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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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两类领导反馈何以带来不同的员工创新绩效?趋近-回避理论框架下的一个整合型解释

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管理工程学报 2025年第2期39卷 27-40页

作者：辛迅刘婷婷西南政法大学商学院

领导情境因素对于员工创新有着重要影响,领导积极反馈和消极反馈在影响员工创新绩效过程中发挥着不同作用。为在同一框架下揭示这种差异性作用,本文在趋近-回避理论框架下构建了两类领导反馈对员工创新绩效影响的综合模型,首先考察了员... 详细信息

领导情境因素对于员工创新有着重要影响,领导积极反馈和消极反馈在影响员工创新绩效过程中发挥着不同作用。为在同一框架下揭示这种差异性作用,本文在趋近-回避理论框架下构建了两类领导反馈对员工创新绩效影响的综合模型,首先考察了员工趋近-回避工作重塑的平行中介作用,然后结合自我决定理论考察了员工的绩效趋近-回避目标导向在其中发挥的调节作用。通过对230名科技员工的三阶段数据分析,本文发现:领导积极反馈通过提升员工趋近型重塑促进员工创新绩效,领导消极反馈通过员工回避型重塑抑制员工创新绩效;绩效趋近目标导向在领导积极反馈通过趋近重塑影响创新绩效中具有互补效应,而绩效回避目标导向在领导消极反馈通过回避重塑影响创新绩效中具有强化效应。本文针对两类领导反馈影响创新绩效的差异作用给出了整合性的解释,打开了领导反馈影响创新的行为过程性“黑箱”,同时也为管理者如何审慎、合理利用两种领导反馈以促进员工创新提供一定启发。

关键词：领导反馈员工创新绩效趋近型工作重塑回避型工作重塑绩效目标导向

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Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during ***:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during ***:Sixteen RCTs with a cumulative sample size of 1178 cases were *** these,964 patients were included in the *** Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low ***:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively ***,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

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In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates

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Virologica Sinica 2022年第3期37卷 398-407页

作者： tingting liu Anlei liu Yong liu Shan Cen Quan Zhang Department of Transfusion Medicine Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Emergency Medicine Peking Union Medical College HospitalChinese Academy of Medical ScienceBeijing100730China Department of Laboratory Medicine Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular MedicineThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Institute of Medicinal Biotechnology Chinese Academy of Medical ScienceBeijing100050China Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China

Hepatitis B virus(HBV)genotype B and C are two major genotypes that are prevalent in Asia and differ in natural history and disease *** impact of HBV genotypes on viral replication and protein expression has been explored by the transfection of hepatoma cells with replication-competent HBV DNA,which mimics the later stages of the viral life ***,the influence of HBV genotypes on the early events of viral infection remains undetermined,mainly due to the difficulties in obtaining sufficient infectious viral particles for infection ***,we report that a high-titer HBV inoculum can be generated from the transient transfection-based cell model after optimizing transfection conditions and modifying the HBV-expressing *** performing in vitro infection assays using transiently transfected derived viruses,we found that clinical genotype C isolates possessed higher infectivity than genotype B ***,we identified a naturally occurring mutation sL21S in small hepatitis B surface protein,which markedly decreased the infectivity of HBV genotype C isolates,but not that of genotype B *** summary,using infectious viral particles provided by the optimized transient transfection-based cell model,we have been able to investigate a wide range of HBV variants on viral infectivity,which may contribute to our understanding of the reasons for different clinical outcomes in HBV infections and the development of therapeutic drugs targeting the early stages of HBV life cycle.

关键词： Hepatitis B virus(HBV) Genotype B Genotype C Clinical isolates Infectivity sL21S

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Multifunctional WSe_(2)/Co_(3)C composite for efficient electromagnetic absorption, EMI shielding, and energy conversion

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Nano Research 2024年第3期17卷 1655-1665页

作者： Yuhang Zhu tingting liu Lin Li Maosheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics&Electron EngineeringHarbin Normal UniversityHarbin 150025China

Currently,as the electromagnetic(EM)environment becomes increasingly complex,single-function EM materials can hardly resist the increasing electromagnetic interference(EMI),and there is an urgent need to develop multifunctional EM *** this work,multifunctional WSe_(2)/Co_(3)C was prepared by simple hydrothermal *** dielectric performance and EM response were *** absorption,shielding performance,and energy conversion devices were *** tailoring the loading content,WSe_(2)/Co_(3)C can switch between EM absorption and EMI *** maximum shielding effectiveness(SE)of WSe_(2)/Co_(3)C reached 36 dB,and high reflection loss(RL)of-60.28 dB and wide effective absorption bandwidth(EAB)of 6.16 GHz can be obtained at low *** multiple EM attenuation mechanisms brought by the combination of two-dimensional(2D)WSe_(2) and magnetic Co_(3)C are considered to be the main reason for the enhanced EM attenuation *** WSe_(2)/Co_(3)C composite provides a viable candidate for developing multifunctional EM materials in 2–18 GHz.

关键词： WSe_(2) Co_(3)C electromagnetic property microwave absorption electromagnetic interference shielding energy conversion

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Fe3O4 encapsulated mesoporous silica nanospheres with tunable size and large void pore

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Frontiers of Chemical Science and Engineering 2014年第1期8卷 114-122页

作者： tingting liu Lihong liu Jian liu Shaomin liu Shi Zhang QIAO Department of Chemical Engineering Curtin University Perth WA 6845 Australia School of Chemical Engineering The University of Adelaide SA5005 Australia

Magnetic Fe3O4 and mesoporous silica core- shell nanospheres with tunable size from 110-800 nm were synthesized via a one step self-assembly method. The morphological, structural, textural, and magnetic proper- ties were well-characterized by scanning electron micro- scopy, transmission electron microscopy, X-ray diffraction, N2 adsorption-desorption and magnetometer. These nanocomposites, which possess high surface area, large pore volume and well-defined pore size, exhibit two dimensional hexagonal （P6mm） mesostructures. Interest- ingly, magnetic core and mesoporous silica shell nano- composites with large void pore （20 nm） on the shell were generated by increasing the ratio of ethanol/water. Additionally, the obtained nanocomposites combined magnetization response and large void pore, implying the possibility of applications in drug/gene targeting delivery. The cell internalization capacity of NH2-functionalized nanocomposites in the case of cancer cells （HeLa cells） was exemplified to demonstrate their nano-medicine application.

关键词： mesoporous silicas magnetic nanoparticles,core-shell nanoparticles cell uptake

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Theoretical Exploration of Stereochemical Nonrigidity for RfCo（PF3）x（CO）4-x（Rf=CF3, C2F5, C3F7, x=0-4）

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Chemical Research in Chinese Universities 2014年第4期30卷 656-660页

作者： liu tingting LU Xi ZHANG Mingtao Computational Center for Molecular Science College of Chemistry Nankai University Tianjin 300071 P. R. China Department of Chemical and Materials Engineering University of Alberta Edmonton AB T6G 2V4 Canada

The stereochemical nonrigidity of RfCo（PF3）x（CO）4-x（Rf=CF3,C2F5,C3F7,x=0-4） was studied at the theoretical level of B3LYP/6-31 1＋G^＊ via Gaussian *** intramolecular rearrangements in these penta-coordinated compounds are mainly caused by the vibrations of perfluoroalkyl *** the barriers along the reaction coordinate are less than 66.9 kJ/mol,which indicates that the rearrangements are kinetically favorable and hard to elucidate by ***,ligand PF3 is a ligand similar to CO,the energy difference between the reactant and product is small.

关键词： Density functional theory(DFT) Intramolecular rearrangement Stereochemical nonrigidity Pentacoordination

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The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice

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Food Science and Human Wellness 2023年第2期12卷 503-511页

作者： Shanshan Zhang Xinle Xu Xu Cao tingting liu School of Food Science and Engineering Jilin Agricultural UniversityChangchun 130118China Scientific Research Base of Edible Mushroom Processing Technology Integration Ministry of Agriculture and Rural AffairsChangchun 130118China Engineering Research Center of Grain Deep-processing and High-effeciency Utilization of Jilin Province Changchun 130118China Key Laboratory of Technological Innovations for Grain Deep-processing and High-effeciency Utilization of By-products of Jilin Province Changchun 130118China

In this study,Tremella fuciformis residues as raw material,dietary fibers from tremella were prepared by multiple *** structure of dietary fibers from tremella was studied by Fourier transform infrared(FTIR),X-ray diffraction analysis(XRD)and scanning electron microscopy(SEM).We analyzed their lipidlowering properties in vitro(water holding,oil holding swelling cholesterol and sodium cholate binding capacitises)and the hypolipidemic effects in *** results showed that tremella dietary fibers presented the infrared absorption spectrum characteristics of polysaccharides and the characteristic diffraction peaks of cellulose type *** results indicated that the surface of insoluble dietary fiber(IDF)was porous,while the soluble dietary fiber(SDF)was relatively compact and *** exhibited significantly higher water holding,oil holding,and swelling binding capacities than the corresponding ***,SDF exhibited significantly higher viscosity than *** results showed tremella dietary fibers were significant in swelling,water holding and oil holding,cholesterol and bile *** vivo experiment results in mice indicated that SDF has the best effect on hyperlipidemia mice than IDF and total dietary fiber(TDF).SDF showed that the total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)contents dropped by 28.33%,18.65%,and 48.97%,respectively,while high density lipoprotein cholesterol(HDL-C)content increased by 43.80%.Compared with the high-fat control(HCM)group,the arteriosclerosis index(AI)and liver index(LI)of the SDF group mice showed significant differences,indicating that SDF has a good auxiliary effect of lowering blood *** administration of tremella fibers improved the lipid metabolism disorderly situation of hyperlipidemia *** results provide a reference for further research and rational development of ***.

关键词： Tremella fuciformis Dietary fiber Structural characterization Hypolipidemic effects

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Changes in area fraction of sediment-laden sea ice in the Arctic Ocean during 2000 to 2021

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Acta Oceanologica Sinica 2024年第9期43卷 81-92页

作者： Yuanyang Xie tingting liu Na Li Ruibo Lei Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430079China Key Laboratory of Polar Environment Monitoring and Public Governance Wuhan UniversityWuhan 430079China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China

Sediment-laden sea ice plays an important role in Arctic sediment transport and biogeochemical cycles,as well as the shortwave radiation budget and melt onset of ice ***,at present,there is a lack of efficient observation approach from both space and in situ for the coverage of Arctic sediment-laden sea ***,both spatial distribution and long-term changes in area fraction of such ice floes are still *** study proposes a new classification method to extract Arctic sediment-laden sea ice on the basic of the difference in spectral characteristics between sediment-laden sea ice and clean sea ice in the visible band using the MOD09A1 data with the resolution of 500 m,and obtains its area fraction over the pan Arctic Ocean during 2000−*** with Landsat-8 true color verification images with a resolution of 30 m,the overall accuracy of our classification method is 92.3%,and the Kappa coefficient is *** impact of clouds on the results of recognition and spatiotemporal changes of sediment-laden sea ice is relatively small from June to July,compared to that in May or ***,sediment-laden sea ice mostly appears over the marginal seas of the Arctic Ocean,especially the continental shelf of Chukchi Sea and the Siberian *** with the retreat of Arctic sea ice extent,the total area of sediment-laden sea ice in June-July also shows a significant decreasing trend of 8.99×10^(4) km^(2) per *** occurrence of sediment-laden sea ice over the Arctic Ocean in June-July leads to the reduce of surface albedo over the ice-covered ocean by 14.1%.This study will help thoroughly understanding of the role of sediment-laden sea ice in the evolution of Arctic climate system and marine ecological environment,as well as the heat budget and mass balance of sea ice itself.

关键词： sea ice sediments optical remote sensing Arctic Ocean

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Investigation of the Laser Powder Bed Fusion Process of Ti-6.5Al-3.5Mo-1.5Zr-0.3Si Alloy

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Chinese Journal of Mechanical Engineering 2023年第2期36卷 78-90页

作者： Changchun Zhang tingting liu Wenhe Liao Huiliang Wei Ling Zhang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Mechanical and Vehicle Engineering West Anhui UniversityLuan 237012China

Laser powder bed fusion(LPBF)is an advanced manufacturing technology;however,inappropriate LPBF process parameters may cause printing defects in *** the present work,the LPBF process of Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy was investigated by a two-step optimization ***,heat transfer and liquid flow behaviors during LPBF were simulated by a well-tested phenomenological model,and the defect formation mechanisms in the as-fabricated alloy were *** optimized process parameters for LPBF were detected as laser power changed from 195 W to 210 W,with scanning speed of 1250 mm/*** LPBF process was divided into a laser irradiation stage,a spreading flow stage,and a solidification *** morphologies and defects of deposited tracks were affected by liquid flow behavior caused by rapid cooling *** findings of this research can provide valuable support for printing defect-free metal components.

关键词： Laser powder bed fusion Ti-6.5Al-3.5Mo-1.5Zr-0.3Si alloy Process parameters Heat transfer and liquid flow Defects

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