检索结果-南通市图书馆

Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： Chang-Sheng Zuo Kang Wang Li-Zhen sun ting-ting sun Department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第3期12卷 575-581页

作者： Qing-Qing Dou ting-ting sun Guo-Qiang Wang Wei-Bing Tong Graduate Student Institute Inner Mongolia Medical UniversityHohhot 010000Inner Mongolia Autonomous RegionChina Central Breast Area B Beijing University Cancer Hospital Inner Mongolia HospitalHohhot 010000Inner Mongolia Autonomous RegionChina

BACKGROUND Breast cancer brain metastasis(BCBM)is an advanced breast disease that is difficult to treat and is associated with a high risk of *** prognosis is usually poor,with reduced quality of *** this context,we report the case of a patient with HER-2-positive BCBM treated with a macromolecular mAb(ine-tetamab)combined with a small molecule tyrosine kinase inhibitor(TKI).CASE SUMMARY The patient was a 58-year-old woman with a 12-year history of type 2 *** was compliant with regular insulin treatment and had good blood glucose *** patient was diagnosed with invasive carcinoma of the right breast(T3N1M0 stage IIIa,HER2-positive type)through aspiration biopsy of the ipsilateral breast due to the discovery of a breast tumor in February *** showed ER(-),PR(-),HER-2(3+),and Ki-67(55-60%+).Preoperative neoadjuvant chemotherapy,i.e.,the AC-TH regimen(epirubicin,cyclophosphamide,docetaxel-paclitaxel,and trastuzumab),was administered for 8 *** underwent modified radical mastectomy of the right breast in November 2019 and received tocilizumab targeted therapy for 1 *** metastasis was found 9 mo after *** underwent brain metastasectomy in August *** showed ER(-)and PR.(-),HER-2(3+),and Ki-67(10-20%+).In November 2020,the patient experienced headache *** an examination,tumor recurrence in the original surgical region of the brain was observed,and the patient was treated with inetetamab,pyrotinib,and ***-brain radiotherapy was *** patient and her family refused radiotherapy for personal *** September 2021,a routine examination revealed that the brain tumor was considerably *** original systemic treatment was continued and combined with intensity-modulated radiation therapy for brain metastases,followed by regular hospitalization and routine *** patient’s condition is generally stable,and she has a relatively high qua

关键词： Breast cancer brain metastasis Resistance to trastuzumab Macromolecule inetetamab Small molecule tyrosine kinase inhibitor Radiation therapy HER2-positive Case report

Inner fission barriers of uranium isotopes in the deformed relativistic Hartree-Bogoliubov theory in continuum

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第10期48卷 214-221页

作者： Wei Zhang Jin-Ke Huang ting-ting sun Jing Peng Shuang-Quan Zhang School of Physics Zhengzhou UniversityZhengzhou 450001China Department of Physics Beijing Normal UniversityBeijing 100875China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The inner fission barriers of the even-even uranium isotopes from the proton to the neutron drip line are examined using the deformed relativistic Hartree-Bogoliubov theory in continuum.A periodic-like evolution for the ground state shapes is shown with respect to the neutron number,i.e.,spherical shapes at shell closures 126,184,258,and prolate dominated shapes between *** to the shape evolution,the inner fission barriers also exhibit a periodic-like behavior:peaks at the shell closures and valleys in the *** triaxial effect on the inner fission barrier is evaluated using triaxial relativistic mean field calculations combined with a simple BCS method for *** the triaxial correction is included,the inner barrier heights show good consistency with available empirical ***,the evolution from the proton to the neutron drip line aligns with results from the multi-dimensionally constrained relativistic mean field theory.A flat valley in the fission barrier height is predicted around the neutron-rich nucleus U which may play a role of fission recycling in astrophysical r-process nucleosynthesis.

关键词： inner fission barrier potential energy curve triaxiality deformed relativistic Hartree-Bogoliubov theory in continuum

Searching for single-particle resonances with the Green’s function method

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第5期32卷 24-32页

作者： Ya-Tian Wang ting-ting sun School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Single-particle resonances in the continuum are crucial for studies of exotic *** this study,the Green’s function approach is employed to search for single-particle resonances based on the relativistic-mean-field ***^(120)Sn as an example,we identify singleparticle resonances and determine the energies and widths directly by probing the extrema of the Green’s *** contrast to the results found by exploring for the extremum of the density of states proposed in our recent study[***.C,44:084105(2020)],which has proven to be very successful,the same resonances as well as very close energies and widths are *** comparing the Green’s functions plotted in different coordinate space sizes,we also found that the results very slightly depend on the space *** findings demonstrate that the approach by exploring for the extremum of the Green’s function is also very reliable and effective for identifying resonant states,regardless of whether they are wide or narrow.

关键词： Single-particle resonances Extrema of Green’s functions Relativistic-mean-field theory

A STUDY ON THE STRUCTURAL TRANSITION OF A SINGLE POLYMER CHAIN BY PARALLEL TEMPERING MOLECULAR DYNAMICS SIMULATION

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2012年第1期30卷 45-55页

作者： Zhou-ting Jiang Peng Xu ting-ting sun Department of Applied Physics China Jiliang University Hangzhou 310018 China College ofInformation and Electronic Engineering Zhejiang Gongshang University Hangzhou 310018 China

The structural transition of a single polymer chain with chain length of 100,200 and 300 beads was investigated by parallel tempering MD *** simulation results can capture the structural change from random coil to orientationally ordered structure with decreasing *** clear transition was observed on the curves of radius of gyration and global orientational order parameter P as the function of temperature,which demonstrated structural formation of a single polymer *** linear relationships between three components of square radius of gyration R_（gx）~2,R_（gx）~2,R_（gz）~2 and global orientational order P can be obtained under the structurally transformational *** slope of the linear relationship between x（or y-axis） component R_（gx）~2（or R_（gy）~2） and P is negative,while that of RL as the function of P is *** absolute value of slope is proportional to the chain *** the single polymer chain takes the random coil or ordered configuration,the linear relationship is *** conformational change was also analyzed on microscopic *** polymer chain can be treated as the construction of rigid stems connecting by flexible *** deviation from exponentially decreased behavior of stem length distribution becomes prominent,indicating a stiffening of the chain arises leading to more and more segments ending up in the trans state with decreasing *** stem length N_（tr） is about 21 bonds indicating the polymer chain is ordered with the specific fold ***,the simulation results,which show the prototype of a liquid-crystalline polymer chain,are helpful to understand the crystallization process of crystalline polymers.

关键词： A polymer chain Structural transition Parallel tempering molecular dynamics

Possible shape coexistence in Ne isotopes and the impurity effect of Λ hyperon

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 29-40页

作者： Chen Chen Qian-Kun sun Yu-Xiao Li ting-ting sun School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

The possible shape coexistence in even-even Ne isotopes and the impurity effects of the sΛ and pΛ hyperons are explored employing the multidimensionally constrained relativistic-mean-field(MDC-RMF) model with the PK1 parameter set for the N N interaction and PK1-Y1 for the ΛN interaction. The quadrupole deformation potential energy surfaces(PESs), nuclear deformations, nuclear radii, binding energies, and density distributions of the hypernuclei and core nuclei are examined. The possible shape coexistence in ^(24,26,28)Ne is predicted with small energy differences of 140, 336, and 128 keV, respectively, between the two local energy minima. Different impurity effects of the sΛand pΛ hyperons are revealed. The sΛ hyperon exhibits clear shrinkage effects, which reduce the nuclear size and facilitate a spherical nuclear shape. The prolate pΛhyperon on the 1/2^(-)[110] orbital renders the nuclear shape more prolate, while the oblate pΛ hyperon on the 3/2^(-)[101] or 1/2^(-)[101] orbital renders the nuclei more oblate. Moreover, the Λ hyperon can increase the probabilities of the shape coexistence by reducing the energy differences between the two local energy minima, although the shape coexistence may disappear owing to the vanishment of one energy minimum on the flat energy surface.

关键词： single-Λhypernuclei shape coexistence impurity effects Ne isotope

RATE OF INTRAMOLECULAR CONTACT FORMATION IN PROTEINS

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2007年第2期25卷 197-201页

作者： Lin-xi Zhang ting-ting sun Xiang-hong Wang Department of Physics Wenzhou University Wenzhou 325027 China Department of Physics Zhejiang University Hangzhou 310027 China

In this paper, we estimate the rate of contact formation between two residues in the interior of the proteins using the Szabo, Schulten, and Schulten formula with the probability distribution P（r） based on 375 proteins from PDB （Protein Data Bank）. The probability distribution for residue pair in proteins is different from the Gaussian distribution, especially for short distance between two residues in proteins. The rate of contact formation in the interior of protein is discussed as a function of distance n （=｜j -i｜） between two residues, and it decreases monotonically with n and follows the scaling relationship of k ∝ n^-γ with γ= 1.43 for the contact radius a = 0.40 nm and γ=1.05 for a = 0.50 nm. The diffusion coefficient for the relative diffusion of two residues in the interior of proteins is estimated as D = 6.4 × 10^-6 cm^2/s, which is close to the result that is found for monomer diffusion.

关键词： Rate of intramolecular contact formation Probability distribution P(r).

Acrosome reaction in the cumulus oophorus revisited:involvement of a novel sperm-released factor NYD-SP8

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2011年第2期2卷 92-98页

作者： ting ting sun Chin Man Chung Hsiao Chang Chan Epithelial Cell Biology Research Center School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina

Fertilization is a process involving multiple steps that lead to the final fusion of one sperm and the oocyte to form the *** of the steps,acrosome reaction(AR),is an exocytosis process,during which the outer acrosome membrane fuses with the inner sperm membrane,leading to the release of acrosome enzymes that facilitate sperm penetration of the egg *** AR has been investigated for decades,the initial steps of AR in vivo,however,remain largely unknown.A well elucidated model holds the view that AR occurs on the surface of the zona pellucida(ZP),which is triggered by binding of sperm with one of the ZP glycosylated protein,***,this model fails to explain the large number of‘falsely’acrosome-reacted sperms found within the cumulus layer in many species *** the emerging evidence of cross-talk between sperm and cumulus cells,the potential significance of AR in the cumulus oophorus,the outer layer of the egg,has been gradually *** we review the acrosome status within the cumulus layer,the cross-talk between sperm and cumulus cells with the involvement of a novel spermreleased factor,NYD-SP8,and re-evaluate the importance and physiological significance of the AR in the cumulus in fertilization.

关键词： sperm acrosome reaction cumulus NYP-SP8 progesterone

An Algorithm of Voice Activity Detection Based on EMD and Wavelet Entropy Ratio

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2017年第1期15卷 64-68页

作者： Xiao-Bing Zhang ting-ting sun Yan-Ping School of Electrical and Information Engineering Anhui University of TechnologyMaanshan 243000China

A new method was proposed to identify speech-segment endpoints based on the empirical mode decomposition（EMD） and a new wavelet entropy ratio with improving the accuracy of voice activity *** the EMD, the noise signals can be decomposed into several intrinsic mode functions（IMFs）. Then the proposed wavelet energy entropy ratio can be used to extract the desired feature for each IMFs component. In view of the question that the method of voice endpoint detection based on the original wavelet entropy ratio cannot adapt to the low signal-to-noise ratio（SNR）condition, an appropriate positive constant was introduced to the basic wavelet energy entropy ratio with effectively improved discriminability between the speech and noise. After comparing the traditional wavelet energy entropy ratio with the proposed wavelet energy entropy ratio, the experiment results show that the proposed method is simple and fast. The speech endpoints can be accurately detected in low SNR environments.

关键词： wavelet entropy decomposed Wavelet adapt environments Voice noisy empirical desired

Continuum Skyrme Hartree-Fock-Bogoliubov theory with Green’s function method for neutron-rich Ca,Ni,Zr,and Sn isotopes

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第7期34卷 162-178页

作者： En-Bo Huo Ke-Ran Li Xiao-Ying Qu Ying Zhang ting-ting sun School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Mechatronics Engineering Guizhou Minzu UniversityGuiyang 550025China Department of Physics School of ScienceTianjin UniversityTianjin 300072China Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology Guangxi Normal UniversityGuilin 541004China

The possible exotic nuclear properties in the neutron-rich Ca,Ni,Zr,and Sn isotopes are examined with the continuum Skyrme Hartree-Fock-Bogoliubov theory in the framework of the Green’s function *** pairing correlation,the couplings with the continuum,and the blocking effects for the unpaired nucleon in odd-A nuclei are properly *** Skyrme interaction SLy4 is adopted for the ph channel and the density-dependentinteraction is adopted for the pp chan-nel,which well reproduce the experimental two-neutron separation energies S_(2n)and one-neutron separation energies *** is found that the criterion S_(n)>0 predicts a neutron drip line with neutron numbers much smaller than those for S_(2n)>*** to the unpaired odd neutron,the neutron pairing energies−E_(pair)in odd-A nuclei are much lower than those in the neighbor-ing even-even *** investigating the single-particle structures,the possible halo structures in the neutron-rich Ca,Ni,and Sn isotopes are predicted,where sharp increases in the root-mean-square(rms)radii with significant deviations from the traditional rA^(1∕3)rule and diffuse spatial density distributions are *** the contributions of various partial waves to the total neutron densityρlj(r)∕ρ(r)reveals that the orbitals located around the Fermi surface-particularly those with small angular momenta-significantly affect the extended nuclear density and large rms *** number of neutrons Nλ(N_(0))occupying above the Fermi surfacen(continuum threshold)is discussed,whose evolution as a function of the mass number A in each isotope is consistent with that of the pairing energy,supporting the key role of the pairing correlation in halo phenomena.

关键词： Neutron-rich nuclei Neutron halo Skyrme Hartree-Fock-Bogoliubov theory Green’s function method