Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in Tianjin, China
作者机构：Department of Clinical LabTianjin First Central HospitalTianjin300192China The First Central Clinical CollegeTianjin Medical UniversityTianjin300192China Department of Clinical LabTianjin Children's HospitalTianjin300074China
出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)
年 卷 期：2022年第37卷第6期
页 面：850-859页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：supported by Tianjin Municipal Health Commission Science and Technology Project (TJWJ2021QN016) Tianjin Key Medical Discipline (Specialty) Construction Project
主 题：COVID-19 SARS-CoV-2 Omicron variant Clinical characteristics Pediatric patients SARS-CoV-2 vaccine
摘 要：COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive(RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron.
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