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Effects of SARS-CoV-2 infection on neuroimaging and neurobehavior in neonates

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World Journal of Pediatrics 2021年第2期17卷 171-179页

作者： Kai Yan Fei-Fan xiao Yu-Wei Jiang tian-tian xiao Da-Jiang Zhang Wen-Hao Yuan Jian-Bo Shao Guo-Qiang Cheng Ling-Kong Zeng Department of Neonatology Children’s Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Key Laboratory of Neonatal Diseases of Ministry of Health ShanghaiChina Center for Molecular Medicine Children's Hospital of Fudan UniversityNational Children’s Medical CenterInstitutes of Biomedical SciencesFudan UniversityShanghai.China Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghaiChina Department of Neonatology Chengdu Women's and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Radiology Children’s Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Department of Neonatology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background We collected neonatal neurological,clinical,and imaging data to study the neurological manifestations and imaging characteristics of neonates with coronavirus disease 2019(COVID-19).Methods This case-control study included newborns diagnosed with COVID-19 in Wuhan,China from January 2020 to July *** included newborns had complete neurological evaluations and head magnetic resonance *** normalized the extracted T2-weighted imaging data to a standard neonate template space,and segmented them into gray matter,white matter,and cerebrospinal *** comparison of gray matter volume was conducted between the two *** A total of five neonates with COVID-19 were included in this *** median reflex scores were 2 points lower in the infected group than in the control group(P=0.0094),and the median orientation and behavior scores were 2.5 points lower in the infected group than in the control group(P=0.0008).There were also significant differences between the two groups in the total scale score(P=0.0426).The caudate nucleus,parahippocampal gyrus,and thalamus had the strongest correlations with the Hammersmith neonatal neurologic examination(HNNE)score,and the absolute correlation coefficients between the gray matter volumes and each part of the HNNE score were all almost greater than *** We first compared the neurological performance of neonates with and without COVID-19 by quantitative neuroimaging and neurological examination *** the limited numbers of patients,more studies focusing on the structural or functional aspects of the virus in the central nervous system in different age groups will be carried out in the future.

关键词： Coronavirus disease 2019 Magnetic resonance imaging Neonates Quantitative neuroimaging Severe acute respiratory syndrome coronavirus 2

Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China

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World Journal of Pediatrics 2021年第3期17卷 253-262页

作者： Ling-Kong Zeng Hua-Ping Zhu tian-tian xiao Si-Cong Peng Wen-Hao Yuan Jian-Bo Shao Lai-Shuan Wang Fei-Fan xiao Shi-Wen Xia Shoo K.Lee Kai Yan Wen-Hao Zhou Department of Neonatology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Neonatology Maternal and Child Health Hospital of Hubei ProvinceWuhanChina National Children’s Medical Center Children’s Hospital of Fudan UniversityShanghaiChina Department of Neonatology Chengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Neonatology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Maternal-Infant Care Research Center(MiCARE)and Department of Pediatrics Mount Sinai HospitalTorontoONCanada Department of Pediatrics Department of Obstetrics and Gynecology and Dal la Lana School of Public HealthUniversity of TorontoTorontoONCanada

Background Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an emerging *** consequences of SARS-CoV-2 exposure in infants remain ***,this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain *** This multicenter observational study was conducted at two designated maternal and children's hospitals in Hubei Province,China's Mainland from February 1,2020 to May 15,*** born to mothers with COVID-19 were *** magnetic resonance imaging(MRI)findings,and volumes of grey and white matters,and physical growth parameters were observed at 44 weeks corrected gestational *** Of 72 neonates born to mothers with COVID-19,8(11%)were diagnosed with COVID-19,8(11%)were critically ill,and no deaths were *** the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks,five neonates were diagnosed with *** these five neonates,three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2,delayed myelination and brain dysplasia in newborn 3,and abnormal signal in the bilateral periventricular in newborn *** other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age(P>0.05).Physical growth parameters for weight,length,and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all *** Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical *** findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2,but further study is required to evaluate the association between the abnormal MRI findings and the exposure

关键词： Coronavirus disease 2019 Follow-up Neonate Severe acute respiratory syndrome coronavirus 2

Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang Fei-Fan xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan Wang Chun-Mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou tian-tian xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

Risk stratification of hemodynamically significant patent ductus arteriosus by clinical and genetic factors

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World Journal of Pediatrics 2023年第12期19卷 1192-1202页

作者： Yu-Xi Chen tian-tian xiao Hui-Yao Chen Xiang Chen Ya-Qiong Wang Qi Ni Bing-Bing Wu Hui-Jun Wang Yu-Lan Lu Li-Yuan Hu Yun Cao Guo-Qiang Cheng Lai-Shuan Wang Fei-Fan xiao Lin Yang Xin-Ran Dong Wen-Hao Zhou Center for Molecular Medicine of Children’s Hospital of Fudan University Institutes of Biomedical SciencesFudan University138 Yi Xue Yuan RoadShanghaiChina Department of Neonatology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Center for Molecular Medicine Children’s Hospital of Fudan University399 Wanyuan RoadShanghai201102China

Background Hemodynamically significant patent ductus arteriosus(hsPDA)is associated with increased comorbidities in *** evaluation of hsPDA risk is critical to implement individualized *** aim of the study was to provide a powerful reference for the early identification of high-risk hsPDA population and early treatment *** We enrolled infants who were diagnosed with PDA and performed exome *** collapsing analyses were used to find the risk gene set(RGS)of hsPDA for model *** credibility of RGS was proven by RNA *** logistic regression was performed to establish models combining clinical and genetic *** models were evaluated by area under the receiver operating curve(AUC)and decision curve analysis(DCA).Results In this retrospective cohort study of 2199 PDA patients,549(25.0%)infants were diagnosed with *** model[all clinical characteristics selected by least absolute shrinkage and selection operator regression(all CCs)]based on six clinical variables was acquired within three days of life,including gestational age(GA),respiratory distress syndrome(RDS),the lowest platelet count,invasive mechanical ventilation,and positive inotropic and vasoactive *** has an AUC of 0.790[95%confidence interval(CI)=0.749–0.832],while the simplified model(basic clinical characteristic model)including GA and RDS has an AUC of 0.753(95%CI=0.706–0.799).There was a certain consistency between RGS and differentially expressed genes of the ductus arteriosus in *** AUC of the models was improved by RGS,and the improvement was significant(all CCs *** CCs+RGS:0.790 vs.0.817,P<0.001).DCA demonstrated that all models were clinically *** Models based on clinical factors were developed to accurately stratify the risk of hsPDA in the first three days of *** features might further improve the model performance.

关键词： Exome sequencing-Hemodynamically significant patent ductus arteriosus Multivariate logistic regression Neonates Risk stratification

Potential role of retina as a biomarker for progression of Parkinson's disease

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 433-438页

作者： tian tian 1, xiao-Hua Zhu 2, Yun-Hai Liu 1 1Department of Neurology, Xiangya Hospital, Central-South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China 2Department of Ophthalmology, the Second Xiangya Hospital, Central-South University, 139 Renmin Middle Road, Changsha 410011, Hunan Province, China Department of Neurology Xiangya Hospital Central-South University 87 Xiangya Road Changsha 410008 Hunan Province China.

Optical coherence tomography (OCT) noninvasively quantifies the thickness of the retinal nerve fiber layer (RNFL). OCT has been studied in several neuro-ophthalmic conditions, including Parkinson’s disease (PD). Recent studies suggest that the quantitative analysis of RNFL can be precisely and noninvasively done by OCT scans and the results suggest that the thickness of RNFL is significantly decreased in patients with PD compared with age-matched controls and the foveal retinal thickness correlates with disease severity in PD. In this article, the application of OCT imaging of the retina in PD was reviewed. Literature survey of PubMed was carried out using the search terms of "Optical Coherence Tomography" combined with "Parkinson’s Disease" and "retinal nerve fiber layer" (without restriction to the year of publication). Some related articles were also included. The search was completed in Jul. 2011 and revised and updated as necessary. The aim of this article is to review the current literatures on the use of optical coherence tomography in patients affected by PD and to enhance its use in clinical practice in neuro-ophthalmology.

关键词： Parkinson disease optical coherence tomography retinal nerve fiber layer thickness

Experimental and Theoretical Investigations on the Terahertz Vibrational Spectroscopy of Polymorphs and cocrystals of Nalidixic Acid

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Experimental and Theoretical Investigations on the Terahertz...

毛细管电泳-电致化学发光联用技术检测烟草中尼古丁含量

第十三届全国量子化学会议

作者： tian-tian xiao Lu-lu Fu Yu-ai Duan Guo Wang Yi Liao Department of Chemistry Capital Normal University

As an efficient spectral measurement tool in the far-infrared region, terahertz time-domain spectroscopy（THz-TDS） has recently been in progress with advantages over other conventional techniques and with a wide range of biophysics and biochenmistry. Moreover, it can be used to probe the molecular vibrations and inter-molecular modes for molecular crystals[1-2].Nalidixic acid（NA） is one of the earliest quinolone antibiotics used in the treatment of urinary tract infections. Here, the polymorphs and cocrystals of NA have been synthesized and confirmed by XRD. And both the experiment and simulation of THz spectra for NA-I and NA-HYQ in the range of 0.1-2.5 THz are presented（Fig.1.）Vibration frequencies calculated based on DFT in the THz region are also *** on the experimental and theoretical results, it is indicated that the distinct features of the spectrum originated from low-frequency vibrational modes caused by intermolecular hydrogen bonding interactions.

关键词： THz-TDS Nalidixic Acid vibrational

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分析化学 2013年第8期41卷 1274-1278页

作者：赵利敏陈晓梅田晓田黄志勇陈曦集美大学生物工程学院厦门大学近海海洋环境科学国家重点实验室

建立了毛细管电泳-电致化学发光联用技术(CE-ECL)检测烟草浸出液中尼古丁含量的方法。考察了检测电位、检测池中Ru(bpy)32+浓度和缓冲液pH值、CE运行缓冲液浓度和pH值、进样时间和电压,以及CE分离电压等实验条件对尼古丁测定的影响。在... 详细信息

建立了毛细管电泳-电致化学发光联用技术(CE-ECL)检测烟草浸出液中尼古丁含量的方法。考察了检测电位、检测池中Ru(bpy)32+浓度和缓冲液pH值、CE运行缓冲液浓度和pH值、进样时间和电压,以及CE分离电压等实验条件对尼古丁测定的影响。在优化的条件下,尼古丁检测的线性范围为低浓度段:1～100μg/L(r>0.999)、高浓度段:100～1500μg/L(r>0.996),检出限为0.5μg/L(S/N=3)。将本方法用于3种品牌的烟草浸出液中尼古丁含量的测量,测定值均与烟盒上尼古丁的标注值相吻合,样品的加标回收率为95%～106%。

关键词：毛细管电泳电致化学发光联吡啶钌尼古丁烟草

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无线接入车载网络MAC协议参数研究

金陵科技学院学报 2016年第4期32卷 1-6页

作者：田锦田潇金陵科技学院网络与通信工程学院江苏南京211169 南京大学软件学院江苏南京210093

对无线接入车载环境网络MAC(介质接入控制)协议性能进行专题研究,分析了IEEE 802.11p/IEEE1609.4标准的特点,提出了以Ad Hoc车间通信为基础单元,借助蜂窝移动通信网络和路边无线接入点构建一个实时、高效的无线异构接入网络拓扑。阐述... 详细信息

对无线接入车载环境网络MAC(介质接入控制)协议性能进行专题研究,分析了IEEE 802.11p/IEEE1609.4标准的特点,提出了以Ad Hoc车间通信为基础单元,借助蜂窝移动通信网络和路边无线接入点构建一个实时、高效的无线异构接入网络拓扑。阐述了网络节点数对吞吐量的影响。改进原有标准参数,可很好地改进最高优先级业务一帧内平均发送数据包数、平均发送时延、数据包成功发送率指标,达到车载通信的时延要求。

关键词： WAVE 异构网络 EDCA 延缓最小竞争窗

肺动脉高压时肺血管内皮间质转化相关miRNAs网络调控的生物信息学分析

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中国药理学通报 2016年第9期32卷 1294-1300页

作者：张卫芳熊爱珍吴卫华祝田田邹小舟刘汀胡长平南昌大学第二附属医院药学部江西南昌330006 中南大学药学院药理学系湖南长沙410078 湖南医药学院药理学教研室湖南怀化418000

目的探索肺动脉高压(pulmonary hypertension,PH)时肺血管内皮间质转化(End MT)相关miRNAs及其下游靶点的网络调控。方法利用文献挖掘PH相关基因及EndMT/EMT相关miRNAs。利用Biological General Repository for Interaction Datasets(Bio GRID)数据库得到基因相互作用关系。利用生物信息学(DIANA3、Miranda4、Pic Tar5、Target Scan6、miRDB7和micro T-CDS8)预测相应miRNAs的靶基因关系,超几何分析预测与肺动脉高压End MT相关miRNAs,通过对miRNAs参与功能分区中的情况筛选评分最高的miRNAs并选择部分进行实验验证,利用Cytocape 3软件构建miRNAs与其下游靶点的相互作用网络。结果根据文献挖掘出与PH有关的基因230个,与End MT/EMT相关miRNAs共189个,对应成熟体322个。其中98个miRNAs可能与PH时End MT有关。其中,仅有22个miRNAs同时参与了TGF-β/BMP、低氧和炎症3个功能通路,评分最高,分别为miR-let-7家族、miR-124、miR-130家族、miR-135、miR-144、miR-149、miR-155、miR-16-1、miR-17、miR-181家族、miR-182、miR-200家族、miR-204、miR-205、miR-21、miR-224、miR-27、miR-29家族、miR-301a、miR-31、miR-361和miR-375。对let-7g、miR-21、miR-124及miR-130家族进行实时荧光定量PCR验证发现其在低氧诱导PH大鼠肺动脉中表达均明显变化。结论利用生物学信息技术从大量miRNAs中筛选得到的22个miRNAs同时参与TGF-β/BMP、低氧和炎症信号通路,可能与PH时End MT相关,为后续深入研究PH时End MT提供了重要的理论依据。

关键词：肺动脉高压 miRNAs 内皮间质转化网络调控生物信息学网络药理相互作用