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Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model

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World Journal of Gastroenterology 2016年第21期22卷 5042-5049页

作者： Jun Qian Elsie Oppermann Andreas Tran Ulli Imlau Kun Qian thomas josef vogl Department of Radiology Union Hospital Huazhong University of Science and Technology Institute for Diagnostic and Interventional Radiology Johann Wolfgang Goethe University

AIM: To compare the effect of transarterial chemoembolization(TACE) plus GRGDSP(Gly-Arg-Gly-Asp-SerPro, integrin-inhibitor) loaded nanoparticles with TACE alone or TACE + GRGDSP in a rat model of liver tumor. METHODS: Morris hepatoma 3924 A tumors were implanted in the livers of 30 ACI rats. The ACI rats were divided randomly into three groups(10 animals each). Tumor volume before treatment(V1) was examined by magnetic resonance imaging(MRI), and then, after laparotomy and placement of a PE-10 catheter into the hepatic artery, the following interventional protocols were performed: TACE(mitomycin C + lipiodol + degradable starch microspheres) + GRGDSP loaded nanoparticles for group A; TACE + GRGDSP for group B(control group 1); TACE alone for group C(control group 2). Tumor volume(V2) was assessed by MRI and the mean ratio of the post-treatment to pretreatment tumor volumes(V2/V1) was calculated. Immunohistochemical analysis was performed to assess the quantification of matrix metalloprotein 9(MMP-9) and vascular endothelial growth factor(VEGF) positive tumor cells in each treatment ***: The mean tumor growth ratios(V2/V1) were 1.3649 ± 0.1194 in group A, 2.0770 ± 0.1595 in group B, and 3.2148 ± 0.1075 in group C. Compared with groups B and C, group A showed a significant reduction in tumor volume. Lower expression of MMP-9 and VEGF in hepatocellular carcinoma was observed in group A than in groups B and C. The angiogenesis of tumor was evaluated using anti-VEGF antibodies, and the metastasis of tumor was assessed using antiMMP-9 antibody. MMP-9 and VEGF were expressed in all specimens. The immunoexpression of these proteins was confirmed by the presence of red cytoplasmic staining in tumor cells. Lower expression of MMP-9 and VEGF in hepatocellular carcinoma was observed in group A than in groups B and ***: Transarterial administration of integrin inhibitor loaded nanoparticles combined with TACE evidently retards tumor growth and intrahepatic met

关键词： Hepatocellular carcinoma Transarterial chemoembolization Integrin inhibitor Nanoparticles Matrix metalloprotein 9 Vascular endothelial growth factor ACI rats

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Dose Efficiency in Dual Source High-Pitch Computed Tomography of the Chest

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Advances in Computed Tomography 2014年第4期3卷 51-58页

作者： Boris Bodelle thomas Lehnert Martin Beeres thomas josef vogl Boris Schulz Department of Diagnostic and Interventional Radiology Clinic of the Goethe University Frankfurt Germany

Objectives: Evaluation of radiation efficiency of dual source high-pitch (DSHP) chest CT in comparison to single source technique with special regards to individual patient anatomy. Methods: 150 consecutive patients who underwent chest CT with automated tube current modulation were evaluated retrospectively and divided into three study groups, each with an equal quantity of 50 patients (DSHP vs. single source 128 slices vs. single source 16 slices). By using a dedicated workstation, volumetric analyses of each of the scanned anatomic area were performed and correlated to the individual dose length product (DLP). The calculated result was defined as dose efficiency. Results: DLP was 203 mGycm (DSHP), vs. 269 mGycm (single source) vs. 273 mGycm (16 slice CT). The total patient volume was lowest in the dual source group with 18956.3 cm3 (vs. 22481.2 cm3 vs. 22133.8 cm3). With regards to the DLP, the calculated dose efficiency of dual source CT was better than the 128 slice CT (p = 0.045) and the 16 slice CT (p < 0.01). Conclusions: DSHP CT has considerably better dose efficiency compared to 16 slice CT. Compared to 128 slice single source technique, the high-pitch mode does not cause any dose penalty when performing chest CT.

关键词： Computed Tomography Lung Radiation Exposure Imaging Dual-Source

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte thomas Gawne thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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Comprehensive review of tribometer dynamics-Cycle-based data analysis and visualization

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Friction 2022年第5期10卷 772-786页

作者： josef PROST Guido BOIDI thomas LEBERSORGER Markus VARGA Georg VORLAUFER AC2Tresearch GmbH Wiener Neustadt 2700Austria

Tribologists often rely on triboexperiments to investigate factors that affect a *** inherent dynamic behavior of the respective tribometer setups and its effect on data interpretation remain often *** this study,a comprehensive analysis of sensor data obtained from lubricated and dry triboexperiments is *** are generated on a pin-on-disc test rig with a silicon nitride ball on a steel disc contact with a rotation frequency of~3 ***-speed acquisition of sensor data up to 5 kHz is performed to resolve changes in the data within individual *** characteristic frequencies of the system and their temporal evolution are determined via time--frequency analysis,which reveals periodic patterns in the sensor ***-based data evaluation allows the detection of localized events and changes during an operation and considerably reduces the apparent measurement uncertainty,as compared with an unreduced *** data analysis and visualization routines presented herein may serve as a prototype for further application to tribometer setups.

关键词： high-speed data acquisition time-frequency analysis(TFA) cycle-resolved analysis pin-on-disc tribometer

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Periprosthetic knee joint infection caused by Brucella melitensis which was first-osteoarticular brucellosis or osteoarthrosis:A case report

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World Journal of Clinical Cases 2023年第3期11卷 677-683页

作者： thomas Stumpner Regina Kuhn josef Hochreiter Reinhold Ortmaier Department of Orthopaedic Surgery Ordensklinikum Linz Barmherzige SchwesternLinz 4010Austria

BACKGROUND Brucellosis is the most common zoonosis worldwide and is endemic in the Middle East,Africa,Asia,and Latin ***,it is uncommon in Central Europe,and periprosthetic infections caused by Brucella are therefore *** to the low prevalence and nonspecific clinical presentation of the disease,accurate diagnosis can be challenging;no gold standard currently exists for treating *** SUMMARY Here,we present a 68-year-old Afghan woman living in Austria with a periprosthetic knee infection caused by Brucella *** interval from total knee arthroplasty to septic loosening was five years.A profound medical history and examinations suggested that the patient had been suffering from unrecognized chronic osteoarticular brucellosis prior to total knee *** was successfully treated by two-stage revision surgery and combined antibiotic therapy over three *** Clinicians should consider brucellosis as a possible cause of chronic arthralgia and periprosthetic infection in patients originating from countries with a high brucellosis burden.

关键词： Brucellosis Arthroplasty Infection Osteoarticular Knee Case report

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Experimentelle Untersuchung zur Effektivitt der transarteriellen Immuno-Chemoembolisation des hepatozellulren Karzinoms im Kleintiermodell

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Current Medical Science 2005年第3期 329-331+334页

作者：钱骏,倪岚,Vossoughi Daryusch,Oppermann Elsie,Maataoui Adel,vogl thomas josef Rntgenabteilung Xiehe Klinik Tongji Medizinische Institut Huazhong Universitt fr Wissenschaft und Technik Zellbiologische Abteilung Tongji Medizinische Institut Huazhong Universitt fr Wissenscha ft und Technik Institut fr Diagnostische und Interventionelle Radiologie Universittsklinikum Frank furt am Main Institut fr Diagnostische und Interventionelle Radiologie Universittsklinikum Frank furt am Main Institut fr Diagnostische und Interventionelle Radiologie Universittsklinikum Frank furt am Main Institut fr Diagnostische und Interventionelle Radiologie Universittsklinikum Frank furt am Main Wuhan 430022 China Wuhan 430030 China 60590 Frankfurt Deuts 60590 Frankfurt Deuts 60590 Frankfurt Deuts 60590 Frankfurt Deuts

Zusammenfassung: Evaluierung der kombinierten Therapie bestehend aus transarterieller Chemoembolisation (TACE) und lokaler Immunotherapie des hepatozellulren Karzinoms (HCC) am Kleintiermodell. Bei mnnlichen ACI-Ratten (n=30) erfolgte nach subkapsulrer Implantation eines soliden Morris Hepatoms (2 mm3) in den linken Leberlappen (Tag 0) die magnettomographische Tumorvolumenbestimmung (V1: Tag 13). Nach retrograder Katheterisierung der Arteria gastroduodenalis wurden die Tiere entsprechend den folgenden Therapieschemata behandelt (Tag 14): (A) TACE (0,1 mg Mitomycin C+0,1 ml Lipiodol)+( TNF (7,5μg)+IL-2 (5×103IU) (n=10); (B) TACE+OK-432 (0,05 mg) +IL-2 (5×103 IU) (n=10); (C) TACE allein (Kontrollgruppe, n=10). Zu Beurteilung des Therapieerfolges der unterschiedlichen Behandlungsprotokolle wurde das Tumorvolumen (V2) erneut magnettomographisch ermittelt (Tag 28). Das durchschnittliche Tumorvolumenverhltnis (V2/V1) betrug 7,30, 6,53 und 9,14 in Gruppe A, B und C. Im Vergleich zur Kontrollgruppe zeigten die Therapiegruppen A (P<0,05) und B (P<0,01) ein statistisch signifikant geringeres Tumorvolumenverhltnis (V2/V1). Das Wachstum des induzierten Morris Hepatom wurde unter der kombinierten Therapie von TACE und lokaler Immunotherapie im Tiermodell signifikant, im Vergleich zur Kontrollgruppe, gehemmt

关键词： hepatozellulres Karzinom Transarterielle Chemoembolisation (TACE) Immunotherapie

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Tierexperimentelle Untersuchungen zur Effektivittder transarteriellen Chemoembolisation (TACE) unter Einsatz von Bletilla striata

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第6期25卷 706-708页

作者：钱骏 Vossoughi Daryusch Maataoui Adel Oppermann Elsie Bechstein Wolf vogl thomas josef Rntgenabteilung Xiehe Klinik Tongji Medizinische Institut Huazhong Universitt Wuhan 430022 China Institut für Diagnostische und Interventionelle Radiologie Universittsklinikum Frankfurt am Main 60590 Frankfurt Deutschland

Zusammenfassung： Evaluierung der Effektivitat yon Bletilla striata bei transerteriellen Chemoembolisation （TACE） im Kleintiermodell. Nach subkapsularer Implantation （Tag 0） eines soliden Morris Hepatoms （2 mm^3） bei ACI-Ratten （n=30） wurden am 13. Tag die Tumorvolumina （V1） magnettomographisch bestimmt. Im Anschlu erfolgten nach Laparatomie die retrograde Katheterisierung der Arteria gastroduodenalis und die Anwendung folgender Therapieprotokolle.. （A） TACE （0,1 mg Mitomycin C ＋ 0,1 mL Lipiodol）＋ Bletilla striata （1,0 mg）（n=10）; （B） TACE （ Bletilla striata （1,0mg）＋ Ligatur （n=10）;（C） TACE allein （Kontrollgruppe, n=10）. Zur Effektivitatsbeurteilung der unterschiedlichen Therapieprotokolle erfolgte am 28. Tag eine erneute magnettomographische Bestimmung der Tumorvolumina （V2）. Das durchschnittliche Tumorvolumen der Gruppen A, B und C vor und nach interventioneller Therapie betrug 0,0355 cm^3 und 0, 2248 cm^3 , 0,0374 cm^3 und 0,0573 cm^3 sowie 0,0380 cm^3 und 0,3674 cm^3. Das errechnete durchschnittliche Verhaltnis （V2/V1） betrug 6,28, 1,53 sowie 9,14. Im Vergleich zur Kontrollgruppe C konnte somit fur Therapiegruppe B eine signifikant （P〈0.01） geringere Tumorvolumenzunahme im Beobachtungszeitraum ermitteh werden, wkhrend zwischen Gruppe A und Gruppe C keine statistisch signifikanten （P〉0.05） Unterschiede im Tumorwachstum festgestelh werden konnten. Das Wachstum der induzierten Lebertumoren konnte unter Behandlung mittels TACE ＋ Bletilla striata ＋Ligatur im Tiermodell statistisch signifikant im Vergleich zur Kontrollgruppe gehemmt werden. Schlüsselworter： Lebertumor; TACE; Bletilla striata

关键词： Lebertumor TACE Bletilla striata

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Wilson disease-the impact of hyperimmunity on disease activity:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1386-1393页

作者： Wolfgang Stremmel thomas Longerich RenéLiere Vladimir Vacata josef van Helden Ralf Weiskirchen Pracice for Gastroenterology Medical Center Baden-BadenBaden-Baden D-76530Germany Department of General Pathology University Heidelberg HospitalInstitute of PathologyUniversity of HeidelbergHeidelberg D-69115Germany MVZ Dr.Stein+Kollegen Labor MönchengladbachMönchengladbach D-41069Germany Institute of Molecular Pathobiochemistry Experimental Gene Therapy and Clinical ChemistryRheinisch-Westfaelische Technische Hochschule University Hospital AachenAachen D-52074Germany

BACKGROUND In Wilson disease lack of biliary copper excretion causes hepatocellular injury by accumulation of free toxic *** overspill to serum accounts for neuronal damage as second common *** with copper chelators or zinc targets the removal of this free ***,in some patients liver disease persists for unknown reason despite normalized free *** discovery of a hyperimmunity as a contributing pathogenetic factor was discovered in this case report with implication also for other liver *** SUMMARY A 9-year-old girl was diagnosed in August 2009 by family screening of having asymptomatic Wilson disease with elevated *** at time of diagnosis antinuclear antibodies(ANA)were elevated without hyperimmunoglobulinemia(immunoglobulin G,IgG).After one year of therapy with Dpenicillamine transaminases normalized together with free serum *** continuous therapy with copper chelators free copper remained normal until today,whereas transaminases raised to alanine aminotransferase values of 571 U/L in December *** hyperimmunity a tentative steroid course on top of Dpenicillamine improved ***,hyperimmunity may have impact on liver inflammation after control of the metabolic disturbance.A retrospective cohort study confirmed the common association of elevated transaminases with ANA,but no IgG *** This hyperimmune-triggered condition may represent a new entity which per se or on top of other liver diseases induces liver inflammation responsive to steroids.

关键词： Wilson disease Copper metabolism Antinuclear antibodies Diagnosis Steroid therapy Case report

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The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

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Neural Regeneration Research 2019年第11期14卷 1950-1960页

作者： Petra Hundehege Manuela Cerina Susann Eichler Christian thomas Alexander M. Herrmann Kerstin Goel thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan thomas Budde Erwin-josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth Department of Neurology with Institute of Translational Neurology Westfalische Wilhelms-UniversitatMunsterGermany Institute of Physiology I Westfalische Wilhelms-UniversitatMunsterGermany Novartis Institutes of Biomedical Research BaselSwitzerland

Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010.

关键词： multiple sclerosis focal experimental autoimmune encephalomyelitis cortical grey matter white matter BAF312 neuroaxonal damage neuroprotection

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Meta-Analysis of Retrograde Signaling in Arabidopsis thaliana Reveals a Core Module of Genes Embedded in Complex Cellular Signaling Networks

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Molecular Plant 2014年第7期7卷 1167-1190页

作者： Christine GlaiBer Georg Haberer Iris Finkemeier thomas Pfannschmidt Tatjana Kleine Dario Leister KarI-josef Dietz Rainer Erich Haiusler Bernhard Grimm Klaus Franz Xaver Mayer Helmholtz Zentrum Munchen German Research Center for Environmental Health Institute of Bioinformatics and Systems Biology(IBIS) Ingolstadter Landstr. 1 D-85764 Neuherberg Germany Biozentrum der LMU Munchen Department of Biologie I-Botanik Groβhaderner Str. 2-4 D-82152 Planegg-Martinsried Germany Friedrich-Schiller-Universitat Jena Institut fur AIIgemeine Botanik und Pflanzenphysiologie Dornburger Str. 159 D-07743 JenaGermany Laboratoire de Physiologie Cellulaire Vegetale (LPCV) CEA/CNRS/UJF iRTSV CEA Grenoble 17 rue des Martyrs 38054 Grenoble cedex 9France Biochemistry and Physiology of Plants Faculty of Biology Bielefeld University Universit~tsstrai3e 25 D-33615 Bielefeld Germany University of Cologne Botanical Institute Cologne Biocenter Zu1picher Str. 47B D-50674 Cologne Germany Humboldt-Universitat zu Berlin Institut fur Biologie AG Pflanzenphysiologie Philippstrasse 13 D-10115 Berlin Germany

Plastid-to-nucleus signaling is essential for the coordination and adjustment of cellular metabolism in response to environmental and developmental cues of plant cells. A variety of operational retrograde signaling path- ways have been described that are thought to be triggered by reactive oxygen species, photosynthesis redox imbalance, tetrapyrrole intermediates, and other metabolic traits. Here we report a meta-analysis based on transcriptome and pro- tein interaction data. Comparing the output of these pathways reveals the commonalities and peculiarities stimulated by six different sources impinging on operational retrograde signaling. Our study provides novel insights into the interplay of these pathways, supporting the existence of an as-yet unknown core response module of genes being regulated under all conditions tested. Our analysis further highlights affiliated regulatory cis-elements and classifies abscisic acid and auxin-based signaling as secondary components involved in the response cascades following a plastidial signal. Our study provides a global analysis of structure and interfaces of different pathways involved in plastid-to-nucleus signaling and a new view on this complex cellular communication network.

关键词： retrograde signaling meta-analysis abscisic acid auxin.

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