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Intraperitoneal dedifferentiated liposarcoma:A case report

World Journal of Gastroenterology 2008年第38期14卷 5927-5929页

作者： Ali Karaman Mehmet Esref Kabalar nder zcan timur koca Dogan Nasir Binici Department of Medical Genetics State HospitalErzurum 25240 Turkey Department of Pathology State HospitalErzurum 25240 Turkey Department of General Surgery State HospitalErzurum 25240 Turkey Department of Radiation Oncology State HospitalErzurum 25240 Turkey Department of Internal Medicine State HospitalErzurum 25240 Turkey

Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum.

关键词： Dedifferentiated liposarcoma p53 gene Mutation Intraperitoneum

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An Evaluation of Inter-Fractional Set-Up Errors in Patients Treated with Distinct Immobilization Equipment for Varying Anatomical Regions

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第2期5卷 121-129页

作者： Sibel Karaca Hamit Başaran timur koca Ferhat Özbayrak Department of Radiation Oncology Erzurum Regional Training and Research Hospital Erzurum Turkey

This study aims to evaluate inter-fractional set-up errors in patients treated with distinct immobilization equipment (thermoplastic mask, knee-fix and feet-fix, wing board and vac-lok) for four anatomical regions including brain, head and neck (HN), thorax and pelvis. Data of randomly selected 140 patients who were treated for four anatomical regions were obtained using Hi-Art Helical Tomotherapy (HT) system. Pre-treatment planning was based on automatic registration readings of computed tomography (CT) and mega-voltage computed tomography (MVCT) on a daily basis. Distinct immobilization equipment was used for varying anatomical regions. Individual mean set-up error (M), systematic error (Σ), and random error (σ) values were calculated through daily translational and rotational deviation values. The size of translational, systematic and random error was 1.31 - 4.93 mm for brain, 2.28 - 4.88 mm for HN, 4.04 - 9.90 mm for thorax, and 6.34 - 14.68 mm for pelvis. Rotational values were as follows: 0.06° - 0.73° for brain, 0.42° - 0.6° for HN, 0.48° - 1.14° for thorax and 0.65° - 1.05° for pelvis. The highest translational, systematic and random error value was obtained from the pelvic regional. The highest standard and random error value in pitch and roll was produced in the rotational direction of the pelvis (0.05° and 0.71°), while the highest error value in yaw was (1.14°) produced from thorax. Inter-fractional set-up errors were most commonly produced in the pelvis, followed by thorax. Our study results suggest that the highest systematic and random errors are found for thorax and pelvis. Distinct immobilization equipment was important in these results. Safety margins around the clinical target volume (CTV) are changeable for different anatomical regions. A future work could be developed to new equipment for immobilization because of the reduced margins CTV.

关键词： Hi-Art Helical Tomotherapy IGRT Inter-Fractional Set-Up Errors Rotational Variation Translational Variation

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The Evaluation of Efficacy and Side Effects of Radiotherapy in Cerebral Meningiomas

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第4期9卷 157-164页

作者： timur koca Rahmi Atil Aksoy Yasemin Sengün Melek Gamze Aksu Nina Tuncel Mine Genc Ozay Aylin Fidan Korcum Department of Radiation Oncology School of Medicine Akdeniz University Konyaalt&#x131 Turkey

Aims: The current study aimed to evaluate the efficacy, side effects of radiotherapy and factors influencing treatment outcome in patients received radiotherapy for cerebral meningiomas. Methods and Material: In the last two decades, a total of 35 patients with cerebral meningioma who received radiotherapy in our clinic were evaluated statistically in terms of survival, toxicity and prognostic factors. The records of patients diagnosed with cerebral meningioma who underwent postoperative radiotherapy were retrospectively analyzed. Statistical analysis used: Statistical comparisons were made using IBM SPSS v24.0. Kaplan-Meier method was used to compare survival times. Results: Five of the patients had grade I meningioma showing recurrence, 18 were grade II meningioma and 12 were grade III meningioma. Patients were treated with 54 or 60 Gy adjuvant radiotherapy with 2 Gy daily fractions according to histopathological grade and operation type. Three and five-year overall survival rates were 56% and 40%, respectively and median overall survival was 36 months. Progression was observed in 15 of the 35 patients included in the study. Three and five-year progression-free survival (PFS) rates of the patients were 56% and 50%, respectively. There was a statistically significant correlation between histopathological grade and overall survival among patients. However;no statistical difference found in overall survival of patients in terms of tumor location, operation type and age. Conclusions: In the treatment of cerebral meningiomas, changes in radiotherapy dose and field designs can be predicted according to the tumor grade and operation type. In addition, it is thought that large scale studies are needed to determine prognostic factors more meticulously.

关键词： Brain Tumor Cerebral Meningioma Atypical Meningioma Anaplastic Meningioma Radiotherapy Overall Survival

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Treatment of Massive Low-Grade Chondrosarcoma of Nasal Septum with Helical Tomotherapy: A Case Report

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 263-269页

作者： Hamit Basaran timur koca Sibel Karaca Ozlem Eser K&iota l&iota nc Fikriye Gul Karauc Okan Ö zdemir Ozan Kuduban Arzu Tatar Sare Ş ipal Department of Radiation Oncology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Regional Training and Research Hospital Erzurum Turkey Department of Otorhinolaryngology Ataturk University Faculty of Medicine Erzurum Turkey Department of Pathology Ataturk University Faculty of Medicine Erzurum Turkey

Chondrosarcomas are malignant bone tumors which develop as a cartilaginous differentiation of primary mesenchymal cells and the second most frequently seen malignant tumor of the bone after osteosarcoma. These malignancies are slowly growing non-epithelial tumors with unknown etiology and most frequently seen during the 4 decades of life. They are frequently localized on pelvis, ribs and long bones. Nasal septum CSs are very rarely seen malignancies. They originate from septal mucosa or cartilage and it is difficult to make a diagnosis unless they reach a certain size. A few cases of CSs with nasal septum have been reported in the literature. In cases of CSs, surgery is the gold standard treatment modality;however in surgically unresectable cases or close to margins, radiotherapy plays a significant role in primary and adjuvant treatment. Based on the position of the tumor in head and neck and extremely closeness of the tumor to vital organs as optic nerve, chiasm and brain, image guided-intensity modulated radiation therapy (IG-IMRT) becomes very effective and reliable modalities and may be a favorable treatment alternative.

关键词： Chondrosarcoma Image Guided Intensity Modulated Radiation Therapy

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