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Mitochondrial transplantation as a promising therapy for mitochondrial diseases

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1028-1035页

作者： tian-guang zhang Chao-yu Miao Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

Mitochondrial diseases are a group of inherited or acquired metabolic disorders caused by mitochondrial dysfunction which may affect almost all the organs in the body and present at any ***,no satisfactory therapeutic strategies have been available for mitochondrial diseases so *** transplantation is a burgeoning approach for treatment of mitochondrial diseases by recovery of dysfunctional mitochondria in defective cells using isolated functional *** models of mitochondrial transplantation in cells,animals,and patients have proved effective via various routes of mitochondrial *** review presents different techniques used in mitochondrial isolation and delivery,mechanisms of mitochondrial internalization and consequences of mitochondrial transplantation,along with challenges for clinical *** some unknowns and challenges,mitochondrial transplantation would provide an innovative approach for mitochondrial medicine.

关键词： Mitochondria Mitochondrial transplantation Mitochondrial disease Mitochondrial isolation Mitochondrial delivery Mitochondrial storage Mitochondrial transplantation rejection Ethical issue

NO_x reduction by coupling combustion with recycling flue gas in iron ore sintering process

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International Journal of Minerals,Metallurgy and Materials 2011年第4期18卷 390-396页

作者： Yan-guang Chen zhan-cheng Guo Gen-sheng Feng School of Chemistry and Chemical Engineering No.beast Petroleum University Daqing 163318 China2 Key Laboratory of the Ministry of Education of China for Recycling ＆ Ecological Metallurgy University of Science and Technology Beijing Beijing 100083 China2

A new process called＇NOx reduction by coupling combustion with recycling flue gas（RCCRF）＇was proposed to decrease NOx emission during the iron ore sintering *** simulation test of NOx reduction was performed over sintered ore and in the process of coke ***,NOx reduction was also carried out by sintering pot *** sintered ore,the amount of NOx emission is reduced by 15wt%-25wt% at 400-550oC using 2.0vol% H2 or 2.0vol% CO,or reduced by 10wt%-30wt% at 560-720oC using 0.15vol% *** reduction is around 10wt% by coupling combustion of pyrolysis gas and coke,or around 16wt% by recycling flue gas into coke *** RCCRF,the maximum NOx reduction ratio is about 23wt% in coke combustion experiment and over 40wt% in sintering pot test.

关键词： nitrogen oxides combustion flue gases iron ores sintering

基于HS-SPME-GC-MS比较分析不同原料对葱香油风味品质的影响

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食品工业科技 2025年第2期46卷 250-257页

作者：张萌王鹏耿敬章詹萍田洪磊陕西师范大学食品工程与营养科学学院陕西理工大学生物科学与工程学院

为探究葱品种对炸制葱香油香气组成的影响，选用三种市售葱为原料，花生油为载体油脂，葱碎于130℃炸制3 min获得葱香油样本（大葱炸制油Fried Dacong Oil,DFO；红葱炸制油Fried Hongcong Oil,HFO及香葱炸制油Fried Xiaocong Oil,XFO）... 详细信息

为探究葱品种对炸制葱香油香气组成的影响，选用三种市售葱为原料，花生油为载体油脂，葱碎于130℃炸制3 min获得葱香油样本（大葱炸制油Fried Dacong Oil,DFO；红葱炸制油Fried Hongcong Oil,HFO及香葱炸制油Fried Xiaocong Oil,XFO），采用定量描述性感官分析（Quantitative descriptive sensory analysis,QDA）和顶空固相微萃取-气相色谱-质谱联用仪（Headspace-solid phase microextraction-gas chromatography-mass spectrometry,HS-SPME-GC-MS）对比分析不同样本间挥发性物质组成差异，并结合多元统计分析筛选造成3个葱香油之间感官属性强度产生差异的关键物质。感官评价结果表明相同工艺参数下所制备的葱香油，XFO表现出较强的葱香味和脂香味，浓郁度高，油腻和辛辣感较弱；GC-MS共分离鉴定出66种物质，利用正交偏最小二乘分析（Orthogonal partial least squares discrimination analysis,OPLS-DA）筛选出18种导致3种葱香油呈香特征产生差异的关键物质。相对香气活性值（Relative odor activity value,ROAV）分析结果表明，2-乙基-6-甲基吡嗪、丙醛、2,6-二乙基吡嗪、苯甲醛、愈创木酚、苯甲醇、5-甲基呋喃醛、2-乙酰基吡嗪、2-正戊基呋喃、3-乙基-2,5-二甲基-吡嗪、（E）-2-辛烯醛、2-吡咯甲醛、N-甲基-2-吡咯甲醛及2,3,5-三甲基吡嗪是引起葱香油样品风味品质差异的物质。与其他两种葱香油相比，XFO得到小组成员喜爱，符合对葱香油香气轮廓预期。本研究利用HS-SPME-GC-MS筛选出与葱香油相关的差异物质，可为我国后期高品质葱香调味油标准化加工奠定理论基础。

关键词：葱白挥发性物质炸制差异成分

来源：博看期刊

DNA methylation detection methods used in colorectal cancer

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World Journal of Clinical Cases 2019年第19期7卷 2916-2929页

作者： Yu-Xia zhan guang-Hua Luo Comprehensive Laboratory Changzhou Key Lab of Individualized Diagnosis and Treatment Associated with High Technology Research the Third Affiliated Hospital of Soochow University

Colorectal cancer(CRC)remains a major contributor to the number of cancerrelated deaths that occur annually *** the development of molecular biology methods,an increasing number of molecular biomarkers have been identified and *** is believed to result from an accumulation of epigenetic changes,and detecting aberrant DNA methylation patterns is useful for both the early diagnosis and prognosis of *** studies are focusing on the development of DNA methylation detection methods or DNA methylation ***,this review will discuss the commonly used techniques and technologies to evaluate DNA methylation,their merits and deficiencies as well as the prospects for new methods.

关键词： Colorectal cancer Cancer screening Marker DNA methylation detection

Discrete and continuum modeling of granular flow in silo discharge

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Particuology 2018年第1期16卷 127-138页

作者： tian tian Jinglin Su Jinhui zhan Shujun Geng guangwen Xu Xiaoxing Liu State Key Laboratory of Multi-Phase Complex System Institute of Process Engineering Chinese Academy of Science Beijing 100190 China University of Chinese Academy ofSdences Beijing 100049 China Sino-Danish Center for Education and Research Beijing 100190 China

Granular material discharge from a flat-bottomed silo has been simulated by using continuum modeling and a three-dimensional discrete-element method （DEM）. The predictive abilities of three commonly used frictional viscosity models （Schaeffer, S-S, and μ（I）） were evaluated by comparing them with the DEM data. The funnel-flow pattern （type C） and the semi-mass-flow pattern （type B） that was predicted by DEM simulations can be represented when the Schaeffer orμ（I） model is used, whereas the S-S model gives a consistent type-B flow pattern. All three models over-estimate the discharge rate compared with the DEM. The profiles of the solids volume fraction and the vertical velocity above the outlet show that the larger discharge rates given by the Schaeffer and μ（I） model result from an over-estimation of volume fraction, whereas the deviation in the S-S model stems from the failure to predict a solid vertical velocity and a volume fraction.

关键词： Silo Flow pattern Discharge rate Discrete-element model Frictional viscosity model

Research on theoretical and numerical methods of single bubble oscillation

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Journal of Hydrodynamics 2021年第4期33卷 872-877页

作者： Jie-min zhan Yue-han Chen Yu-tian Li Department of Applied Mechanics and Engineering Sun Yat-sen UniversityGuangzhou510275China

A comparison of theoretical investigation and numerical simulation of a single bubble oscillation is carried out in this *** theoretical research is based on solving Rayleigh-Plesset(R-P)equation and Keller-Miksis(K-M)equation using Runge-Kutta *** numerical method focuses on the two discrete methods in the volume of fluid(VOF)method,geometric reconstruction(GR)and modified high resolution interface capturing(MHRIC).The results show that the interface captured by MHRIC in the collapse stage is more stable,and the evolution of bubble radius agrees better with the theoretical *** R-P equation and K-M equation,which omit the effect of the energy equation,have limitations when the bubble collapses under ultra-high pressure.

关键词： Cavitation bubble dynamics volume of fluid method geometric reconstruction(GR)

Temperature effect on aerobic denitrification and nitrification

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Journal of Environmental Sciences 2003年第5期15卷 669-673页

作者： XIE Shu guang zhanG Xiao jian WANG zhan sheng Department of Environmental Science and Technology Tsinghua UniversityBeijing 100084China.

Nitrogen loss without organic removal in biofilter was observed and its possible reason was explained. A lower hydraulic loading could improve aerobic denitrification rate. Aerobic denitrification was seriously affected by low temperature(below 10℃). However, nitrification rate remained high when the temperature dropped from 15℃ to 5℃. It seemed the autotrophic biofilm in BAF could alleviate the adverse effect of low temperature.

关键词： aerobic denitrification nitrification biofilter temperature effect

Emerging approaches to probing ion channel structure and function

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Neuroscience Bulletin 2012年第4期28卷 351-374页

作者： Wei-guang Li tian-Le Xu Neuroscience Division Department of Biochemistry and Molecular Cell BiologyInstitute of Medical SciencesShanghaiJiao Tong University School of MedicineShanghai 200025China

Ion channels,as membrane proteins,are the sensors of the *** act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable *** of their importance in cellular communication,ion channels have been intensively studied at the structural and functional ***,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of *** emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.

关键词： ion channel structure and function mutagenesis covalent modification voltage-clamp fluorometry computational chemistry

p-adic Measures of Algebraic Independence for the Values of Ramanujan Functions and Klein Modular Functions

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Acta Mathematica Sinica,English Series 2007年第1期23卷 83-88页

作者： tian Qin WANG guang Shan XU Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China Institute of Data and Knowledge Engineering Henan University Kaifeng 475001 P. R. China

In this paper, we give the p-adic measures of algebraic independence for the values of Ramanujan functions and Klein modular functions at algebraic points.

关键词： p-adic value Measure of algebraic independence Ramanujan function Klein modular function