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Scalable Ambient Pressure Synthesis of Covalent Organic Frameworks and Their Colorimetric Nanocomposites through Dynamic Imine Exchange Reactions

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Chinese Journal of Polymer Science 2018年第1期36卷 1-1,2-7页

作者： Wei Zhao Jia Qiao tian-li ning Xi-Kui liu College of Polymer Science and Engineering Sichuan University

A novel scale-up ambient pressure synthetic strategy for the preparation of imine-based covalent organic frameworks（COFs） was proposed through dynamic imine exchange reaction mechanism. The obtained COFs exhibited good crystallinity and much higher porosity comparable to their solvothermally synthesized counterparts. Moreover, under ambient pressure, the COF nanofibers could readily grow on the surface of polyimide films, and the resulted nanocomposite film showed an interesting colorimetric acid-responsive behavior.

关键词： Covalent organic frameworks(COFs) Dynamic imine exchange Ambient pressure synthesis

Signature Based on Six Autophagy-related Genes to Predict Prognosis of Head and Neck Squamous Cell Carcinoma

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Current Medical Science 2022年第3期42卷 597-605页

作者： Hua ZHANG liang ZHANG Ya-tong FAN tian-ning li li-su PENG Kun-peng WANG Jun MA Clinical Laboratory Diagnostics Tianjin Medical University General Hospital Airport SiteTianjin 300308China Department of Health Statistics Public Health School of Tianjin Medical UniversityTianjin 300070China School and Hospital of Stomatology Tianjin Medical UniversityTianjin 300070China Department of Physiology and Pathophysiology Tianjin Medical UniversityTianjin 300070China

Objective The present study aimed to develop an autophagy-related gene prognostic prediction model to provide survival risk prediction for head and neck squamous cell carcinoma(HNSCC)*** The K-mean cluster analysis was performed on HNSCC samples based on the expression values of 210 autophagy-related genes for candidate signature gene *** Cox regression analysis was generated using the potential genes and the risk score was calculated from the prognosis *** risk score was processed as an independent prognostic indicator to construct the nomogram *** immune status including immune cell infiltration ratio and checkpoints of patients with HNSCC in high-and low-risk groups was also *** LASSO Cox regression analysis was performed on the selected autophagy-related *** to the lambda value corresponding to the number of different genes in the LASSO Cox analysis,six genes(GABARAPL2,SAR1A,ST13,GAPDH,FADD and LAMP1)were finally *** risk score based on the genes was generated,which was an independent prognostic marker for *** prognostic prediction model(nomogram)was further optimized by the independent prognostic factors(risk score),which can better predict the prognosis and survival of *** the risk score and prognosis model,eight types of immune cells and six key immune checkpoints(CTLA4,PD1,IDO1,TDO2,LAG3,TIGIT)displayed expression *** This study identified several potential prognostic biomarkers and established an autophagy-related prognostic prediction model for HNSCC,which provides a valuable reference for future clinical research.

关键词： head and neck squamous cell carcinoma autophagy risk score Cox regression nomogram immune cell infiltration ratio

Treatment of hemolymphangioma by robotic surgery: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 596-600页

作者： tian-ning li Yan-Hong liu Jia Zhao Hong Mu Lei Cao Department of Clinical Lab Tianjin First Central HospitalTianjin 300000China Nankai University Tianjin Union Medical CenterTianjin 300000China tianjin Medical University Tianjin First Center HospitalTianjin 300000China

BACKGROUND Hemolymphangioma of the jejunum is rare and lacks clinical specificity,and can manifest as gastrointestinal bleeding,abdominal pain,and intestinal *** tomography,magnetic resonance imaging,and other examinations show certain characteristics of the disease,but lack *** capsule endoscopy and enteroscopy make up for this deficiency,the diagnosis also still re-quires *** SUMMARY A male patient was admitted to the hospital due to abdominal distension and abdominal pain,but a specific diagnosis by computed tomography examination was not *** resection of the small intestine was performed by robotic surgery,and postoperative pathological biopsy confirmed the diagnosis of *** recurrence in the follow-up examination was *** Robotic surgery is an effective way to treat hemolymphangioma through minima-lly invasive techniques under the concept of rapid rehabilitation.

关键词： Hemolymphangioma Enteroscopy Robotic surgery Rehabilitation Case report

Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in tianjin, China

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Virologica Sinica 2022年第6期37卷 850-859页

作者： Jing-Yu Wang tian-ning li Chun-Lei Zhou Jie Zhao Meng Wang Yuan Wang Yan Jiang He-Nan Dong Qian-Ru Qi Hong Mu Department of Clinical Lab Tianjin First Central HospitalTianjin300192China The First Central Clinical College Tianjin Medical UniversityTianjin300192China Department of Clinical Lab Tianjin Children's HospitalTianjin300074China

COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron”, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive(RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron.

关键词： COVID-19 SARS-CoV-2 Omicron variant Clinical characteristics Pediatric patients SARS-CoV-2 vaccine

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao Yin Yanting li Zhiying tian Qichao li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Smart Gas Sensors:Recent Developments and Future Prospective

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Nano-Micro Letters 2025年第3期17卷 55-86页

作者： Boyang Zong Shufang Wu Yuehong Yang Qiuju li tian Tao Shun Mao College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai 200092People’s Republic of China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092People’s Republic of China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280People’s Republic of China

Gas sensor is an indispensable part of modern society withwide applications in environmental monitoring,healthcare,food industry,public safety,*** the development of sensor technology,wireless communication,smart monitoring terminal,cloud storage/computing technology,and artificial intelligence,smart gas sensors represent the future of gassensing due to their merits of real-time multifunctional monitoring,earlywarning function,and intelligent and automated *** electronicand optoelectronic gas sensors have been developed for high-performancesmart gas *** the development of smart terminals and the maturityof integrated technology,flexible and wearable gas sensors play an increasingrole in gas *** review highlights recent advances of smart gassensors in diverse *** structural components and fundamentalprinciples of electronic and optoelectronic gas sensors are described,andflexible and wearable gas sensor devices are ***,sensorarray with artificial intelligence algorithms and smart gas sensors in“Internet of Things”paradigm are ***,the challengesand perspectives of smart gas sensors are discussed regarding the future need of gas sensors for smart city and healthy living.

关键词： Smart gas sensor Electronic sensor Optoelectronic sensor Flexible and wearable sensor Artificial intelligence

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren tian li Xueer liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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冻融循环条件下粗砂岩物理力学性质变化规律

煤田地质与勘探 2016年第5期44卷 102-107页

作者：徐拴海田延哲李宁西安理工大学岩土工程研究所陕西西安710048 中煤科工集团西安研究院有限公司陕西西安710077 冻土工程国家重点实验室甘肃兰州730000 兰州交通大学土木工程学院甘肃兰州730000

岩体经受自然冻融循环过程后,其物理力学性质的劣化是引起岩石工程灾害的主要原因。借助于MTS815液伺服岩石试验系统对经历不同冻融循环次数的粗砂岩进行三轴压缩试验,研究经历不同冻融循环次数后岩石在不同围压下的强度和变形特性,分... 详细信息

岩体经受自然冻融循环过程后,其物理力学性质的劣化是引起岩石工程灾害的主要原因。借助于MTS815液伺服岩石试验系统对经历不同冻融循环次数的粗砂岩进行三轴压缩试验,研究经历不同冻融循环次数后岩石在不同围压下的强度和变形特性,分析冻融循环次数和围压对岩石强度和变形的影响规律。研究结果表明,在冻融循环次数一定的条件下,随着围压的增加,岩石的三轴抗压强度、弹性模量和峰值轴向应变逐渐增加,表明粗砂岩的破坏逐渐由脆性破坏向塑形破坏变化;在围压相同的情况下,随着冻融循环次数的增加,岩石的三轴抗压强度、弹性模量逐渐减小,峰值应力对应的轴向应变逐渐增加;随着冻融循环次数的增加,粗砂岩的黏聚力均呈指数衰减形式降低,内摩擦角变化很小。

关键词：冻融循环物理力学性质变化规律

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing li Zixuan He Weitai Chai Meng tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan