检索结果-南通市图书馆

2型糖尿病合并高血压患者葡萄糖在目标范围内时间与左心室质量指数的相关性研究

在线全文

学校读者我要写书评

暂无评论

重庆医学 2024年第12期53卷 1823-1827页

作者：闫波姚远钟兴潘天荣明光市人民医院内分泌科安徽滁州239000 安徽医科大学第二附属医院内分泌科合肥230601

目的研究2型糖尿病(T2DM)合并高血压患者葡萄糖在目标范围内时间(TIR)与左心室质量指数(LVMI)的相关性。方法选取2022年1-12月明光市人民医院住院T2DM患者102例作为研究对象,行连续动态葡萄糖监测,依据TIR水平,TIR≤40%者纳入A组(n=31),... 详细信息

目的研究2型糖尿病(T2DM)合并高血压患者葡萄糖在目标范围内时间(TIR)与左心室质量指数(LVMI)的相关性。方法选取2022年1-12月明光市人民医院住院T2DM患者102例作为研究对象,行连续动态葡萄糖监测,依据TIR水平,TIR≤40%者纳入A组(n=31),TIR>40%~70%者纳入B组(n=41),TIR>70%者纳入C组(n=30),收集3组患者的临床资料、实验室指标和超声心动图参数并进行比较。结果与A组比较,C组年龄、病程、收缩压、糖化血红蛋白(HbA1c)、静脉血浆空腹血糖(FPG)、血肌酐(SCr)和甘油三酯(TG)降低,高密度脂蛋白胆固醇(HDL-C)升高,差异有统计学意义(P<0.05)。与B组比较,C组年龄、SCr、TG、HDL-C、HbA1c和FPG降低,差异有统计学意义(P<0.05)。与A组和B组比较,C组左心房内径(LAD)、左室后壁厚度(LVPW)、室间隔厚度(IVS)和LVMI降低,差异有统计学意义(P<0.05)。多元线性逐步回归分析结果显示,TIR是LVMI的保护因素(OR=0.562,95%CI:0.413~0.673,P<0.05),病程和收缩压是危险因素(OR=1.511,95%CI:1.067~2.947;OR=2.325,95%CI:1.086~5.574,P<0.05)。结论T2DM合并高血压患者的TIR与LVMI相关,TIR可能是心血管早期事件的影响因素。

关键词： 2型糖尿病动态葡萄糖监测葡萄糖目标范围内时间左心室质量指数

The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

The role of serum and urinary biomarkers in the diagnosis of...

第十二次全国中西医结合内分泌代谢病学术大会暨糖尿病、甲状腺疾病高峰论坛

作者： Deyuan Zhang Shandong Ye tianrong pan Department of Endocrinology The second Affiliated Hospital of Anhui Medical University

Background:Previous studies have shown that a variety of bio markers are closely related to the occurrence and development of early-stage di abetic nephropathy(DN) in *** aim of this study was to evaluate the role of multiple sera and urinary biomarkers in the diagnosis of early-stage DN in patients with type 2 ***:We enrolled 287 patients with type 2 diabetes,who were classified into normoalbuminuria(n=144),microalbumi nuria(n=94),or macroalbuminuria(n=49) groups based on their urine albumin to creatinine ratios,along with 42 healthy *** assessed 13 biomarkers,including transferrin(Tf),immunoglobulin G(IgG),podocalyxin(PCX),neutro philgelatinase-associated lipocalin(NGAL),N-acetyl-beta-glucosaminidase(NA G),α-1-microglobulin(α1 MG),8-hydroxy-deoxyguanosine(8-OHdG),tumor nec rosis factor-alpha(TNF-α),and interleukin-18(IL-18) in urine samples,along with cystatin C(CysC),total bilirubin(TBIL),and uric acid(UA) in sera sam ples,to evaluate their diagnostic *** the measurements,the blood neutr ophil to lymphocyte ratio(NLR) was also ***:Urinary Tf,IgG,NGAL,and TNF-α were significantly related to the *** calculated the area under the receiver operating characteristic curves(ROC AUC) and found that urinary IgG(0.894),NGAL(0.875),Tf(0.861),TNF-α(0.763),and the co mbination of urinary Tf + IgG + TNF-α + NGAL(0.922) showed good diagn ostic value for early-stage ***:Urinary Tf,IgG,NGAL,TNF-α,and the combination of all four biomarkers demonstrated excellent diagnostic value for early-stage DN in patients with type 2 diabetes.

关键词： The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes

Effects of liraglutide and dapagliflozin on bone mineral density and bone turnover markers in post menopausal overweight/obese type 2 diabetes mellitus

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effects of liraglutide and dapagliflozin on bone mineral den...

第十二次全国中西医结合内分泌代谢病学术大会暨糖尿病、甲状腺疾病高峰论坛

作者： Zhong Xing Yang Lina Ye Yongjian pan tianrong Department of Endocrinology The Second Affiliated Hospital of Anhui Medical University

Objective To observe the effects of liraglutide and dapagliflozin on bone mineral density and bone turnover markers in postmenopausal overwei ght/obese type 2 diabetes mellitus(T2DM).Methods Sixty-three cases of post menopausal overweight/obese T2DM were randomly divided into liraglutide group(n=32) and dapagliflozin group(n=31).The levels of blood sugar,total cho lesterol(TC),low density lipoprotein(LDL-C),bone mineral density(BMD),type I collagen C-terminal peptide cross-linking(β-CTX),type 1 collagen N-ter minal pro-peptide(P1NP) and alkaline phosphatase(AKP) were compared befor e treatment and 26 weeks after *** *** with baseline,BMI,FPG,HbA1c,TG,TCH and LDL in liraglutide group and dapagliflozin group decreased significantly after 26 weeks of treatment(P0.05).*** with baseli ne,P1 NP in liraglutide group increased significantly after treatment(P<0.05),beta-CTX decreased significantly(P<0.05),and beta-CTX in dapagliflozin gr oup increased significantly after treatment(P<0.05).After treatment,L2-4 B MD was significantly lower in the dapagliflozin group than that in the liragluti de group(P<0.05);β-CTX was significantly higher in the dapagliflozin grou p than that in the liraglutide group(P<0.05);and P1NP was significantly lo wer than that in the liraglutide group(P<0.05).Conclusion Liraglutide and d apagliflozin,two drugs with both hypoglycemic and weight-reducing effects,ha ve no significant improvement on BMD in bone metabolism,However,liragluti de can inhibit bone resorption and promote bone formation,while dapagliflozin can promote bone resorption.

关键词： CTX Effects of liraglutide and dapagliflozin on bone mineral density and bone turnover markers in post menopausal overweight/obese type 2 diabetes mellitus BMD FPG

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Lower Extremity Vascular Lesions in Chinese Patients with Type 2 Diabetes

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ra...

第十二次全国中西医结合内分泌代谢病学术大会暨糖尿病、甲状腺疾病高峰论坛

作者： Nina Liu Jianlong Sheng tianrong pan Youmin Wang Department of Endocrinology The First Affiliated Hospital of Anhui Medical University Department of Endocrinology The Second Affiliated Hospital of Anhui Medical University Department of Cardiology The Second Affiliated Hospital of Anhui Medical University

Background:Neutrophil to lymphocyte ratio(NLR) and platelet to lymphocyte ratio(PLR) are inflammatory markers used for prediction of chr onic complications of *** extremity arterial disease(LEAD) is one of chronic complications of type 2 diabetes mellitus(T2DM).The correlation between NLR,PLR,and lower extremity vascular lesions was investigated in subjects with T2DM to determine the best predictive marker for ***:Three hundred thirty-five patients with T2DM(199 males and 136 females;age 54.12 ± 14.07 years) were *** differential counts and ankle-brachial index(ABI) were *** were divided into the LEAD group(ABI ≤ 0.9,n=236) and non-LEAD group(ABI>0.9,n=99),and NLR and PLR were compared between the two *** independent risk factors for LEAD were analyzed using a logistic regression *** operating characteristic(ROC) curve analysis was used to assess the optimal cutoffvalues of PLR and NLR for prediction of ***:NLR and PLR in the LEAD group were significantly increased compared to non-LEAD group *** analyses identified that NLR was positively correlated with age,gl ycosylated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),lowdensity lipoprotein(LDL),and 2-hours postprandial glucose *** was po sitively correlated with age,duration of T2DM,HbA1c,TG,TC,and LDL,but negatively correlated with diastolic blood pressure and fasting C-peptide *** logistic regression analysis identified that age,total number of white blood cells,PLR,and TC were significant and independent factors of diabetic ***,ROC curve analysis showed that NLR and PLR were both predictive markers of LEAD in diabetes,and that the area under the PLR curve was larger than ***:NLR and PLR are positively correlated with LEAD in *** was superior to NLR as a predictor of LEAD in diabetes.

关键词： PLR NLR Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Lower Extremity Vascular Lesions in Chinese Patients with Type 2 Diabetes

Liraglutide increases bone formation and inhibits bone resorption in rats with glucocorticoid-induced osteoporosis

在线全文

cnki会议

学校读者我要写书评

暂无评论

Liraglutide increases bone formation and inhibits bone resor...

第十二次全国中西医结合内分泌代谢病学术大会暨糖尿病、甲状腺疾病高峰论坛

作者： Lina Yang Jing Yang tianrong pan Xing Zhong Department of Endocrinology The second Affiliated Hospital of Anhui Medical University

Objective:This study aimed to investigate the effects of liragluti de on bone metabolism markers in rat models with glucocorticoid-induced oste oporosis(GIOP),including the effects on bone mass,bone tissue microstructure,bone biomechanics,and bone turnover ***:Thirty male Sprague–Dawley rats aged 8 weeks were randomly divided into three groups:the control group(n=10) was intramuscularly injected with an equal volume of 0.9% s odium chloride,the dexamethasone group(n=10) was intramuscularly injected with dexamethasone at 1 mg/kg(twice a week) to induce GIOP,the dexameth asone plus liraglutide group(n=10) was subcutaneously injected with liragluti de at 200 μg/kg daily,*** bilateral femurs and the fifth lumbar vertebrae were collected after 12 weeks to perform micro-computed tomograph y and bone biomechanical ***,tartrate-resistant acid phosphatase (TRACP),cross-linked carboxy-terminal telopeptide of type I collagen(CTX-I),alkaline phosphatase(ALP),and osteocalcin(OC) were ***:The b one mineral density(BMD),bone microstructure,and bone biomechanical markers reduced significantly in the dexamethasone group compared with the control *** bone resorption indicators(TRACP and CTX-I) increased,while the bone formation indicators(ALP and OC) *** liraglutide treatment,BMD,bone microstructure,and bone biomechanical markers improved ***,TRACP and CTX-I decreased significantly,while ALP and OC increased compared with the dexamethasone *** :Liraglutide i mproved BMD,bone microstructure,and bone strength and reversed GIOP,primarily through the reduction of bone resorption and promotion of bone formati on.

关键词： Liraglutide increases bone formation and inhibits bone resorption in rats with glucocorticoid-induced osteoporosis

KCNQ1基因rs2237892多态性与合肥地区汉族人2型糖尿病的相关性

在线全文

cnki会议

学校读者我要写书评

暂无评论

安徽医科大学学报 2018年第1期53卷 110-113页

作者：陈建丰潘天荣安徽医科大学第二附属医院内分泌科合肥230601

目的探讨KCNQ1基因rs2237892多态性与合肥地区2型糖尿病(T2DM)的相关性。方法运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,在合肥地区人群中对84例T2DM患者和104例健康对照者(NC组)KCNQ1基因rs2237892多态性进行检测,并比较... 详细信息

目的探讨KCNQ1基因rs2237892多态性与合肥地区2型糖尿病(T2DM)的相关性。方法运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,在合肥地区人群中对84例T2DM患者和104例健康对照者(NC组)KCNQ1基因rs2237892多态性进行检测,并比较分析各组间基因型、等位基因频率、相关临床和生化指标。结果 T2DM组与NC组的KCNQ1基因rs2237892各基因型和等位基因比较差异无统计学意义,Logistic回归分析显示rs2237892位点CT基因型T2DM患病风险是CC基因型的1.44倍(OR=1.44,95%CI:1.06~1.95,P=0.02)。结论 KCNQ1基因rs2237892可能是合肥地区T2DM的易感基因之一。

关键词： 2型糖尿病 KCNQ1 rs2237892 基因多态性

在线全文

学校读者我要写书评

暂无评论

甲亢合并重症肝功能损害的诊治

安徽医科大学学报 2011年第1期46卷 70-72页

作者：邢时妹潘天荣安徽医科大学第二附属医院内分泌科合肥230601

目的探讨甲状腺功能亢进(甲亢)合并重症肝损害患者的临床特点及治疗措施。方法回顾性分析55例甲亢合并重症肝损害患者的临床资料,根据肝功能生化指标将患者分为单纯黄疸组、转氨酶升高组、黄疸兼转氨酶升高组,探讨其临床特点、可能的相... 详细信息

目的探讨甲状腺功能亢进(甲亢)合并重症肝损害患者的临床特点及治疗措施。方法回顾性分析55例甲亢合并重症肝损害患者的临床资料,根据肝功能生化指标将患者分为单纯黄疸组、转氨酶升高组、黄疸兼转氨酶升高组,探讨其临床特点、可能的相关影响因素及防治措施。结果 3组性别、年龄、甲状腺功能比较差异无统计学意义,而单纯黄疸组病程明显长于转氨酶升高组。在影响因素方面,病程长、并发甲亢性心脏病、有甲巯咪唑片长期不规则服药史或有"服用不详中药"史的患者易出现黄疸。经治疗44例患者肝功能改善;8例治疗无效;2例死亡;1例因并发肝性脑病家属放弃治疗。结论导致甲亢合并重症肝损害的因素来自多方面,重在防治。选择合适的抗甲亢方案对肝功能的恢复至关重要。

关键词：甲状腺功能亢进症/并发症肝疾病

达格列净对血糖控制不佳的2型糖尿病患者肾脏保护作用的研究

在线全文

学校读者我要写书评

暂无评论

中国糖尿病杂志 2019年第11期27卷 806-811页

作者：张德园钟兴潘天荣安徽医科大学第二附属医院内分泌科

目的探讨达格列净对血糖控制不佳的T2DM患者肾脏保护作用。方法选取90例既往未使用钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂、血糖控制不佳的T2DM住院患者,其中1例失访,1例因经济原因停用,最终纳入88例患者,分为达格列净治疗组(Dap,n=44),... 详细信息

目的探讨达格列净对血糖控制不佳的T2DM患者肾脏保护作用。方法选取90例既往未使用钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂、血糖控制不佳的T2DM住院患者,其中1例失访,1例因经济原因停用,最终纳入88例患者,分为达格列净治疗组(Dap,n=44),不使用达格列净为对照组(Con,n=44)。治疗12周后,比较治疗前后UACR、24 h UAlb、尿N-乙酰-β-氨基葡萄糖苷酶(NAG)、eGFR、血肌酐(Scr)、血胱抑素C(CysC)、血尿酸(SUA)和其他相关代谢指标。结果 Dap组治疗后SBP[(126. 04±9. 72)vs(135. 62±20. 07)mmHg]、DBP[(71. 84±5. 92)vs(81. 53±9. 34)mmHg]、体重[74. 35(68. 10,76. 50)vs 76. 70(69. 50,77. 25)kg]、BMI[26. 04(24. 13,28. 12)vs 26. 81(24. 60,29. 13)kg/m^2]、FBG[(7. 33±1. 36)vs(8. 87±2. 86)mmol/L]、HbA1c[(8. 06±1. 06)vs(9. 26±1. 74)%]、TC[(4. 09±1. 35)vs(4. 94±1. 36)mmol/L]、LDL-C[(2. 49±0. 74)vs(2. 96±0. 90)mmol/L]、UACR[17. 70(9. 70,36. 30)vs 19. 90(9. 50,39. 20)mg/g]、NAG[12. 20(10. 00,14. 90)vs16. 80(11. 30,21. 35)U/L]、CysC[0. 65(0. 51,0. 78)vs 0. 67(0. 56,0. 90)mg/L]和SUA[(312. 29±92. 84)vs(339. 40±97. 55)μmol/L]低于治疗前(P<0. 05或P<0. 01);Dap组UACR[4. 00(3. 05,14. 15)vs 2. 10(0. 20,5. 00)mg/g]、DBP[(9. 69±9. 22)vs(5. 42±7. 48)mmHg]、BMI[(0. 89±1. 04)vs(0. 28±1. 13)kg/m^2]和NAG[2. 70(0. 40,6. 20)vs 1. 60(1. 20,3. 30)U/L]治疗后较治疗前下降幅度大于Con组(P<0. 05或P<0. 01)。结论达格列净可减少血糖控制不佳的T2DM患者蛋白尿,降低肾小管标记物,可能具有肾脏保护作用。

关键词：达格列净糖尿病,2型尿白蛋白/肌酐比值 N-乙酰-β-氨基葡萄糖苷酶

IL-23/IL-17轴因子在初诊Graves病患者治疗前后的变化

在线全文

学校读者我要写书评

暂无评论

安徽医科大学学报 2017年第11期52卷 1718-1720,1725页

作者：杨铭潘天荣钟兴安徽医科大学第二附属医院内分泌科合肥230601

目的检测IL-23/IL-17轴在Graves病(GD)患者外周血中的表达水平,以及^(131)Ⅰ或抗甲状腺药物(ATD)治疗后的变化趋势。方法收集初诊GD患者40例作为GD组,其中^(131)Ⅰ治疗组(20例)和ATD治疗组(20例);40例性别、年龄匹配的健康者设为对照组... 详细信息

目的检测IL-23/IL-17轴在Graves病(GD)患者外周血中的表达水平,以及^(131)Ⅰ或抗甲状腺药物(ATD)治疗后的变化趋势。方法收集初诊GD患者40例作为GD组,其中^(131)Ⅰ治疗组(20例)和ATD治疗组(20例);40例性别、年龄匹配的健康者设为对照组。使用ELISA法检测GD组治疗前后及对照组IL-17、IL-23水平。结果 (1)两组比较,治疗前GD组血清IL-23、IL-17表达水平明显高于对照组(P<0.05);(2)^(131)Ⅰ治疗后第6个月IL-23、IL-17的外周血水平较治疗前有明显降低(P<0.05),仍明显高于对照组(P<0.05)。ATD组治疗前后差异无统计学意义。结论 IL-23、IL-17在初诊GD患者外周血中高表达,提示IL-23/IL-17轴可能参与Graves发病,同时放射性^(131)Ⅰ治疗甲亢改善病情可能与IL-23/IL-17轴因子变化部分相关。

关键词： Graves病 131Ⅰ 抗甲状腺药物 IL-23/IL-17轴