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Transcriptomic profiling of sorghum leaves and roots responsive to drought stress at the seedling stage

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Journal of Integrative Agriculture 2019年第9期18卷 1980-1995页

作者： ZHANG Deng-feng zeng ting-ru LIU Xu-yang GAO Chen-xi LI Yong-xiang LI Chun-hui SONG Yan-chun SHI Yun-su WANG Tian-yu LI Yu Institute of Crop Sciences Chinese Academy of Agricultural Sciences

Drought stress affects the growth and productivity of crop plants including *** study the molecular basis of drought tolerance in sorghum,we conducted the transcriptomic profiling of sorghum leaves and roots under drought stress using RNA-Seq method.A total of 510,559,and 3 687 differentially expressed genes(DEGs)in leaves,3 368,5 093,and 4 635 DEGs in roots responding to mild drought,severe drought,and re-watering treatments were identified,*** them,190 common DEGs in leaves and 1 644 common DEGs in roots were responsive to mild drought,severe drought,and re-watering *** Ontology(GO)enrichment analysis revealed that the GO categories related to drought tolerance include terms related to response to stimulus especially response to water deprivation,abscisic acid stimulus,and reactive oxygen *** major transcription factor genes responsive to drought stress include heat stress transcription factor(HSF),ethylene-responsive transcription factor(ERF),Petunia NAM,Arabidopsis ATAF1/2 and CUC2(NAC),WRKY transcription factor(WRKY),homeodomain leucine zipper transcription factor(HD-ZIP),basic helix-loop-helix transcription factor(bHLH),and V-myb myeloblastosis viral oncogene homolog transcription facotr(MYB).Functional protein genes for heat shock protein(HSPs),late-embryogenesis-abundant protein(LEAs),chaperones,aquaporins,and expansins might play important roles in sorghum drought ***,the genomic regions enriched with HSP,expansin,and aquaporin genes responsive to drought stress could be used as powerful targets for improvement of drought tolerance in sorghum and other ***,our results provide a genome-wide analysis of DEGs in sorghum leaves and roots under mild drought,severe drought,and re-watering *** study contributes to a better understanding of the molecular basis of drought tolerance of sorghum and can be useful for crop improvement.

关键词： sorghum(Sorghum bicolor L.) transcriptomic profiling drought leaves roots

Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 22-32页

作者： Yi-Ming Zhao Rong-Sha Sun Fang Duan Fang-Yu Wang Yu-Jie Li Xiao-Bing Qian Jie-ting zeng Yao Yang Xiao-Feng Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Xi’an People’s Hospital(Xi’an Fourth Hospital) Shaanxi Eye HospitalXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular ***:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham *** eyes were used as normal *** intraocular pressure(IOP)was monitored using an iCare *** severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence ***:During the observation period,PVR severity gradually *** Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR *** significantly alleviated PVR development and Müller cell ***-traumatic inflammation fluctuated and was *** interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after *** expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1β*** suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal ***:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over *** treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR *** study highlights the important role of IL-1β,and Ozurdex inhibites inflammation pres

关键词： ocular trauma proliferative vitreoretinopathy gliosis Ozurdex inflammation rabbit

Elevated procalcitonin levels in the absence of infection in procalcitonin-secretin hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10811-10816页

作者： Jian-ting zeng Yu Wang Yang Wang Zheng-Hua Luo Zhou Qing Yi Zhang Yan-Lin Zhang Jie-Feng Zhang De-Wei Li Xian-Zhang Luo Key Laboratory for Biological Science and Technology of Ministry of Education Chongqing UniversityChongqing University Cancer HospitalChongqing 400044China

BACKGROUND Serum procalcitonin(PCT)is widely used to diagnose bacterial infection and ***,PCT may be elevated in some *** is important to distinguish infection from no infection in such *** relationship between hepatocellular carcinoma(HCC)and PCT is *** SUMMARY A 62-year-old male was admitted due to a hepatic lesion of unknown *** patient had an elevated PCT *** diseases were excluded after appropriate *** then underwent exploratory laparotomy and a left lateral hepatectomy was *** patient recovered with an uneventful postoperative course and PCT level decreased gradually and was normal on day *** was diagnosed by histopathology and no evidence of infection was ***,immunohistochemical analyses revealed that tumor cells were positive for *** HCC cells can secrete PCT in the absence of infection and PCT may be used as a marker to monitor the efficacy of tumor therapy.

关键词： Hepatocellular carcinoma Procalcitonin Infection Case report

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“以癖为美”:晚明生活美学样态的畸变

河南师范大学学报（哲学社会科学版） 2013年第4期40卷 144-148页

作者：曾婷婷广东技术师范学院文学院广东广州510665

在晚明,以"癖"为美逐渐演变为文人阶层普遍追求的生活品貌及价值观。与以往相比,晚明文人癖好呈现出感官化、世俗化、生活化等特点,它是晚明经济、政治、文化、思想等各方面的合力所共同塑就的独特文化景观。晚明文人以"癖"为美,"癖"既... 详细信息

在晚明,以"癖"为美逐渐演变为文人阶层普遍追求的生活品貌及价值观。与以往相比,晚明文人癖好呈现出感官化、世俗化、生活化等特点,它是晚明经济、政治、文化、思想等各方面的合力所共同塑就的独特文化景观。晚明文人以"癖"为美,"癖"既反映出一种人性解放、反抗社会世俗价值的意图,又显示一种以"癖"来寄托、承载生命价值、意义,透过"癖"让生命超拔于世俗世界之上的理想。"癖"是审美感官力发展的极致,这种身心与外物的紧密结合,开启了一个新的美学时代。经由癖、疵等偏执之美成就的主体的独特性,深刻反映了文人对生命本真意义的思索与追寻,体现了晚明文人生活美学样态的畸变。

关键词： “癖” 日常生活审美美学内涵畸变

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论中国古典诗词中的重复与意境建构

深圳大学学报（人文社会科学版） 2011年第3期28卷 116-120页

作者：曾婷婷中山大学中文系广东广州510275 广东技术师范学院广东广州510665

前苏联美学家洛特曼从结构主义符号学的角度强调了重复作为一个重要原则对诗歌的意义。而重复性作为中国古典诗词的重要特征,不仅属于诗歌的形式和结构因素,对诗歌意境的建构也起着重要作用。在中国古典诗歌文本中,词语(言语)在语调、... 详细信息

前苏联美学家洛特曼从结构主义符号学的角度强调了重复作为一个重要原则对诗歌的意义。而重复性作为中国古典诗词的重要特征,不仅属于诗歌的形式和结构因素,对诗歌意境的建构也起着重要作用。在中国古典诗歌文本中,词语(言语)在语调、语义、句法、结构等诸多方面的相等(相似)或成对的相等,激活了差异,差异转为对立,进而形成张力,使诗歌文本成为无尽的信息源。平仄、押韵、对偶、重章叠句等重复性因素对意境建构具有重要意义,其所造成的高度语义结构以及特殊浓度思想,是创造中国古典诗词意境的重要源泉。

关键词：意境重复差异张力

Antidepressant-Like Effects of Ginseng and Ginsenosides in Central Nervous System

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神经药理学报 2018年第6期 27-28页

作者： zeng ting WANG Zhen-zhen CHEN Nai-hong College of Pharmacy Hunan University of Chinese Medicine State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical College

Depression is a devastating mental disorder and major depressive disorder afflicts 16% of the global population in their lives. Currently available classical antidepressants require a minimum of 2～4 weeks of continuous treatment to elicit therapeutic relief in depressed patients and are associated with high rates of non-responsiveness and various side effects. Therefore,more safe and effective antidepressant therapies are needed. Here,we review recent advances in understanding the molecular mechanisms underlying the efficacy of traditional chinese medicine-ginseng and ginsenosides in ameliorating the symptoms of depression in humans and animal models. For instance,Panax ginseng exhibited an antidepressant-like effect through the BDNF/TrkB and Sirt 1/NF-κB signaling pathways. The anti-depression efficacy of ginseng total saponins may be largely attributable to its peripheral anti-inflammatory activity,interfering with hippocampal GSK-3β-CREB signaling pathway,reversing decrease of some plasticity-related proteins,and modulating 5-HT and 5-HT2 AR expressions after depression. P. ginseng extract exerts antidepressant-like effect of CRS-induced depression by antineuroinflammatory and antioxidant( nuclear factor erythroid 2 related factor 2/heme oxygenase-1 activation) activities by inhibiting the HPA axis mechanism. Wild ginseng extract and intestinal metabolite of ginseng,20(S)-protopanaxadiol modulates depression-like behavior by regulating the expression of hypothalamic corticotrophin-releasing factor,Neuropeptide Y,glucocorticoid receptor,BDNF and neurofilament-L in hippocampus. Ginsenoside Rg1 displayed antidepressant activity through alleviating CORT-induced gap junction dysfunction,modulating the HPA and the HPG axis,activating the BDNF signaling pathway,upregulating hippocampal neurogenesis,and increasing protein kinase A( PKA) and cAMP-CREB phosphorylation levels. Ginsenoside Rg3 exerted antidepressant effect by regulating noradrenaline,adrenocorticotropic horm

关键词： Antidepressant-Like Effects of Ginseng and Ginsenosides in Central Nervous System

H1亚型禽流感病毒RT-RPA-LFD快速检测方法的建立及应用

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江西农业学报 2024年第3期36卷 61-66页

作者：曾婷婷李孟谢芝勋李丹谢丽基罗思思张民秀王盛谢志勤范晴阮志华粟永春广西壮族自治区兽医研究所广西兽医生物技术重点实验室/农业农村部中国(广西)-东盟跨境动物疫病防控重点实验室广西南宁530001 广西金陵农牧集团有限公司/广西博士后创新实践基地广西南宁530049

以H1亚型AIV的HA基因为研究对象,采用重组聚合酶核酸等温扩增技术(RPA),通过RT-PCR方法优选出1套引物,进而优化体系的反应温度、最佳探针及引物浓度,使用优化后的最佳反应体系进行敏感性及特异性试验,并探索该方法能达到的最短反应时间... 详细信息

以H1亚型AIV的HA基因为研究对象,采用重组聚合酶核酸等温扩增技术(RPA),通过RT-PCR方法优选出1套引物,进而优化体系的反应温度、最佳探针及引物浓度,使用优化后的最佳反应体系进行敏感性及特异性试验,并探索该方法能达到的最短反应时间,利用侧向流动免疫(LFD)试纸条观测反应后的结果,最终建立检测H1亚型AIV的RT-RPA-LFD快速检测方法。结果表明:建立的RT-RPA-LFD快速检测方法在探针工作浓度为0.14 mmol/L,37℃条件下反应20 min,可最低检测到1.5×10^(2)copies/反应的H1亚型AIV RNA,其他常见家禽病原体未见阳性反应。该方法与RT-PCR及鸡胚分离鉴定测序结果完全一致,可满足H1亚型AIV临床快速鉴别诊断的需求,为基层兽医现场快速检测提供技术支撑。

关键词： H1亚型AIV 等温扩增技术快速检测 RT-RPA-LFD

Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

我院2012-2014年第二类精神药品使用分析

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中国药房 2015年第32期26卷 4479-4481页

作者：曾婷重庆市第六人民医院重庆400060

目的:为第二类精神药品的合理使用提供参考。方法:对我院2012-2014年使用的第二类精神药品用量、销售金额、用药频度(DDDs)、日均费用(DDC)进行统计分析,评估我院第二类精神药品使用的趋势以及用药结构的合理性。结果:我院2012-2014使... 详细信息

目的:为第二类精神药品的合理使用提供参考。方法:对我院2012-2014年使用的第二类精神药品用量、销售金额、用药频度(DDDs)、日均费用(DDC)进行统计分析,评估我院第二类精神药品使用的趋势以及用药结构的合理性。结果:我院2012-2014使用的第二类精神药品有9个品种,其中口服剂5种,注射剂4种。2012-2014年第二类精神药品销售总金额分别为22 551.33、31 489.95、57 742.87元,2013和2014年增长率分别为39.64%和83.37%。用量逐年递增,其中艾司唑仑片用量最大,连续3年排第1位,且3年DDDs均排第1位;苯巴比妥片DDC值最小。结论:我院2012-2014年第二类精神药品以口服药物为主,结构合理。使用数量和金额逐年增长,增长幅度较为合理。

关键词：第二类精神药品销售金额用药频度日均费用