miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma

作     者：Weiqi Tan Yang Li Seng-Gee Lim Theresa MC Tan 

作者机构：Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore S117597 Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore S117597 Singapore 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第20期

页      面：5962-5972页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：miR-106b-25 cluster miR-17-92 cluster Hepatocellular carcinoma Liver cirrhosis MicroRNAs 

摘      要：MicroRNAs are small endogenously expressed RNA molecules which are involved in the process of silencing gene expression through translational *** polycistronic miR-17-92 cluster is the first microRNA cluster shown to play a role in *** has two other paralogs in the human genome,the miR-106b-25 cluster and the miR-106a-363 ***,the microRNAs encoded by these clusters can be further grouped based on the seed sequences into four families,namely the miR-17,the miR-92,the miR-18and the miR-19 ***-expression of the miR-106b-25 and miR-17-92 clusters has been reported not only during the development of cirrhosis but also subsequently during the development of hepatocellular *** of these clusters have also been shown to affect the replication of hepatitis B and hepatitis C *** targets of these microRNAs have been identified,and these targets are involved in tumor growth,cell survival and *** this review,we first describe the regulation of these clusters by c-Myc and E2F1,and how the members of these clusters inturn regulate E2F1 expression forming an auto-regulatory *** addition,the roles of the various members of the clusters in affecting relevant target gene expression in the pathogenesis of hepatocellular carcinoma will also be discussed.