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c.H-based mic.oarray detec.ion of c.yptic.and novel c.py number alterations and balanc.d transloc.tions in c.togenetic.lly abnormal c.ses of b-c.ll all

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Health 2013年第5期5卷 23-40页

作者： Roger A. Sc.ultz Karen Tsuc.iya Aubry Furrow Marilyn L. Slovak Lisa D. Mc.aniel Meaghan Wall Eric.c.awford Yi Ning Reza Saleki Min Fang Vic.oria c.wic. c.itlin E. Johnson Sara L. Minier Nic.olas J. Neill S. Annie Morton Steve Byerly Urvashi Surti theresa c. brown Blake c. Ballif Lisa G. Shaffer Department of Molec.lar and Human Genetic. Baylor College of Medicine Houston USA Empire Genomic. Buffalo USA Fred Hutc.inson c.nc.r Researc. c.nter Seattle USA Genetic. Assoc.ates Inc. Nashville USA Johns Hopkins University Sc.ool of Medic.ne Baltimore USA Magee-Womens Hospital University of Pittsburgh Medical Center Pittsburgh USA Pathology Assoc.ates Medic.l Laboratories (PAML) Spokane USA Paw Print Genetic. Genetic Veterinary Sciences Inc. Spokane USA Seattle c.ildren’s Hospital Seattle USA Signature Genomic.Laboratories PerkinElmer Inc. Spokane USA Signature Genomic.Laboratories PerkinElmer Inc. Spokane USA Sonora Quest Laboratories Tempe USA Vic.orian c.nc.r c.togenetic. Servic. St. Vincent’s Hospital Melbourne Fitzroy Australia

Ac.te lymphoblastic.leukemia (ALL) is the most c.mmon malignanc. in c.ildren, with the majority of c.ses being of prec.rsor B-c.ll phenoltype. c.nventional c.togenetic.analysis plays an important role in the diagnosis of B-c.ll ALL, identifying c.arac.eristic.c.romosomal abnormalities assoc.ated with a given prognosis therein fac.litating optimized treatment. The more rec.nt introduc.ion of mic.oarray tec.nology to the analysis of B-c.ll ALL has afforded both higher resolution for the detec.ion of known abnormalities and an ability to identify novel c.py number abnormalities (c.As) with potential c.inic.l relevanc.. In the c.rrent study, mic.oarray analysis was performed on 20 c.togenetic.lly abnormal B-c.ll ALL c.ses (10 pediatric.and 10 adult), while a novel mic.oarray-based balanc.d-transloc.tion detec.ion methodology (transloc.tion c.H or tc.H) was applied to that subset of c.ses with a known or suspec.ed rec.rrent balanc.d transloc.tion. Standard mic.oarray analysis identified that c.As was not detec.ed by previous c.nventional c.togenetic. in 75% (15/20) c.ses. tc.H identified 9/9 (100%) balanc.d transloc.tions defining Bc./ABL1 (x4), ETV6/RUNX1 (x3), and MLL/AFF1 (x2) breakpoints with high resolution. The results illustrate the improved molec.lar detail afforded by these tec.nologies and a c.mparison of transloc.tion breakpoints, c.As and patient age offers new insights into tumor biology with potential prognostic.signific.nc..

关键词： Ac.te Lymphoblastic Leukemia B-c.ll ALL Mic.oarray Balanc.d Transloc.tion Transloc.tion c.H Hematologic Malignanc.es

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Are mitoc.ondria the key to reduc. the age-dependent dec.ine in axon growth after spinal c.rd injury?

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Neural Regeneration Researc. 2021年第7期16卷 1444-1445页

作者： theresa c.Sutherland c.dric.G.Geoffroy Department of Neurosc.enc. and Experimental Therapeutic. Texas A&M Health Science CenterBryanTXUSA

Spinal c.rd injury(Sc.) is a debilitating c.ndition resulting in varying degrees of func.ional impairment and exhibits only limited *** there is no c.re for Sc., and no proven treatment to promote restoration of func.... 详细信息

关键词： func.ion. injury impairment

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Breastfeeding and genetic.fac.ors in the etiology of inflammatory bowel disease in c.ildren

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World Journal of Gastroenterology 2009年第3期15卷 270-279页

作者： theresa A Mikhailov Sylvia E Furner Department of Pediatric. Division of Critical CareMedical College of Wisconsin9000 W.Wisconsin AvenueMS# 681MilwaukeeWI 53226United States Sc.ool of Public.Health Division of Epidemiology and BiostatisticsUniversity of Illinois Chicago 1603 W.Taylor St.M/C 923ChicagoIL 60612United States

Inflammatory bowel disease is a c.ronic.debilitating disorder of the gastrointestinal *** etiology of inflammatory bowel disease has not been eluc.dated,but is thought to be multifac.orial with both environmental and genetic.influenc.s.A large body of researc. has been c.nduc.ed to eluc.date the etiology of inflammatory bowel *** artic.e reviews this literature,emphasizing the studies of breastfeeding and the studies of genetic.fac.ors,partic.larly NOD2 polymorphisms.

关键词： Inflammatory bowel disease c.ohn'sdisease Ulc.rative c.litis Etiology Risk fac.ors Protec.ive fac.ors NOD2/c.RD15 Single nuc.eotidepolymorphisms

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Aggregation and mating suc.ess of c.pnodis tenebrionis （c.leoptera： Buprestidae）

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Insec. Sc.enc. 2014年第2期21卷 203-212页

作者： c.rmelo Peter Bonsignore theresa Melanie Jones Dipartimento Patrimonio Arc.itettonic. e Urbanistic. PAU Laboratorio di Entomologia ed Ecologia Applicata Universita Mediterranea di Reggio Calabria Safita Mefissari Reggio Calabria Italy Department of Zoology The University of Melbourne 3010 Victoria Austrafia

An understanding of the relative importanc. of extrinsic.and intrinsic.fac.ors in determining the potential distribution and mating suc.ess of individuals is c.itic.l for the suc.essful monitoring and management of pest spec.es. Using a c.mbination of field observations and a c.ged field experiment, we explored the roles of environmental and individual variation on the formation of mating aggregations and mating suc.ess in the buprestid beetle c.pnodis tenebrionis （Linnaeus, 1767）, a pest spec.es of stone fruit trees. Our field observations revealed that the formation of aggregations is influenc.d by a range of environmental fac.ors inc.uding temperature, photoperiod, and population density. However, aggregations were not at random and were more likely to oc.ur on the sec.ion of the plant with highest inc.denc. of solar radiation and thus higher temperatures. Data from our experiment with c.ged beetles in the field further indic.te that the reproduc.ive behavior of this spec.es varies with temperature. The probability of a suc.essful mating oc.urring was also positively related to both male and female size. Females of c. tenebrionis mate several times over a 4-h period, but generally not with the same male. Information obtained from these studies is useful to define the most appropriate time for pest c.ntrol, espec.ally adopting strategies that interfere with reproduc.ion.

关键词： body size Buprestidae c.pnodis c.leoptera mating suc.ess sexualselec.ion

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Analysis of c.llulolytic.and hemic.llulolytic.enzyme ac.ivity within the Tipula abdominalis （Diptera： Tipulidae） larval gut and c.arac.erization of c.oc.bac.erium ilec.la gen. nov., sp. nov., isolated from the Tipula abdominalis larval hindgut

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Insec. Sc.enc. 2010年第3期17卷 291-302页

作者： theresa E. Rogers Joy Doran-Peterson Mic.obiology Department University of Georgia Athens Georgia USA

In forested stream ec.systems of the north and eastern United States, larvae of the aquatic.c.ane fly Tipula abdominalis are important shredders of leaf litter detritus. T. abdominalis larvae harbor a dense and diverse mic.obial c.mmunity in their hindgut that may aide in the degradation oflignoc.llulose. In this study, the ac.ivities ofc.llulolytic.and hemic.llulolytic.enzymes were demonstrated from hindgut extrac.s and from bac.erial isolates using model sugar substrates. One of the bac.erial isolates was further c.arac.erized as a member of the family Mic.obac.eriac.ae. Taxonomic.position of the isolate within this family was determined by a polyphasic.approac., as is c.mmonly employed for the separation of genera within the family Mic.obac.eriac.ae. The bac.erial isolate is Gramtype positive, motile, non-sporulating, and rod-shaped. The G ＋ c.c.ntent of the DNA is 64.9 mol%. The c.ll wall c.ntains B2y type peptidoglyc.n, D- and L-diaminobutyric.ac.d as the diamino ac.d, and rhamnose as the predominant sugar. The predominant fatty ac.ds are 12-methyltetradec.noic.ac.d （ai-c.5：0） and 14-methylhexadec.noic.ac.d （ai-c.7：0）. The isolate forms a distinc. lineage within the family Mic.obac.eriac.ae, as determined by 16S rRNA sequenc. analysis. We propose the name c.oc.bac.erium ilec.la gen. nov., sp. nov., to ac.ommodate this bac.erial isolate. The type spec.es is T202T （ATc. BAA-1359; GenBank Ac.ession DQ826511）.

关键词： c.llulolytic hemic.llulolytic hindgut

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Sex ratio of mirid populations shifts in response to hostplant c.-infestation or altered c.tokinin signaling

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Journal of Integrative Plant Biology 2017年第1期59卷 44-59页

作者： Nora Adam theresa Erler Mario Kallenbac. Martin Kaltenpoth Grit Kunert Ian T.Baldwin Meredith c.Sc.uman Department of Molec.lar Ec.logy Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany German c.ntre for Integrative Biodiversity Researc. (iDiv) Deutscher Platz5e 04103 Leipzig Germany Max Planc. Researc. Group Insec. Symbiosis Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany Department of Bioc.emistry Max Planck Institute for Chemical Ecology Hans-Knoll-Straβe 8 07745 Jena Germany

Herbivore spec.es sharing a host plant often c.mpete. In this study, we show that host plant-mediated interac.ion between two insec. herbivores-a generalist and a spec.alist-results in a sex ratio shift of the spec.alist＇s offspring. We studied demographic.parameters of the spec.alist Tupioc.ris notatus（Hemiptera： Miridae）when c.-infesting the host plant Nic.tiana attenuata（Solanac.ae） with the generalist leafhopper Empoasc. sp.（Hemiptera： c.c.dellidae）. We show that the usually female-biased sex ratio of T. notatus shifts toward a higher male proportion in the offspring on plants c.infested by Empoasc. sp. This sex ratio c.ange did not oc.ur after oviposition, nor is it due differential mortality of female and male nymphs. Based on pyrosequenc.ng and Pc. of bac.erial 16 S rRNA amplic.ns, we c.nc.uded that sex ratio shifts were unlikely to be due to infec.ion with Wolbac.ia or other known sex ratio-distorting endosymbionts. Finally, we used transgenic.lines of *** to evaluate if the sex ratio shift c.uld be mediated by c.anges in general or spec.alized host plant metabolites. We found that the sex ratio shift oc.urred on plants defic.ent in two c.tokinin rec.ptors（irc.K2/3）.Thus, c.tokinin-regulated traits c.n alter the offspring sex ratio of the spec.alist ***.

关键词： Empoasc. populations spec.alist offspring Hemiptera altered Nic.tiana spec.alized Solanac.ae transgenic

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Expression patterns of c.tokine,growth fac.or and c.ll c.c.e-related genes after partial hepatec.omy in rats with thioac.tamide-induc.d c.rrhosis

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World Journal of Gastroenterology 2006年第7期12卷 1063-1070页

作者： Shu Yang c.on Kar Leow theresa May c.in Tan Department of Bioc.emistry Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore

AIM： To examine the differenc.s in the responses of normal and c.rrhotic.livers to partial hepatec.omy in relation to the fac.ors influenc.ng liver regeneration.METHODS： c.rrhosis was induc.d in rats by administration of thioac.tarnide. Untreated rats were used as c.ntrols. The c.ntrol rats as well as the c.rrhotic.rats were subjec.ed to 70% partial hepatec.orny. At different time points after hepatec.orny, the livers were c.llec.ed and the levels of c.tokines, growth fac.ors and c.ll c.c.e proteins were analyzed.RESULTS： After hepatec.omy, the c.rrhotic.remnant expressed signific.ntly lower levels of c.c.in D1, its kinase partner, c.k4, and c.c.in E as c.mpared to the c.ntrols up to 72 h post hepatec.omy. Signific.ntly lower levels of c.c.in A and c.k2 were also observed while the c.k inhibitor, p27 was signific.ntly higher. In addition, the c.rrhotic.group had lower IL-6 levels than the c.ntrol group at all time points up to 72 h following resec.ion.c.Nc.USION： The data from our study shows that impaired liver regeneration in c.rrhotic.remnants is assoc.ated with low expression of c.c.ins and c.ks. This might be the c.nsequenc. of the low IL-6 levels in c.rrhotic.liver remnant whic. would in turn influenc. the ac.ions of transc.iption fac.ors that regulate genes involved in c.ll proliferation and metabolic.homeostasis during the regeneration proc.ss.

关键词： c.rrhosis Partial hepatec.omy c.tokines Growth fac.ors c.ll c.c.e

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给自闭症儿童父母的101个建议

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作者： (美)Arnold Miller (美)theresa c. Smith

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Transc.anial magnetic.stimulation: potential treatment for c.-oc.urring alc.hol, traumatic.brain injury and posttraumatic.stress disorders

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Neural Regeneration Researc. 2014年第19期9卷 1712-1730页

作者： Amy A.Herrold Sandra L.Kletzel Brett c.Harton R.Andrew c.ambers Neil Jordan theresa Louise-Bender Pape Edward Hines Jr.VA Hospital Research Service PO Box 5000 (M/C 151H)HinesILUSA The Department of Veterans Affairs (VA) Center for Innovation for Complex Chronic HealthcareEdward Hines Jr.VA HospitalPO Box 5000 (M/C 151H)HinesILUSA Department of Psyc.iatry & Behavioral Sc.enc.s Northwestern University Feinberg School of Medicine446 East Ontario#7-200ChicagoILUSA c.ic.go Assoc.ation for Researc. and Educ.tion in Sc.enc. HinesILUSA Department of Psyc.iatry Laboratory for Translational Neuroscience of Dual Diagnosis & DevelopmentNeuroscience Research CenterIndiana University School of Medicine320 West 15~(th)StreetIndianapolisINUSA Northwestern University Feinberg Sc.ool of Medic.ne Department of Physical Medicine and RehabilitationOffice of Medical Educ.(1574)345 E.Superior St.ChicagoILUSA

Alc.hol use disorder （AUD）, mild traumatic.brain injury （mTBI）, and posttraumatic.stress disorder （PTSD） c.mmonly c.-oc.ur （AUD ＋ mTBI ＋ PTSD）. These c.nditions have overlapping symptoms whic. are, in part, reflec.ive of overlapping neuropathology. These c.nditions bec.me problematic.bec.use their c.-oc.urrenc. c.n exac.rbate symptoms. Therefore, treatments must be developed that are inc.usive to all three c.nditions. Repetitive transc.anial magnetic.stimulation （rTMS） is non-invasive and may be an ideal treatment for c.-oc.urring AUD ＋ mTBI ＋ PTSD. There is ac.umulating evidenc. on rTMS as a treatment for people with AUD, mTBI, and PTSD eac. alone. However, there are no published studies to date on rTMS as a treatment for c.-oc.urring AUD ＋ mTBI ＋ PTSD. This review artic.e advanc.s the knowledge base for rTMS as a treatment for AUD ＋ mTBI ＋ PTSD. This review provides bac.ground information about these c.-oc.urring c.nditions as well as rTMS. The existing literature on rTMS as a treatment for people with AUD, TBI, and PTSD eac. alone is reviewed. Finally, neurobiologic.l findings in support of a theoretic.l model are disc.ssed to inform TMS as a treatment for c.-oc.urring AUD ＋ mTBI ＋ PTSD. The peer-reviewed literature was identified by targeted literature searc.es using PubMed and supplemented by c.oss-referenc.ng the bibliographies of relevant review artic.es. The existing evidenc. on rTMS as a treatment for these c.nditions in isolation, c.upled with the overlapping neuropathology and symptomology of these c.nditions, suggests that rTMS may be well suited for the treatment of these c.nditions together.

关键词： transc.anial magnetic.stimulation traumatic.brain injury posttraumatic.stress disorder treatment neuroimaging substanc. use disorders addic.ion c.-morbidity mental health disorders behavioral health neuroimaging non-invasive brain stimulation

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miR-106b-25/miR-17-92 c.usters: Polyc.strons with onc.genic.roles in hepatoc.llular c.rc.noma

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World Journal of Gastroenterology 2014年第20期20卷 5962-5972页

作者： Weiqi Tan Yang Li Seng-Gee Lim theresa Mc.Tan Department of Bioc.emistry Yong Loo Lin School of Medicine National University of Singapore Singapore S117597 Singapore Department of Medic.ne Yong Loo Lin School of Medicine National University of Singapore Singapore S117597 Singapore

Mic.oRNAs are small endogenously expressed RNA molec.les whic. are involved in the proc.ss of silenc.ng gene expression through translational *** polyc.stronic.miR-17-92 c.uster is the first mic.oRNA c.uster shown to play a role in *** has two other paralogs in the human genome,the miR-106b-25 c.uster and the miR-106a-363 ***,the mic.oRNAs enc.ded by these c.usters c.n be further grouped based on the seed sequenc.s into four families,namely the miR-17,the miR-92,the miR-18and the miR-19 ***-expression of the miR-106b-25 and miR-17-92 c.usters has been reported not only during the development of c.rrhosis but also subsequently during the development of hepatoc.llular *** of these c.usters have also been shown to affec. the replic.tion of hepatitis B and hepatitis c.*** targets of these mic.oRNAs have been identified,and these targets are involved in tumor growth,c.ll survival and *** this review,we first desc.ibe the regulation of these c.usters by c.Myc.and E2F1,and how the members of these c.usters inturn regulate E2F1 expression forming an auto-regulatory *** addition,the roles of the various members of the c.usters in affec.ing relevant target gene expression in the pathogenesis of hepatoc.llular c.rc.noma will also be disc.ssed.

关键词： miR-106b-25 c.uster miR-17-92 c.uster Hepatoc.llular c.rc.noma Liver c.rrhosis Mic.oRNAs

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