeast Poland)were the most inbred(FROH ranged from 0.10 to 0.23 and 0.11 to 0.44,respectively).These levels are comparable to other highly inbred populations of *** Grouse from northern China and Chinese Grouse residing in the Qinghai-Tibetan Plateau showed relatively lower inbreeding *** of the ratio between deleterious missense mutations and synonymous mutations revealed higher levels in Chinese Grouse as compared to Hazel *** results are possibly explained by higher fixation rates,mutational melt down,in the range-restricted Chinese Grouse compared to the wide-ranging Hazel ***,when we compared the relatively more severe class of loss-of-function muta-tions,Hazel Grouse had slightly higher levels than Chinese Grouse,a result which may indicate that purifying selection(purging)has been more efficient in Chinese Grouse on this class of mutations.

关键词： Genetic load Inbreeding Purifying selection Qinghai-Tibetan Plateau ROH Tetrastes

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Insights into the hydrogen evolution reaction in vanadium redox flow batteries:A synchrotron radiation based X-ray imaging study

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Journal of Energy Chemistry 2024年第4期91卷 132-144页

作者： Kerstin Köble Alexey Ershov Kangjun Duan Monja Schilling Alexander Rampf Angelica Cecilia tomášFaragó Marcus Zuber Tilo Baumbach Roswitha Zeis Helmholtz Institute Ulm Karlsruhe Institute of Technology89081 UlmGermany Laboratory for Applications of Synchrotron Radiation Karlsruhe Institute of Technology76131 KarlsruheGermany Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany Department of Electrical Electronicsand Communication EngineeringFaculty of EngineeringFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)91058 ErlangenGermany Department of Mechanical and Industrial Engineering University of TorontoToronto M5S 3G8OntarioCanada

The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency ***,a deeper understanding of this process and the accompanying bubble formation is *** benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray *** large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in *** study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V *** hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt ***,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon *** detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance *** described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.

关键词： vanadium redox flow battery Synchrotron X-ray imaging tomography Hydrogen evolution reaction Gas bubbles Deep learning

No evidence for a genetic association between female mating preference and male secondary sexual trait in a Lake Victoria cichlid fish

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Current Zoology 2010年第1期56卷 57-64页

作者： Inke van der SLUIJS Ole SEEHAUSEN tom J.M.van DOOREN Jacques J.M.van ALPHEN Department of Animal Ecology Institute of Biology Leiden University Department of Biology McGill University Institute of Ecology and Evolution University of Bern Department of Fish Ecology & Evolution Centre of Ecology Eawag Swiss Federal Institute for Aquatic Science and TechnologyEvolution & Biogeochemistry

Sexual selection by female mating preference for male nuptial coloration has been suggested as a driving force in the rapid speciation of Lake Victoria cichlid fish. This process could have been facilitated or accelerated by genetic associations between female preference loci and male coloration loci. Preferences, as well as coloration, are heritable traits and are probably determined by more than one gene. However, little is known about potential genetic associations between these traits. In turbid water, we found a population that is variable in male nuptial coloration from blue to yellow to red. Males at the extreme ends of the phenotype distribution resemble a reproductively isolated species pair in clear water that has diverged into one species with blue-grey males and one species with bright red males. Females of the turbid water population vary in mating preference coinciding with the male phenotype distribution. For the current study, these females were mated to blue males. We measured the coloration of the sires and male offspring. Parents-offspring regression showed that the sires did not affect male offspring coloration, which confirms earlier findings that the blue species breeds true. In contrast, male offspring coloration was determined by the identity of the dams, which suggests that there is heritable variation in male color genes between females. However, we found that mating preferences of the dams were not correlated with male offspring coloration. Thus, there is no evidence for strong genetic linkage between mating preference and the preferred trait in this population [Current Zoology 56 （1）： 57-64 2010].

关键词： Speciation Sexual selection Mate choice Genetic association Cichlid fish Lake Victoria

Humeral retroversion and shoulder muscle changes in infants with internal rotation contractures following brachial plexus birth palsy

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World Journal of Orthopedics 2018年第12期9卷 292-299页

作者： Fabian van de Bunt Michael L Pearl tom van Essen Johannes A van der Sluijs Department of Orthopedics Amsterdam UMCVU University Medical Center Department of Shoulder and Elbow Surgery Kaiser Permanente Medical Cente

AIM To examine humeral retroversion in infants who sustained brachial plexus birth palsy(BPBI) and suffered from an internal rotation contracture. Additionally, the role of the infraspinatus(IS) and subscapularis(SSc) muscles in the genesis of this bony deformation is *** Bilateral magnetic resonance imaging(MRI) scans of 35 infants(age range: 2-7 mo old) with BPBI were retrospectively analyzed. Retroversion was measured according to two proximal axes and one distal axis(transepicondylar axis). The proximal axes were:(1) the perpendicular line to the borders of the articular surface(humeral centerline); and(2) the longest diameter through the humeral head. Muscle cross-sectional areas of the IS and SSc muscles were measured on the MRI-slides representing the largest muscle belly. The difference in retroversion was correlated with the ratio of muscle-sizes and passive external rotation *** Retroversion on the involved side was significantly decreased, 1.0° vs 27.6°(1) and 8.5° vs 27.2°(2),(P < 0.01), as compared to the uninvolved side. The size of the SSc and IS muscles on the involved side was significantly decreased, 2.26 cm2 vs 2.79 cm2 and 1.53 cm2 vs 2.19 cm2, respectively(P < 0.05). Furthermore, the muscle ratio(SSc/IS) at the involved side was significantly smaller compared to the uninvolved side(P = 0.007).CONCLUSION Even in our youngest patient population, humeral retroversion has a high likelihood of being decreased. Altered humeral retroversion warrants attention as a structural change in any child being evaluated for the treatment of an internal rotation contracture.

关键词： Humeral retroversion Infants Brachial plexus Brachial plexus neuropathies Shoulder Humerus

Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

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World Journal of Gastroenterology 2017年第6期23卷 1018-1029页

作者： Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong Department of Gastroenterology and Hepatology Leiden University Medical Center C.J.Gorter Center Leiden University Medical Center Department of Radiology Leiden University Medical Center Department of Medical Statistics Leiden University Medical Center Center for Inflammatory Bowel Diseases University of California Los Angeles Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Psychiatry Leiden University Medical Center Department of Rheumatology Leiden University Medical Center Department of Neuropsychology Leiden University Medical Center Department of Radiology Leiden University Medical CenterLeiden

To evaluate brain involvement in quiescent Crohn’s disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI).METHODSMultiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study *** glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine (P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow (P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P 1-weighted analysis. In addition, no correlation was found between mental status and MRI *** work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

关键词： Magnetic resonance imaging Systemic inflammation Fatigue Crohn’s disease Cognition

Mangrove forests as a nature-based solution for coastal flood protection:Biophysical and ecological considerations

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Water Science and Engineering 2023年第1期16卷 1-13页

作者： Rosanna van Hespen Zhan Hu Bas Borsje Michela De Dominicis Daniel AFriess Svetlana Jevrejeva Maarten GKleinhans Maria Maza Celine EJvan Bijsterveldt tom van der Stocken Bregje van Wesenbeeck Danghan Xie Tjeerd JBouma NIOZ Royal Netherlands Institute for Sea Research Department of Estuarine and Delta SystemsP.O.Box 1404400 AC Yersekethe Netherlands Faculty of Geosciences Department of Physical GeographyUtrecht UniversityP.O.Box 80.1153508 TC Utrechtthe Netherlands School of Marine Science Sun Yat-Sen University Zhuhai Campus2 University RoadZhuhai 519000China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510275China Pearl River Estuary Marine Ecosystem Research Station Ministry of EducationZhuhai 519082China Water Engineering&Management University of TwenteP.O.Box 2177500 AE Enschedethe Netherlands National Oceanography Centre Joseph Proudman Building6 Brownlow StreetLiverpool L35DAUK Department of Geography National University of Singapore1 Arts LinkSingapore 117570Singapore Centre for Nature-based Climate Solutions National University of Singapore16 Science Drive 4Singapore 117558Singapore Instituto de Hidraulica Ambiental de La Universidad de Cantabria(IHCantabria) Isabel Torres 1539011 SantanderSpain Wetlands International P.O.Box 4716700 AL Wageningenthe Netherlands Ecology and Biodiversity Group Department of BiologyVrije Universiteit BrusselPleinlaan 2B-1050 BrusselsBelgium Earth Science Section Jet Propulsion LaboratoryCalifornia Institute of Technology4800 Oak Grove DrivePasadenaCA 91109USA Unit for Marine and Coastal Systems Deltares2600 MH Delftthe Netherlands Department of Hydraulic Engineering Delft University of Technology2600 GA Delftthe Netherlands

Nature-based coastal protection is increasingly recognised as a potentially sustainable and cost-effective solution to reduce coastal flood *** uses coastal ecosystems such as mangrove forests to create resilient designs for coastal flood ***,to use mangroves effectively as a nature-based measure for flood risk reduction,we must understand the biophysical processes that govern risk reduction capacity through mangrove ecosystem size and *** this perspective,we evaluate the current state of knowledge on local physical drivers and ecological processes that determine mangrove functioning as part of a nature-based flood *** show that the forest properties that comprise coastal flood protection are well-known,but models cannot yet pinpoint how spatial heterogeneity of the forest structure affects the capacity for wave or surge ***,there is relatively good understanding of the ecological processes that drive forest structure and size,but there is a lack of knowledge on how daily bed-level dynamics link to long-term biogeomorphic forest dynamics,and on the role of combined stressors influencing forest *** simulation models of forest structure under changing physical(*** to sea-level change)and ecological drivers with hydrodynamic attenuation models will allow for better projections of long-term natural coastal protection.

关键词： Forest dynamics Seedling establishment Hydrodynamic energy attenuation Bed-level dynamics Forest structure Mangrove tree mortality

Fuel Consumption Potential of the Pushbelt CVT

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重庆理工大学学报（自然科学） 2011年第7期25卷 1-13页

作者： van der Sluis, Francis van Dongen, tom van Spijk, Gert-Jan van der Velde, Arie van Heeswijk, Ad van Doorne＇ s Transmissie-Bosch Group Netherlands

The efforts to further reduce fuel consumption of vehicles equipped with a pushbelt type Continuously Variable Transmission(CVT) focus on different sources of *** this paper the magnitude of these losses and their potential for reduction is *** the CVT,the variator,its control strategy and the hydraulic actuation circuit can be distinguished as the main potentials.A major opportunity is offered by a new control strategy that takes the actual slip between belt and pulley as the control *** resulting decrease of clamping forces on the pushbelt leads to a reduction of variator and actuation *** potential is found in the hydraulic actuation circuit by an improved tuning of the power supply to the actual power *** the CVT additional potential is found in start-stop functionality as supported by measures inside the *** paper describes the theoretical background as well as practical fuel savings of up to 5.5% that were obtained in tests on vehicle *** control adds an inherent robustness to the operation of the pushbelt and opens up the fuel saving potential of the CVT thus reinforcing its position as the benchmark for the near future.

关键词： CVT pushbelt fuel consumption reduction control strategy hydraulics