Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
作者机构：Department of NeonatologyWuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of NeonatologyMaternal and Child Health Hospital of Hubei ProvinceWuhanChina National Children’s Medical CenterChildren’s Hospital of Fudan UniversityShanghaiChina Department of NeonatologyChengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of NeonatologyChildren's Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Maternal-Infant Care Research Center(MiCARE)and Department of PediatricsMount Sinai HospitalTorontoONCanada Department of PediatricsDepartment of Obstetrics and Gynecology and Dal la Lana School of Public HealthUniversity of TorontoTorontoONCanada
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2021年第17卷第3期
页 面：253-262页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：supported by the Fundamental Research Funds for the Central Universities(No.2020kfyXGYJ006) Wuhan Emergency Research Project of COVID-19(No.EX20D24)
主 题：Coronavirus disease 2019 Follow-up Neonate Severe acute respiratory syndrome coronavirus 2
摘 要：Background Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an emerging *** consequences of SARS-CoV-2 exposure in infants remain ***,this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain *** This multicenter observational study was conducted at two designated maternal and children s hospitals in Hubei Province,China s Mainland from February 1,2020 to May 15,*** born to mothers with COVID-19 were *** magnetic resonance imaging(MRI)findings,and volumes of grey and white matters,and physical growth parameters were observed at 44 weeks corrected gestational *** Of 72 neonates born to mothers with COVID-19,8(11%)were diagnosed with COVID-19,8(11%)were critically ill,and no deaths were *** the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks,five neonates were diagnosed with *** these five neonates,three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2,delayed myelination and brain dysplasia in newborn 3,and abnormal signal in the bilateral periventricular in newborn *** other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age(P0.05).Physical growth parameters for weight,length,and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all *** Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical *** findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2,but further study is required to evaluate the association between the abnormal MRI findings and the exposure
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