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Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing

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Identification of a novel salt tolerance gene in wild soybea...

Convergence Rate for Galerkin Approximation of the Stochastic Allen–Cahn Equations on 2D Torus

第十四届全国中药和天然药物学术研讨会

作者： Xinpeng Qi Man-Wah Li Min Xie Xin Liu Meng Ni Guihua Shao Chi Song Aldrin Kay-Yuen Yim Ye Tao Fuk-Ling Wong Sachiko Isobe Chi-Fai Wong Kwong-Sen Wong Chunyan Xu Chunqing Li Ying Wang Rui Guan Fengming Sun Guangyi Fan Zhixia Xiao Feng Zhou Tsui-Hung Phang Xuan Liu Suk-Wah Tong ting-fung chan Siu-Ming Yiu Satoshi Tabata Jian Wang Xun Xu Hon-Ming Lam School of Life Sciences and Center for Soybean Research of the State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong BGI-Shenzhen Institute of Crop Sciences The Chinese Academy of Agricultural Sciences Kazusa DNA Research Institute Department of Computer Science The University of Hong Kong

＜正＞Using a whole-genome-sequencing approach to explore germplasm resources can serve as an important strategy for crop improvement,especially in investigating wild accessions that may contain useful genetic resources that have been lost during the domestication *** we sequence and assemble a draft genome of wild soybean and construct a

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来源： cnki会议评论

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Acta Mathematica Sinica,English Series 2021年第3期37卷 471-490页

作者： ting MA Rong chan ZHU College of Mathematics Sichuan UniversityChengdu 610065P.R.China Department of Mathematics Beijing Institute of TechnologyBeijing 100081P.R.China Department of Mathematics University of BielefeldD-33615 BielefeldGermany

In this paper we discuss the convergence rate for Galerkin approximation of the stochastic Allen–Cahn equations driven by space-time white noise on T^(2). First we prove that the convergence rate for stochastic 2D heat equation is of order α-δ in Besov space C^(-α) for α∈(0, 1) and δ > 0 arbitrarily small. Then we obtain the convergence rate for Galerkin approximation of the stochastic Allen–Cahn equations of order α-δ in C^(-α) for α∈(0, 2/9) and δ > 0 arbitrarily small.

关键词： Stochastic Allen–Cahn equations convergence rate Galerkin projection Besov space white noise

Acrosome reaction in the cumulus oophorus revisited:involvement of a novel sperm-released factor NYD-SP8

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Protein & Cell 2011年第2期2卷 92-98页

作者： ting ting Sun Chin Man Chung Hsiao chang chan Epithelial Cell Biology Research Center School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina

Fertilization is a process involving multiple steps that lead to the final fusion of one sperm and the oocyte to form the *** of the steps,acrosome reaction(AR),is an exocytosis process,during which the outer acrosome membrane fuses with the inner sperm membrane,leading to the release of acrosome enzymes that facilitate sperm penetration of the egg *** AR has been investigated for decades,the initial steps of AR in vivo,however,remain largely unknown.A well elucidated model holds the view that AR occurs on the surface of the zona pellucida(ZP),which is triggered by binding of sperm with one of the ZP glycosylated protein,***,this model fails to explain the large number of‘falsely’acrosome-reacted sperms found within the cumulus layer in many species *** the emerging evidence of cross-talk between sperm and cumulus cells,the potential significance of AR in the cumulus oophorus,the outer layer of the egg,has been gradually *** we review the acrosome status within the cumulus layer,the cross-talk between sperm and cumulus cells with the involvement of a novel spermreleased factor,NYD-SP8,and re-evaluate the importance and physiological significance of the AR in the cumulus in fertilization.

关键词： sperm acrosome reaction cumulus NYP-SP8 progesterone

Integrating traditional Chinese (herbal) medicines into risk based regulation-With focus on non-clinical requirements to demonstrate safety

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 88-94页

作者： Vivian S.W.chan fung Independent Scholar 2 Woodward PlaceSt IvesNSW2075Australia

Within the public health sector of Hong Kong(China),there is a consensus around the important role of traditional Chinese *** Hong Kong(China)to play a bridging role to bring Chinese medicines to the global market requires a concerted effort from the government,academic institutes and *** release of the final version of the European Medicines Agencies guidance document,which details the acceptance of minimum requirements to nonclinical package in bibliographical applications,grants the opportunity for well-established and traditional herbal medicines to demonstrate an‘acceptable safe’status for registration in the European *** is anticipated that this minimum nonclinical package can be applied to demonstrate the safe use of many traditional Chinese medicines regardless of their eligibility to be registered under the simplified procedure within the European *** paper conceptualizes an integration of a simplified evaluation route for eligible proprietary Chinese medicines(pCm)with long history of use into the existing drug regulatory framework in Hong Kong(China).Such integration utilizing the minimum nonclinical package,based on bibliographical data or expert report,as proof of evidence to demonstrate safety for pCm with long history of use requires less demand in scientific *** Hong Kong(China)conducting‘first hand’review for eligible pCm,it provides an option for overseas and local pharmaceutical companies to register their products in Hong Kong(China)without the need to rely on issuance of Certificate of Pharmaceutical Product from other *** could bring eligible pCm with long history of use to reach international risk-based standard and to be marketed globally as‘medicines’to reach their full therapeutic *** important process to positioning Hong Kong(China)to compete with other countries in promoting importation and exportation of pCm to better serve the global health.

关键词： Proprietary and traditional Chinese herbal medicines Internationalization Nonclinical Drug regulation and registration reform Certificate of pharmaceutical product

Duplex kidneys and the risk of urinary tract infection in children

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World Journal of Pediatrics 2022年第2期18卷 144-146页

作者： Chon In Kuok Wun fung Hui Winnie Kwai Yu chan Department of Paediatrics Queen Elizabeth Hospital30 Gascoigne RoadKowloonHong KongChina

Duplex kidney,also known as duplicated kidney or renal duplication,is a form of congenital anomaly of kidney and urinary tract(CAKUT)characterized by the presence of two pelvicalyceal systems,dividing a kidney into up... 详细信息

关键词： kidney Duplex urinary

Protein Residue Contact Prediction Based on Deep Learning and Massive Statistical Features from Multi-Sequence Alignment

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Tsinghua Science and Technology 2022年第5期27卷 843-854页

作者： Huiling Zhang Min Hao Hao Wu Hing-fung ting Yihong Tang Wenhui Xi Yanjie Wei Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China College of Electronic and Information Engineering Southwest UniversityChongqing 400715China School of Software Engineering University of Science and Technology of ChinaHefei 230051China Department of Computer Science The University of Hong KongHong Kong 999077China School of Computer Science Beijing University of Posts and TelecommunicationsBeijing 100876China

Sequence-based protein tertiary structure prediction is of fundamental importance because the function of a protein ultimately depends on its 3 D *** accurate residue-residue contact map is one of the essential elements for current ab initio prediction protocols of 3 D structure ***,with the combination of deep learning and direct coupling techniques,the performance of residue contact prediction has achieved significant ***,a considerable number of current Deep-Learning(DL)-based prediction methods are usually time-consuming,mainly because they rely on different categories of data types and third-party *** this research,we transformed the complex biological problem into a pure computational problem through statistics and artificial *** have accordingly proposed a feature extraction method to obtain various categories of statistical information from only the multi-sequence alignment,followed by training a DL model for residue-residue contact prediction based on the massive statistical *** proposed method is robust in terms of different test sets,showed high reliability on model confidence score,could obtain high computational efficiency and achieve comparable prediction precisions with DL methods that relying on multi-source inputs.

关键词： multi-sequence alignment residue-residue contact prediction feature extraction statistical information Deep Learning(DL) high computational efficiency

A harmonisation approach to traditional Chinese medicine registration in Asian countries

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 143-147页

作者： Vivian S.W.chan fung Independent Scholar 2 Woodward PlaceSt IvesNSW 2075Australia

The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic *** to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in ***,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing *** author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world *** this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is *** like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the ***,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing *** are valuable information for future drug *** therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory *** early establishment of a harmonized risk-based registration process for TCM in Asian countries is *** will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.

关键词： Traditional Chinese medicines Population genetic Harmonization Registration Asian countries

Magnetically controllable multimode interference in topological photonic crystals

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Light(Science & Applications) 2024年第5期13卷 998-1005页

作者： Weiyuan Tang Mudi Wang Shaojie Ma Che ting chan Shuang Zhang New Cornerstone Science Laboratory Department of PhysicsThe University of Hong KongHong KongChina. Department of Physics The Hong Kong University of Science and TechnologyHong KongChina. Department of Optical Science and Engineering Fudan UniversityShanghai 200433China

Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp *** number of topological edge states relies on the difference between the bulk Chern numbers across the boundary,as dictated by the bulk edge *** interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic *** this work,we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different *** successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of *** work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.

关键词： multimode controllable microwave

Ion channels/transporters as epigenetic regulators?——a microRNA perspective

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Science China(Life Sciences) 2012年第9期55卷 753-760页

作者： JIANG XiaoHua ZHANG Jie ting chan Hsiao chang Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong China Key Laboratory for Regenerative Medicine Jinan University-The Chinese University of Hong Kong Ministry of Education of China Guang- zhou 510632 China Sichuan University-The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine West China Women and Childern's Hospital Chengdu 610041 China

MicroRNA （miRNA） alterations in response to changes in an extracellular microenvironment have been observed and consid- ered as one of the major mechanisms for epigenetic modifications of the cell. While enormous efforts have been made in the understanding of the role of miRNAs in regulating cellular responses to the microenvironment, the mechanistic insight into how extracellular signals can be transduced into miRNA alterations in cells is still lacking. Interestingly, recent studies have shown that ion channels/transporters, which are known to conduct or transport ions across the cell membrane, also exhibit changes in levels of expression and activities in response to changes of extraceUular microenvironment. More importantly, al- terations in expression and function of ion channels/transporters have been shown to result in changes in miRNAs that are known to change in response to alteration of the microenvironment. In this review, we aim to summarize the recent data demonstrating the ability of ion channels/transporters to transduce extracellular signals into miRNA changes and propose a potential link between cells and their microenvironment through ion channels/transporters. At the same time, we hope to pro- vide new insights into epigenetic regulatory mechanisms underlying a number of physiological and pathological processes, in- eluding embryo development and cancer metastasis.

关键词： ion channel miRNAs epigenetic microenvironment