检索结果-南通市图书馆

Novel ecosystems in the restoration of cultural landscapes of Tl’chés,West Chatham Island,British Columbia,Canada

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2013年第1期2卷 143-155页

作者： thiago C Gomes School of Environmental Studies University of VictoriaPO Box 3060 STN CSCVictoriaBC V8W 3R4Canada

Introduction:The small archipelago of Tl’chés,in coastal British Columbia,has gone through drastic social-ecological change culminating in the decline of traditional management practices,invasion of exotic plant species and,in the early 1960s,land *** is a common trend in cultural landscapes around the *** landscapes have great social-ecological significance,including cultural safeguarding and renewal,as well as maintenance of biodiversity,ecosystem functions and services,making them objects of special attention in conservation and restoration *** study investigates the relationship between the Lekwungen people and heavily altered ecosystems in the context of ecological restoration for the cultural landscapes of Tl’ché***:In order to thoroughly explore the ecological,social and cultural aspects and processes involved in the restoration of Tl’chés,this study combined different environmental sciences methodologies,including historical and archival research,semi-structured interviews and participatory observation with Lekwungen participants,as well as ecological field assessments and an innovative mapping approach termed Terrestrial Cultural Ecosystem Mapping(TCEM).Results:This study generated historical and spatial references for ecosystem and land use change in West Chatham Island,as well as cultural and ecological understandings to support *** important native species such as Camassia *** still thriving,present-day ecosystems on this island are heavily altered from the natural Garry oak ecosystem reference sites and are largely dominated by exotic invasive shrubs and graminoid *** investigation indicates that the Lekwungen value both the historical ecological conditions of the island and particular types of the present-day novel or hybrid ecological states,such as the overgrown heritage orchard and nonnative berries found on the ***:Present-day ecosystems of Tl’chés are a result of

关键词： Ecological restoration Novel ecosystems Cultural landscapes Traditional ecological knowledge and wisdom(TEKW) Historical ecology Garry oak ecosystems Lekwungen

Trials of testosterone replacement reporting cardiovascular adverse events

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2018年第2期20卷 131-137页

作者： thiago Gagliano-Juca Shehzad Basaria Research Program in Men's Health: Aging and Metabolism Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

The numbers of testosterone prescriptions written have increased several-fold worldwide, but the incidence of pathological hypogonadism due to hypothalamic, pituitary, and testicular disease has remained unchanged. Most of these prescriptions are being dispensed to middle-aged and older men who have experienced age-related decline in serum testosterone levels; a subset of the population in which benefits of testosterone replacement is at best, modest. Recently, some randomized controlled trials have reported increased cardiovascular events in men （mainly older men and those with prevalent cardiovascular disease） with testosterone use, and a few recent meta-analyses have confirmed these findings, in this review, we discuss trials of testosterone therapy that have reported higher cardiovascular events, relevant trials that have not reported increased cardiovascular events and large trials that have focused on cardiovascular risk （mainly atherosclerosis progression） as their main outcome. We also review findings from meta-analyses that have evaluated cardiovascular events in various testosterone trials. Finally, we discuss some potential mechanisms by which testosterone use might result in an increased cardiovascular risk. As none of the trials conducted to date were adequately powered to evaluate cardiovascular events, no firm conclusions can be drawn regarding the cardiovascular safety of testosterone therapy at this time. In the interim, we hope that this review will help practitioners make informed decisions regarding the care of their patients.

关键词： atherosclerosis cardiovascular frailty testosterone thromboembolism

Quantitative Progress Evaluation of Post-stroke Patients Using a Novel Bimanual Cable-driven Robot

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2021年第6期18卷 1331-1343页

作者： thiago Alves Rogério Sales Gonçalves Giuseppe Carbone Laboratory of Automation and Robotics School of Mechanical EngineeringFederal University of UberlândiaUberlândia38400-902Brazil Department of Mechanical Energy and Management EngineeringUniversity of Calabria87036RendeItaly

Rehabilitation is the most effective way to reduce motor impairments in post-stroke *** process demands several hours with a specialized *** resources and personnel shortages,the literature reports a high interest in robotic assisted rehabilitation ***,cable-driven robotic architectures are attracting significant research interest for post-stroke ***,the existing cable-driven robots are mostly unilateral devices allowing the rehabilitation only of the most affected *** leaves unaddressed the rehabilitation of bimanual activities,which are predominant within the common Activities of Daily Living(ADL).Thus,this paper presents a specific novel design to achieve bimanual rehabilitation tasks that has been named as BiCAR ***,this paper provides a full insight on the BiCAR system as well as on its dedicated developed software *** particular,BiEval software has been developed as based on a serious game strategy and a virtual reality environment to track the patient exercising duration,motion ranges,speeds,and forces over time for achieving a quantitative assessment of the rehabilitation ***,the paper presents the BiCAR/BiEval capabilities by referring to a pilot Randomized Controlled Trial(RCT).The clinical trials have been used to validate the BiCAR/BiEval in terms of engineering feasibility and user acceptance to achieve an innovative cost-oriented integrated hardware/software device for the bimanual assistive rehabilitation of post-stroke patients.

关键词： Cable-driven robots Low cost Stroke rehabilitation Bimanual Progress tracking Serious games

Landslide susceptibility mapping using the infinite slope,SHALSTAB,SINMAP,and TRIGRS models in Serra do Mar,Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2022年第4期19卷 1018-1036页

作者： thiago Machado do PINHO Oswaldo AUGUSTO FILHO University of Sao Paulo Sao CarlosSP13566-590Brazil

Slope failure triggered by heavy rainfall is very common in tropical and subtropical regions and a cause of major social and economic *** susceptibility maps can be generated using geographical information systems(GIS)and limit equilibrium slope stability models coupled or not to hydrological *** study investigated the efficacy of four models used for slope stability analysis in predicting landslide-susceptible areas in a GIS *** selected models are the infinite slope,the shallow slope stability model(SHALSTAB),the stability index mapping(SINMAP),and the transient rainfall infiltration and grid-based regional slope-stability(TRIGRS).For comparisons,the authors(a)included the infinite slope equation in all models,(b)clearly defined input parameters and failure triggering mechanisms for each simulation(soil depth,water table height,rainfall intensity),(c)determined appropriate values for each model to obtain stability levels that represented similar hydrogeotechnical conditions,and(d)considered upper-third areas of landslide scars to estimate the reliability of susceptibility maps using validation *** intense rainfall event occurred in Serra do Mar,Brazil in January 2014 triggered hundreds of landslides and was used for back analysis and evaluation of the slope stability analysis *** rainfall intensity is not considered,the four models produced very similar *** most reliable landslide susceptibility map was generated using TRIGRS and considering the granite residual granite soils geological-geotechnical unit,subjected to a rainfall intensity of 210 mm for 2 h under unsaturated conditions.

关键词： Geographical information system Safety factor Heavy rainfall Geomechanical parameters Residual soils of phyllite and granite Serra do Mar

The Global Leprosy Assessment Index(GLAI):A new approach for measuring the severity of disease in Brazil

在线全文

学校读者我要写书评

暂无评论

Infectious Medicine

Infectious Medicine 2023年第2期2卷 128-135页

作者： Lucas Silva thiago Rocha Dalson Figueiredo Filho Department of Medicine Universidade Estadual de Ciências da Saúde do Estado de AlagoasMaceio 57010-382ALBrazil Department of Political Science Universidade Federal de PernambucoRecife 50670-901PEBrazil

Background:In Brazil,the Ministry of Health(MH)monitors leprosy using 15 indicators,with the aim of imple-menting and evaluating evidence-based public ***,an excessive number of variables can compli-cate the definition of objectives and verification of epidemiological ***:In this paper,we develop the Global Leprosy Assessment Index(GLAI),a composite measure that integrates two key dimensions for the control the disease:epidemiological and *** a confirmatory factor analysis model to examine 2020 state-level data,we have standardized GLAI to a range of 0 to ***:Higher values within this range indicate a greater severity of the *** mean value of the GLAI was 0.67,with a standard deviation of *** has the highest value,followed by Paraíba with 0.88 while Tocantins records the lowest value of the indicator,followed by Mato Grosso with *** epidemiological and operational indicators have a positive but statistically insignificant correlation(r=0.25;p-value=0.20).Conclusions:The development of evidence-based public policies depends on the availability of valid and reliable *** GLAI presented in this paper is easily reproducible and can be used to monitor the disease with disaggregated ***,the GLAI has the potential to serve as a more robust parameter for evaluating the impact of actions designed to eradicate leprosy in Brazil.

关键词： Leprosy Transmissible disease control Public health policy Health indicator Factor analysis

Dendritic spine density changes and homeostatic synaptic scaling:a meta-analysis of animal studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 20-24页

作者： thiago C.Moulin Danielle Rayêe Helgi B.Schiöth Functional Pharmacology Unit Department of NeuroscienceUppsala UniversityUppsalaSweden Institute of Medical Biochemistry Federal University of Rio de JaneiroRio de JaneiroBrazil Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroBrazil Department of Ophthalmology and Visual Sciences Albert Einstein College of MedicineNYUSA Institute for Translational Medicine and Biotechnology Sechenov First Moscow State Medical UniversityMoscowRussia

Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network *** type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative *** of the most studied homeostatic processes is synaptic scaling,where global synaptic adjustments take place to restore the neuronal firing rate to a physiological range by the modulation of synaptic receptors,neurotransmitters,and ***,despite the comprehensive literature on the electrophysiological properties of homeostatic scaling,less is known about the structural adjustments that occur in the synapses and dendritic *** this study,we performed a meta-analysis of articles investigating the effects of chronic network excitation(synaptic downscaling)or inhibition(synaptic upscaling)on the dendritic spine density of *** results indicate that spine density is consistently reduced after protocols that induce synaptic scaling,independent of the intervention ***,we discuss the implication of our findings to the current knowledge on the morphological changes induced by homeostatic plasticity.

关键词： chronic inhibition chronic stimulation dendritic spines downscaling excitability homeostatic plasticity spine density synaptic scaling upscaling

Development and application of a SPE-LC-QTOF method for the quantification of micropollutants of emerging concern in drinking waters from the Brazilian capital

在线全文

学校读者我要写书评

暂无评论

Emerging Contaminants 2020年第1期6卷 72-81页

作者： Fernando Fabriz Sodre thiago Rosa Sampaio Institute of Chemistry University of BrasiliaBrasilia70910-000Brazil

The Brazilian Federal District is located under a savannah climate characterized by an intense dry season,resulting in severe problems related to water *** situation motivates the search for alternate water sources,leading to the indirect water reuse in the Paranoa Lake,an artificial reservoir located in the heart of the Brazilian *** work aimed the assessment of 35 micropollutants of emerging concern by ultra-performance liquid chromatography coupled to high-resolution mass ***-phase extraction conditions(Oasis HLB)were optimized by a factorial *** were then assessed in 0.45 mm filtered samples(1 L)under three different pH by matrix-matched calibration with standard additions and high-resolution multiple reaction monitoring ***,bisphenol A and the insect repellant DEET were detected in all investigated samples(n=14),followed by atrazine(86%of the samples),carbamazepine(71%),paraxanthine(71%),mefenamic acid(64%),nicotine(57%),atenolol(43%)and sulfamethoxazole(43%).Although not frequently detected,the reproductive hormones,estrone,17β-estradiol and estriol,as well as the ovulation inhibitor 17α-ethinylestradiol were detected in a sample from the Paranoa Lake WTP in concentrations ranging from 3.71±0.08 and 5.6±0.1 ng L^-*** these levels,risk quotients indicate the potential for adverse effects to both human health and the environment.

关键词： Emerging contaminants Drinking waters Endocrine disrupting chemicals Hormones Risk assessment

Butyrate in combination with forskolin alleviates necrotic enteritis,increases feed efficiency,and improves carcass composition of broilers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第4期13卷 1115-1125页

作者： Qing Yang Binlong Chen Kelsy Robinson thiago Belem Wentao Lyu Zhuo Deng Ranjith Ramanathan Guolong Zhang Department of Animal and Food Sciences Oklahoma State UniversityStillwaterOKUSA College of Animal Science Xichang UniversityXichangSichuanChina Poultry Production and Product Safety Research Unit USDA–Agricultural Research Service(ARS)FayettevilleARUSA State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhouChina Center for Excellence in Hip Disorders Texas Scottish Rite Hospital for ChildrenDallasTXUSA.

Background:The emergence of antimicrobial resistance has necessitated the development of effective alternatives to antibiotics for livestock and poultry *** study investigated a possible synergy between butyrate and forskolin(a natural labdane diterpene)in enhancing innate host defense,barrier function,disease resistance,growth performance,and meat quality of ***:The expressions of representative genes involved in host defense(AvBD9 and AvBD10),barrier function(MUC2,CLDN1,and TJP1),and inflammation(IL-1β)were measured in chicken HD11 macrophages in response to butyrate and forskolin in the presence or absence of bacterial lipopolysaccharides(LPS).Intestinal lesions and the Clostridium perfringens titers were also assessed in ***-challenged chickens fed butyrate and forskolincontaining Coleus forskohlii(CF)extract individually or in ***,growth performance and carcass characteristics were evaluated in broilers supplemented with butyrate and the CF extract for 42 ***:Butyrate and forskolin synergistically induced the expressions of AvBD9,AvBD10,and MUC2 in chicken HD11 cells(P<0.05)and the synergy was maintained in the presence of *** and forskolin also suppressed LPS-induced IL-1βgene expression in HD11 cells in a synergistic manner(P<0.05).The two compounds significantly reduced the intestinal lesions of ***-challenged chickens when combined(P<0.05),but not ***,butyrate in combination with forskolin-containing CF extract had no influence on weight gain,but significantly reduced feed intake(P<0.05)with a strong tendency to improve feed efficiency(P=0.07)in a 42-d feeding ***,the butyrate/forskolin combination significantly decreased abdominal fat deposition(P=0.01)with no impact on the carcass yield,breast meat color,drip loss,or pH of d-42 ***:Butyrate and forskolin has potential to be developed as novel antibiotic alternatives to improve

关键词： Antibiotic alternatives Butyrate Forskolin Necrotic enteritis Poultry

Partitioning between primary and secondary metabolism of carbon allocated to roots in four maize genotypes under water deficit and its effects on productivity

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2015年第5期3卷 379-386页

作者： Alyne Oliveira Lavinsky Paulo Cesar Magalhaes Roniel Geraldo avila Mariana Melo Diniz thiago Correa de Souza Embrapa Milho e Sorgo Sete LagoasMGCEP:35701-970Brazil Universidade Federal de Lavras LavrasMGCEP 37200-000Brazil Universidade Federal de Sao Joao Del Rey Sete LagoasMGCEP 35701-970Brazil Universidade Federal de Alfenas AlfenasMGCEP 37130-000Brazil

Plants may respond to drought by altering biomass allocation to shoots and roots or by changing the metabolic activities in these organs. To determine how drought changes the partitioning of carbon allocated to growth and secondary metabolism in maize roots and how it affects photosynthesis(A) and productivity in maize, we evaluated leaf gas exchange, yield componentes, root morphology, and primary and secondary metabolites including total soluble sugars(TSS), starch(S), phenolics(PHE), and lignin(LIG). Data were collected from pot-grown plants of four maize genotypes: BRS 1010 and 2B710(sensitive genotypes) and DKB390 and BRS1055(tolerant genotypes) under two soil water tensions: field capacity(FC,-18 kP a) and water deficit(WD,-138 kP a). WD was applied at the pre-flowering stage for 12 days and then the water supply was restored and maintained at optimum levels until the end of the cycle. For genotype BRS 1055 under FC, the greatest A did not result in greater grain biomass(DGB) because the accumulated photoassimilates had already filled the cells, and thus the excessive TSS synthesized in leaves was allocated to roots in large amounts. However, the sharp decrease in A caused by WD imposition in this genotype did not affect the influx pressure of leaf TSS, which was due largely to conversion of primary metabolites to PHE compounds to increase the length of fine roots. In leaves of DKB390 under WD, both S and TSS were reduced, whereas PHE were increased to prevent excessive water loss and xylem cavitation. Under WD, both BRS1010 and2B710 genotypes displayed reduced allocation of biomass to shoots and roots and LIG content in leaves, as well as lower A and DGB values. In BRS1010 this response was coupled to S decrease in leaves and TSS increase in roots, whereas in 2B710 there was a concomitant S increase in roots.

关键词： Starch Sugars Lignin Phenols WinRHIZO