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Ginsenoside Rg1 inhibits proliferation of vascular smooth muscle cells stimulated by tumor necrosis factor-α

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Acta Pharmacologica Sinica 2006年第8期27卷 1000-1006页

作者： Zeng-chun MA Yue GAO~2 Yu-guang WANG Hong-ling TAN Cheng-rong XIAO Sheng-qi WANG Institute of Radiation medicine Sciences,Academy of Military medical Sciences,Beijing 100850,China Institute of Radiation medicine Sciences Academy of Military Medical Sciences Beijing China

Aim:To investigate the proliferation of vascular smooth muscle cells(VSMC)affected by ginsenoside Rg1 and further explore the molecular mechanism ofginsenoside Rg1 using ***:The proliferation of VSMC wasmeasured by MTS assay kit and flow *** alterations were ana-lyzed using two-dimensional electrophoresis and peptide mass *** proteins found in proteomics were confirmed by ***:The proliferation of VSMC was enhanced significantly after tumor necrosis fac-tor-α(TNF-α)treatment,and ginsenoside Rg1 treatment inhibited proliferation ina dose-dependent *** analysis showed 24 protein spots werechanged,including 17 spots that were increased and 7 spots that were *** Rg1 could restore the expression levels of these proteins,at leastpartly,to basic levels of untreated *** expression of G-protein coupledreceptor kinase,protein kinase C(PKC)-ζ,N-ras protein were decreased,whilecycle related protein p21 was increased by ginsenoside Rgl in TNF-α ***:PKC-ζ and p21 pathway might be the mechanism for inhibi-tory effects of ginsenoside Rg1 on proliferation of VSMC.

关键词： cell cycle ginsenoside Rg1 proteomics tumor necrosis factor-α vascular smooth muscle cells

A New Model of Erythrocyte Injury in Rats with Xueyu Syndrome and Its Application

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Journal of Huazhong University of Science and Technology(medical Sciences) 2000年第4期20卷 327-329页

作者：陈琢焦新福叶望云舒沪英 Department of traditional chinese medicine Tongji Hospital Tongji Medical University Wuhan 430030

A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model in Xueyu Syndrome and Huoxuequyu treatment study, but also be used for screening of drugs with the effect of preventing and treating damage of red blood cells.

关键词： erythroeyte injury Xueyu Syndrome lipid peroxidation rat smoking model

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住院患者中药使用比例及其对费用的影响

中国初级卫生保健 2015年第9期29卷 11-13页

作者：杜俊楠殷实赵茜卞鹰澳门大学中华医药研究院澳门999078

目的探讨使用中药是否可以降低住院患者的药费和住院费用。方法采用个案研究的方法,对山西省某县级医院2008—2013年使用和未使用过中药的住院患者的药费、住院费进行对比和统计学分析。结果总体来看,使用中药患者的药费、住院费均显著... 详细信息

目的探讨使用中药是否可以降低住院患者的药费和住院费用。方法采用个案研究的方法,对山西省某县级医院2008—2013年使用和未使用过中药的住院患者的药费、住院费进行对比和统计学分析。结果总体来看,使用中药患者的药费、住院费均显著高于未使用中药的患者;在使用中药的患者中,随着中药费比例的增加住院费和药费减少;使用中药的患者住院费和药费逐年减少,而未使用中药的患者住院费和药费逐年增加(分别为2013年较2010年下降了23.0%和16.0%,上升了71.9%和63.5%)。结论当以中药治疗为主时,使用中药才可以降低住院患者的药费和住院费,这或是控制医疗费用过快增长的方式之一。

关键词：中药住院医疗费用药费

中国非肌层浸润性膀胱癌治疗与监测循证临床实践指南(2018简化版)

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中国循证医学杂志 2018年第12期18卷 1267-1272页

作者：无王行环贺大林靳英辉曾宪涛中国研究型医院学会泌尿外科学专业委员会中国医疗保健国际交流促进会泌尿健康促进分会中国医疗保健国际交流促进会循证医学分会国家重点研发计划微创等离子手术体系及云规划解决方案项目组不详

1指南的目标用户泌尿外科医师及护理人员、全科医生及护理人员、从事膀胱癌治疗的临床医学教学和研究人员。

关键词：非肌层浸润性膀胱癌经尿道膀胱肿瘤切除术卡介苗治疗与监测循证临床实践指南

血清(浆)类固醇激素液相色谱-串联质谱检测质量保证专家共识

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中华检验医学杂志 2024年第4期47卷 379-390页

作者：中国质谱学会临床质谱专家委员会蒋黎潘柏申王成彬中国质谱学会临床质谱专家委员会

液相色谱-串联质谱(LC-MS/MS)在人体血清(浆)类固醇激素检测中展现出优于传统免疫学方法的特异性高、分析测量范围宽、多标志物同时检测等特点, 已成为国际内分泌学领域相关疾病实验室诊断的首选方法。目前, 国内医学实验室开展血清(浆... 详细信息

液相色谱-串联质谱(LC-MS/MS)在人体血清(浆)类固醇激素检测中展现出优于传统免疫学方法的特异性高、分析测量范围宽、多标志物同时检测等特点, 已成为国际内分泌学领域相关疾病实验室诊断的首选方法。目前, 国内医学实验室开展血清(浆)类固醇激素LC-MS/MS检测多参考已发表学术论文和仪器厂家说明书提供的通用操作和检测程序。然而, 血清(浆)类固醇激素LC-MS/MS检测的技术难度大, 临床实验室检验人员大多数缺少质谱领域专业培训和实践经验, 而通用程序缺乏针对性和实操性, 尤其我国尚无针对该检测程序和质量保证的系统性文件, 导致实验室间检测结果存在较大差异, 阻碍了该技术的临床应用。为规范我国血清(浆)类固醇激素LC-MS/MS检测, 共识从检验前、中、后程序及其质量保证进行详细说明, 并提出针对性建议, 为实验室开展该检测项目提供参考, 以推动我国血清(浆)类固醇激素LC-MS/MS检测的临床应用和结果一致性。

关键词：液相色谱-质谱法类固醇激素标准化质量保证

Knowledge Grid Application in the Digital TCM Hospital System

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Effects of Hesl signaling pathway on differentiation of bone marrow stromal cells into neurons in vitro

2008 IEEE International Symposium on IT in medicine and Education(ITME 2008)

作者： Bing Chen 1,Xuchu Weng 2,Changle Zhou 1,Xueqin Hu 31.Department of Cognitive Science,Xiamen University,Xiamen,361005,China 2.Institute of Psychology,chinese Academy of Sciences,Beijing,100101,China 3.College of Basic medical Science,Shanghai University of traditional chinese medicine,Shanghai,201203,China

The application of Knowledge Grid technology in the process of TCM diagnosis and therapy is introduced in this *** idea that combines Knowledge Grid and PACS with digital hospital system to integrate mass heterogeneous medical data is ***,a meta-model of diagnosis and treatment process of TCM in Grid databases is ***,the application of Knowledge Grid can eliminate the information isolation between each hospital,so as to accelerate the construction of digital TCM hospital.

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Effects of Hesl signaling pathway on differentiation of bone...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Zhong-Li HU~1,Hong-En WEI~2,Chun-Fang WANG~(3,*) 1 Hospital of traditional chinese medicine of Taiyuan,Taiyuan,030009 2 Department of Anatomy & Institute of Biomedical Engineering,Second Military medical University,Shanghai 200433 3 Department of Biotechnology,Shanxi medical University,Taiyuan 030001

＜正＞At present our understanding of the molecular mechanisms underlying the bone marrow stromal cells（BMSCs） differentiating into neural cells is still *** signaling pathways,such as Hes1 signaling molecular,have an important role in neural stem cell *** this study,the putative involvement of the Hes1 signaling pathway in the neuronal differentiation of BMSCs was investigated through RNA interference（RNAi）.We isolated BMSCs from adult rats with complete bone marrow blood *** found that Hes1-siRNA could efficiently block expression of Hes1 in *** induction,immunocytochemistry,reverse transcriptase-PCR and Western blot analysis,all indicated that the expression of neuron-specific markers such as neuron-specific enolase was higher in Hes1-siRNA BMSCs than that in control *** the level of Mash1 expression increased in Hes1-siRNA BMSCs than that in control *** data indicate that Hes1-Mash1 signaling plays a role in the differentiation of BMSCs into neurons in *** or genetic interference with Hes1 signaling may provide a novel method to obtain neurons for therapeutic use.

关键词： bone marrow stromal cells differentiation neurons Hes1

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医院护理队伍现状分析与思考

上海中医药大学学报 2001年第4期15卷 58-60页

作者：张殷华上海中医药大学附属岳阳中西医结合医院上海200437

为研究医院护理队伍的现状 ,采用问卷测评法 ,随机抽取上海中医药大学系统 886名护士 ,就其对护理专业在市场经济条件下的医院管理、卫生改革、护士的继续教育等热点问题发表看法并对结果进行分析、研究。认为要加强护士队伍建设 ,科学... 详细信息

为研究医院护理队伍的现状 ,采用问卷测评法 ,随机抽取上海中医药大学系统 886名护士 ,就其对护理专业在市场经济条件下的医院管理、卫生改革、护士的继续教育等热点问题发表看法并对结果进行分析、研究。认为要加强护士队伍建设 ,科学地管理好这支队伍 ,使之成为素质过硬、作风过硬、技能过硬的“白衣天使” ,是积极推进医疗卫生改革和发展的重要前提。

关键词：护士素质医院管理医疗卫生改革

Anti-inflammatory and Analgesic Effects of Extract from Roots and Leaves of Citrullus lanatus

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chinese Herbal medicines 2010年第3期2卷 231-235页

作者： DENG Jia-gang1, WANG Shuo2, GUO Li-cheng3, FAN Li-li1 1. Guangxi traditional chinese medical University, Nanning 530001, China 2. The Key Laboratory of Academician YAO Xin-sheng, Guangxi Institute of Guangxi Medicinal Plant, Nanning 530023, China 3. Institute of Guangxi national medicine, Guangxi Nanning 530023, China Guangxi traditional chinese medical University Nanning 530001China The Key Laboratory of Academician YAO Xin-sheng Guangxi Institute of Guangxi Medicinal PlantNanning 530023China Institute of Guangxi national medicine Guangxi Nanning 530023China

Objective To study anti-inflammatory and analgesic effects of extract from the roots and leaves of Citrullus lanatus and assess their acute toxicity in animals. Methods The mouse model with ear edema induced by xylene and the rat model with paw edema or granuloma by carrageenin or cotton pellet were used for anti-inflammatory effects of the extract. Effects of the extract on analgesia was tested respectively by measuring the latency of mice licking hind foot from hot plates and by counting the times of body twisting in response to acetic acid. The acute toxicity of the extract was determined with the method of Bliss. Results The extract significantly inhibited the ear edema, granuloma hyperplasia, and paw edema. It significantly lifted the pain threshold on mouse hot-plate responses and reduced their writhing times. During the 7 d observation period in its acute toxicity assay, no apparent toxic reaction was shown and all mice survived at a dose of 87 g extract per kg body weight. Conclusion The extract could protecte mice/rates from inflammation and analgesia, and may be safe as an orally administered natural product for humans.

关键词： acute toxicity analgesia anti-inflammation Citrullus lanatus