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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell tobias steinschaden Rose Horowitz Yuanquan song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNs)and the poor regenerative capacity of the central nervous system(CNs)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Boundary behavior of Gleason's problem in hyperbolic harmonic Bergman spaces

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science China Mathematics 2005年第2期48卷 145-154页

作者： Uwe khler Department of Mathematics

Necessary and sufficient conditions are obtained for the boundedness of Berezin transformation on Lebesgue space Lp(B,dVβ) in the real unit ball B in Rn. As an application, we prove that Gleason type problem is solvable in hyperbolic harmonic Bergman spaces. Furthermore we investigate the boundary behavior of the solutions of Gleason type problem.

关键词： hyperbolic harmonic functions Berezin transformation Gleason’s problem.

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Correction of Breathing Motion in the Thorax for Helical CT

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Tsinghua science and Technology 2010年第1期15卷 87-95页

作者： Thomas khler tobias klinder Udo van stevendaal Cristian Lorenz Peter Forthmann Philips Research Europe-Hamburg Rontgenstrasse 24-26HamburgGermany Institut für Informationsverarbeitung Leibniz University HannoverHannover 30167Germany

This paper investigates a reconstruction method for helical computed tomography which compensates for the motion artifacts in the thorax caused by patient breathing. The method takes into account a motion vector field determined from a four-dimensional （4-D） uncompensated image data set. surface models of the lung and the ribs are tracked through the 4-D data set to create motion information within the entire thorax. Finally, an image is reconstructed using motion compensated back-projection. The results show that due to the use of shape models for the motion estimation, the method is fast and robust. Furthermore, since the surfaces are tracked individually, reconciling the opposite motion direction of the lung and rib cage in one motion vector field is avoided.

关键词： computed tomography (CT) motion compensation reconstruction respiratory motion

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

A Glimpse into the Natural History of Leiolepis rubritaeniata Mertens,1961(squamata:Leiolepididae)

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Asian Herpetological Research 2023年第2期14卷 147-155页

作者： Gunther kÖhler Panupong THAMMACHOTI senckenberg Forschungsinstitut und Naturmuseum Senckenberganlage 25Frankfurt a.M.60325Germany Department of Biology Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand

During the months of April through July 2020 we studied aspects of the natural history of Leiolepis rubritaeniata,a species of butterfly lizard that occurs on the khorat Plateau in Thailand and adjacent regions of Laos and Cambodia as well as in south-central *** present data on population size and structure,as well as location,size,compass orientation,and structure of the lizard’s ***,we present climatic data(ambient air temperature and precipitation)at the study site for the duration of our field work as well as temperature data for the complete year ***,we provide data on egg laying,incubation conditions and characteristics of the ***,we present an easy to use and reliable non-invasive method for the long-term recognition of individual butterfly lizards based on their unique dorsal *** lizards are utilized as a food source for the local human *** far,there are no farming projects in Thailand involving this species and all individuals are collected from the wild *** data are available on the population dynamics of *** but it can be assumed that habitat destruction due to land use change as well as its utilization for human consumption have negative effects on the long-term survival of the local populations of this lizard *** baseline data presented here are essential for any meaningful conservation strategy for these lizards.

关键词： Burrow structure butterfly lizard ecology khorat Plateau southeast Asia squamata

Targeting the EGF receptor family in non-small cell lung cancerincreased complexity and future perspectives

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Cancer Biology & Medicine 2022年第11期19卷 1543-1564页

作者： tobias Boch Jens kohler Melanie Janning sonja Loges DkFZ-Hector Cancer Institute at the University Medical Center Mannheim Mannheim 68135Germany Division of Personalized Medical Oncology(A420) German Cancer Research Center(DKFZ)Heidelberg 69120Germany Department of Personalized Oncology University Medical Center MannheimMedical Faculty MannheimHeidelberg UniversityMannheim 68135Germany

Lung cancer remains the leading cause of cancer-associated mortality worldwide,but with the emergence of oncogene targeted therapies,treatment options have tremendously *** to their biological relevance,members of the ERBB receptor family,including the EGF receptor(EGFR),HER2,HER3 and HER4,are among the best studied oncogenic *** EGFR mutations are frequently observed in non-small cell lung cancer(NsCLC),and small molecule tyrosine kinase inhibitors(TkIs)are the established first line treatment option for patients whose tumors bear"typical/classical"EGFR mutations(exon 19 deletions,L858R point mutations).Additionally,new TkIs are rapidly evolving with better efficacy to overcome primary and secondary treatment resistance(e.g.,that due to T790M or C797s resistance mutations).some atypical EGFR mutations,such as the most frequent exon 20 insertions,exhibit relative resistance to earlier generation TkIs through steric *** this subgroup,newer TkIs,such as mobocertinib and the bi-specific antibody amivantamab have recently been approved,whereas less frequent atypical EGFR mutations remain *** contrast to EGFR,HER2 has long remained a challenging target,but better structural understanding has led to the development of newer generations of *** recent FDA approval of the antibody-drug conjugate trastuzumab-deruxtecan for pretreated patients with HER2 mutant NsCLC has been an important therapeutic ***3 and HER4 also exert oncogenic potential,and targeted treatment approaches are being developed,particularly for ***,strategies to inhibit the oncogenic function of ERBB receptors in NsCLC are currently evolving at an unprecedented pace;therefore,this review summarizes current treatment standards and discusses the outlook for future developments.

关键词： Oncology NsCLC EGFR HER2 HER3 HER4

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating