Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis

作     者：Ivan Shabo Joar Svanvik Annelie Lindström Tanguy Lechertier Sara Trabulo James Hulit Tim Sparey John Pawelek 

作者机构：Endocrine and Sarcoma Surgery UnitDepartment of Molecular Medicine and SurgeryKarolinska InstituteStockholm SE 17177Sweden Patient Area of Breast CancerSarcoma and Endocrine TumoursTheme CancerKarolinska University HospitalStockholm SE 17176Sweden The Transplant InstituteSahlgrenska University HospitalGothenburg SE 41345Sweden Division of SurgeryDepartment of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58183Sweden Division of Cell BiologyDepartment of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58185Sweden Novintum Bioscience LtdLondon Bioscience Innovation CentreLondon NW10NHUnited Kingdom Department of Dermatology and the Yale Cancer CenterYale University School of MedicineNew HavenCT 06520United States 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2020年第11卷第3期

页      面：121-135页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cell fusion Hybrid formation Polyploidization Macrophage Cancer progression Oncologic treatment resistance 

摘      要：Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and *** cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random *** that stimulate cell fusion are inflammation and *** of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal *** is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer *** the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation *** phenomenon that has been largely overlooked yet plays a role in these processes is *** of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to *** we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer *** addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.