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催化学报 2011年第8期32卷 1312-1322页

作者： Achim STOLLE[a] Christine SCHM?GER[a] Bernd ONDRUSCHKA[a] Werner BONRATH[b] thomas f.keller[c] Klaus D.JANDT[c] [a]Institute for Technical Chemistry and Environmental Chemistry(ITUC) Friedrich-Schiller University JenaLessingstrasse 12D-07743 JenaGermany [b]R&D Chemical Process Technology DSM Nutritional ProductsP.O.Box 2676CH-4002 BaselSwitzerland [c]Institute of Materials Science and Technology(IMT) Friedrich-Schiller University JenaLobdergraben 32D-07743 JenaGermany

Innovative catalysts based on a "porous glass" support material were developed and investigated for the reduction of benzalace-tophenone. The easy preparation conditions and possibility to use different metals (e.g. Pd, Pt, Rh) for impregnation gave a broad variety of these catalysts. Hydrogenation experiments with these supported catalysts were carried out under different hydrogen pressures and temperatures. Porous glass catalysts with Pd as the active component gave chemoselective hydrogenation of benzalacetophenone, while Pt- and Rh-catalysts tended to further reduce the carbonyl group, especially at elevated hydrogen pressures and temperatures. Kinetic analysis of the reactions revealed these had zero order kinetics, which was independent of the type of porous glass support and solvent used.

关键词： chalcone hydrogenation porous glass supported catalyst

Neutralizing antibodies in hepatitis C virus infection

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World Journal of Gastroenterology 2007年第36期13卷 4824-4830页

作者： Mirjam B Zeisel Samira fafi-Kremer Isabel fofana Heidi Barth franoise Stoll-keller Michel Doffo■l thomas f Baumert Inserm U748Strasbourg France Université Louis Pasteur Strasbourg France Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutesof Health Bethesda MD United States Universitaires de Strasbourg Strasbourg France Service d'Hépatogastro-entérologie Hpitaux Universitaires de Strasbourg

Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis.

关键词： Hepatitis C virus Virus-host cell interaction Viral entry Neutralizing antibodies

The embryology of persistent cloaca and urogenital sinus malformations

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Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： David f M thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSMS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

Hepatitis B virus mutations potentially conferring adefovir/ tenofovir resistance in treatment-naive patients

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World Journal of Gastroenterology 2009年第6期15卷 753-755页

作者： Rebecca Pastor franois Habersetzer Samira fafi-Kremer Michel Doffoёl thomas f Baumert Jean-Pierre Gut franoise Stoll-keller Evelyne Schvoerer Laboratoire de Virologie CHRU de Strasbourg3 Rue Koeberlé67000 StrasbourgFrance Service d'Hépato-gastroentérologie Nouvel Hpital Civil1 Place de l'Hpital67091 StrasbourgFrance Inserm U 748 Strasbourg3 Rue Koeberlé67000 StrasbourgFrance Université Louis Pasteur Facultéde Médecine4 Rue Kirschleger67084 StrasbourgFrance

Anti-hepatitis B virus(HBV)therapy leads to the emer- gence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants with primary antiviral resistance may be important for treatment choice. We studied two patients with chronic HBV infection by sequencing the HBV polymerase *** had adefovir-and tenofovir-related mutations in the viral polymerase,although they had never been treated. These mutations were rtV214A/rtN238T in one patient and rtA194T in the ***,mutations in untreated patients deserve cautious *** data indicate that mutations that can theoretically confer adefovir or tenofovir resistance may emerge in treatmentnaive patients.

关键词： Hepatitis B virus Viral polymerase mutations Treatment-naive patients

Teichmller space of negatively curved metrics on complex hyperbolic manifolds is not contractible

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Science China Mathematics 2017年第4期60卷 569-580页

作者： fARRELL f. thomas SORCAR Gangotryi Yau Mathematical Sciences Center and Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematics Ohio State University Columbus OH 43210 USA

We prove that for all n = 4k- 2 and k 2 there exists a closed smooth complex hyperbolic manifold M with real dimension n having non-trivial π1(T<0(M)). T<0(M) denotes the Teichm¨uller space of all negatively curved ... 详细信息

We prove that for all n = 4k- 2 and k 2 there exists a closed smooth complex hyperbolic manifold M with real dimension n having non-trivial π1(Tf all negatively curved Riemannian metrics on M, which is the topological quotient of the space of all negatively curved metrics modulo the space of self-diffeomorphisms of M that are homotopic to the identity.

关键词： space of Riemannian metrics negative curvature complex hyperbolic space

Origin of Symmetry Breaking and Confinement in Conducting Polymers with Ring Structures

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Communications in Theoretical Physics 2007年第2X期48卷 366-368页

作者： YUAN Yuan thomas f. George SUN Xin Research Center for Quantum Manipulation Fudan University Shanghai 200433 China National Lab of Infrared Physics Shanghai 200083 China Office of the Chancellor and Center for Molecular Electronics Departments of Chemistry & Biochemistry and Physics & Astronomy Univ.ersity of Missouri-St. Louis St. Louis Missouri 63121 USA

A model to describe the main features of conjugated polymers with ring structures, such as polythiophene and polypyrrole, is constructed. It is shown that the origin of the symmetry breaking and confinement of a solit... 详细信息

关键词： polymer branch hopping symmetry breaking confinement

A nano-engineered graphene/carbon nitride hybrid for photocatalytic hydrogen evolution

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Journal of Energy Chemistry 2016年第2期25卷 223-225页

作者： Xiaobo Li Yao Zheng Anthony f.Masters thomas Maschmeyer Laboratory of Advanced Catalysis for Sustainability School of ChemistryThe University of Sydney School of Chemical Engineering University of AdelaideAdelaide Australian Institute of Nanoscale Science and Technology The University of Sydney

A metal-free photocatalytic hydrogen evolution system was successfully fabricated using heteroatom doped graphene materials as electron-transfer co-catalysts and carbon nitride as a semiconductor. The catalytic role of graphene is significantly dependent on the heteroatom dopant of the graphene, such as O, S, B, N doped/undoped graphene co-catalysts, and N-graphene shows the best catalytic hydrogen evolution rate.

关键词： Carbon nitride Co-catalyst Graphene Hydrogen evolution Photocatalysis

Pathogenesis of hepatitis B virus infection

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World Journal of Gastroenterology 2007年第1期13卷 82-90页

作者： thomas f Baumert Robert Thimme fritz von Weizscker Department of Medicine II University of Freiburg Freiburg Germany INSERM U748 Université Louis Pasteur Strasbourg France Department of Medicine II University of Freiburg Freiburg Germany Department of Medicine II University of Freiburg Freiburg Germany Schlosspark-Klinik Charité Humboldt University Berlin Germany

Infection with hepatitis B virus (HBV) leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. Infection with HBV is one of the most common viral diseases affecting man. Both viral factors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of HBV infection. In this review, we will discuss the impact of virus-host interactions for the pathogenesis of HBV infection and liver disease. These interactions include the relevance of naturally occurring viral variants for clinical disease, the role of virus-induced apoptosis for HBV-induced liver cell injury and the impact of antiviral immune responses for outcome of infection.

关键词： Host response Viral hepatitis Mutants Pathogenesis Resistance

Inequality and workforce development in the post-COVID-19 environment:The case of Maine

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Economic and Political Studies 2023年第2期11卷 211-233页

作者： thomas f.Remington Department of Government Harvard UniversityCambridgeMAUSA Department of Political Science Emory UniversityAtlantaGAUSA International Centre for the Study of Institutions and Development National Research University Higher School of EconomicsMoscowRussia

The article analyses the interaction between the COVID-19 pandemic and social inequality in the United States,taking the state of Maine as a case *** pandemic has revealed the effects of high economic inequality on public health in the United States,where in comparison to most developed capitalist democracies,the health care system is expensive,inefficient,and highly skewed in quality and ***,for industries that were already losing jobs,the pandemic has accelerated a painful transition and intensified the harsh social and economic consequences of high and rising inequality,especially for low-wage *** case of Maine underscores the point that policies aimed at reducing the disparities in the distribution of income,health care,education,and opportunity will reduce inequality,protect public health,and stimulate economic growth.

关键词： Maine COVID-19 pandemic inequality skill formation workforce development

Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

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Light(Science & Applications) 2020年第1期9卷 1086-1094页

作者： Isabel Barth Donato Conteduca Christopher Reardon Steven Johnson thomas f.Krauss Department of Physics University of YorkYO105DD YorkUK Department of Electronic Engineering University of YorkYO105DD YorkUK

Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity,low-cost,and reliable *** the most sensitive modalities,interferometry offers particularly high performance,but typically lacks the required operational simplicity and ***,we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent *** sensor exploits the simultaneous excitation of two orthogonally polarized modes,and detects the relative phase change caused by biomolecular binding on the sensor *** wide dynamic range of the sensor,which is essential for fabrication and angle tolerance,as well as versatility,is controlled by integrating multiple,tuned structures in the field of *** approach circumvents the trade-off between sensitivity and dynamic range,typical of other phase-sensitive modalities,without increasing *** sensor enables the challenging label-free detection of procalcitonin,a small protein(13 kDa)and biomarker for infection,at the clinically relevant concentration of 1 pg mL^(−1),with a signal-to-noise ratio of *** result indicates the utility for an exemplary application in antibiotic guidance,and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality.

关键词： dielectric integrating simplicity