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Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells

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Bioactive Materials 2022年第9期7卷 120-130页

作者： Zhule Wang Liebert Parreiras Nogueira Håvard Jostein Haugen Ingrid CM.Van Der Geest Patricia Caetano de Almeida Rodrigues Dennis Janssen thom bitter Jeroen J.J.P.van den Beucken Sander CG.Leeuwenburgh Radboud University Medical Center Department of Dentistry-Regenerative BiomaterialsRadboud Institute for Molecular Life SciencesNijmegenthe Netherlands University of Oslo Department of BiomaterialsInstitute of Clinical DentistryFaculty of DentistryOsloNorway Radboud University Medical Center Department of OrthopedicsRadboud Institute for Health SciencesNijmegenthe Netherlands

Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft ***(PMMA)cement is the most commonly used bone substitute in clinical orthopedics in view of its ***,the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone ***,we introduce porosity into PMMA cement by adding carboxymethylcellulose(CMC)to facilitate such local delivery of chemotherapeutic drugs,while retaining sufficient mechanical properties for bone reconstruction in load-bearing *** results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC *** incorporation of≥3%CMC,the PMMA-based cements released up to 18%of the loaded cisplatin,in contrast to cements containing lower amounts of CMC which only released less than 2%of the cisplatin over 28 *** release of cisplatin efficiently killed osteosarcoma cells in vitro and the fraction of dead cells increased to 91.3%at day 7,which confirms the retained chemotherapeutic activity of released cisplatin from these PMMA-based ***,tibias filled with PMMA-based cements containing up to 3%of CMC exhibit comparable compressive strengths as compared to intact *** conclusion,we demonstrate that PMMA cements can be rendered therapeutically active by introducing porosity using CMC to allow for release of cisplatin without compromising mechanical properties beyond critical *** such,these data suggest that our dual-functional PMMA-based cements represent a viable treatment option for filling bone defects after bone tumor resection in load-bearing sites.

关键词： Porous polymethylmethacrylate cement Bone tumor treatment Local drug delivery Chemotherapeutic drug Ex vivo biomechanical assessment

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Geoscience for the public： Geotopes and National GeoParks in Germany

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Episodes 2004年第4期27卷 279-283页

作者： Heinz-GerdRioehling MichaelSchmidt-thomè LowerSaxonyGeologicalSurveyStilleweg2 D-30657Hartnover.Germany FederalInstitUteforGeoscienceandNaturalResources.Stilleweg2 D-30657Hannover.Germany.

Geotopes or geological sites provide information on the evolution, structure and properties of the Earth's crust and on the geological past. They also represent the great variety of features that characterize a landscape, For this reason, their preservation is of special concern to geosciences. As early as in the 19th century, outstanding rock formations became important tourist sites although the modern terms ""geosites"" and ""geotourism"" were unknown. The paper describes the German initiatives on geotope conservation and the implementation of National GeoParks in Germany and their use for education and tourism.

关键词：地质公园德国演化信息地壳结构教育价值旅游产业

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Minor fibrillar collagens,variable regions alternative splicing,intrinsic disorder,and tyrosine sulfation

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Protein & Cell 2012年第6期3卷 419-433页

作者： Ming Fang Reed Jacob Owen McDougal Julia thom Oxford Department of Biological Sciences Boise State UniversityBoiseID 83725USA Department of Chemistry and Biochemistry Boise State UniversityBoiseID 83725USA Biomolecular Research Center Boise State UniversityBoiseID 83725USA

Minor fibrillar collagen types V and XI,are those less abundant than the fibrillar collagen types I,II and *** alpha chains share a high degree of similarity with respect to protein sequence in all domains except the variable *** variation and,in some cases,extensive alternative splicing contribute to the unique sequence characteristics of the variable *** unique expression patterns in tissues exist,the functions and biological relevance of the variable regions have not been *** this review,we summarize the existing knowledge about expression patterns and biological functions of the collagen types V and XI alpha *** of biochemical similarities among the peptides encoded by each exon of the variable region suggests the potential for a shared *** alternative splicing,conservation of biochemical characteristics in light of low sequence conservation,and evidence for intrinsic disorder,suggest modulation of binding events between the surface of collagen fibrils and surrounding extracellular molecules as a shared function.

关键词： minor fibrillar collagens variable regions alternative splicing fibrillogenesis heparan sulfate binding sites intrinsic disorder tyrosine sulfation

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Seasonal biostabilization and erosion behavior of fluvial biofilms under different hydrodynamic and light conditions

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International Journal of Sediment Research 2015年第04期30卷 273-284页

作者： Moritz thom Holger Schmidt Sabine U.Gerbersdorf Silke Wieprecht Institute for Modelling Hydraulic and Environmental Systems Department of Hydraulic Engineering and Water Resources ManagementUniversity of Stuttgart

Biofilm growth may considerably influence the erodibility of river bed sediments and is,thus,an important morphological *** extent to which the sediment is stabilized depends on many environmental conditions and even though it is well accepted that these conditions are responsible for the variance of results obtained from field studies,little is known about their impact on *** this article,the results from five long-term(4-8 weeks) experiments are presented,investigating the impact of hydrodynamics and light intensity on biostabilization in different *** are cultivated in a sophisticated setup of six identical straight flumes by circulating natural river water over glass beads with diameters between 0.1 and 0.2 *** the course of the experiments biofilm samples are eroded regularly to determine the critical shear stress and to learn more about the erosional behavior of biostabilized *** results indicate a large variance of biostabilization between seasons with the highest values in spring and the lowest in late ***,this is explained by the differences in biofilm growth and composition resulting in mechanically diverse responses to the increased bed shear *** bed shear stress during cultivation delayed biofilm growth possibly due to reduced net attachment and growth of formerly advected microbes on the sediment ***,no substantial biostabilization effect is detected in experiments where biofilms are cultivated in *** focus in this article is the analysis of the mechanical behavior observed during erosion of the biofilms,that is shown to be an important aspect for the understanding of freshwater biostabilization caused by young growing biofilms.

关键词： Biofilm Critical bed shear stress Erosion mechanisms Environmental conditions Seasonal variations

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Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa thoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<*** 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

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Finite element analysis of overlay incorporating stress absorbing membrane interlayers against reflective cracking

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Journal of Modern Transportation 2014年第2期22卷 104-111页

作者： O.M.Ogundipe N.H.thom A.C.Collop Civil Engineering Department Ekiti State University NTEC University of Nottingham Faculty of Technology De-Montfort University

A wheel tracking test was modelled to gain better understanding of the deflection and stress-strain distribution in an overlaid cracked pavements with and without membrane interlayer （SAMI）. For this purpose, commercial finite element software Abaqus 6.7-1 was used. Two different models were considered, one incorporating stress absorbing membrane interlayers （SAMIs） and the other without SAMI. In the study, full bond condition was assumed for the boundaries between the layers, and a linear elastic model was used for the analysis. The results show that introduction of SAMI caused greater deflection of the pavement. It is found that although with SAMIs, low stiffness is required, a very low stiffness may yield undesirable results. The results show that the introduction of SAMIs results in high strain concentration around the crack region, whilst the strain in the overlay is smaller than the values predicted in the models without SAMIs.

关键词： Overlay Interlayers Crack - Strain Stress

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The Central Axis of Beijing and Chinese Wisdom

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China Today 2023年第1期72卷 42-45页

作者： LARS ULRIK thom Beijing Postcards

A foreigner’s probe into the cultural connotations and origins of the Central Axis of *** pioneering journalist Eliza Scidmore,National Geographic’s first official female writer,photographer,and board member,visited... 详细信息

关键词： Axis Central journal

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Le reflet de la sagesse chinoise

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今日中国（法文版） 2022年第8期60卷 34-36页

作者： LARS ULRIK thom Beijing Postcards

Eliza Scidmore,une journaliste du National Geographie,avait visité Beijing en *** n'avait pas tari d’éloges sur 20 pages pour présenter Beijing sous tous les *** que j'ai trouvé curieux,c'est que nulle part ell... 详细信息

关键词： let journal pour

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Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients

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World Journal of Gastroenterology 2014年第38期20卷 13930-13935页

作者： Regina Attiê Ludmilla thomé Domingos Chinen Eliane Muta Yoshioka Michele Cristina F Silva Vladmir Cláudio Cordeiro de Lima Pharmacy Department A.C.Camargo Cancer Center Medical Oncology Department International Research Center Research Department A.C.Camargo Cancer Center

AIM:To assess the impact of bacterial infections on cancer-specific survival in patients with colorectal cancer. METHODS:This was a retrospective cohort study of colorectal cancer patients treated at the A.C. Camargo Cancer Center between January 2006 and April 2010. The presence of bacterial infection during cancer treatment,or up to one year after,was confirmed by laboratory tests or by the physician. Infections of the urinary,respiratory or digestive tracts,bloodstream,skin or surgical site were defined by testing within a single laboratory. Criteria for exclusion from the study were:chronically immunosuppressed patients;transplant patients(due to chronic immunosuppression);human immunodeficiency virus carriers;chronic use of corticosteroids or other immunosuppressive drugs;patients with autoimmune disease or primary immunodeficiency;known viral or parasitic infections. Patients with infections that did not require hospitalization were not included in the study because of the difficulty of collecting and tracking data related to infectious processes. In addition,patients hospitalized for pulmonary thromboembolism,stroke,acute myocardial infarction,uncontrolled diabetes,malignant hypercalcemia or other serious non-infectious complications not directly related to infection were also excluded. Survival curves were plotted using the Kaplan-Meier method,and logrank tests(univariate analysis) and a Cox test assuming a proportional hazards model(multivariate analysis) were performed to examine associations between clinical history and characteristics of infection with cancer-specific survival. RESULTS:One-hundred and six patients with colorectal cancer were divided into two groups based on the presence or absence of bacterial infection. Patient ages ranged from 23 to 91 years,with a median of 55 years. The majority of patients were male(57/106,53.77%) with stage Ⅲ colorectal cancer(45/106,44.11%). A total of 86 bacteriologic events were recorded. Results indicate that t

关键词： Colorectal cancer Bacterial infections Survival

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Improving cover and management factor (C-factor) estimation using remote sensing approaches for tropical regions

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International Soil and Water Conservation Research 2019年第4期7卷 325-334页

作者： André Almagro Thais Caregnatto thomé Carina Barbosa Colman Rodrigo Bahia Pereira José Marcato Junior Dulce Buchala Bicca Rodrigues Paulo Tarso Sanches Oliveira Federal University of Mato Grosso do Sul CxP 549 Campo Grande MS 79070-900 Brazil

The Revised Universal Soil Loss Equation (RUSLE)'s cover and management factor (C-factor) is one of the most difficult factors to obtain,mainly because long-term monitoring soil erosion plots under natural rainfall are ***,remote sensing approaches have been used as an alternative for obtaining this ***,there is a lack of studies comparing values of this factor computed from remote sensing approaches with measured *** this study,we compare two widely used remote sensing approaches (CrA and CVK) to estimate the C-factor based on the Normalized Difference Vegetation Index (NDVI) with the literature (CLIT) and field experimental data..We also investigated the influence of C-factor methods on the prediction of soil loss and sediment yield (SY) using measured data in the Guariroba basin,Central-West *** obtained mean C-factor values of 0.032,0.023 and 0.137 for CLIT,CrA and CVK,*** found an average annual soil loss of 2.20 tha-1 yr-1,2.02 t ha-1 yr-1 and 10.07 tha-1 yr-1 and SY values of 6875 tyr-1,6468 tyr-1 and 33,435 t yr1,for CLIT,CrA and CVK *** results indicated a significant improvement in soil loss and SY estimations by using the CrA approach developed for tropical regions,with a bias of 13% to the measured SY (5709tyr-1).We conclude that the CrA method present the most suitable alternative to compute soil loss and SY in tropical ***,this approach allows large-scale evaluation and temporal monitoring,therefore enhancing multi spatial and temporal assessment of soil erosion processes.

关键词： Soil erosion RUSLE NDVI Landsat 8 Land use/land cover

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