检索结果-南通市图书馆

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

Zoological Research 2024年第4期45卷 747-766页

作者： Hong-Yi Zheng tian-zhang song Yong-Tang Zheng State Key Laboratory of Genetic Evolution&Animal Models KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019(COVID-19)immunobiology,often resulting in a lack of reproducibility when extrapolated to the whole ***,developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** review summarizes current progress related to COVID-19 animal models,including non-human primates(NHPs),mice,and hamsters,with a focus on their roles in exploring the mechanisms of immunopathology,immune protection,and long-term effects of SARS-CoV-2 infection,as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 *** among these animal models and their specific applications are also highlighted,as no single model can fully encapsulate all aspects of *** effectively address the challenges posed by COVID-19,it is essential to select appropriate animal models that can accurately replicate both fatal and non-fatal infections with varying courses and *** animal model libraries and associated research tools is key to resolving the global COVID-19 pandemic,serving as a robust resource for future emerging infectious diseases.

关键词： SARS-CoV-2 COVID-19 Animal models Infection immunology Immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zika virus infection induces glycometabolic disorder in northern pig-tailed macaques

引用

Science China Life Sciences 2024年

作者： Qing Li Ren-Hua Yang Yan Hu Bei-Bei Tang Ying-Jie Jiang Chang-Bo Zheng tian-zhang song State Key Laboratory of Genetic Evolution&Animal Models Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University University of Chinese Academy of Sciences KIZ-SU Joint Laboratory of Animal Model and Drug Development College of Pharmaceutical SciencesSoochow University

Dear Editor,The Zika virus (ZIKV) was first identified in Africa in 1947 but remained relatively obscure for nearly 70 ***,from 2014 to 2016,ZIKV was introduced into Brazil from the Pacific Islands,leading to its rapid dissemination throughout the Americas (Fauci and Morens,2016).This mosquito-borne virus is distinguished by its capacity to cause congenital defects,as evidenced by the microcephaly epidemic in Brazil,and has been declared a Public Health Emergency of International Concern (Gulland,2016).

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Monkeypox,wild animals,and potential big problem

引用

Zoological Research 2022年第4期43卷 612-614页

作者： tian-zhang song Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

A new outbreak of monkeypox virus(MPV)is currently occurring in several regions of the *** the beginning of May 2022,3040 cases have been reported to the World Health Organization(WHO)*** of its usual“endemic”base in Africa,the virus has so far been detected in 47 countries,including in Europe,America,Oceania,and Asia,where monkeypox is uncommon or previously *** 25 June 2022,the WHO Emergency Committee declared that the outbreak does not currently constitute a Public Health Emergency of International Concern,but unanimously acknowledged the emergency nature of the event and that controlling further spread will require a vigorous ***,new cases of MPV infection have been confirmed in Korea,Singapore,and Taiwan,***,a better understanding of MPV and enhanced surveillance are essential for preventing disease recurrence.

关键词： globally Taiwan currently

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

引用

动物学研究 2024年第4期 747页

作者： Hong-Yi Zheng tian-zhang song Yong-Tang Zheng

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Successful implementation of intestinal resection and anastomosis in non-human primates suggests the possibility of longitudinal intestinal research

引用

Zoological Research 2020年第4期41卷 449-454页

作者： Xue-Hui Wang tian-zhang song Lei Li Ren-Rong tian Yong-Tang Zheng School of Life Sciences University of Science and Technology of ChinaHefeiAnhui 230026China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Dong fang Animal Hospital KunmingYunnan 650228China

DEAR EDITOR,Intestinal biopsy is a basic experimental method for studying pathological changes in the intestinal tract during human immunodeficiency virus(HIV)*** this study,jejunal resection and anastomosis were succ... 详细信息

关键词： anastomosis resection biopsy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina)infected with SIVmac239

引用

Zoological Research 2018年第1期39卷 42-51页

作者： tian-zhang song ming-xu zhang yu-jie xia yu xiao wei pang yong-tang zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China University of Chinese Academy of Sciences Bejing 100049China Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China

Parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus （HIV） patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromised hosts during HIV infection Due to the lack of direct evidence from animal experiments, the effects of immunocompromised hosts parasitic infections on remain unclear. Here we detected 14 different parasites in six northern pig-tailed macaques （NPMs） before or at the 50th week of simian immunodeficiency virus （SIV） infection by ELISA. The NPMs all carried parasites before viral injection. At the 50th week after viral injection, the individuals with negative results in parasitic detection （i.e., 08247 and 08287） were characterized as the Parasites Exit （PE） group, with the other individuals （i.e., 09203, 09211, 10205, and 10225） characterized as the Parasites Remain （PR） group. Compared with the PR group, the NPMs in the PE group showed higher viral loads, lower CD4＋ T cells counts, and lower CD4/CD8 rates. Additionally, the PE group had higher immune activation and immune exhaustion of both CD4~ and CD8~ T cells. Pathological observation showed greater injury to the liver, cecum, colon, spleen, and mesenteric lymph nodes in the PE group This study showed more seriously compromised immunity in the PE group, strongly indicating that parasites might exit an immunocompromised host.

关键词： AIDS Immunocompromised Northernpig-tailed macaque Parasite SIVmac239

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tissue distribution of SARS-CoV-2 in non-human primates after combined intratracheal and intranasal inoculation

引用

Science China(Life Sciences) 2021年第10期64卷 1792-1794页

作者： tian-zhang song Jian-Bao Han Xiang Yang Ming-Hua Li Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunming 650107China

Dear Editor,As of 5 July,2020,approximately 20,162,000 confirmed cases of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),have been reported globally,including an estimated 740,000 *** the clinical manifestations of COVID-19 are heterogeneous,viral infection and pathological changes in the respiratory system,especially the lungs,still represent common characteristics of *** nose,served as the entrance to the respiratory system,seems to produce absent or minimal symptoms of nasal congestion or rhinorrhea during SRAS-CoV-2 infection,while other viral rhinitis(i.e.,adenovirus,rhinovirus,influenza virus,etc.)are characterized by typical nasal symptoms,including nasal congestion,rhinorrhea,and *** studies suggest that,despite a lack of other nasal symptoms,anosmia is an important sign of early-stage COVID-19(Lechien et al.,2020).

关键词： nasal respiratory acute

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques(Macaca leonina)

引用

Zoological Research 2019年第6期40卷 522-531页

作者： Ming-Xu zhang tian-zhang song Hong-Yi Zheng Xue-Hui Wang Ying Lu Han-Dan zhang Ting Li Wei Pang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province National Kunming High Level Biosafety Research Center for Non-human PrimatesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China School of Life Sciences University of Science and Technology of ChinaHefei Anhui 230026China KIZ-SU Joint Laboratory of Animal Models and Drug Development College of Pharmaceutical SciencesSoochow UniversitySuzhou Jiangsu 215123China

Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation (Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.

关键词： Immune activation Intestinal integrity Microbial translocation SIVmac239 Macaca leonina Northern pig-tailed macaques Macaca mulatta Chinese rhesus macaques

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prognostic factors associated with gastrointestinal dysfunction after gastrointestinal tumor surgery:A meta-analysis

引用

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1420-1429页

作者： Jia song Cong Zhou tian zhang Department of Operating Room The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjing 210031Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongji Hospital of Huazhong University of Science and TechnologyWuhan 430073Hubei ProvinceChina Department of Disinfection Supply Center The Fourth Affiliated Hospital of Nanjing Medical UniversityNanjing 210031Jiangsu ProvinceChina

BACKGROUND Explore the risk factors of gastrointestinal dysfunction after gastrointestinal tumor surgery and to provide evidence for the prevention and intervention of gastrointestinal dysfunction in patients with gastrointestinal tumor *** To investigate the potential risk factors for gastrointestinal dysfunction following gastrointestinal tumor surgery and to present information supporting the prevention and management of gastrointestinal dysfunction in surgery *** Systematically searched the relevant literature from PubMed,Web of Science,Cochrane Library,Embase,CNKI,China Biomedical Database,Wanfang Database,and Weipu Chinese Journal Database self-established until October 1,*** Manager 5.3 software was used for meta-analysis after two researchers independently screened literature,extracted data,and evaluated the risk of bias in the included *** A total of 23 pieces of literature were included,the quality of which was medium or above,and the total sample size was *** results of meta-analysis showed that the patients were male(OR=1.58,95%CI:1.25-2.01,P=0.002)and≥60 years old(OR=2.60,95%CI:1.76-2.87,P<0.001),physical index≥25.3 kg/m2(OR=1.6,95%CI:1.00-1.12,P=0.040),smoking history(OR=1.89,95%CI:1.31-2.73,P<0.001),chronic obstructive pulmonary disease(OR=1.49,95%CI:1.22-1.83,P<0.001),enterostomy(OR=1.47,95%CI:1.26-1.70,P<0.001),history of abdominal surgery(OR=2.90,95%CI:1.67-5.03,P<0.001),surgical site(OR=1.2,95%CI:1.40-2.62,P<0.001),operation method(OR=1.68,95%CI:1.08-2.62,P=0.020),operation duration(OR=2.65,95%CI:1.92-3.67,P<0.001),abdominal adhesion grade(OR=2.52,95%CI:1.90-3.56,P<0.001),postoperative opioid history(OR=5.35,95%CI:3.29-8.71,P<0.001),tumor TNM staging(OR=2.58,95%CI:1.84-3.62,P<0.001),postoperative blood transfusion(OR=2.92,95%CI:0.88-9.73,P=0.010)is a risk factor for postoperative gastrointestinal dysfunction in patients with gastrointestinal *** There are many factors affecting gastroint

关键词： Gastrointestinal tumor surgery Postoperative gastrointestinal dysfunction Intestinal paralysis Risk factors Metaanalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis

引用

Neural Regeneration Research 2019年第11期14卷 1919-1931页

作者： Nan-Xing Yi Long-Yun Zhou Xiao-Yun Wang Yong-Jia song Hai-Hui Han tian-song zhang Yong-Jun Wang Qi Shi Hao Xu Qian-Qian Liang Ting zhang Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina Institute of Spine Shanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghaiChina School of Rehabilitation Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina Jing'an District Center Hospital Fudan UniversityShanghaiChina

OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain *** SOURCES: Key terms were "stroke","brain diseases","brain injuries","brain hemorrhage, traumatic","acute brain injury","dizocilpine maleate","dizocilpine","MK-801","MK801","rat","rats","rattus" and "murine". PubMed, Cochrane library, EMBASE, the China National Knowledge Infrastructure, WanFang database, the VIP Journal Integration Platform(VJIP) and SinoMed databases were searched from their inception dates to March *** SELECTION: Studies were selected if they reported the effects of MK-801 in experimental acute brain injury. Two investigators independently conducted literature screening, data extraction, and methodological quality *** MEASURES: The primary outcomes included lesion volume and brain edema. The secondary outcomes included behavioral assessments with the Bederson neurological grading system and the water maze test 24 hours after brain ***: A total of 52 studies with 2530 samples were included in the systematic review. Seventeen of these studies had a high methodological quality. Overall, the lesion volume(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P < 0.00001) and degree of cerebral edema(5 studies, n = 75, MD =-1.21, 95% CI:-1.50 to-0.91;P < 0.00001) were significantly decreased in the MK-801 group compared with the control group. MK-801 improved spatial cognition assessed with the water maze test(2 studies, n = 60, MD =-10.88, 95% CI:-20.75 to-1.00;P = 0.03) and neurological function 24 hours after brain injury(11 studies, n = 335, MD =-1.04, 95% CI:-1.47 to-0.60;P < 0.00001). Subgroup analysis suggested an association of reduction in lesion volume with various injury models(34 studies, n = 966, MD =-58.31, 95% CI:-66.55 to-50.07;P = 0.004). Further network analysis showed that 0–1 mg/kg MK-801 may be the optimal dose for treatment in the middle cerebral artery occlusion animal

关键词： nerve regeneration acute brain injury neurological function spatial cognition water maze test lesion volume brain edema rat systematic review meta-analysis neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：