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Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah thuy-Tien nguyen Warren Macdonald Anthony MJ.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

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Ethyl acetate extract of Smilax glabra Roxb roots and its major active compound astilbin promote osteoblastogenesis in vitro by upregulating bone cell differentiation-associated genes

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 553-560页

作者： Huyen T.T.nguyen Minh T.H.nguyen thu X.nguyen Quan M.Pham Ha X.nguyen Phuong T.M.nguyen University of Science and Technology of Hanoi Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam Institute of Natural Products Chemistry Vietnam Academy of Science and TechnologyHanoiVietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:To investigate the osteoblastogenic activity of the ethyl acetate(EtOAc)extract of Smilax glabra Roxb roots and its major active compound ***:Astilbin was isolated from EtOAc extract using silica gel chromatography combined with fraction *** structure of astilbin was determined by analysis of the spectroscopic data in comparison with the *** method was used to detect the *** phosphatase(ALP)activity was determined by the spectrophotometric method at 405 nm using p-nitrophenyl phosphate as a *** deposition was stained with alizarin red-S,distained with cetylpyridium chloride,and quantified at 562 *** silico model for astilbin-ALP interaction was analyzed using AutoDock *** changes in expression of osteoblast differentiation related genes were determined using quantitative real-time ***:Both the EtOAc extract and astilbin had no toxicity toward osteoblast MC3T3-E1 cells at 5.0,10,25,and 50μg/*** 25μg/mL,they enhanced ALP activity and mineralization of osteoblasts up to 30%and 55%for the EtOAc extract and 22%and 41%for astilbin,*** docking analysis of astilbin-ALP interaction revealed Arg167,Asp320,His324,and His437 were key residues participating in hydrophobic interaction;meanwhile,His434 and Thr436 residues were involved in hydrogen bond formation in the active site of human tissue-nonspecific ***,the expression level of genes opn,col1,osx,and runx2 were up-regulated in astilbin treated samples with the fold changes as 2.2;3.7;4.1;2.3,respectively at 10μg/mL(P<0.05).Conclusions:The EtOAc extract and its major compound astilbin exhibit osteoblastogenic activity by up-regulating important markers for bone cell *** could be a new and promising osteogenic agent with dual actions for therapeutic applications.

关键词： Smilax glabra Roxb Astilbin Cytotoxicity Osteogenesis Osteoblast Ethyl acetate extract

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Hybrid model to optimize object-based land cover classification by meta-heuristic algorithm:an example for supporting urban management in Ha Noi,Viet Nam

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International Journal of Digital Earth 2019年第10期12卷 1118-1132页

作者： Quang-Thanh Bui Manh Pham Van nguyen Thi thuy Hang Quoc-Huy nguyen nguyen Xuan Linh Pham Minh Hai Tran Anh Tuan Pham Van Cu Center for Applied Research in Remote sensing and GIS(CARGIS) VNU University of ScienceHa NoiViet Nam VNU University of Science Ha NoiViet Nam Vietnam Institute of Geodesy and Cartography Ha NoiViet Nam Ministry of Education and Training Ha NoiViet Nam

This study proposed a novel object-based hybrid classification model named GMNN that combines Grasshopper Optimization Algorithm(GOA)and the multiple-class Neural network(MNN)for urban pattern detection in Hanoi,*** bands of SPOT 7 image and derivable NDVI,NDWI were used to generate image segments with associated attributes by PCI Geomatics *** segments were classified into four urban surface types(namely water,impervious surface,vegetation and bare soil)by the proposed ***,three training and validation datasets of different sizes were used to verify the robustness of this *** all tests,the overall accuracies of the classification were approximately 87%,and the Area under Receiver Operating Characteristic curves for each land cover type was ***,the performance of this model was examined by comparing several statistical indicators with common benchmark *** results showed that GMNN out-performed established methods in all comparable *** results suggested that our hybrid model was successfully deployed in the study area and could be used as an alternative classification method for urban land cover *** a broader sense,classification methods will be enriched with the active and fast-growing contribution of metaheuristic algorithms.

关键词： Urban remote sensing object-based classification neural network grasshopper optimization algorithm

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Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,thua Thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le Phuong thuy nguyen Hien Thao Thi Pham Dien Thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,thua Thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

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Does green growth in E-7 countries depend on economic policy uncertainty,institutional quality,and renewable energy?Evidence from quantile-based regression

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Geoscience Frontiers 2023年第6期14卷 224-233页

作者： Yongzhong Jiang Arshian Sharif Ahsan Anwar Phan The Cong Bawani Lelchumanan Vu Thi Yen nguyen Thi thuy Vinh College of Management Science Chengdu University of TechnologyChengdu 610059China Department of Economics and Finance Sunway Business SchoolSunway UniversitySubang JayaMalaysia University of Economics and Human Sciences in Warsaw WarsawPoland Faculty of Management Sciences Department of Business AdministrationILMA UniversityKarachiPakistan Faculty of Economics Thuongmai UniversityHanoiViet Nam Foreign Trade University HanoiViet Nam

Environmental degradation is one of the most debatable topics at international forums and it is considered a prime concern for the entire ***,researchers and policymakers have turned their attention from conventional economic growth to green *** the existing literature has discussed several determinants of green growth,the impact of economic policy uncertainty(EPU),renewable energy consumption(RENE),and institutional quality(IQ)on green growth(GGDP)is relatively ***,this study is the earliest attempt to investigate the impact of EPU,IQ,and RENE on GGDP for emerging seven(E-7)countries from 1996 to *** doing so,we apply panel quantile regression(PQR).The empirical findings delineate that EPU has a negative impact on GGDP,whereas IQ and RENE enhance the GGDP in E-7 *** on the outcomes,this study suggests policy implications for achieving targets of the SDG 07,SDG 08,SDG 13,and SDG *** governments of these countries can achieve higher GGDP by ensuring political stability and reliable macroeconomic policies and through making such flexible policies that can easily control or address unpredictable future economic issues.

关键词： Green growth Economic policy uncertainty Institutional quality Renewable energy Sustainable development goals

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Comparative Chemical Research in Essential Oils from Six Apiaceae Species Growing in the Northern Region of Vietnam

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1677-1687页

作者： nguyen Quang Hung nguyen Thanh Tung nguyen Phuong Hanh Chu Thi thu Ha nguyen Thi Nhung nguyen Thai An Vu Xuan Giang Luong Van Hao Oleh Koshovyi Ain Raal Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Department of Pharmacognosy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa Pa Research Center of Medicinal Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essential oil(EO)concentration and composition of several Apiaceae species growing in the Northern region of *** yields of EOs from materials ranged from 0.03%(root EO of Angelica acutiloba and aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselinum vietnamense).Gas chromatography-mass spectrometry(GC-MS)allowed the identiﬁcation of 74 components in the EOs of six Apiaceae species,making up 94.4%–100.0%of the *** EO from Angelica acutiloba,(Z)-ligustilide accounted for an extremely large proportion(94.9%).EO of Angelica pubescens was dominated by six character-istic components includingα-pinene(21.5%),β-phellandrene(18.1%),p-cymene(12.2%),3-methylnonane(8.7%),o-cymene(8.1%),and D-sylvestrene(6.2%).The EO from Cryptotaenia japonica was characterized by high amounts ofα-selinene(48.7%),β-selinene(23.7%),and trans-β-farnesene(5.4%).The EOs from leaves and stems of Xyloselinum vietnamense were characterized by high concentrations of sabinene(69.8%and 33.8%),4-terpineol(8.7%and 7.4%)andβ-pinene(4.0%and 6.5%)while EOs from aerial parts and root of Xylo-selinum leonidii comprise four characteristic monoterpenes includingα-pinene(28.2%and 52.8%),β-pinene(7.9%and 10.3%),β-phellandrene(7.6%and 15.3%),and sabinene(3.0%and 4.1%).Additionally,cryptone is also one of the major components in the EO of Xyloselinum leonidii(13.2%in the aerial parts oil and 2.8%in the root oil).In the EOs isolated from the aerial parts and root of Heracleum bivittatum,α-pinene(22.5%and 70.2%)andβ-pinene(43.2%and 20.0%)were the predominant *** appeared in the EO from aerial parts of Heracleum bivittatum with a relatively high concentration(13.5%)while bornyl acetate(5.1%)was also one of the main components in the EO from its aerial parts but was not detected in other Apiaceae species in the present *** databases help identify and control the quality of plant material studied from the family Apiaceae growing in Vietnam.

关键词： Apiaceae essential oil terpenoids gaschromatography-mass spectrometry

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Two-Stage Production Planning Under Stochastic Demand:Case Study of Fertilizer Manufacturing

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Computers, Materials & Continua 2022年第1期70卷 1195-1207页

作者： Chia-Nan Wang Shao-Dong Syu Chien-Chang Chou Viet Tinh nguyen Dang Van thuy Cuc Department of Industrial Engineering and Management National Kaohsiung University of Science and TechnologyKaohsiung80778Taiwan Sunline NP Telecommunications Co.Ltd Kaohsiung80778Taiwan Department of Shipping Technology National Kaohsiung University of Science and TechnologyKaohsiung80778Taiwan Faculty of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam Faculty of Industrial Engineering and Management International UniversityHo Chi Minh City70000Vietnam

Agriculture is a key facilitator of economic prosperity and nourishes the huge global *** achieve sustainable agriculture,several factors should be considered,such as increasing nutrient and water efficiency and/or improving soil health and *** fertilizer is one of the fastest and easiest ways to improve the quality of nutrients inland and increase the effectiveness of crop *** supplies most of the necessary nutrients for plants,and it is estimated that at least 30%-50%of crop yields is attributable to commercial fertilizer nutrient *** is always a major concern in achieving sustainable and efficient *** reasonable and customized fertilizerswill require a significant increase in the number of formulae,involving increasing costs and the accurate forecasting of the right time to apply the suitable *** alternative solution is given by two-stage production planning under stochastic demand,which divides a planning schedule into two *** primary stage has non-existing demand information,the inputs of which are the proportion of raw materials needed for producing fertilizer products,the cost for purchasing materials,and the production *** total quantity of purchased material and produced products to be used in the blending process must be defined to meet as small as possible a paid *** the second stage,demand appears under multiple scenarios and their respective *** stage will provide a solution for each occurring scenario to achieve the best *** two-stage approach is presented in this paper,the mathematical model of which is based on linear integer *** the diversity of fertilizer types,themathematicalmodel can advise manufacturers about which products will generate as much as profit as ***,two objectives are taken into ***,the paper’s thesis focuses on minimizing overall system costs,e.g.,including inventory cost,pur

关键词： Two-stage stochastic programming demand uncertainty planning blending fertilizer

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Antibiofilm activity of a-mangostin extracted from Garcinia mangostana L. against Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1154-1160页

作者： nguyen Thi Mai Phuong Ngo Van Quang Ta thu Mai nguyen Vu Anh Chutima Kuhakarn Vichai Reutrakul Albert Bolhuis Institute of Biotechnology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiViet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiViet Nam Institute of Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadHanoiViet Nam Center of Excellence for Innovation in Chemistry and Department of Chemistry Faculty of ScienceMahidol UniversityRama 6 RoadBangkok 10400Thailand Department of Pharmacy and Pharmacology University of BathClaverton Down BathBA2 7AYBathUK

Objective: To isolate a-mangostin(AMG) from the peels of mangosteen(Garcinia mangostana L.), grown in Vietnam, and to investigate antibiofilm activity of this compound against three Staphylococcus aureus(S. aureus) strains, one of which was methicillin-resistant S. aureus(MRSA) and the other two strains were methicillinsensitive S. aureus(MSSA).Methods: AMG in n-hexane fraction was isolated on a silica gel column and chemically analyzed by HPLC and NMR. The antibiofilm activity of this compound was investigated by using a 96-well plate model for the formation of biofilms. Biofilm biomass was quantified using crystal violet. The viability of cells was observed under confocal microscopy using LIVE/DEAD Bac Light stains. Biofilm composition was determined using specific chemical and enzyme tests for polysaccharide, protein and DNA. Membranedamaging activity was assayed by measuring the hemolysis of human red blood cells in presence of ***: The results indicated that the isolated AMG, with a purity that exceeded 98%,had minimal inhibitory concentrations in the range of 4.6–9.2 mmol/L for the three strains tested. Interestingly, the MSSA strains were more sensitive to AMG than the MRSA strain. Minimal bactericidal concentrations were 2-fold higher than the minimal inhibitory concentration values for the three strains, indicating that AMG was a bactericidal compound. AMG also prevented biofilm formation effectively, albeit that again the MRSA strain was the most resistant. Interestingly, biofilms of the MRSA strain contained protein as a main component of the extracellular matrix, whereas this was polysaccharide in the MSSA strains. This might relate to the resistance of the MRSA 252 strain to *** using human red blood cells indicated that AMG caused significant membrane damage with 50% of cell lysis occurred at concentration of about 36 mmol/***: Our results provide evidence that the isolated AMG has inhibitory activity against biofilm formation

关键词： α-Mangostin Garcinia mangostana Biofilms Methicillin resistance Staphylococcus aureus

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Genome-wide association study identifies QTL for eight fruit traits in cultivated tomato (Solanum lycopersicum L.)

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Horticulture Research 2021年第1期8卷 2698-2707页

作者： Minkyung Kim thuy Tien Phan nguyen Joon-Hyung Ahn Gi-Jun Kim Sung-Chur Sim Department of Bioresources Engineering Sejong UniversitySeoulRepublic of Korea Asia Seed R&D center IcheonRepublic of Korea Plant Engineering Research Institute Sejong UniversitySeoulRepublic of Korea

Genome-wide association study(GWAS)is effective in identifying favorable alleles for traits of interest with high mapping resolution in crop *** this study,we conducted GWAS to explore quantitative trait loci(QTL)for eight fruit traits using 162 tomato accessions with diverse genetic *** eight traits included fruit weight,fruit width,fruit height,fruit shape index,pericarp thickness,locule number,fruit firmness,and *** variations of these traits in the tomato collection were evaluated with three replicates in field trials over three *** filtered 34,550 confident SNPs from the 51K Axiom®tomato array based on5%of minor allele frequency for association *** 162 tomato accessions were divided into seven clusters and their membership coefficients were used to account for population structure along with a kinship *** identify marker-trait associations(MTAs),four phenotypic data sets representing each of three years and combined were independently analyzed in the multilocus mixed model(MLMM).A total of 30 significant MTAs was detected over data sets for eight fruit traits at P<*** number of MTA per trait ranged from one(brix)to seven(fruit weight and fruit width).Two SNP markers on chromosomes 1 and 2 were significantly associated with multiple traits,suggesting pleiotropic effects of ***,16 of 30 MTAs suggest potential novel QTL for eight fruit *** results facilitate genetic dissection of tomato fruit traits and provide a useful resource to develop molecular tools for improving fruit traits via marker-assisted selection and genomic selection in tomato breeding programs.

关键词： breeding traits membership

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Effects of Processing Parameters on Mechanical Properties and Structure of Banana Fiber-Reinforced Composites

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Journal of Renewable Materials 2018年第6期6卷 662-670页

作者： Dan-thuy Van-Pham Minh Tri nguyen Chanh-Nghiem nguyen Thi Truc Duyen Le Thi Yen Nhu Pham Khai Thinh nguyen Yukihiro Nishikawa Qui Tran-Cong-Miyata Department of Chemical Engineering Can Tho UniversityCan Tho CityViet Nam Department of Automation Technology Can Tho UniversityCan Tho CityViet Nam Department of Macromolecular Science and Engineering Graduate School of Science and TechnologyKyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan

The mechanical properties of unidirectional natural fiber-reinforced composites are generally affected by several processing parameters during compression *** study investigates the effects of processing temperature,time,and pressure on the tensile and flexural properties of acrylonitrile butadiene styrene reinforced by banana fibers.X-ray CT imaging was employed to find the relationship between the mechanical properties and structure of the processed ***,the water absorption of composites was observed and the way in which the mechanical properties evolved after water absorption was *** tensile and flexural properties of the unidirectional banana fiber-reinforced composite were found to be inversely proportional to the *** addition,high-pressure compression molding might result in cracks and floating fibers that would significantly reduce its mechanical *** composite with the highest strength,smallest porosity and lowest water absorption was optimally prepared at T=170℃,t=20 min,and P=100 kg cm^-2.

关键词： Banana fiber composite compression molding porosity X-ray CT

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