Butyrate in combination with forskolin alleviates necrotic enteritis,increases feed efficiency,and improves carcass composition of broilers

作     者：Qing Yang Binlong Chen Kelsy Robinson Thiago Belem Wentao Lyu Zhuo Deng Ranjith Ramanathan Guolong Zhang Qing Yang;Binlong Chen;Kelsy Robinson;Thiago Belem;Wentao Lyu;Zhuo Deng;Ranjith Ramanathan;Guolong Zhang

作者机构：Department of Animal and Food SciencesOklahoma State UniversityStillwaterOKUSA College of Animal ScienceXichang UniversityXichangSichuanChina Poultry Production and Product Safety Research UnitUSDA–Agricultural Research Service(ARS)FayettevilleARUSA State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-productsInstitute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhouChina Center for Excellence in Hip DisordersTexas Scottish Rite Hospital for ChildrenDallasTXUSA. 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2022年第13卷第4期

页      面：1115-1125页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0832[工学-食品科学与工程（可授工学、农学学位）] 090502[农学-动物营养与饲料科学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 09[农学] 0703[理学-化学] 0836[工学-生物工程] 

基　　金：supported by the USDA National Institute of Food and Agriculture (grant no. 2018–68003-27462 and 2020–67016-31619) Oklahoma Center for the Advancement of Science and Technology (grant no. AR19–027) Boulware Endowment Fund Oklahoma Agricultural Experiment Station Project H-3112 supported by the USDA-NIFA Predoctoral Fellowship grant 2018–67011-28041 

主　　题：Antibiotic alternatives Butyrate Forskolin Necrotic enteritis Poultry 

摘      要：Background:The emergence of antimicrobial resistance has necessitated the development of effective alternatives to antibiotics for livestock and poultry *** study investigated a possible synergy between butyrate and forskolin(a natural labdane diterpene)in enhancing innate host defense,barrier function,disease resistance,growth performance,and meat quality of ***:The expressions of representative genes involved in host defense(AvBD9 and AvBD10),barrier function(MUC2,CLDN1,and TJP1),and inflammation(IL-1β)were measured in chicken HD11 macrophages in response to butyrate and forskolin in the presence or absence of bacterial lipopolysaccharides(LPS).Intestinal lesions and the Clostridium perfringens titers were also assessed in ***-challenged chickens fed butyrate and forskolincontaining Coleus forskohlii(CF)extract individually or in ***,growth performance and carcass characteristics were evaluated in broilers supplemented with butyrate and the CF extract for 42 ***:Butyrate and forskolin synergistically induced the expressions of AvBD9,AvBD10,and MUC2 in chicken HD11 cells(P0.05)and the synergy was maintained in the presence of *** and forskolin also suppressed LPS-induced IL-1βgene expression in HD11 cells in a synergistic manner(P0.05).The two compounds significantly reduced the intestinal lesions of ***-challenged chickens when combined(P0.05),but not ***,butyrate in combination with forskolin-containing CF extract had no influence on weight gain,but significantly reduced feed intake(P0.05)with a strong tendency to improve feed efficiency(P=0.07)in a 42-d feeding ***,the butyrate/forskolin combination significantly decreased abdominal fat deposition(P=0.01)with no impact on the carcass yield,breast meat color,drip loss,or pH of d-42 ***:Butyrate and forskolin has potential to be developed as novel antibiotic alternatives to improve