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Multi-clustering study on the association between human leukocyte antigen-DP-DQ and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam

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World Journal of Gastroenterology 2024年第46期30卷 4880-4903页

作者： thuy thu nguyen Tu Cam Ho Huong Thi thu Bui Van-Khanh Tran Tue Trong nguyen Center for Gene and Protein Research Hanoi Medical UniversityHanoi 116177Viet Nam Institute of Virology TUM School of MedicineTechnical University of MunichMunich 81675Germany Department of Biochemistry Thai Nguyen University of Medicine and PharmacyThai Nguyen 251540Viet Nam Medical Technology Department Hanoi Medical UniversityHanoi 116177Viet Nam Clinical Laboratory Hanoi Medical University HospitalHanoi 116177Viet Nam

BACKGROUND Human leukocyte antigen(HLA)class II molecules are cell surface receptor proteins found on antigen-presenting *** and mutations in the HLA gene can affect the immune system and the progression of hepatitis *** To study the relation between rs2856718 of HLA-DQ,rs3077,and rs9277535 of HLA-DP,hepatitis B virus(HBV)-related cirrhosis,and hepatocellular carcinoma(HCC).METHODS In this case-control study,the genotypes of these single nucleotide polymorphisms(SNPs)were screened in 315 healthy controls,471 chronic hepatitis B patients,250 patients with HBV-related liver cirrhosis,and 251 patients with HCC using TaqMan real-time *** conducted Hardy-Weinberg equilibrium and linkage disequilibrium tests on the genotype distributions of rs2856718,rs3077,and rs9277535 before hierarchical clustering analysis to build the complex interaction between the markers in each patient *** The physical distance separating these SNPs was 29816 kB with the disequilibrium(D’)values ranging from 0.07 to *** close linkage between rs3077 and rs9277535 was attributed to a distance of 21 *** D’value decreased from moderate in the healthy control group(D’=0.50,P<0.05)to weak in the hepatic disease group(D’<0.3,P<0.05).In a combination of the three variants rs2856718,rs3077,and rs9277535,the A allele decreased hepatic disease risk[A-A-A haplotype,risk ratio(RR)=0.44(0.14;1.37),P<0.05].The G allele had the opposite effect[G-A/G-G haplotype,RR=1.12(1.02;1.23),P<0.05].In liver cancer cases,the A-A-A/G haplotype increased the risk of HCC by 1.58(P<0.05).CONCLUSION Rs9277535 affects liver fibrosis progression due to HBV infection,while rs3077 is associated with a risk of HBVrelated *** link between rs2856718,rs3077,and rs9277535 and disease risk was determined using a multiclustering analysis.

关键词： Human leukocyte antigen Multi-clustering study Hepatitis B virus Hepatocellular carcinoma Cirrhosis

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： thu nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Transient response of doubly-curved bio-inspired composite shells resting on viscoelastic foundation subject to blast load using improved first-order shear theory and isogeometric approach

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Defence Technology（防务技术） 2024年第8期38卷 171-193页

作者： thuy Tran Thi thu Tu nguyen Anh Hue nguyen Thi Hong nguyen Thi School of Mechanical and Automotive Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Technical Fundamental University of Transport TechnologyHanoiViet Nam Faculty of Mechanical Engineering Thuyloi University175 Tay SonDong DaHanoiViet Nam

Investigating natural-inspired applications is a perennially appealing subject for scientists. The current increase in the speed of natural-origin structure growth may be linked to their superior mechanical properties and environmental resilience. Biological composite structures with helicoidal schemes and designs have remarkable capacities to absorb impact energy and withstand damage. However, there is a dearth of extensive study on the influence of fiber redirection and reorientation inside the matrix of a helicoid structure on its mechanical performance and reactivity. The present study aimed to explore the static and transient responses of a bio-inspired helicoid laminated composite(B-iHLC) shell under the influence of an explosive load using an isomorphic method. The structural integrity of the shell is maintained by a viscoelastic basis known as the Pasternak foundation, which encompasses two coefficients of stiffness and one coefficient of damping. The equilibrium equations governing shell dynamics are obtained by using Hamilton's principle and including the modified first-order shear theory,therefore obviating the need to employ a shear correction factor. The paper's model and approach are validated by doing numerical comparisons with respected publications. The findings of this study may be used in the construction of military and civilian infrastructure in situations when the structure is subjected to severe stresses that might potentially result in catastrophic collapse. The findings of this paper serve as the foundation for several other issues, including geometric optimization and the dynamic response of similar mechanical structures.

关键词： Blast load Modified first-order shear theory Biological composite structures

Static and dynamic analysis of functionally graded fluidinfiltrated porous skew and elliptical nanoplates using an isogeometric approach

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 477-502页

作者： Tran Thi thu thuy Faculty of Mechanical Engineering Hanoi University of IndustryHanoi 100000Vietnam

The analysis of static bending and free and forced vibration responses of functionally graded fluidinfiltrated porous(FGFP)skew and elliptical nanoplates placed on Pasternak’s two-parameter elastic foundation is performed for the first time using isogeometric analysis(IGA)based on the non-uniform rational B-splines(NURBSs)basis *** types of porosity distributions affect the mechanical characteristics of materials:symmetric distribution,upper asymmetric distribution,and lower asymmetric *** stress–strain relationship for Biot porous materials was determined using the elastic *** general equations of motion of the nanoplates were established using the four-unknown shear deformation plate theory in conjunction with the nonlocal elastic theory and Hamilton’s principle.A computer program that uses IGA to determine the static bending and free and forced vibration of a nanoplate was developed on MATLAB software *** accuracy of the computational program was validated via numerical comparison with confidence *** set of programs presents the influence of the following parameters on the static bending and free and forced vibrations of nanoplates:porosity distribution law,porosity coefficient and geometrical parameters,elastic foundation,deviation angle,nonlocal coefficient,different boundary conditions,and Skempton *** numerical findings demonstrated the uniqueness of the FGFP plate’s behavior when the porosities are saturated with liquid compared with the case without *** findings of this study have significant implications for engineers involved in the design and fabrication of the aforementioned type of ***,this can form the basis for future research on the mechanical responses of the structures.

关键词： static bending free and forced vibrations nonlocal theory isogeometric analysis fluid-infiltrated porous nanoplates

Usefulness of Mac-2 binding protein glycosylation isomer in noninvasive probing liver disease in the Vietnamese population

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World Journal of Hepatology 2020年第5期12卷 220-229页

作者： thuy Thi thu Pham Dat Tan Ho Toan nguyen MEDIC Medical Center Ho Chi Minh 72517Vietnam

BACKGROUND Early diagnosis is critical for successful intervention before liver disease progresses to cirrhosis and hepatocellular *** To examine a novel biomarker for probing early liver disease quickly using an automated immunology *** This was a cross-sectional study.140 patients at various stages of liver disease were randomly *** cohort consisted of patients who were treatment naïve and currently undergoing *** included patients with diverse liver disease ***-2 binding protein glycosylation isomer(M2BPGi)levels in addition to different clinical parameters,co-morbidities and transient elastography results were collected and *** M2BPGi levels were significantly correlated with transient elastography for liver fibrosis staging across all disease *** significant differences were observed in patients with F0-1;F2 and>F3 liver *** examination showed that M2BPGi levels were two-fold higher in F4 than F3 hepatitis C(HCV)patients.M2BPGi was observed to be etiology-specific and HCV patients had higher mean M2BPGi *** also observed significant correlations with aspartate aminotransferase to platelet ratio index and fibrosis-4 index as well as HBV DNA *** M2BPGi levels for HBV patients with a viral load lower than 2000 IU/mL was 1.75-fold lower than those with a viral load greater than 2000 IU/*** M2BPGi was observed to be a good indicator of early liver disease in patients with different *** results provide reference cut-offs for different causes of liver disease and demonstrated the utility of this marker for early disease *** is useful for remote regions in developing countries.

关键词： Hepatitis B Hepatitis C Noninvasive fibrosis markers Mac-2 binding protein glycosylation isomer Liver disease

Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： thu Dang Kim Hai nguyen Thanh Duong nguyen thuy Loi Vu Duc thu Vu Thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

Activated carbon derived from rice husk by NaOH activation and its application in supercapacitor

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Progress in Natural Science:Materials International 2014年第3期24卷 191-198页

作者： Khu Le Van thu thuy Luong Thi Physical Chemistry Department Hanoi University of Education

Four activated carbon(AC) samples prepared from rice husk under different activation temperatures have been characterized by N2adsorption–desorption isotherms, thermogravimetric analysis(TGA–DTA), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). The specific surface area of AC sample reached 2681 m2 g 1under activation temperature of 800 1C. The AC samples were then tested as electrode material; the specific capacitance of the as-prepared activated carbon electrode was found to be 172.3 F g 1using cyclic voltammetry at a scan rate of 5 mV s 1and 198.4 F g 1at current density 1000 mA g 1in the charge/discharge mode.& 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.

关键词： Rice husk Activated carbon Supercapacitor Surface area Micropore

Use of Stance Adverbs in Academic English:A Comparison of L1 English and L1 Vietnamese Authors’ Writing

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外语教育 2016年第1期 83-93页

作者： nguyen Thi thu thuy School of Foreign Languages Huazhong University of Science and Technology

The present study investigates authorial stance in research articles of native and non-native academic authors of English. It aims to analyze evaluation adverbs in research articles written by native authors of English(NAEs) and Vietnamese-speaking authors of English(VAEs) between 2012 and 2015. The data of 120 articles was investigated to examine whether there is a significant difference in using stance adverbs between the two groups of authors. It was found that NAEs and VAEs used stance adverbs in a considerably different way. Most of the stance adverb categories were variously overused by NAEs against VAEs. It was also found that English native authors of research articles preferred indirect approaches of expressing their evaluation by an illocutionary way of manner-of-speaking,metalinguistic and expectation markers,while Vietnamese authors favored an epistemic way of modal adverbs.

关键词： Stance adverbs Academic writing Corpus-based L1 English authors L1 Vietnamese authors

A hybrid machine learning model to estimate self-compacting concrete compressive strength

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Frontiers of Structural and Civil Engineering 2022年第8期16卷 990-1002页

作者： Hai-Bang LY thuy-Anh nguyen Binh Thai PHAM May Huu nguyen Civil Engineering Department University of Transport TechnologyHanoi 100000Vietnam Civil and Environmental Engineering Program Graduate School of Advanced Science and EngineeringHiroshima UniversityHiroshima 739-8527Japan

This study examined the feasibility of using the grey wolf optimizer(GWO)and artificial neural network(ANN)to predict the compressive strength(CS)of self-compacting concrete(SCC).The ANN-GWO model was created using 115 samples from different sources,taking into account nine key SCC *** validation of the proposed model was evaluated via six indices,including correlation coefficient(R),mean squared error,mean absolute error(MAE),IA,Slope,and mean absolute percentage *** addition,the importance of the parameters affecting the CS of SCC was investigated utilizing partial dependence *** results proved that the proposed ANN-GWO algorithm is a reliable predictor for SCC’s *** that,an examination of the parameters impacting the CS of SCC was provided.

关键词： artificial neural network grey wolf optimize algorithm compressive strength self-compacting concrete