Fe3O4 encapsulated mesoporous silica nanospheres with tunable size and large void pore

作     者：Tingting LIU Lihong LIU Jian LIU Shaomin LIU Shi Zhang QIAO 

作者机构：Department of Chemical Engineering Curtin University Perth WA 6845 Australia School of Chemical Engineering The University of Adelaide SA5005 Australia 

出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)

年 卷 期：2014年第8卷第1期

页      面：114-122页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：supported by the Australian Research Council (ARC) through Discovery Project program 

主　　题：mesoporous silicas magnetic nanoparticles,core-shell nanoparticles cell uptake 

摘      要：Magnetic Fe3O4 and mesoporous silica core- shell nanospheres with tunable size from 110-800 nm were synthesized via a one step self-assembly method. The morphological, structural, textural, and magnetic proper- ties were well-characterized by scanning electron micro- scopy, transmission electron microscopy, X-ray diffraction, N2 adsorption-desorption and magnetometer. These nanocomposites, which possess high surface area, large pore volume and well-defined pore size, exhibit two dimensional hexagonal （P6mm） mesostructures. Interest- ingly, magnetic core and mesoporous silica shell nano- composites with large void pore （20 nm） on the shell were generated by increasing the ratio of ethanol/water. Additionally, the obtained nanocomposites combined magnetization response and large void pore, implying the possibility of applications in drug/gene targeting delivery. The cell internalization capacity of NH2-functionalized nanocomposites in the case of cancer cells （HeLa cells） was exemplified to demonstrate their nano-medicine application.