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Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population

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Journal of Environmental Sciences 2024年第9期143卷 224-234页

作者： Zekang Su Yali zhang Shiyi Hong Qiaojian zhang Jiayu Xu Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu tianchen Wang Guang Jia Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China National Center for Occupational Safety and Health Beijing 102308China Department of Occupational Health and Radiological Health Chongqing Centers for Disease Control and PreventionChongqing 400042China Henan Institute for Occupational Medicine Zhengzhou 450052China Department of Clinical Laboratory Third Hospital of Peking UniversityBeijing 100191China

Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and *** it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly *** address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic ***(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic *** the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,***,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,*** addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or *** findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关键词： Blood chromate Liver injury Systemic inflammation Mediation analysis

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Physical-property cutoffs of tight reservoirs by field and laboratory experiments: a case study from Chang 6, 8–9 in Ordos Basin

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Frontiers of Earth Science 2021年第2期15卷 471-489页

作者： Bingbing SHI Xiangchun CHANG Zhongquan LIU Ye LIU tianchen GE Pengfei zhang Yongrui WANG Yue WANG Lixin MAO College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China Petroleum Exploration and Development Research Institute Shengli Oilfield Company of SINOPECDongying 257015China Jiangsu Design Institute of Geology for Mineral Resources Xuzhou 221006China

Tight sandstone reservoirs are generally characterized by complex reservoir quality,non-Darcy flow,and strong *** utilized for evaluating physical property cutoffs of conventional reservoirs maybe ***,a comprehensive investigation on physical property cutoffs of tight sandstone reservoirs is crucial for the reserve evaluation and successful *** this study,a set of evaluation approaches take advantage of field operations(i.e.,core drilling,oil testing,and wireline well logging data),and simulation experiments(i.e.,high-pressure mercury injection-capillary pressure(MICP)experiment,oil-water relative permeability experiment,nuclear magnetic resonance(NMR)experiment,and biaxial pressure simulation experiment)were comparatively optimized to determine the physical property cutoffs of effective reservoirs in the Upper Triassic Chang 6,Chang 8 and Chang 9 oil layers of the Zhenjing *** results show that the porosity cutoffs of the Chang 6,Chang 8,and Chang 9 oil layers are 7.9%,6.4%,and 8.6%,and the corresponding permeability are 0.08 mD,0.05 mD,and 0.09 mD,*** with wireline well logging,mud logging,and oil testing,the cut-off of the thickness of single-layer effective reservoirs are approximately 3.0 m,3.0 m,and 2.0 m,*** on the cutoffs of critical properties,a superimposed map showing the planar distribution of the prospective targets can be mapped,which may delineate the effective boundary of prospective targets for petroleum exploration of tight sandstone reservoirs.

关键词： tight sandstone reservoirs cutoffs of petrophysical property field operations simulation experiments Yanchang Formation Ordos Basin

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肠道微生物群-TLR4-肝轴参与肝细胞癌的发生发展

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胃肠病学和肝病学杂志 2021年第1期30卷 38-41页

作者：李建辉聂耶毛珍珍张天辰雷鑫焌王彦芳宋文杰西安医学院陕西西安710021 空军军医大学西京医院肝胆外科

肝癌是大多数慢性肝病终末期的表现(如:肝炎、肝硬化等),其发生是基因突变、环境改变、病毒影响等多因素共同作用的结果,经历多阶段发展的结果。肝癌最常见的类型是肝细胞癌(hepatocellular carcinoma,HCC),且HCC的死亡率高、术后复发... 详细信息

肝癌是大多数慢性肝病终末期的表现(如:肝炎、肝硬化等),其发生是基因突变、环境改变、病毒影响等多因素共同作用的结果,经历多阶段发展的结果。肝癌最常见的类型是肝细胞癌(hepatocellular carcinoma,HCC),且HCC的死亡率高、术后复发率居高不下成为了全球第三大死因。大量的研究表明,肠道微生物群-TLR4-肝轴(即:肠-肝轴)在HCC形成过程中起着重要作用。大多数肝病患者存在肠道微生物群失调,引起脂多糖产生过多和胆汁淤积,胆汁淤积及脂多糖与肝内TLR4结合可引发一系列细胞毒害反应,包括细胞过度增殖、NF-κB激活、DNA氧化损伤,进而诱发肝细胞损伤,最终促进HCC的发生发展。此外,肠道微生物群能影响免疫检查点抑制剂(如PD-1单抗)在HCC治疗中的效果,改善HCC患者预后。本文就肠道微生物群-TLR4-肝轴、TLR信号传导途径、胆汁酸代谢在HCC形成中的作用分子机制及相关处理策略作一概述,为临床HCC的预防和治疗提供参考。

关键词：肝细胞癌肠道微生物群 Toll样受体-4 脂多糖肠-肝轴

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3D nano-printed geometric phase metasurfaces for generating accelerating beams with complex amplitude manipulation

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 86-95页

作者： tianchen Tang Saima Kanwal Yongzheng Lu Yuelong Li Shuangbao Wu Lei Chen Ziheng Qian Zhouyu Xie Jing Wen Dawei zhang Research Center of Optical Instrument and System Ministry of Education and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Metasurface,a forefront in emerging optical devices,has demonstrated remarkable potential for complex amplitude manipulation of light ***,prevailing approaches face challenges in spatial resolution and complexities associated with integrating dynamic phases,impeding the simplified design and reproducible fabrication of ***,we introduce an innovative approach for complex amplitude modulation within 3D nano-printed geometric phase *** approach enables the generation of self-accelerating beams by encoding amplitude through phase-only manipulation,achieving high spatial ***,this method circumvents the conventional need to adjust the geometric parameters of metasurface unit structures for amplitude manipulation,offering a streamlined and efficient route for design and fabrication *** novel methodology holds promise for expedited and low-cost manufacturing of complex amplitude manipulation metasurfaces.

关键词： metasurface complex amplitude manipulation geometric phase 3D nano-printing Airy beam accelerating parabolic beam

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现代数字技术赋能公共卫生高质量发展

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中国公共卫生管理 2024年第5期40卷 681-685页

作者：罗通张天琛潘欢弘宗俊毛向群李晨薇叶兴彭子婧刘晓青江西省疾病预防控制中心/江西省医学领先学科“流行病学” 江西南昌330029 南昌大学公共卫生学院

在当今信息多元和数字爆炸的时代,物联网、大数据、人工智能、云计算等现代数字技术相互依托、互为补充,共同推动了我国数字化建设。新冠病毒感染的全球大流行更是加速了数字技术在公共卫生领域的应用和发展,使得公共卫生有关数据来源... 详细信息

在当今信息多元和数字爆炸的时代,物联网、大数据、人工智能、云计算等现代数字技术相互依托、互为补充,共同推动了我国数字化建设。新冠病毒感染的全球大流行更是加速了数字技术在公共卫生领域的应用和发展,使得公共卫生有关数据来源更加广泛且数据结构愈发多样化。在回顾国内外公共卫生信息化发展进程后,发现物联网、遥感技术、5G通信技术、大数据、人工智能、云计算等前沿技术已在传染病监测预测预警、卫生应急处置、慢性病和免疫规划管理、食品安全管理、人才培养、健康宣教等公共卫生多个领域得到了有效应用并取得了诸多成果。尽管数字技术在公共卫生领域应用过程中面临新的挑战,但毋庸置疑的是,公共卫生数字化发展已成为未来的必然方向。

关键词：公共卫生数字技术 5G 传染病监测预测预警卫生应急处置

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Revealing the frequency-dependent oscillations in the nonlinear terahertz response induced by the Josephson current

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National Science Review 2023年第11期10卷 110-117页

作者： Sijie zhang Zhiyuan Sun Qiaomei Liu Zixiao Wang Qiong Wu Li Yue Shuxiang Xu tianchen Hu Rongsheng Li Xinyu Zhou Jiayu Yuan Genda Gu Tao Dong Nanlin Wang International Center for Quantum Materials School of PhysicsPeking University State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Condensed Matter Physics and Materials Science Department Brookhaven National Lab Beijing Academy of Quantum Information Sciences

Nonlinear responses of superconductors to intense terahertz radiation has been an active research *** terahertz pump-terahertz probe spectroscopy, we investigate the c-axis nonlinear optical response of a high-temperature superconducting cuprate. After excitation by a single-cycle terahertz pump pulse, the reflectivity of the probe pulse oscillates as the pump-probe delay is varied. Interestingly, the oscillatory central frequency scales linearly with the probe frequency, a fact widely overlooked in pump-probe experiments. By theoretically solving the nonlinear optical reflection problem on the interface, we show that our observation is well explained by the Josephson-type third-order nonlinear electrodynamics, together with the emission coefficient from inside the material into free space. The latter results in a strong enhancement of the emitted signal whose physical frequency is around the Josephson plasma edge. Our result offers a benchmark for and new insights into strong-field terahertz spectroscopy of related quantum materials.

关键词： high-temperature superconducting cuprates nonlinear optics time-domain tarahertz

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Tight sandstone reservoir sensitivity and damage mechanism analysis: A case study from Ordos Basin, China and implications for reservoir damage prevention

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Energy Geoscience 2022年第4期3卷 394-416页

作者： Zhongquan Liu Bingbing Shi tianchen Ge Fenggui Sui Yue Wang Pengfei zhang Xiangchun Chang Ye Liu Yongrui Wang Zhaoyang Wang Petroleum Exploration and Development Research Institute Shengli Oilfield Company of SINOPECDongying257015China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong266590China Institute of Western Frontier Area Shengli Oilfield CompanySINOPECDongying257000China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China

Analysis of reservoir sensitivity to velocity,water,salt,acid,alkali and stress is critical for reservoir *** study the tight sandstone reservoir sensitivity at different formation depths(effective stress)and formation water conditions(pH,salinity,and fluid velocity),a series of dynamic core flow tests under different pH,salinity,acid,and effective stress conditions were performed on samples from tight sandstone reservoirs of the Upper Triassic Yanchang 8(T_(3)y^(8))Member and conventional reservoirs of the Middle-Lower Jurassic Yan'an 9(J_(1-2)y^(9))Member in the Ordos *** results indicate that,compared with the conventional reservoirs,the tight sandstone reservoirs are more sensitive to velocity and stress,less sensitive to water,alkali and salinity,and respond better to acid *** addition,the critical conditions(salinity,velocity,pH,and stress)for pumping drilling,completion,and fracturing fluids into tight sandstone reservoirs were investigated.A combination of scanning electron microscopy coupled with energy-dispersive spectrometry(SEM-EDS),cathodoluminescence(CL),casting thin section(CTS)and nuclear magnetic resonance(NMR)images,high-pressure mercury injection capillary pressure(MICP)measurements as well as X-ray fluorescence spectral(XRF)analyses were employed to analyze the damage mechanisms of the conventional reservoirs(J_(1-2)y^(9))and tight sandstone reservoirs(T_(3)y^(8))caused by fluid *** results suggest that reservoir sensitivity is primarily conditioned by the composition of detrital components and interstitial fillings,petrophysical properties,pore-throat structure,and diagenetic *** these factors control the sensitivity types and extent of the *** results indicate that the poorer the reservoir physical properties,the stronger the reservoir heterogeneity and sensitivity,implying that tight sandstone reservoirs are more susceptible to changes in fluids than conventional *** study offer

关键词： Formation damage prevention Reservoir sensitivity Tight sandstone reservoir Yanchang Formation Ordos basin

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Horizontal oscillation processed large MXene with Low Ti–Ti coordination for fast sodium storage

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Science China Chemistry 2024年第11期67卷 3729-3738页

作者： Hang Wang Xingwu Zhai Yujian Xia Zhixin Sun tianchen Wei Guangyu Chen Yuhuan Li Xinfeng Tang Liang Wu Zhaodi Fan Hongjun zhang Bangjiao Ye Xueyuan Leng Min Zhou Hefei National Laboratory for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

MXene stands out as a rising family of transition metal carbides/nitrides with exceptional size-dependent properties and versatile potential applications. However, the realization of large MXene with a controllable surface at atomic level remains challenging to keep the balance among the conductivity, stability and activity. Herein, the horizontal oscillation-induced delamination(HOD)strategy is proposed to acquire Ti_(3)C_(2) flakes with large size and low Ti–Ti coordination(HO-Ti_(3)C_(2)). The average size of the asobtained flakes can reach 6.48 μm to keep the overall conductive skeleton and merits from large size. Simultaneously, metal atoms at surface can be partially removed due to the enhanced local vibrational turbulence during the reciprocating horizontal oscillation process. Such MXenes with clear and unique surface states exhibit high potentials in ion adsorption together with satisfied electric conductivity and stability. As proof of concept, HO-Ti_(3)C_(2) anode exhibits remarkable rate capability and longterm stability during sodium storage. A capacity of 100.5 m Ah g^(-1)with a long-life cycle(4,500 cycles) at a high rate of 1.0 A g^(-1)originates from the increased s-d interaction between Na and Ti. Therefore, the HOD strategy provides a controllable surface design to promote the clear criteria into size-dependent research on MXene.

关键词： horizontal oscillation induced delamination shear force large flakes coordination environment fast sodium storage

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机器人胰十二指肠切除术:手术步骤及技术要领

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协和医学杂志 2024年第4期15卷 751-757页

作者：张天辰张修平刘荣中国人民解放军总医院第一医学中心肝胆胰外科医学部北京100853

机器人微创化的发展一直是学科焦点,胰十二指肠切除术因其风险高、难度大而被誉为外科手术的“珠穆朗玛峰”。标准化的手术步骤和简单易行的操作技巧有助于机器人胰十二指肠切除术(robotic pancreaticoduodenectomy,RPD)的推广应用。本... 详细信息

机器人微创化的发展一直是学科焦点,胰十二指肠切除术因其风险高、难度大而被誉为外科手术的“珠穆朗玛峰”。标准化的手术步骤和简单易行的操作技巧有助于机器人胰十二指肠切除术(robotic pancreaticoduodenectomy,RPD)的推广应用。本文结合中国人民解放军总医院第一医学中心大量RPD实操经验,将RPD归纳总结为18个手术步骤,并对环血管切除技术、重建吻合技术进行要点解析,以期推动机器人在胰腺外科的深入应用,促进RPD规范和应用标准的进一步建立。

关键词：机器人手术胰十二指肠切除术环血管切除胰肠吻合

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Strong coupling with absorption and emission features of Ag@Au hollow nanoshells interacting with J-aggregated dye molecules

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Chinese Optics Letters 2021年第12期19卷 137-142页

作者： tianchen Zhao Qiang Ma Yajie Bian Yuyi zhang Yiting Liu Xiaolei zhang Botao Wu E Wu Shitao Lou Qingyuan Jin State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi

We investigate the strong coupling from 5,5’,6,6’-tetrachloro-1,1’-diethyl-3,3’-di(4-sulfobutyl)-benzimidazolocarbocyanine(TDBC)molecules near pure nano-triangular Ag prisms or Ag@Au hollow *** TDBC molecules are deposited on pure Ag nanoprisms or Ag@Au hollow nanoshells with the plasmonic resonance peak,matching very closely with the absorption band of TDBC J-aggregates,obvious Rabi splitting can be observed due to the strong coupling ***,the photoluminescence intensity decreased with the increasing of the temperature,verifying the decreasing plasmon-exciton coupling interaction in the higher *** experimental results are coincident with the simulation results calculated by finite-difference time-domain method.

关键词： surface plasmon nanoshells plasmon-exciton coupling Rabi splitting

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