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Central pancreatectomy for benign or low-grade malignant pancreatic tumors in the neck and body of the pancreas

World Journal of Gastrointestinal Surgery 2022年第9期14卷 896-903页

作者： Yi-Wen Chen Jian Xu Xiang Li Wei Chen Shun-liang Gao Yan Shen Min Zhang Jian Wu Ri-Sheng Que Jun Yu ting-Bo liang Xue-Li Bai Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Pancreatic Disease Zhejiang Provincial Key LaboratoryHangzhou 310000Zhejiang ProvinceChina The Study of Pancreatic Disease Zhejiang Provincial Innovation CenterHangzhou 310000Zhejiang ProvinceChina The Study of Hepatobiliary&Pancreatic Diseases Zhejiang Provincial Clinical Research CenterHangzhou 310003Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND For tumors in the neck and body of the pancreas,distal pancreatectomy(DP)has been the standard surgical procedure for the last few decades and central pancreatectomy(CP)is an alternative surgical *** CP better preserves remnant pancreatic endocrine and exocrine functions after surgery remains a subject of *** To evaluate the safety and efficacy of CP compared with DP for benign or lowgrade malignant pancreatic tumors in the neck and body of the *** This retrospective study enrolled 296 patients who underwent CP or DP for benign and low-malignant neoplasms at the same hospital between January 2016 and March *** outcomes and long-term morbidity of endocrine/exocrine function were prospectively *** No significant difference was observed in overall morbidity or clinically relevant postoperative pancreatic fistula between the two groups(P=0.055).Delayed gastric emptying occurred more frequently in the CP group than in the DP group(29.4%vs 15.3%;Pting benign or low-grade malignant neoplasms in suitable patients.

关键词： Central pancreatectomy Distal pancreatectomy Endocrine function Exocrine function Morbidity

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Research on Consumption Structure of Rural Residents in Gansu Province Based on ELES Model

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Asian Agricultural Research 2011年第9期3卷 34-37页

作者： LI ting-ting,SHI Chang-liang,ZHANG An-liang Beijing Forestry University,Beijing 100045,China

By using cross-section data on consumption structure of rural residents in Gansu Province in 2007 and 2008,this paper adopts ELES model to conduct empirical analysis on consumption structure of rural residents in Gansu *** indicates that in the current consumption structure of rural residents in Gansu Province,food expenditure is still at the most important and basic level;the overall consumption level of rural residents in Gansu Province is not high;at present,the consumption of rural residents in Gansu Province still hinges in a large measure on income,vulnerable to the price ***,increasing farmers' income and stabilizing the level of commodity price,turns out to be a foundation as well as an important approach to improve consumption structure of rural residents in Gansu Province.

关键词： ELES model Consumption structure Rural residents G

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Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2+)-dependent AMPK/mTOR pathway

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-Hui Huang Jiao Lyu Sheng Chen ting-Yi liang Yu-Qing Rao Ping Fei Jing Li Hai-Ying Jin Pei-Quan Zhao Department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 270,300,400,500,or 600 mOsm for 6,12,18,24h in *** chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein *** transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy *** electron microscopy was used to detect the existence of *** interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related *** cytometry was employed to test the apoptosis and intracellular Ca^(2+)*** membrane potential was measured by JC-1 *** cell counting kit-8 assay was used to calculate the cellular *** wound healing assay was used to evaluate the wound closure *** 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in *** 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression *** Ca^(2+)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early *** on this evidence,autophagy activation through the Ca^(2+)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic *** stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration *** of autophagy by ATG7 knockdown had sim

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

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Early degeneration of meniscus revealed by micro-biomechanical alteration

Early degeneration of meniscus revealed by micro-biomechanic...

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第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： ting liang Zongping Luo The First Affiliated Hospital of Soochow University

Objective The micro-biomechanical properties of meniscus is critical to define the cell response to surround-ing biomechanical environment, and to understand meniscus repairing and healing. Up to date, however, this information still remains ambiguous. This study aim to characterize the micro-biomechanical properties of meniscus after degeneration in a rabbit anterior cruciate ligament transection model and to analyze the corresponding

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Reduced-size liver transplantation for glycogen storage disease

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 106-108页

作者： Ji, Hao-Feng Wang, Wei-Lin Shen, Yan Zhang, Min liang, ting-Bo Wu, Jian Xu, Xiao Yan, Sheng Zheng, Shu-Sen Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Hepatobiliary Pancreat Surg Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Glycogen storage disease (GSD) is an inherited metabolic disorder in which the concentration and/or structure of glycogen in tissues is abnormal. Essentially, abnormalities in all known enzymes involved in the synthesis or degradation of glycogen and glucose have been found to cause some type of GSD. Liver and muscle have abundant quantities of glycogen and are the most common and seriously affected tissues. This study was to assess reduced-size liver transplantation for the treatment of GSD. METHODS: The clinical data from one case of GSD type I with hepatic adenoma was retrospectively analyzed. The clinical manifestations were hepatomegaly, delayed puberty, growth retardation, sexual immaturity, hypoglycemia, and lactic acidosis, which made the young female patient eligible for reduced-size liver transplantation. RESULTS: The patient recovered uneventfully with satisfactory outcome, including 12 cm growth in height and 5 kg increase in weight during 16 months after successful reduced-size liver transplantation. She has been living a normal life for 4 years so far. CONCLUSIONS: Reduced-size liver transplantation is an effective treatment for GSD with hepatomegaly and hepatic adenoma. Delayed puberty, growth retardation, hypoglycemia and lactic acidosis can be cured by surgery.

关键词： reduced-size liver transplantation glycogen storage disease hepatic adenoma von Gierke's disease

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Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions

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Chinese Medical Journal 2011年第8期124卷 1221-1228页

作者： LIU Bing WANG Qin YUAN Dong-dong HONG Xiao-ting TAO liang Department of Pharmacology Zhongshan School of Medicine SunYat-sen University Guangzhou Guangdong 510080 China

Background Clinical combination of some traditional Chinese medical herbs, including berberine, with irradiation is demonstrated to improve efficacy of tumor radiotherapy, yet the mechanisms for such effect remain largely unknown. The present study investigated the effect of berberine on apoptosis induced by X-rays irradiation and the relation between this effect and gap junction intercellular communication （GJIC）.Methods The role of gap junctions in the modulation of X-rays irradiation-induced apoptosis was explored by manipulation of connexin （Cx） expression, and gap junction function, using oleamide, a GJIC inhibitor, and *** In transfected HeLa cells, Cx32 expression increased apoptosis induced by X-rays irradiation, while inhibition of gap junction by oleamide reduced the irradiation responses, indicating the dependence of X-rays irradiation-induced apoptosis on GJIC. Berberine, at the concentrations without cytotoxicity, enhanced apoptosis induced by irradiation only in the presence of functional gap *** These results suggest that berberine potentizes cell apoptosis induced by X-rays irradiation, probably through enhancement of gap junction activity.

关键词： berberine gap junctions X-rays irradiation apoptosis

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Early detection of joint degeneration in the subtalar and talonavicular joints secondary to ankle instability in a mouse model

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Medicine in Novel Technology and Devices 2021年第3期11卷 168-175页

作者： Zhi Chen ting liang Junkun Li Chao Gao Fan He Zongping Luo Huilin Yang Hongtao Zhang Jia Yu Department of Orthopedics The First Affiliated Hospital of Soochow UniversityNo.188 Shizi StSuzhou215006Jiangsu ProvincePR China Orthopedic Institute Medical CollegeSoochow UniversityNo.708 Renmin RdSuzhou215006Jiangsu ProvincePR China Department of Orthopedics Changshu Hospital Affiliated to Soochow UniversityChangshu No.1 People's HospitalNo.1 Shuyuan StChangshu215500Jiangsu ProvincePR China

Background:Many patients with ankle sprain have secondary subtalar and talonavicular injuries,which have a great impact on their life and ***::This study aimed to investigate the biomechanical impact of ankle instability on the subtalar joint(STJ)and talonavicular joint(TNJ)using a mouse model to enhance the clinical understanding of early stage secondary joint ***:Twenty four 8-week old male C57BL/6 J mice were randomly allocated to three *** the calcaneofibular ligament(CFL)and anterior talofibular ligament(ATFL)of the left ankle were cut off in the CFLþATFL group to simulate severe ankle instability while only the CFL was excised in the CFL group to mimic moderate ankle *** operation was done in SHAM group to simulate the normal *** histological analysis,atomic force microscopy(AFM)–based nanoindentation tests and inspection by scanning electron microscopy(SEM)were used to assess the degree of joint degeneration in the tibiotalar joint(TTJ),STJ and TNJ of three ***:A significant increase of histological score for both CFL and CFLþATFL group was demonstrated in the TTJ,compared with the SHAM *** in the STJ and TNJ,the histological score only increased for CFLþATFL ***-based nanoindentation results demonstrated significant differences in elastic modulus between all groups in the TTJ,while for the STJ and TNJ,only the comparison between the CFLþATFL group and SHAM group was considered statistically *** SEM presented signs of cracking and disintegration within the subchondral bone(SCB)interface in the CFLþATFL group ***:The findings indicate that severe ankle instability resulted in early degeneration of the STJ and TNJ in a mouse model,which may provide referential values for clinical practice.

关键词： Biomechanics Atomic force microscopy Adjacent joint Animal model

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GEOCHEMICAL CHARACTERISTICS OF GRANITES AND ITS STRUCTURAL GENETIC ENVIRONMENT IN THE NANDAN-HECHI METALLOGENETIC BELT, NORTHWEST GUANGXI

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Geotectonica et Metallogenia 2004年第2期28卷 128-141页

作者： CAI Minghai liang ting WU Decheng HUANG Huimin Yichang Institute of Geology and Minerals Yichang Hubei443003China Liuzhou Huaxi Co. Ltd. Liuzhou Guangxi 545006China Department of Geology and Mineral Resources Chang''an University Xi''an Shanxi710054China Liuzhou Huaxi Co. Ltd. Liuzhou Guangxi 545006China Liuzhou Huaxi Co. Ltd. Liuzhou Guangxi 545006China

The Nandan-Hechi metallogenetic belt is the most important tin-polymetallic producing district in China, and is the location of the Dachang super-large tin deposit. Based on the detailed field investigation and isotopic data, the stages of magmatic activity in the Nandan-Hechi metallogenetic belt have been lined out in this paper. Through the study about the geochemical characteristics of different granites, and by using ω(Al2O3)-ω(SiO2), ω(TFeO)/[ω(TFeO)+ω(MgO)]-ω(SiO2), AFM, ACF and Rb-Yb+Ta, Rb-Y+Nb, Ta-Yb, Nb-Y discrimination diagrams in combination with regional geological setting analysis, the authors carried out analyses about the structural environment for the formation of the granites, and discussed the structural environment and dynamic setting for the large scale mineralization in this area. Our study indicates that the majority of the granites in Nandan-Hechi metallogenetic belt belong to the POG type, while the later stage alaskite belongs to the RRG+CEUG type. The granites were formed at the stage of structural transformation from postorogenic phase to intraplate setting. But the major structural environment is characterized by steady regional extension. The formation age for the granites coincides with the time for this transformation, and this translation environment is favored for large-scale metallogenesis.

关键词： granite geochemistry structural environment Nandan-Hechi metallogenetic belt northwest Guangxi

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不确定无序量测系统的最优网络化状态估计

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电子学报 2011年第A3期39卷 7-13页

作者：葛泉波冯肖亮徐廷梁杭州电子科技大学信息与控制研究所浙江杭州310018 浙江大学工业控制技术国家重点实验室浙江杭州310027 河海大学计算机与信息工程学院江苏南京210098

本文以线性时不变或系统参数预先确定的单传感器系统为对象,研究带有不确定随机无序量测约束下的最优网络化估计问题.基于线性时不变或参数预先确定系统的滤波器系数矩阵离线计算和线性最小方差估计的线性加权求和特性,首先介绍传统Kal... 详细信息

本文以线性时不变或系统参数预先确定的单传感器系统为对象,研究带有不确定随机无序量测约束下的最优网络化估计问题.基于线性时不变或参数预先确定系统的滤波器系数矩阵离线计算和线性最小方差估计的线性加权求和特性,首先介绍传统Kalman滤波的等价测量值加权求和形式.然后,以该测量值加权求和滤波器为基础,结合布尔二值开关和无序量测直接求和补偿技术,针对两种典型无序量测跟踪系统分别设计全局最优网络化Kalman滤波器.最后,四个仿真例子验证了本文算法的有效性和优越性.

关键词：线性时不变系统不确定延迟无序量测线性最小均方误差估计 Kalman滤波

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Arcuate ligament syndrome inducing hepatic artery thrombosis after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 433-436页

作者： Jiang, Zhi-Jun liang, ting-Bo Feng, Xiao-Ning Wang, Wei-Lin Shen, Yan Zhang, Min Wu, Jian Xu, Xiao Zheng, Shu-Sen Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Hepatobiliary & Pancreat Surg Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Hepatic artery thrombosis (HAT) is a frequent complication following liver transplantation, but it is rarely caused by arcuate ligament compression of the celiac artery. This article mainly describes our experience in managing a patient with celiac artery stenosis and HAT after liver transplantation. METHODS: A 44-year-old man with a 15-year history of hepatitis B was admitted to our hospital for hepatocellular carcinoma. Before the operatiori, he received transarterial chemoembolization once, and pretransplant MR angiography indicated a suspected stenosis at the initiation of the celiac artery, while color Doppler showed normal blood flow in the arterial system. In this case, orthotopic liver transplantation was performed for radical cure of hepatocellular carcinoma. However, B-ultrasonography detected poor blood flow in the intra- and extra-hepatic artery on the first posttransplant day, and during exploratory laparotomy a thrombus was found in the hepatic artery. Thus, re-transplantation was conducted with a bypass between the graft hepatic artery and the recipient abdominal aorta with the donor's splenic artery. RESULTS: The patient made an uneventful recovery and color Doppler showed good blood flow in the artery and portal system. Histology confirmed extensive thrombosis in the left and right hepatic artery of the explanted graft, indicating HAT. CONCLUSIONS: Although HAT caused by celiac trunk compression is rarely reported in liver transplantation, the diagnosis should be considered in patients with pretransplant hepatic artery stenosis on angiography and abnormal blood flow on B-ultrasonography. Once HAT is formed, treatment such as thrombectomy or retransplantation should be performed as early as possible.

关键词： liver transplantation arcuate ligament syndrome hepatic artery thrombosis re-transplantation

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