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Coseismic Effects of the 2011 Magnitude 9.0 Tohoku-Oki Earthquake Measured at Far East Russia Continental Coast by Gravity and GPS Methods

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International Journal of Geosciences 2013年第2期4卷 362-370页

作者： vladimir timofeev Ruslan Kulinich Maxim Valitov Yuri Stus Eugeniy Kalish Bernard Ducarme Pavel Gornov Dmitriy Ardyukov Igor Sizikov Anton timofeev Gulshat Gil’manova Tatyana Kolpashikova Zoya Proshkina Institute of Petroleum Geology and Geophysics Siberian Branch of Russian Academy of SciencesNovosibirskRussia V.I.Il’ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of ScienceVladivostokRussia Institute of Automatic and Electrometry Siberian Branch of Russian Academy of SciencesNovosibirskRussia Georges Lemaitre Centre for Earth and Climate Research Catholic University of LouvainLeuvenBelgium Institute of Tectonics and Geophysics Far Eastern Branch of Russian Academy of SciencesKhabarovskRussia

This work presents the results of complex gravity observation performed at Shults Cape, Gamov peninsula (42.58°N, 131.15°E), Russia. Absolute laser gravimeter GABL type and Scintrex type relative gravimeter were used for measurement. To investigate the accuracy of tidal corrections we compared the observed tidal parameters of the main tidal waves O1 and M2 with modeled ones computed from 6 different ocean tidal models: CSR4, FES02, FES04, GOT00, NAO99 and TPX06. After discussion a theoretical model based on TPX06 ocean tides model and DDW99 non hydrostatic body tides model was used for tidal correction of absolute gravity data. Preliminary estimate of gravity effect induced by the Tohoku-Oki earthquake of11 March 2011Mw = 9.0 at Primorye territory (Russia) was found to be 5.1 ± 2.0 μGal. Co-seismic crustal displacements revealed by GPS data at Far EastRussiacontinental coast are also investigated. Volumetric dilatation of this area is observed at +1.7 × 10-8 level.

关键词： Absolute Gravimetry GPS Tidal Gravity Modeling and Observation Scintrex Gravimeter Co-Seismic Effect for Tohoku-Oki Earthquake

Static loading and vertical displacement at southern Siberia

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Geodesy and Geodynamics 2017年第3期8卷 160-168页

作者： Anton V.timofeev Dmitriy G.Ardyukov vladimir Yu.timofeev trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch Russian Academy of Sciences 630090 Russia

Seismic method is usually used for elastic parametric estimation. This is why this method presents dynamic parameters of Earth. Frequency seismic range changes greatly from geodynamic modelling time. Now we have opportunity to use geodesy result for some years for elastic parameters estimation. Static solution from elastic theory may be used for the interpretation of long term results. It presents static elastic parameter. The inverse problem for different types of vertical surface loading on one year period is calculated. Two cases of loading with maximal and minimal area are presented. Results are determined by space geodesy and leveling methods. Current relation between atmospheric pressure and vertical displacements was estimated at the center of Siberian Anti Cyclone with size varied from 2000 km to 3000 kin. Pressure-displacement coefficients （PDC） can be achieved by three years obser- vation （0.997 mm/mbar for NVSK GPS station）. It is used for elastic module study of geology medium with maximum thickness up to 600 km. In the context of elastic model, the modulus of rigidity is estimated to be 113 GPa. Vast expanse of anti-cyclone may relate with rheology of crust and upper mantle. Smaller size of surface loading - local loading is seasonal variation of water reservoir. Annual vertical changes were obtained by leveling near the dam of the reservoir. PDC ratio was 1.15 mm/bar for these places. In elastic theory, the Young modulus E = 80 GPa （Poisson ratio = 0.25, the modulus of rigidity - 32 GPa） was calculated by sixteen years of leveling measurements. This result can effectively be represented for upper crust. Our results were checked by solution for coseismic displacement of Chyia- Altai earthquake （Sep. 27, 2003, M = 7.3）. Coseismic results calculated by static modules agree with experimental coseismic GPS data at 10% level.

关键词： Static loading Vertical annual subsidence Space geodesy and leveling method Barometry Elastic modules Earthquake

Gravity observation at continental borderlands (Russia, Primorie, Cape Shults)

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Geodesy and Geodynamics 2017年第3期8卷 193-200页

作者： vladimir Yu. timofeev Eugenii N. Kalish Dmitriy G. Ardyukov Maksim G. Valitov Anton V. timofeev Yurii F. Stus Ruslan G. Kulinich Dmitrii A. Nosov Igor S. Sizikov Bernard Ducarme Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch Russian Academy of Sciences 630090 Novosibirsk Akademika Koptyuga Prsp..3 Russian Federation Institute of Automatic and Electrometry of Siberian Branch Russian Academy of Sciences 630090 Novosibirsk Akademika Koptyuga Prsp. 1 Russian Federation Il'ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of Science 690041 Vladivostok Baltivskayast. 43 Russian Federation Georges Lemaotre Centre for Earth and Climate Research. Catholic University of Louvain Leuven Belgium

The paper is focused on different kinds of gravity results obtained in Shults Cape Observatory for 2010 -2015. Gravity observation is interpreted together with GPS observation data which was obtained from 2012 to 2015 at the same station, The station is situated on Gamov peninsular （42.58° N, 131.15° E, Russia） at the coast of Japan Sea, This region constitutes the eastern boundary of Eurasia. This major continental tectonic feature is associated with a seismic activity, high heat flow and anomalous thickness of earth＇s crust. The goal of the observation was the investigation of gravity variation with time and seismicity situation monitoring. Gravity observation was developed at special basement by absolute gravimeter （GABL type） and by spring gravimeter （SCINREX CG-5and gPhone type）. Tidal models were tested by results of observation with spring gravimeters. Reduction task was solved, as the experimental data received from different points of Shults Cape Observatory was used. Applied reduction coefficient is 203.3 12Gal m l, and agrees with theoretical calculation. Next goal was studying structure of earth＇s crust by means of gravity models. Gravity anomaly varied from 30 mGal to 46 mGal, which also depend on difference reference system, Experimental results were used for testing of the structure of continental boundary, which also depends on the sea bottom flexion. Thickness of elastic layer was estimated from 12 km to 18 km by using different models.

关键词： Absolute and relative gravity observation Space geodesy Reduction task for gravity Structure models Crust

Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC Coupled with Mass Spectrometry

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International Journal of Analytical Mass Spectrometry and Chromatography 2014年第2期2卷 25-32页

作者： Olga S. Brushinina Roman V. Gurto Maksim S. timofeev Galina A. Frelikh vladimir A. Slepichev Elena A. Yanovskaya Natalia U. Polomeeva Yulya G. Zyuz’kova vladimir V. Udut Federal Governmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name” Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia Federal Governmental Budgetary Institution “Research Institute of Pharmacology E.D. Goldberg’s Name”Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia

Quantitative determination of hydrochlorothiazide (HCTZ) and candesartan (CDS) in human plasma in volunteers was performed using a sensitive, selective and specific LC-MS method which has been developed and validated before the study. The study was performed by means of a liquid chromatograph Shimadzu Prominence equipped with a mass spectrometer LCMS-2020. Analytical column PerfectBond ODS-HD HPLC-column 5 μm 250 × 3.0 mm with a pre-column cartridge PerfectBond ODS-HD 5 μm 10 × 3.0 mm, double source of ionization for LCMS-2020 (electrospray (ESI) and chemical (APCI)) and software LabSol LCMS V5 LCMS2020 systempack were used. The low limit of the quantitative determination for HCTZ and CDS made up 10 ng/ml. m/z for CDS 441.20—positive scan, m/z for HCTZ 295.90—negative scan. The method has been applied to a pharmacokinetic study of 12.5 mg HCTZ and 16 mg CDS tablet in healthy volunteers.

关键词： Candesartan Hydrochlorothiazide LC-MS Pharmacokinetic

Determination of Mitochondrial Functional State in Vital Tissues by Cytobiochemical Analysis of Peripheral Blood Lymphocytes

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Open Journal of Endocrine and Metabolic Diseases 2013年第2期3卷 10-13页

作者： Galina A. Frelikh Elena A. Yanovskaya Natalia Yu. Polomeeva Maxim S. timofeev vladimir A. Slepichev Olga S. Bryushinina Yulia G. Zyuz’kova Roman V. Gurto Alexander S. Vasil’ev Elena V. Semiglazova vladimir V. Udut Laboratory of Physiology Molecular and Clinical Pharmacology Federal Governmental Budgetary Organization “Research Institute of Pharmacology” Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia

In the work, we offer a brief report by research results demonstrating correlations between energy status of peripheral blood lymphocytes and functional state of vital tissues mitochondria. Basing on our preliminary data, showing correlations between succinate dehydrogenase (SDH) activity in peripheral blood lymphocytes and speed or duration of pyridine nucleotides reduction in mitochondria of rat brain and liver tissues, we propose an idea of using cytobiochemical method of SDH estimation in peripheral blood lymphocytes for evaluation of tissue mitochondria status. The method could be successfully used in clinical practice for early revealing of energy metabolism disturbances that allows preventing disease development and optimizing the diseases therapy.

关键词： Mitochondria Energy Metabolism Lymphocyte Succinate Dehydrogenase Cytobiochemical