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Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

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Chinese Chemical Letters 2008年第9期19卷 1068-1070页

作者： Wei Zhang tian tian sun Duo Mei Jun Fei Wang Ying Xia Li Key laboratory of Marine Drugs The Ministry of Education of China School of Pharmacy Ocean University of China Qingdao 266003 China

The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关键词： Synthesis Amino acid Schollkopf methodology Culicinins

Marine-derived fungi as a source of bioactive indole alkaloids with diversifed structures

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Marine Life Science & Technology 2021年第1期3卷 44-61页

作者： Zhi-Hui Meng tian-tian sun Guo-Zheng Zhao Yu-Fei Yue Qing-Hua Chang Hua-Jie Zhu Fei Cao College of Pharmaceutical Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China

Marine-derived fungi are well known as rich sources of bioactive natural *** evidences indicated that indole alkaloids,isolated from a variety of marine-derived fungi,have attracted considerable attention for their diverse,challenging structural complexity and promising bioactivities,and therefore,indole alkaloids have potential to be pharmaceutical lead *** compilation of the relevant *** this review,we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities,covering literatures published during 1982–2019.

关键词： Indole alkaloid Marine-derived fungus Chemical diversity Bioactivity

Crosstalk between STAT3 signaling and COX-2 in Helicobacter pyloriassociated human gastric tumorigenesis

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Crosstalk between STAT3 signaling and COX-2 in Helicobacter ...

Specific Patterns of Auxin-controlled Cytokinin Distribution Are Essential for Stem Cell Induction during Shoot Regeneration

2012中国消化系疾病学术大会

作者： Hua Xiong Wan Du tian-tian sun Ji-lin Wang Jie Hong Jing-yuan Fang Department of Gastroenterology Ren-Ji HospitalShanghai Jiao-Tong University School of Medicine Shanghai Institute of Digestive Disease

Objective Persistent infection with Helicobacter pylori(***) contributes to gastric *** COX- 2 and STAT3 are known to contribute to the initiation and progression of ***-associated gastric inflammation and tumorigenesis,the mechanisms by which ***-induced increase in COX-2 expression or STAT3 activation have yet not been identified.

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Specific Patterns of Auxin-controlled Cytokinin Distribution...

Specific Patterns of Auxin-controlled Cytokinin Distribution Are Essential for Stem Cell Induction during Shoot Regeneration

2010全国植物生物学研讨会

作者： Zhi Juan Cheng Chao Zhou Ying Hua Su Wei Li Liang Wang tian tian sun Wei sun Xiang Yu Zhao Xing Guo Li Youfa Cheng Yunde Zhao Qi Xie Xian Sheng Zhang

Shoot regeneration is an important mechanism for in vitro plant *** process is mainly mediated by plant hormones cytokinin and *** is believed that the induction of stem cells is important for plant meristem establish...

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Specific Patterns of Auxin-controlled Cytokinin Distribution...

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

植物分子生物学与现代农业——2010全国植物生物学研讨会

作者： Zhi Juan Cheng,Chao Zhou,Ying Hua Su,Wei Li,Liang Wang,tian tian sun,Wei sun,Xiang Yu Zhao,Xing Guo Li,Youfa Cheng,Yunde Zhao,Qi Xie,and Xian Sheng Zhang

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi tian Tang Yunfan Zhang Zhiyuan Ma Jingwen sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

叶酸对AD模型小鼠脑内Aβ沉积及BACE1表达影响

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中国公共卫生 2018年第3期34卷 368-372页

作者：田甜孙杨王渭诗刘欢黄国伟西安医学院第一附属医院陕西西安710003 天津医科大学公共卫生学院营养与食品卫生学系

目的探讨叶酸对阿尔茨海默病(AD)小鼠脑内β–淀粉样蛋白(Aβ)沉积影响及机制。方法将6月龄雄性APP/PS1模型小鼠随机分为4组:叶酸缺乏组、叶酸对照组、叶酸低、高剂量组(120、600μg/kg);同月龄野生型小鼠作为阴性对照组。叶酸缺乏组小... 详细信息

目的探讨叶酸对阿尔茨海默病(AD)小鼠脑内β–淀粉样蛋白(Aβ)沉积影响及机制。方法将6月龄雄性APP/PS1模型小鼠随机分为4组:叶酸缺乏组、叶酸对照组、叶酸低、高剂量组(120、600μg/kg);同月龄野生型小鼠作为阴性对照组。叶酸缺乏组小鼠饲以叶酸缺乏饲料,其他各组饲以普通饲料,干预60 d。采用实时荧光定量PCR法(RT-PCR)检测β位淀粉样前体裂解酶–1(BACE1)mRNA水平;免疫印迹法(WB)检测脑组织BACE1蛋白表达;免疫组化法检测脑组织Aβ表达;酶联免疫吸附法检测脑组织中和含量。结果与叶酸对照组比较,叶酸高剂量组小鼠脑组织中Aβ蛋白表达降低,叶酸缺乏组Aβ蛋白表达升高(P<0.05);与叶酸对照组(0.295±0.034)比较,叶酸高剂量组小鼠脑组织含量(0.209±0.041)降低,叶酸缺乏组含量(0.396±0.043)升高(P<0.05);与叶酸对照组(15.99±1.434)比较,叶酸缺乏组小鼠脑组织BACE1 mRNA水平(21.97±4.396)升高,叶酸低、高剂量组小鼠脑组织中BACE1 mRNA表达水平[分别为(9.932±1.903)、(10.53±2.750)]均降低(均P<0.05);与叶酸对照组(1.371±0.213)比较,叶酸缺乏组小鼠脑组织中BACE1蛋白表达水平(1.655±0.241)升高,叶酸低、高剂量组小鼠脑组织中BACE1蛋白表达水平[分别为(1.003±0.271)、(0.906±0.188)]均降低,差异均有统计学意义(均P<0.05)。结论补充叶酸可减少AD小鼠脑组织中Aβ沉积及含量,其机制可能与叶酸抑制小鼠脑组织中淀粉样蛋白生成途径的分泌酶BACE1表达有关。

关键词：叶酸阿尔茨海默病(AD) β位淀粉样前体裂解酶-1(BACE1) β-淀粉样蛋白(Aβ) APP/PS1小鼠

上皮性卵巢癌组织ATF4和RPL41表达及其临床意义

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中华肿瘤防治杂志 2017年第14期24卷 996-1002页

作者：郁万媛赵田田王昊孙世洁韩淑玉王岩焦伊胜中国医科大学附属盛京医院妇产科辽宁沈阳110004

目的探讨转录激活因子4(activating transcription factor 4,ATF4)在许多肿瘤细胞的缺氧区被检测到呈高表达,并且与肿瘤的恶性程度相关。核糖体蛋白L41(ribosomal protein L41,RPL41)能够诱导肿瘤细胞死亡和细胞周期停滞,在调节ATF4的... 详细信息

目的探讨转录激活因子4(activating transcription factor 4,ATF4)在许多肿瘤细胞的缺氧区被检测到呈高表达,并且与肿瘤的恶性程度相关。核糖体蛋白L41(ribosomal protein L41,RPL41)能够诱导肿瘤细胞死亡和细胞周期停滞,在调节ATF4的水平方面发挥着重要作用。本研究探讨ATF4和RPL41在上皮性卵巢癌组织中的表达及其与临床病理学特征的关系。方法利用免疫组化技术SP法分别检测中国医科大学附属盛京医院病理科2000-01-01-2015-12-31470例上皮性卵巢癌、42例交界性卵巢肿瘤、27例良性卵巢肿瘤和46例正常卵巢组织切片及芯片中ATF4和RPL41的表达情况。结果 ATF4在上皮性卵巢癌组织中阳性表达率为86.60%(407/470),明显高于正常卵巢与良性卵巢肿瘤组的39.73%(29/73)及交界性卵巢肿瘤组的73.81%(31/42),差异有统计学意义,P值分别为0.05。Spearman相关性分析显示,ATF4和RPL41在上皮性卵巢癌组织中呈中等程度相关,r=-0.508。结论 ATF4表达升高和RPL41表达降低可能在上皮性卵巢癌的发生、分化进展过程中起重要作用。

关键词： ATF4 RPL41 上皮性卵巢癌转录激活因子

a-Synuclein: A fusion chaperone significantly boosting the enzymaticperformance of PET hydrolase

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Chinese Journal of Chemical Engineering 2023年第12期64卷 18-25页

作者： Renwen tian Yan sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Extensive use of polyethylene terephthalate (PET) has brought about global environmental problems. Arecently reported PET hydrolase (PETase) discovered from Ideonella sakaiensis showed high potentialfor degrading PET at moderate temperatures, but its activity and stability need further improvementfor practical applications. Herein, we proposed to use a-synuclein (aS) as a fusion chaperone and createdsix PETase-aS fusion enzymes with linkers of different types and lengths. All the fusion enzymes exhibited improved enzymatic performance, presenting 1.5 to 2.6-fold higher activity towards bis-2(hydroxyethyl) terephthalate than PETase, as well as significantly increased stabilities. Fluorescencespectroscopy indicated that the chaperone fusion tightened the overall conformation and resulted inthe opening of the substrate binding pocket, which led to the improved thermal stability and catalyticactivity of the fusion enzymes. Remarkably, one of the fusion proteins, PETase-[(GS)(EK)]10-aS, showed3.2 to 5.1 times higher PET degradation capability than PETase. The significantly boosted PET degradationperformance was not only attributed to the enhanced enzymatic activity and stability, but also possiblydue to the binding affinity of the fused aS domain for PET. These findings demonstrated that aS was aneffective fusion chaperone for significantly enhancing the enzymatic performance of PETase.

关键词： PET hydrolase a-Synuclein Fusion enzyme Stability Pollution Degradation