Acrosome reaction in the cumulus oophorus revisited:involvement of a novel sperm-released factor NYD-SP8

作     者：Ting Ting Sun Chin Man Chung Hsiao Chang Chan 

作者机构：Epithelial Cell Biology Research CenterSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2011年第2卷第2期

页      面：92-98页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the authors’lab was supported in parts by the National 973 Project(Nos.2006CB504002 and 2006CB944002) the Focused Investment Scheme on Major Areas of The Chinese University of Hong Kong 

主　　题：sperm acrosome reaction cumulus NYP-SP8 progesterone 

摘      要：Fertilization is a process involving multiple steps that lead to the final fusion of one sperm and the oocyte to form the *** of the steps,acrosome reaction(AR),is an exocytosis process,during which the outer acrosome membrane fuses with the inner sperm membrane,leading to the release of acrosome enzymes that facilitate sperm penetration of the egg *** AR has been investigated for decades,the initial steps of AR in vivo,however,remain largely unknown.A well elucidated model holds the view that AR occurs on the surface of the zona pellucida(ZP),which is triggered by binding of sperm with one of the ZP glycosylated protein,***,this model fails to explain the large number of‘falsely’acrosome-reacted sperms found within the cumulus layer in many species *** the emerging evidence of cross-talk between sperm and cumulus cells,the potential significance of AR in the cumulus oophorus,the outer layer of the egg,has been gradually *** we review the acrosome status within the cumulus layer,the cross-talk between sperm and cumulus cells with the involvement of a novel spermreleased factor,NYD-SP8,and re-evaluate the importance and physiological significance of the AR in the cumulus in fertilization.