Cardiovascular response to nanosecond pulses is milder in percutaneous ablation of hepatocellular carcinoma compared with microsecond pulses

作     者：Hai-Ying Kong Qian-Hui Jin Xin-Hua Chen Dan-Xia Xu Qi-Yu Zhao Xiong-Xin Zhang R James Swanson Tian-An Jiang 

作者机构：Department of AnesthesiologyThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic SurgeryDepartment of SurgeryThe First Hospital of JiaxingJiaxing University College of MedicineJiaxing 314000China Key Laboratory of Pulsed Power Translational Medicine of Zhejiang ProvinceHangzhou 310003China Department of Ultrasound MedicineThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Anatomy DepartmentLiberty University College of Osteopathic MedicineLynchburgVAUSA 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志(英文版))

年 卷 期：2025年第24卷第1期

页      面：114-116页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National S&T Ma-jor Project of China (2018ZX10301201) National Natural Sci-ence Foundation of China (82027803) 

主　　题：microwave consequences ablation 

摘      要：To the Editor:Irreversible electroporation(IRE)is a promising ablative technique for hepatobiliary *** has unique advantages,including no detrimental heat sink effect[1]and no injury of the surrounding tissues[2].For lesions in complex areas,bile duct[3],and large blood vessels[4],IRE has been developed as an alternative to thermal ablation such as radiofrequency and *** IRE tumor ablative technique combines cell biology and pulsed high-voltage *** high-voltage,high-frequency and transient pulses can create irreversible electroporation in the phospholipid bilayer of the cell membrane and nuclear envelope,resulting in cell *** with radiofrequency ablation and microwave ablation[5],IRE does not cause damage to important vessels and *** has some unique shortcomings in delivering high currents,which has limited its clinical applications in the *** animal and clinical studies,side effects including muscle contraction,procedural hypertension,and arrhythmia are frequently reported[6].However,during the ablation process,if the pulse is synchronized with the heart rhythm,the risk of arrhythmia is *** muscle relaxant eliminates muscle ***,arrhythmia[7],hypertension[8],and myocardial infarction[9]are potential risks requiring proper *** adverse events are mostly moderate and self-limiting,but they may have serious consequences for patients with coronary artery *** to the potential risks,patients with a history of cardiovascular disease are not recommended for IRE treatment.