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Stem cells as vehicles for the treatment of brain cancer

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中国神经肿瘤杂志 2007年第1期5卷 58-58页

作者： mapara KY Stevenson CB thompson RC Ehtesham m Department of Neurological Surgery Vanderbilt University Medical Center Nashville TN 37232 USA

WONCA研究论文摘要汇编——体温计包装说明书儿童发烧信息适切性评估

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中国全科医学 2015年第27期 3319-3319页

作者： Hernandez J Nicholson BD thompson m 本刊编辑部

背景大多数家长均备有体温计,但是对于体温计包装说明书信息的质量和准确性却不甚了解,这些信息是否符合最新发烧管理指南也有待检验。目的对常用体温计包装说明书信息和英国国家健康护理研究中心(NICE)儿童发烧管理指南进行比较。设计... 详细信息

背景大多数家长均备有体温计,但是对于体温计包装说明书信息的质量和准确性却不甚了解,这些信息是否符合最新发烧管理指南也有待检验。目的对常用体温计包装说明书信息和英国国家健康护理研究中心(NICE)儿童发烧管理指南进行比较。设计和场所2013年2—5月,从英国零售商处进行体温计系统取样。方法由体温计包装和说明书中获取信息,包括基本信息、体温计种类、使用说明、参考范围和发烧临界值。将上述信息同2013版NICE儿童发烧管理指南与父母建议进行对比。探讨体温计价格和信息水平的关系。结果共123个体温计(价格从0.99英镑到69.99英镑不等)纳入研究,其中无一体温计标明参考2013版NICE儿童发烧管理指南。大多数体温计(n=81,65.9%)建议的测量体位与2013版NICE儿童发烧管理指南一致,但是只有17(13.8%)个体温计设定了正确的发烧临界值(≥38.0℃),仅有少数体温计(n=12,9.8%)提供了发烧管理建议,有4个体温计说明书的管理建议内容并未在2013版NICE儿童发烧管理指南中提及。体温计价格和体温及说明书与2013版NICE儿童发烧管理指南一致性并无关系。结论家长和照顾者的体温计使用频率较大,但是其缺乏发烧检测和管理的实证信息,一些体温计说明书甚至提供了错误信息。这影响了2013版NICE儿童发烧管理指南的传播和实践,应规定体温计生产商根据2013版NICE儿童发烧管理指南对包装信息进行修改,使包装信息和2013版NICE儿童发烧管理指南内容一致。

关键词：体温计英国大不列颠及北爱尔兰联合王国 WONCA 包装说明书

原发性膀胱输尿管反流患儿的排泄式膀胱尿道造影的随访时间:一个临床方案的研发与应用

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 52-53页

作者： thompson m. Simon S.D. Sharma V. Alon U.S. 郭战宏 Section of Nephrology Children's Mercy Hospital2401 Gillham RdKansas CityMO 64108United States Dr.

Background and Objectives. Of children diagnosed with urinary tract infection,30% to 40% have primary vesicoureteral reflux (VUR). For the majority of these children,treatment involves long-term prophylactic antibiotics (ABX) and a periodic voiding cystourethrogram (VCUG) until resolution of VUR as detected by VCUG. Radiation exposure and considerable discomfort have been associated with VCUG. To date,no clear guidelines exist regarding the timing of follow-up VCUGs. The objective of this study was to develop a clinically applicable algorithm for the optimal timing of repeat VCUGs and validate this algorithm in a retrospective cohort of children with VUR. methods. Based on previously published data regarding the probability of resolution of VUR over time,a decision-tree model (DTm) was developed. The DTm compared the differential impact of 3 timing schedules of VCUGs (yearly,every 2 years,and every 3 years) on the average numbers of VCUGs performed,years of ABX exposure,and overall costs. Based on the DTm,an algorithmoptimizing the timing of VCUG was developed. The algorithm then was validated in a retrospective cohort of patients at an urban pediatric referral center. Data were extracted from the medical records regarding number of VCUGs,time of ABX prophylaxis,and complications associated with either. VUR in patients in the cohort was grouped into mild VUR (grades I and II and unilateral grade III for those ≤ 2 years old),and moderate/ severe VUR (other grade III and grade IV). Kaplan-meier survival curves were created from the cohort data. From the survival curves,the median times to resolution of VUR were determined for the cohort,and these times were compared with the median times to VUR resolution of the data used for the DTm. The numbers of VCUGs performed,time of ABX exposure,and costs in the cohort were compared with those that would have occurred if the algorithm had been applied to both mild and moderate/severe VUR groups. Results. Using an algorithm that

关键词：膀胱尿道造影膀胱输尿管反流预防性抗生素总体费用重度患儿生存曲线检查次数方案应用决策树

美国家庭医学诊所应用护理现场检验的有利及不利因素分析

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中国全科医学 2016年第35期 4315-4315页

作者： VICTORIA HARDY V thompson m ALTO W 本刊编辑部

背景护理现场检验已被广泛应用于美国的家庭医学诊所。尽管诊断产业界预计护理现场检验在使用次数上会越来越多,使用范围会越来越广,但是临床医务人员对护理现场检验的看法还鲜为人知。本文旨在调查基层医务人员、实验室及临床行政/支... 详细信息

背景护理现场检验已被广泛应用于美国的家庭医学诊所。尽管诊断产业界预计护理现场检验在使用次数上会越来越多,使用范围会越来越广,但是临床医务人员对护理现场检验的看法还鲜为人知。本文旨在调查基层医务人员、实验室及临床行政/支持人员视角下的在家庭医学中应用护理现场检验的有利及不利因素。方法来自于美国两个州3家诊所的52名员工被分为7组,对其进行4场半结构式访谈。使用持续比较法对本研究中的定性资料进行分析。结果调查结果显示以下几个方面对临床决策产生影响:护理现场检验结果的不准确性,护理现场检验对医务人员及工作流程的影响,患者经历及医患关系,以及涉及护理现场检验成本、监管与质量控制的相关事务。总体来说,研究对象对使用护理现场检验持有不同的态度。不过其相信护理现场检验提供的额外数据可能有利于临床治疗、准确诊断以及医患交流。开展护理现场检验遇到的不利因素包括护理现场检验结果的不准确性,缺少医务人员支持更多的检验项目,以及开展这种检验成本效益的不确定性。结论在家庭医学诊所中开展护理现场检验既存在有利因素也存在不利因素。此种检验的应用程度取决于这些不利因素的解决情况。临床研究人员、诊断产业、健康保险机构以及社区医疗的通力协作可以确保护理现场检验满足临床和患者的需求。

关键词：现场检验不利因素不准确性家庭医学诊所应用护理美国美利坚合众国北美洲

带有地质和地形约束的加利福尼亚州VS30图

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世界地震译丛 2016年第2期47卷 147-159页

作者： E.m.thompson D.J.Wald C.B.Worden 杨国栋(译) 高曙德(译) 金严(校) 不详甘肃省地震局中国地震局地球物理研究所

许多地震工程应用工作中,场地响应由直到30m深度的时间平均剪切波速(V_(S30))的经验关系式估计。因此这些工作要么依赖于特定场地的V_(S30)测量数据,要么依赖于全球、区域或局部尺度的V_(S30)图。由于V_(S30)测量数据稀少,所以我们通常... 详细信息

许多地震工程应用工作中,场地响应由直到30m深度的时间平均剪切波速(V_(S30))的经验关系式估计。因此这些工作要么依赖于特定场地的V_(S30)测量数据,要么依赖于全球、区域或局部尺度的V_(S30)图。由于V_(S30)测量数据稀少,所以我们通常需要代用值来估计未采样区域的V_(S30)值。我们给出了一幅计及像地质、地形与特定场地V_(S30)测量数据多源不同空间尺度观测约束的新加利福尼亚州V_(S30)图。我们使用回归克里格(RK)地学统计方法结合这些约束预测V_(S30)。对V_(S30)趋势,我们以基于地质的V_(S30)值开始,识别了两种清晰的介于地形梯度和地质V_(S30)模型残差的趋势。一种趋势适用于深、细砂第四纪冲积层,而第二种趋势略强,适用于更新世沉积单元。回归克里格框架确保形成的加利福尼亚州图在局部上精细地反映了整个加利福尼亚州快速扩展的V_(S30)数据库。我们比较了这种新制图方法与以前绘制的加利福尼亚州V_(S30)图的精度。通过比较使用我们的新图和现有图V_(S30)值的真实场景地震动区划图,我们也说明了地震动对新V_(S30)图的敏感性。

关键词：加利福尼亚州 S30 克里格地震动沉积单元地学统计剪切波速残差图地震工程制图方法

众脑之力:通过开放神经影像数据和大规模协作催化神经精神疾病的创新发现（英文）

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Science Bulletin 2024年第10期 1536-1555页

作者：鲁彬陈骁 Francisco Xavier Castellanos Paul m.thompson 左西年臧玉峰严超赣 CAS Key Laboratory of Behavioral Science Institute of Psychology Department of Psychology University of Chinese Academy of Sciences Department of Child and Adolescent Psychiatry NYU Grossman School of Medicine Nathan Kline Institute for Psychiatric Research Imaging Genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern California Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal University National Basic Science Data Center Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal University Institute of Psychological Science Hangzhou Normal University Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of Sciences magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of Sciences

Recent advances in open neuroimaging data are enhancing our comprehension of neuropsychiatric disorders. By pooling images from various cohorts, statistical power has increased, enabling the detection of subtle abnormalities and robust associations, and fostering new research methods. Global collaborations in imaging have furthered our knowledge of the neurobiological foundations of brain disorders and aided in imaging-based prediction for more targeted treatment. Large-scale magnetic resonance imaging initiatives are driving innovation in analytics and supporting generalizable psychiatric *** also emphasize the significant role of big data in understanding neural mechanisms and in the early identification and precise treatment of neuropsychiatric disorders. However, challenges such as data harmonization across different sites, privacy protection, and effective data sharing must be addressed. With proper governance and open science practices, we conclude with a projection of how large-scale imaging resources and collaborations could revolutionize diagnosis, treatment selection, and outcome prediction,contributing to optimal brain health.

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An efficient method for unfolding kinetic pressure driven VISAR data

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High Power Laser Science and Engineering 2015年第3期3卷 50-58页

作者： m.Hess K.Peterson A.Harvey-thompson Sandia National Laboratories

Velocity Interferometer System for Any Reflector(VISAR) [Barker and Hollenbach, J. Appl. Phys. 43, 4669(1972)]is a well-known diagnostic that is employed on many shock physics and pulsed-power experiments. With the VISAR diagnostic, the velocity on the surface of any metal flyer can be found. For most experiments employing VISAR, either a kinetic pressure [Grady, mech. mater. 29, 181(1998)] or a magnetic pressure [Lemke et al., Intl J. Impact Eng. 38,480(2011)] drives the motion of the flyer. moreover, reliable prediction of the time-dependent pressure is often a critical component to understanding the physics of these experiments. Although VISAR can provide a precise measurement of a flyer's surface velocity, the real challenge of this diagnostic implementation is using this velocity to unfold the timedependent pressure. The purpose of this paper is to elucidate a new method for quickly and reliably unfolding VISAR data.

关键词： laser driven blast wave pulsed-power VISAR

Ballistic response of armour plates using Generative Adversarial Networks

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Defence Technology（防务技术） 2022年第9期18卷 1513-1522页

作者： S.thompson F.Teixeira-Dias m.Paulino A.Hamilton Institute for Infrastructure and Environment(IIE) School of EngineeringThe University of Edinburgh Alexander Graham Bell BuildingThe King's BuildingsEdinburghEH93FGUnited Kingdom School of Engineering Faculty of ScienceEngineering and Built EnvironmentDeakin University Waurn PondsVictoria3220Australia Data Science and AI EngineeringGroup Chief Information O CeLloyds Banking Group69 Morrison StEdinburghEH38BWUnited Kingdom

It is important to understand how ballistic materials respond to impact from projectiles such that informed decisions can be made in the design process of protective armour systems. Ballistic testing is a standards-based process where materials are tested to determine whether they meet protection, safety and performance criteria. For the V50ballistic test, projectiles are fired at different velocities to determine a key design parameter known as the ballistic limit velocity(BLV), the velocity above which projectiles perforate the target. These tests, however, are destructive by nature and as such there can be considerable associated costs, especially when studying complex armour materials and systems. This study proposes a unique solution to the problem using a recent class of machine learning system known as the Generative Adversarial Network(GAN). The GAN can be used to generate new ballistic samples as opposed to performing additional destructive experiments. A GAN network architecture is tested and trained on three different ballistic data sets, and their performance is compared. The trained networks were able to successfully produce ballistic curves with an overall RmSE of between 10 and 20 % and predicted the V50BLV in each case with an error of less than 5 %. The results demonstrate that it is possible to train generative networks on a limited number of ballistic samples and use the trained network to generate many new samples representative of the data that it was trained on. The paper spotlights the benefits that generative networks can bring to ballistic applications and provides an alternative to expensive testing during the early stages of the design process.

关键词： machine learning Generative Adversarial Networks GAN Terminal ballistics Armour systems

δ^(18)O record and temperature change over the past 100 years in ice cores on the Tibetan Plateau

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Science China Earth Sciences 2006年第1期49卷 1-9页

作者： Lonnie thompson Byrd Polar Research Center the Ohio State UniviersityCohumbusOH 43210USBLaboratory of Environment and Process on Tibetan Plateau Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China

The 213 m ice core from the Puruogangri Ice Field on the Tibetan Plateau facilitates the study of the regional temperature changes with its δ18O record of the past 100 years. Here we combine information from this core with that from the Dasuopu ice core (from the southern Tibetan Plateau), the Guliya ice core (from the northwestern Plateau) and the Dunde ice core (from the northeastern Plateau) to learn about the regional differences in temperature change across the Tibetan Plateau. Theδ18O changes vary with region on the Plateau, the variations being especially large between South and North and between East and West. moreover, these four ice cores present increasing δ18O trends, indicating warming on the Tibetan Plateau over the past 100 years. A comparative study of Northern Hemisphere (NH) temperature changes, the δ18O-reflected temperature changes on the Plateau, and available meteorological records show consistent trends in overall warming during the past 100 years.

关键词： Tibetan Plateau, ice core, temperature.