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电子商务 2002年第5期3卷 56-57页

作者： tim Landgrave 智德

新技术的出现使得CRM决定比以前更有趣。

关键词： CRM 企业客户关系管理

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设计辞典

2016年

作者： (德)迈克尔·厄尔霍夫(Michael erthoff) (德)蒂姆·马歇尔(tim Marshall)

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树立IT员工的内部用户服务意识

电子商务 2002年第4期3卷 84-85页

作者： tim Landgrave 智德

向用户提供服务不是一项义务。

关键词：企业管理信息产业 IT员工内部用户服务意识

Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis

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World Journal of Clinical Oncology 2020年第3期11卷 121-135页

作者： Ivan Shabo Joar Svanvik Annelie Lindström Tanguy Lechertier Sara Trabulo James Hulit tim Sparey John Pawelek endocrine and Sarcoma Surgery Unit Department of Molecular Medicine and SurgeryKarolinska InstituteStockholm SE 17177Sweden Patient Area of Breast Cancer Sarcoma and Endocrine TumoursTheme CancerKarolinska University HospitalStockholm SE 17176Sweden The Transplant Institute Sahlgrenska University HospitalGothenburg SE 41345Sweden Division of Surgery Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58183Sweden Division of Cell Biology Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58185Sweden Novintum Bioscience Ltd London Bioscience Innovation CentreLondon NW10NHUnited Kingdom department of dermatology and the Yale Cancer Center Yale University School of MedicineNew HavenCT 06520United States

Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and *** cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random *** that stimulate cell fusion are inflammation and *** of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal *** is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer *** the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation *** phenomenon that has been largely overlooked yet plays a role in these processes is *** of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to *** we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer *** addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.

关键词： Cell fusion Hybrid formation Polyploidization Macrophage Cancer progression Oncologic treatment resistance

中高纬大气ISO对夏季鄂海阻高形成和维持的调节作用

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大气科学学报 2020年第1期43卷 104-115页

作者：杨双艳李天明南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心江苏南京210044 夏威夷大学马诺阿分校大气科学学院国际太平洋研究中心檀香山夏威夷96822

运用1979—2015年的逐日NCeP-DOe再分析资料,探讨了夏季鄂霍次克海阻塞高压(简称“鄂海阻高”)与中高纬大气季节内振荡(简称“ISO”)之间的可能联系。研究发现,ISO扰动与夏季鄂海阻高在关键区(130°~160°e,60°~75°N)有最好的耦合关系... 详细信息

运用1979—2015年的逐日NCeP-DOe再分析资料,探讨了夏季鄂霍次克海阻塞高压(简称“鄂海阻高”)与中高纬大气季节内振荡(简称“ISO”)之间的可能联系。研究发现,ISO扰动与夏季鄂海阻高在关键区(130°~160°e,60°~75°N)有最好的耦合关系,且关键区位势高度表现出显著的10~30 d的振荡周期。超前滞后合成分析表明,与鄂海阻高相联系的ISO扰动具有明显的向西传播的特征。波活动通量分析结果显示,波能量在中高纬140°W附近累积,因此西传的ISO扰动可能源自中高纬140°W附近。对位势倾向方程的诊断结果显示,动力作用对关键区位势高度的时间变化起主要作用。进一步运用尺度分析表明,在夏季鄂海阻高发生和维持的过程中,ISO经向风引导的平均涡度平流对位势高度的时间变化起主导作用。

关键词：鄂海阻高中高纬季节内振荡波活动通量位势倾向诊断

Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five european centres

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World Journal of Gastroenterology 2019年第39期25卷 5991-6005页

作者： Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara department of Medical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom department of Analytics and development The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom department of Pathology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom department of Medical Oncology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom UCL Cancer Institute University College LondonLondon WC1E 6AGUnited Kingdom department of Histopathology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom department of Gastroenterology and Medical Oncology Edouard Herriot HospitalHospices Civils de LyonLyon 69003France department of Gastroenterology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom department of Cellular Pathology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom department of Hepatology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom department of Surgical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Division of Cancer Sciences University of ManchesterManchester M13 9PLUnited Kingdom

BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNeN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic *** is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be *** To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of *** Consecutive patients with a histologically proven diagnosis of MiNeN were identified at 5 european *** data were retrospectively collected from medical *** samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of *** responses to systemic treatment were assessed according to the Response evaluation Criteria in Solid Tumours ***-Meier analysis was applied to estimate survival *** between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).ReSULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 ***:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases *** distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine ***-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of *** was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal *** localised cases,median recurre

关键词： Mixed neuroendocrine non-neuroendocrine neoplasm 2017 World Health Organisation classification Mixed adeno-neuroendocrine carcinoma Gastro-enteropancreatic tract Digestive system Neuroendocrine neoplasms Survival outcomes

采用新型活化氢技术进行大规模无助焊剂晶圆凸点回流焊

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电子工业专用设备 2017年第3期46卷 1-5,25页

作者： C.Christine Dong Richard e.Patrick Gregory K.Arslanian tim Bao Kail Wathne Phillip Skeen Air Products and Chemicals Sikama International Inc.

介绍了Air Products和Sikama International共同努力获得的一项新成果。一种以电子附着方式为基础的新型活化氢技术被首次应用于无助焊剂晶圆凸点回流焊。具有这项技术的原型焊炉的设计、制造及初步测试工作均已完成。这一成果即将推向... 详细信息

介绍了Air Products和Sikama International共同努力获得的一项新成果。一种以电子附着方式为基础的新型活化氢技术被首次应用于无助焊剂晶圆凸点回流焊。具有这项技术的原型焊炉的设计、制造及初步测试工作均已完成。这一成果即将推向市场。

关键词：电子附着技术无助焊剂晶圆回流焊

南亚高压季节内变化与热带季节内振荡之间的关系

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大气科学 2021年第3期45卷 633-650页

作者：林爱兰 LItim 王璐李春晖中国气象局广州热带海洋气象研究所广东省区域数值天气预报重点实验室广州510640 IPRC and department of department of Atmospheric Sciences University of HawaiiHonoluluHawaii 968223 南京信息工程大学气象灾害教育部重点实验室/气候与环境变化国际合作联合实验室/气象灾害预报预警与评估协同创新中心南京210044

采用观测分析和数值试验等方法,分析夏季南亚高压与热带季节内振荡(ISO)之间的关系,并对两者之间的相互作用进行量化诊断,探讨其物理过程。主要结果表明:南亚高压ISO与热带ISO活动关系密切,当热带ISO处于印度洋位相(第1、2、3位相),则... 详细信息

采用观测分析和数值试验等方法,分析夏季南亚高压与热带季节内振荡(ISO)之间的关系,并对两者之间的相互作用进行量化诊断,探讨其物理过程。主要结果表明:南亚高压ISO与热带ISO活动关系密切,当热带ISO处于印度洋位相(第1、2、3位相),则南亚高压东脊点位置偏西,当ISO处于太平洋位相(第5、6、7位相),则南亚高压东脊点位置偏东。与热带ISO关系最密切的是南亚高压东部附近区域,即东亚—西太平洋地区(15°~25°N,110°~140°e),该关键区也是南亚高压ISO最显著区域。在热带ISO的调制下,关键区对流层大气垂直结构产生斜压性异常变化,导致高层南亚高压东脊点的东伸(西退)对应中低层西太平洋副热带高压西脊点的东退(西伸)。在南亚高压与热带ISO之间关系中,主要是热带ISO对南亚高压的影响,南亚高压东部关键区ISO强度40%来源于热带ISO的贡献,而南亚高压对热带ISO平均强度的影响很弱。热带ISO影响南亚高压的物理过程如下,热带ISO从印度洋向东传播至西太平洋时,强对流产生分支,部分由于东亚—西太平洋的有利夏季风背景转为向北传播,ISO向北传播过程中对流强度进一度加强,这就相当于存在一个赤道非对称热源。在热源的作用下,大气产生异常响应,在热源的西北侧,即东亚—西太平洋地区,对流层低层为气旋性环流异常、位势高度负异常,对流层高层为反气旋性环流异常、位势高度正异常,从而导致南亚高压东脊点偏东。而当热带ISO处于印度洋位相时,大气异常响应与上述相反,南亚高压东部位势高度降低,南亚高压东脊点西撤。

关键词：季节内振荡(ISO) 南亚高压东脊点斜压东伸西退

etiologies, Clinical Presentation and Outcome of Adult Patients Presenting with Bowel Obstruction on a Virgin Abdomen

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Surgical Science 2023年第3期14卷 252-269页

作者： Georges Bwelle Motto tim Fabrice Yannick Mahamat ekani Boukar el-Alaoui Mounjid Khadija emmanuella Joseph Cyrille Chopkeng Ngoumfe Arthur essomba department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences The University of Yaounde 1 Yaounde Cameroon departement of Visceral and Digestive Surgery Yaounde Central Hospital Yaounde Cameroon departement of General Surgery Soa District Hospital Yaounde 2 Yaounde Cameroon

Context: Generally in Africa, BO remains the leading cause of acute abdomen. We therefore sought to study the current etiological factors of intestinal obstruction on a virgin abdomen or unhealed abdomen at the central hospital of Yaoundé in order to better understand the main causes and to better anticipate and improve the diagnosis, management and the evolution of intestinal obstruction on a virgin abdomen. Method: The patients were prospectively included from June 2021 to May 2022, these patients were recruited from the digestive and emergency surgery units of the Yaoundé Central Hospital during the study period and who met the inclusion criteria, with suspicion of partial or total intestinal obstruction or those with an intraoperative confirmed diagnosis were enrolled. Results: We recruited 73 patients including 43 (60.3%) men and 29 (39.7%) women whose mean age was 42.5 years with extremes ranging from 16 to 70 years. Most of them consulted after 72 hours, i.e. 65.2% of cases due to self-medication or even prior consultations in the lower level center at the Central Hospital of Yaoundé. The patients retained for this work presented in majority the symptoms according to the abdominal pains, the stop of the materials and gases;meteorism and vomiting. Abdominal wall hernias with incarcerated intestinal loops were the most common cause of intestinal obstruction in an unscarred abdomen in adults at 38.4% of cases, followed by digestive tumors 23.3% and adhesions 17.8%. exceptionally, a cluster of roundworms was found as the cause of intestinal obstruction in two of our patients. Complications occurred in 25 patients or 31.5% of cases and were dominated respectively by nausea and hematoma (36%), local infections (24%) and malaria (24%). death occurred in 5 of our patients, or 6.8% of cases, and was mostly caused by hypovolemic shock (40%) and pulmonary embolism (40%). Conclusion: Intestinal obstructions on the abdomen without scarring remain the prerogative of young

关键词： Acute Abdomen Intestinal Obstructions etiologies

戊型肝炎病毒Ⅳ型在300例急性肝炎中的感染比例

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中华微生物学和免疫学杂志 2002年第3期22卷 276-278页

作者：蓝海云王佑春李卓张华远郝娃辜文洁林京香李河民 tim J Harrison 中国药品生物制品检定所北京市佑安医院英国伦敦大学皇家免费医学院

目的　调查戊型肝炎病毒 (HeV)Ⅳ型在北京地区的急性散发性肝炎中的分布。方法采用RT nPCR的方法检测 30 0例急性散发性肝炎患者中HeVRNA ,并对阳性产物进行克隆测序 ,然后对其基因型进行分析。结果　在 30 0例急性散发性肝炎患者中PCR... 详细信息

目的　调查戊型肝炎病毒 (HeV)Ⅳ型在北京地区的急性散发性肝炎中的分布。方法采用RT nPCR的方法检测 30 0例急性散发性肝炎患者中HeVRNA ,并对阳性产物进行克隆测序 ,然后对其基因型进行分析。结果　在 30 0例急性散发性肝炎患者中PCR阳性为 2 5例 ,测序证实 2 5例PCR阳性者中 ,2 4例为HeV的基因序列 ;其中 9例为HeVⅠ型 ,15例为HeVⅣ型 ,占HeV感染的 6 2 .5 %(15 / 14 )。结论　在北京地区的部分急性散发性肝炎中HeVⅣ型感染占戊型肝炎的较大比例。

关键词：戊型肝炎病毒Ⅳ型戊型肝炎病毒基因型聚合酶链反应急性散发性肝炎