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Late Quaternary paleoenvironments of ancient Lake Mojave-reconstructing the history from stratigraphy,sedimentology,soils,geomorphology and radiocarbon dating plus some modeling on the paleohydrology

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地球环境学报 2011年第1期 326-326页

作者： Wells S G Enzel Y Brown W j Anerson R Y McFadden L D Desert Research Institute Institute of Earth Sciences Hebrew University of Jerusalem Dames and Moore Inc. Department of Earth and Planetary Sciences University of New Mexico

Late Quaternary fluctuations of pluvial Lake Mojave are recorded in subsurface,cored lake deposits and shoreline features in the terminal depositional basins(Silver Lake and Soda Lake) of the Mojave *** Mojave was one of two large late Quaternary lakes sustained by the Mojave River with the other being the upstream Lake *** Lake Depositional Basin(SiLDB) contains a high resolution stratigraphic sequence due to its shallowness and minimal relief across the pre-lake basin *** building in SiLDB began at22 ka with two major high and persistent lake stands occurring between18.4 ka and16.6 ka(LMI) and13.7 ka and11.4 ka(LMII).Overflow from Lake Manix sustained LMI which stabilized at the A-shoreline(elevation 287288 m).LMII coincided with breaching and draining of Lake Manix,reducing the storage capacity of Lake Mojave,increasing its evaporative surface area,and enhancing overflow from Lake Mojave into Death *** overflow downcut the Lake Mojave outlet spillway between 12 ka and 11 ka,ultimately stabilizing at an elevation of 285.5 m(B-shoreline).The majority of shoreline features currently found around the margins of Silver Lake and Soda Lake date to LMII/B-shoreline,as the shallow lake conditions resulted in erosion of older LMI *** also experienced alternating periods of intermittent lake conditions and periods of desiccation some during higher stands and more continuous Lake Mojave phases with a significant drying event occurring15.5 *** drying of Lake Mojave occurred by8.7 ka,with playa conditions dominating the *** the history of lake level elevations and a simplified,precipitationdischarge/evaporation model,we infer that the late Pleistocene hydrologic conditions resulting in Lake Mojave overflow at Spillway bay in Silver Lake lie between two sets of conditions:(1) a 50%increase in precipitation in the headwater catchment resulting in annual flood events reaching SiLDB with discharges three times that of the

关键词： Lake Late Quaternary paleoenvironments of ancient Lake Mojave-reconstructing the history from stratigraphy,sedimentology,soils,geomorphology and radiocarbon dating plus some modeling on the paleohydrology

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鼻咽癌放化疗过程中的不良反应

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中国临床医学 2016年第6期23卷 833-837页

作者：李骥王培林黄新生复旦大学附属中山医院耳鼻喉科上海200032

鼻咽癌是我国南方地区高发的头颈肿瘤之一。由于其病理类型多为低分化鳞癌,因此调强放疗联合化疗取得了较好的疗效。同时放化疗也会对机体产生严重的急性和迟发性毒性反应,而严重的不良反应会对患者造成生理和心理上的创伤,亦会导致治... 详细信息

鼻咽癌是我国南方地区高发的头颈肿瘤之一。由于其病理类型多为低分化鳞癌,因此调强放疗联合化疗取得了较好的疗效。同时放化疗也会对机体产生严重的急性和迟发性毒性反应,而严重的不良反应会对患者造成生理和心理上的创伤,亦会导致治疗中断甚至失败。重视不良反应并及时进行干预,对提高患者依从性及改善预后具有重要意义。本文就鼻咽癌患者放化疗过程中的不良反应和影响因素进行综述。

关键词：鼻咽癌放疗化疗不良反应

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热压过滤诸影响因素的研究

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过滤与分离 1999年第3期9卷 9-13页

作者：徐新阳姜立新罗茜东北大学资源与土木工程学院沈阳110006

设计了一套实验室型热气体压滤机，在此设备上进行了热压过滤实验，研究了一些操作因素对浮选精煤过滤效果的影响。结果表明：在热压过滤条件下，可以提高过滤速度，并有效地降低滤饼水分，浆体浓度、气体温度、过滤压差和吹气时间都对... 详细信息

设计了一套实验室型热气体压滤机，在此设备上进行了热压过滤实验，研究了一些操作因素对浮选精煤过滤效果的影响。结果表明：在热压过滤条件下，可以提高过滤速度，并有效地降低滤饼水分，浆体浓度、气体温度、过滤压差和吹气时间都对过滤有较大影响。

关键词：浮选精煤热压过滤脱水处理选煤

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Human clotting factor Ⅸ (hF Ⅸ ) secretion in goat milk after direct transfer with hF Ⅸ minigene into mammary gland by using retroviral vectors

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Chinese Science Bulletin 1997年第15期42卷 1308-1313页

作者： ZHANG Kezhong, WANG Hongwei, BAO Yun, LU Daru,XUE jinglun (j. L. Hsueh), QIU Xinfang, HUANG Shuzhen,HUANG Ying, LI Bingyan, LI Hua and ZENG Yitao1. Institute of Genetics, Fudan University, Shanghai 200433, China 2 Shanghai Children’s Hospital, Shanghai Institute of Medical Genetics, Shanghai 200040, China

THE mammary gland bioreactor system of lactating animal, established by germ-linemicroinjection and embryo transplantation, has been one of the most exciting projects in thefield of biotechnology. However, this system is costly, laborious and tim-cosuming. In 1994,johanna et al. reported that secretion of a foreign protein, human growth hormone (hGH),in milk had been achieved after direct introduction of the cDNA into the mammary gland ofgoats by replication-defective retroviral vector. In that work, the in vivo expression of

关键词： mammary-specific expression human clotting factor Ⅸ (hF Ⅸ) retroviral vectors.

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增加干扰素β-1a剂量和频率治疗复发性多发性硬化症提高药物疗效的EVIDENCE研究

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 22-22页

作者： Schwid S.R. Thorpe j. Sharief M. 江山 Department of Neurology University of Rochester Box 605 601 Elmwood Ave Rochester NY 14642 United StatesDr.

Background: The EVIDENCE (Evidence of Interferon Dose-Response: European Nort h American Comparative Efficacy) Study demonstrated that patients with multiple sclerosis (MS) who initiate interferon beta-1a therapy with 44 μg 3 times week ly (TIW) were less likely to have a relapse or activity on magnetic resonance im aging (MRI) compared with those who initiate therapy at a dosage of 30 μg 1 tim e weekly (QW). Objective: To determine the effect of changing the dosage from 30 μg QW to 44 μg TIW in this extension of the EVIDENCE Study. Design/Patients: Patients with relapsing MS originally randomized to interferon beta-1a, 30 μg QW, during the comparative phase of the study changed to 44 μg TIW, whereas pat ients originally randomized to 44 μg TIW continued that regimen. Patients were followed up, on average, for an additional 32 weeks. Main Outcome Measure: The w ithin-patient pretransition to posttransition change in relapse rate. Results: At the transition visit, 223 (73%) of 306 patients receiving 30 μg QW converte d to 44 μg TIW, and 272 (91%) of 299 receiving 44-μg TIW continued the same therapy. The posttransition annualized relapse rate decreased from 0.64 to 0.32 for patients increasing the dose (P < .001) and from 0.46 to 0.34 for patients c ontinuing 44-μg TIW (P=.03). The change was greater in those increasing dose a nd frequency (P=.047). Patients converting to the 44-μg TIW regimen had fewer active lesions on T2-weighted MRI compared with before the transition (P=.02), whereas those continuing the 44-μg TIW regimen had no significant change in T2 active lesions. Patients who converted to high-dose/high-frequency interferon beta-1a therapy had increased rates of adverse events and treatment terminatio ns consistent with the initiation of high-dose subcutaneous interferon therapy. Conclusions: Patients receiving interferon beta-1a improved on clinical and MR I disease measures when they changed from 30 μg QW to 44 μg TIW.

关键词：多发性硬化症 EVIDENCE 复发率疗效研究比用

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超声心动对围生期心肌病的预测价值

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 55-55页

作者： Chapa j.B. Heiberger H.B. Weinert L. 高雪莲 Department of Obs tetrics University Hospitals of Cleveland MacDonald Women's Hospital 11100 E uclid Avenue Cleveland OH 44106 United States Dr.

OBj ECTIVE: To estimate whether echocardiography findings at the time of diag no sis of peripartum cardiomyopathy are predictive of persistent cardiac dysfunctio n. METHODS: Chart review of patients with peripartum cardiomyopathy between 1988 and 2001 was performed. Data from echocardiography, including fractional shorte ning and left ventricular end diastolic dimension, were recorded both at the tim e of diagnosis and at follow-up. Left ventricular dysfunction was defined by ec hocardiography as fractional shortening less than 30%and left ventricular end d iastolic dimension of 4.8 cm or more. RESULTS: Of 32 patients meeting our defini tion for peripartum cardiomyopathy and for whom follow-up data were available, 13 (41%) had recovery of ventricular function, while 19 (59%)continued to have persistent left ventricular dysfunction. Those who did not recover cardiac func tion had a higher left ventricular end diastolic dimension and a lower fractiona l shortening at diagnosis than those who recovered. A fractional shortening valu e less than 20%and a left ventricular end diastolic dimension 6 cm or greater a t the time of diagnosis was associated with a more than 3-fold higher risk for persistent left ventricular dysfunction. CONCLUSION: Along with being an importa nt diagnostic tool in peripartum cardiomyopathy, echocardiography may provide si gnificant prognostic information with regards to recovery of cardiac function.

关键词：围生期心肌病预测价值左室短轴缩短率左室功能心脏功能心室功能功能失调持续性诊断标准

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多灶性脉络膜炎及全葡萄膜炎患者的长期随访观察

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 17-17页

作者： Vianna R.N.G. Ozdal P.C. Filho j.P.S. 程燕 Avenue Ary Pa rreiras 438 Niteroi Rio de Janeiro 2423-322 Brazil Dr.

Purpose: To report the visual prognosis and longterm complications in patients with multifocal choroiditis and panuveitis (MCP). Methods: A retrospective stud y was performed with patients who met inclusion criteria for MCP at the Uveitis Clinic, Royal Victoria Hospital, McGill University, Montreal, Canada. Informatio n collected included duration of follow-up, visual acuity (VA) measured at each clinical visit, ocular and systemic treatment and ocular complications observed during follow-up. Results: Nineteen patients (37 eyes) with MCP with a mean fo llow-up of 76.9 months were studied. Kaplan-Meier survival analysis showed a d ecrease in the proportion of patients with a final VA ≥20/40 over time. Cystoid macular oedema was seen in 29.7%of the eyes and was the most frequent macular abnormality observed in our group. On the other hand, choroidal neovascularizati on was detected in only six (16.2%) of the eyes, but was related to VA tim e. Visual loss can occur from complications following the inflammation itself an d/or iatrogenic induced by the chronic use of corticosteroids.

关键词：葡萄膜炎脉络膜炎多灶性脉络膜新生血管黄斑囊样水肿黄斑病变白内障手术眼部并发症生存分析后囊

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扩频通信抗干扰中的时频域信号处理技术

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通信技术 2003年第8期36卷 25-26,50页

作者：朱丽平胡光锐赵海波上海交通大学电子工程系

时频分析对非平稳信号具有良好的压缩能力,因而成为扩频通信系统抗干扰的研究热点。综述了近年来时频信号处理技术在扩频通信抗非平稳干扰中的应用,并对该技术的发展趋势作出了展望。

关键词：时频分析线性时频域干扰抑制技术非线性时频域干扰抑制技术扩频通信

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多中心卒中遗传学研究中隐私保护对患者征集的影响

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 53-53页

作者： Worrall B.B. Brown jr. R.D. j.F.Meschia 李一明 Department of Neurology Mayo Clinic 4500 SanPablo Road Jacksonville FL 32224 United States Dr.

The authors reviewed the recruitment of stroke-affected sibling pairs using a letter-based, proband-initiated contact *** authors randomly sampled 99 proband enrollment forms(Phase 1) and randomly sampled 50 sibling reply card s (Phase 2). The sibling response rate was 30.6%, for a pedigree response rate of 58%. Of the siblings who replied, 96%authorized further contact. Median tim e from proband enrollment to pedigree DNA banking, which required 3+probands, w as 134 days.

关键词：隐私保护先证者随机抽样调查应答率沟通策略

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西班牙的4个乳腺癌筛查项目中数字化钼靶片与增感屏X线钼靶片在乳腺影像学分型、肿瘤特征以及诊断准确性的差异

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国际医学放射学杂志 2011年第6期 605-605页

作者： L.Domingo A.Romero F.Belvis M.Sánchez j.Ferrer D.Salas 杨绮华 Department of Epidemiology and Evaluation IMIM-Hospital del MarPasseig Marítim 25-2908003 BarcelonaSpain

目的比较增感屏X线钼靶片(SFM)和数字化钼靶片(DM)显示乳腺癌的特征,评估其对召回病人进一步评价、有创性操作以及某些独特影像特征的阳性预测值(PPV)。方法将西班牙4个乳腺筛查中心共103613例女性病人的242838张乳腺片(包括171191张SFM... 详细信息

目的比较增感屏X线钼靶片(SFM)和数字化钼靶片(DM)显示乳腺癌的特征,评估其对召回病人进一步评价、有创性操作以及某些独特影像特征的阳性预测值(PPV)。方法将西班牙4个乳腺筛查中心共103613例女性病人的242838张乳腺片(包括171191张SFM和71647张DM)纳

关键词：数字化钼靶片增感屏X线钼靶片筛查乳腺癌乳腺影像原位导管癌

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