检索结果-南通市图书馆

Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy

引用

Chinese Journal of Integrative Medicine 2025年第1期31卷 19-27页

作者： LIU tian-yi HAO yu MAO Qin ZHOU Na LIU Meng-hua WU Jun WANG Yi YANG Ming-rui School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Experimental Research Center China Academy of Chinese Medical SciencesBeijing100700China

Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages infected with influenza A virus and the underlying mechanism based on mitophagy pathway. Methods:The inflammatory model of murine macrophage J774A.1 induced by influenza A virus [strain A/Puerto Rico/8/1934(H1N1), PR8] was constructed and treated by TRQ, while the mitochondria-targeted antioxidant Mito-TEMPO and autophagy specific inhibitor 3-methyladenine(3-MA) were used as controls to intensively study the anti-inflammatory mechanism of TRQ based on mitophagy-mitochondrial reactive oxygen species(mt ROS)-NLRP3 inflammasome pathway. The levels of NLRP3, Caspase-1 p20, microtubule-associated protein 1 light chain 3 Ⅱ(LC3Ⅱ) and P62 proteins were measured by Western blot. The release of interleukin-1β(IL-1β) was tested by enzyme linked immunosorbent assay, the mt ROS level was detected by flow cytometry, and the immunofluorescence and co-localization of LC3 and mitochondria were observed under confocal laser scanning microscopy. Results: Similar to the effect of Mito-TEMPO and contrary to the results of 3-MA treatment, TRQ could significantly reduce the expressions of NLRP3, Caspase-1 p20, and autophagy adaptor P62, promote the expression of autophagy marker LC3Ⅱ, enhance the mitochondrial fluorescence intensity, and inhibit the release of mt ROS and IL-1β(all P<0.01).Moreover, LC3 was co-localized with mitochondria, confirming the type of mitophagy. Conclusion: TRQ could reduce the level of mt ROS by promoting mitophagy in macrophages infected with influenza A virus, thus inhibiting the activation of NLRP3 inflammasome and the release of IL-1β, and attenuating the inflammatory response.

关键词： Tanreqing Injection influenza virus anti-inflammation mitophagy nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Valence electron matching law for MXene-based single-atom catalysts

引用

Journal of Energy Chemistry 2025年第2期101卷 641-650页

作者： Pei Song yuhang Zhou Zishan Luo Hang Zhang Xi Sun Sen Lu Zepeng Jia Hong Cui Weizhi tian Rong Feng Lingxia jin Hongkuan yuan School of Mechanical Engineering Shaanxi University of Technology Shaanxi Key Laboratory of Industrial Automation Shaanxi University of Technology Shaanxi Key Laboratory of Catalysis College of Chemical & Environment Science Shaanxi University of Technology School of Physical Science and Technology Southwest University

Single-atom catalysts（SACs） have attracted considerable interest in the fields of energy and environmental science due to their adjustable catalytic *** this study,we investigated the matching of valence electron numbers between single atoms and adsorbed intermediates（O,N,C,and H） in MXene-anchored SACs（M-Ti2C/M-Ti2CO2）.The density functional theory results demonstrated that the sum of the valence electron number（VM） of the interface-doped metal and the valence electron number（VA） of the adsorbed intermediates in M-Ti2C followed the 10-valence electron matching ***,based on the 10-valence electron matching law,we deduced that the sum of the valence electron number（k） and VMfor the molecular adsorption intermediate interactions in M-Ti2CO2adhered to the 11-valence electron matching *** repulsion between the interface electrons in M-Ti2CO2and H2O weakened the adsorption of intermediates,Furthermore,we applied the 11-valence electron matching law to guide the design of catalysts for nitrogen reduction reaction,specifically for N2→ NNH conversion,in the *** sure independence screening and sparsifying operator algorithm was used to fit a simple three-dimensional descriptor of the adsorbate（R2up to 0.970） for catalyst *** study introduced a valence electron matching principle between doped metals（single atoms） and adsorbed intermediates（atomic and molecular） for MXene-based catalysts,providing new insights into the design of high-performance SACs.

关键词： Density functional theory Nitrogen reduction reaction Sure independence screening and sparsifying operator Valence electron matching law

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

蔬菜复合鱼肉饼营养成分分析

引用

食品研究与开发 2012年第12期33卷 190-193页

作者：梁鹏田宇静马俪珍天津农学院食品科学系天津300384 国家大宗淡水鱼加工技术研发分中心天津300384 山西农业大学食品学院山西太谷030801

对自制的蔬菜复合鱼肉饼的营养成分进行了测定,实验结果表明蔬菜复合鱼肉饼与空白鱼肉饼相比,水分含量高,脂肪减少,含有少量的膳食纤维,其中必需氨基酸含量高,两者都含有丰富的不饱和脂肪酸和Ca、Fe、Zn、Mg矿质元素。特别是富含亚麻酸... 详细信息

对自制的蔬菜复合鱼肉饼的营养成分进行了测定,实验结果表明蔬菜复合鱼肉饼与空白鱼肉饼相比,水分含量高,脂肪减少,含有少量的膳食纤维,其中必需氨基酸含量高,两者都含有丰富的不饱和脂肪酸和Ca、Fe、Zn、Mg矿质元素。特别是富含亚麻酸和亚油酸,不饱和度达到了99%～100%,两种鱼肉饼总氨基酸含量为11%～13.5%,组合比例均衡,其中含有人体所必需的各种氨基酸,必需氨基酸占总氨基酸含量达到46%以上。

关键词：蔬菜鱼肉饼营养成分

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tailoring Cathode-Electrolyte Interface for High-Power and Stable Lithium-Sulfur Batteries

引用

Nano-Micro Letters 2025年第4期17卷 181-211页

作者： Mengting Liu Ling-Jiao Hu Zhao-Kun Guan tian-Ling Chen Xin-yu Zhang Shuai Sun Ruoli Shi Panpan jing Peng-Fei Wang Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Low-Dimensional Materials and Photo/Electrochemical Technology Lab School of Materials Science and EngineeringShaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021People’s Republic of China

Global interest in lithium-sulfur batteries as one of the most promising energy storage technologies has been sparked by their low sulfur cathode cost,high gravimetric,volumetric energy densities,abundant resources,and environmental ***,their practical application is significantly impeded by several serious issues that arise at the cathode-electrolyte interface,such as interface structure degradation including the uneven deposition of Li_(2)S,unstable cathode-electrolyte interphase(CEI)layer and intermediate polysulfide shuttle ***,an optimized cathode-electrolyte interface along with optimized electrodes is required for overall ***,we comprehensively outline the challenges and corresponding strategies,including electrolyte optimization to create a dense CEI layer,regulating the Li_(2)S deposition pattern,and inhibiting the shuttle effect with regard to the solid-liquid-solid pathway,the transformation from solid-liquid-solid to solid-solid pathway,and solid-solid pathway at the cathode-electrolyte *** order to spur more perceptive research and hasten the widespread use of lithium-sulfur batteries,viewpoints on designing a stable interface with a deep comprehension are also put forth.

关键词： Lithium-sulfur batteries Shuttle effect Cathode-electrolyte interface Structural enhancement Reaction pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高校考试与创新能力的培养

引用

中国环境管理干部学院学报 2006年第1期16卷 90-92页

作者：田雨金中国环境管理干部学院河北秦皇岛066004

考试是高校检测学生学习情况的重要手段,但当前这种手段走入了误区,我们需要反思,我们需要明确教育的终极目标是学生创新能力的培养。只有通过改变旧的观念,进行考试的改革,我们才能达到考试与创新能力培养完美地结合。

关键词：高校考试创新能力观念改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高职院校英语教学中的差生分析与转变

引用

中国环境管理干部学院学报 2005年第1期15卷 118-120页

作者：田雨金中国环境管理干部学院河北秦皇岛066004

就高职院校英语科差生所存在的问题和原因进行了剖析,既有个人内在因素又有教学中的外在因素,对于如何深挖学生潜力,作好学生思想工作,培养学生学习英语兴趣提出了一些具体的解决办法。

关键词：英语差生问题原因解决办法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论公安治理能力现代化

引用

北京警察学院学报 2016年第3期 63-66页

作者：金天宇中国人民公安大学北京100038

全面深化改革,实现国家治理体系与治理能力现代化,是十八大之后党政工作改革的重要方向,是各政府部门进行转型升级的最终目标。公安机关作为社会治理工作的重要部门,当前面临的社会治安形势愈加严峻、多变,社会民众对公安机关的社会治... 详细信息

全面深化改革,实现国家治理体系与治理能力现代化,是十八大之后党政工作改革的重要方向,是各政府部门进行转型升级的最终目标。公安机关作为社会治理工作的重要部门,当前面临的社会治安形势愈加严峻、多变,社会民众对公安机关的社会治理能力也提出了更高的要求。因而,解放思想,全面深化公安改革,加快建设法治公安的步伐,真正实现公安治理能力现代化是当务之急。

关键词：治理能力解放思想公安改革法治公安建设

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

英语分级教学中大班授课的问题与思考

引用

中国环境管理干部学院学报 2006年第3期16卷 94-97页

作者：田雨金中国环境管理干部学院秦皇岛河北066004

英语大班授课存在诸如认识学生困难,纪律难以维持,因材施教原则难以实施,课堂互动困难等问题。通过教学实践发现,抓好课堂常规尤为重要;尽快认识学生,了解学生个性特点有利于教师与学生的情感交流、课堂的互动和因材施教原则的实施;利... 详细信息

英语大班授课存在诸如认识学生困难,纪律难以维持,因材施教原则难以实施,课堂互动困难等问题。通过教学实践发现,抓好课堂常规尤为重要;尽快认识学生,了解学生个性特点有利于教师与学生的情感交流、课堂的互动和因材施教原则的实施;利用信息时代的网络教学平台建立适合个性化发展的课程体系和新教学模式来实现学生自主学习,引进网络系统下的视听说课的“五步式”教学法来强化学生学习英语效果,从而英语分级教学中大班授课问题会迎刃而解,教学质量得到不断提升。

关键词：大班问题对策网络

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

引用

Science China Chemistry 2025年

作者： yuan tian Jiang-Bo Chen Jie Ying Ge tian yu-Xuan Xiao Yi Lu Si-Ming Wu Wei Geng Ling Shen Xiao-yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cardiovascular response to nanosecond pulses is milder in percutaneous ablation of hepatocellular carcinoma compared with microsecond pulses

引用

Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 114-116页

作者： Hai-Ying Kong Qian-Hui jin Xin-Hua Chen Dan-Xia Xu Qi-yu Zhao Xiong-Xin Zhang R James Swanson tian-An Jiang Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Department of SurgeryThe First Hospital of JiaxingJiaxing University College of MedicineJiaxing 314000China Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province Hangzhou 310003China Department of Ultrasound Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Anatomy Department Liberty University College of Osteopathic MedicineLynchburgVAUSA

To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary *** has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues[2].For lesions in complex areas,bile duct[3],and large blood vessels[4],IRE has been developed as an alternative to thermal ablation such as radiofrequency and *** IRE tumor ablative technique combines cell biology and pulsed high-voltage *** high-voltage,high-frequency and transient pulses can create irreversible electroporation in the phospholipid bilayer of the cell membrane and nuclear envelope,resulting in cell *** with radiofrequency ablation and microwave ablation[5],IRE does not cause damage to important vessels and *** has some unique shortcomings in delivering high currents,which has limited its clinical applications in the *** animal and clinical studies,side effects including muscle contraction,procedural hypertension,and arrhythmia are frequently reported[6].However,during the ablation process,if the pulse is synchronized with the heart rhythm,the risk of arrhythmia is *** muscle relaxant eliminates muscle ***,arrhythmia[7],hypertension[8],and myocardial infarction[9]are potential risks requiring proper *** adverse events are mostly moderate and self-limiting,but they may have serious consequences for patients with coronary artery *** to the potential risks,patients with a history of cardiovascular disease are not recommended for IRE treatment.

关键词： microwave consequences ablation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：