检索结果-南通市图书馆

Human B7-H3 binds to Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) and enhances T cell responses

引用

Open Journal of Immunology 2012年第1期2卷 9-16页

作者： Masaaki Hashiguchi Yuka Inamochi Shoya Nagai Noriko Otsuki Jinhua Piao Hiroko Kobori Yumiko Kanno Hidefumi Kojima tetsuji kobata Miyuki Azuma Department of Immunology Dokkyo Medical University School of Medicine Mibu Tochigi Japan Department of Molecular Immunology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

The B7 family member B7-H3 is broadly expressed in many tissue and tumor types. B7-H3 expression is induced on some immune cells;however, its immunological function remains controversial, because both immunoenhancing and immunoinhibitory effects have been reported in human and mouse systems. We have previously reported the following: 1) murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2), a member of the TREM family of receptors;and 2) the B7-H3:TLT-2 pathway up-regulated T cell responses. However, the expression and function of human TLT-2 has not yet been clarified. A recent study found no evidence to support the existence of an interacttion between human B7-H3 and TLT-2. In this study, we demonstrated that human B7-H3 binds to TLT-2 and augments T cell responses. Human and mouse B7-H3Ig chimeric proteins cross-interacted with both human and mouse species of TLT-2-transduced cells. Human TLT-2 was expressed on freshly isolated, peripheral blood B cells and monocytes, and subpopulations of CD4+ and CD8+ T cells. Human TLT-2 expression on T cells did not correlate with na?ve or memory phenotypes and was diminished after culture, despite the presence of mitogenic stimuli. Constitutive TLT-2 expression on monocytes was also down-regulated after culture. Human B7-H3 transfectants augment IL-2 production from TLT-2-transduced T cell hybridomas, and IFN-γ production from peripheral blood CD4+ and CD8+ T cells. The enhanced responses were inhibited by the addition of anti-TLT-2 mAbs, suggesting TLT-2-mediated costimulatory effect. Our results demonstrate the existence of a functional interaction between human B7-H3 and TLT-2, and the restricted expression of TLT-2 on T cells and monocytes.

关键词： B7-H3 Co-Signal Molecule T Cell TLT-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes

引用

World Journal of Gastroenterology 2013年第11期19卷 1834-1840页

作者： Hideki Fujii Naoki Ohnishi Kazuho Shimura Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Tatsuro kobata Kanji Yamaguchi Yoshito Itoh Department of Internal Medicine Aiseikai Yamashina HospitalShichouno-choTakehanaYamashinakuKyoto 602-8086Japan Department of Gastroenterology and Hepatology Uji Tokushukai HospitalKyoto 611-0042Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan

Autoimmune hepatitis(AIH) is a necroinflammatory liver disease of unknown *** disease is characterized histologically by interface hepatitis,biochemically by increased aspartate aminotransferase and alanine aminotransferase levels,and serologically by increased autoantibodies and immunoglobulin G *** we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes(HLLNs,diameter,50 mm).Based on these observations,the differential diagnoses were AIH,lymphoma,or Castleman's *** biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute *** node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration;immunohistochemical examination excluded the presence of lymphoma ***,he was administered corticosteroid therapy:after 2 mo,the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in *** could not find AIH cases with such enlarged lymph nodes(diameter,50 mm) in our literature ***,we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated,humoral immune response in AIH.

关键词： Autoimmune hepatitis Humoral immune response Hepatoduodenal ligament lymph nodes Corticosteroid Hepatomegaly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

手术治疗大脑前动脉远端外伤性假性动脉瘤(附1例报告及文献复习)

引用

中国临床神经外科杂志 2010年第10期15卷 594-596页

作者：赵明珠 Sugie Akira Yagi Ryokichi kobata Hikoshi 刘卫东浦东新区浦南医院神经外科上海200125 大阪府三岛救命救急中心神经外科

目的探讨外伤性颅内假性动脉瘤的临床表现、病理特点、影像学特征、治疗及预后。方法患者男性,34岁,因车祸致重型闭合性颅脑损伤,表现为大量脑内血肿和脑室、蛛网膜下腔出血。经急诊头颅CT、CTA和DSA检查拟诊为左侧大脑前动脉远端假性... 详细信息

目的探讨外伤性颅内假性动脉瘤的临床表现、病理特点、影像学特征、治疗及预后。方法患者男性,34岁,因车祸致重型闭合性颅脑损伤,表现为大量脑内血肿和脑室、蛛网膜下腔出血。经急诊头颅CT、CTA和DSA检查拟诊为左侧大脑前动脉远端假性动脉瘤,并行外科手术治疗。结果术中清除血肿后证实左侧大脑前动脉远端分叉处血管裂伤,用10-0的尼龙线缝合了裂伤的血管壁。术后DSA复查假性动脉瘤消失且胼胝体缘动脉主干供血良好。考虑为大脑前动脉分叉处的剪切力造成了动脉裂伤。结论外伤性颅内假性动脉瘤罕见,易频发再破裂,致残率高,在颅脑损伤的临床诊治上需引起神经外科医生足够的重视。

关键词：颅脑损伤假性动脉瘤大脑前动脉诊断治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

主动脉夹层致急性缺血性脑卒中的诊治(附1例报告及文献复习)

引用

中国临床神经外科杂志 2014年第12期19卷 757-759页

作者：赵明珠朱景伟刘向阳钱忠心 Sugie Akira kobata Hikoshi 刘卫东上海市浦东新区浦南医院神经外科 200125 大阪府三岛救命救急中心神经外科

目的总结主动脉夹层致急性缺血性脑卒中的诊断及治疗经验。方法回顾性分析1例主动脉夹层致急性缺血性脑卒中患者的临床资料,并结合文献进行分析。结果本例患者以急性缺血性脑卒中症状起病,急诊头颅MRI弥撒加权成像检查示左侧枕叶、颞叶... 详细信息

目的总结主动脉夹层致急性缺血性脑卒中的诊断及治疗经验。方法回顾性分析1例主动脉夹层致急性缺血性脑卒中患者的临床资料,并结合文献进行分析。结果本例患者以急性缺血性脑卒中症状起病,急诊头颅MRI弥撒加权成像检查示左侧枕叶、颞叶后部早期缺血性改变;急诊胸部CT平扫及CT血管造影检查示Stanford A型胸主动脉解离伴血栓形成,同时伴左侧颈动脉和左侧锁骨下动脉血栓形成。保守治疗1月后,行血管重建手术治疗,移植人工血管置换解离的升主动脉且与双侧腋动脉搭桥。术后颈部磁共振血管造影检查示左侧颈动脉和左侧锁骨下动脉再通;放射性碘苯丙胺单光子放射计算机断层扫描检查示局部灌注改善。结论主动脉夹层致急性缺血性脑卒中的临床诊断需仔细鉴别,为改善脑血流动力学,血管重建治疗是一种有效的方法。

关键词：急性缺血性脑卒中主动脉夹层 Stanford A型诊断治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

颅内多发性动脉瘤患者术前破裂责任动脉瘤的判断

引用

中国综合临床 2011年第2期27卷 169-172页

作者：赵明珠朱景伟张宇一钱忠心王宇卉 Sugie Akira kobata Hikoshi 刘卫东上海市浦东新区浦南医院神经外科 200125 上海市浦东新区浦南医院神经内科日本大阪三岛救命救急中心神经外科

目的探讨多发性颅内动脉瘤患者诊疗过程中误判破裂责任动脉瘤的原因和解决方法。方法对2003—2009年上海市浦东新区浦南医院收治的25例颅内多发性动脉瘤致自发性蛛网膜下腔出血（SAH）患者的临床资料进行回顾分析，术前根据Nehls等报... 详细信息

目的探讨多发性颅内动脉瘤患者诊疗过程中误判破裂责任动脉瘤的原因和解决方法。方法对2003—2009年上海市浦东新区浦南医院收治的25例颅内多发性动脉瘤致自发性蛛网膜下腔出血（SAH）患者的临床资料进行回顾分析，术前根据Nehls等报道的评判原则诊断破裂责任动脉瘤，被确定破裂的责任动脉瘤均在48h内完成夹闭手术治疗。不能通过一次手术入路夹闭治疗的多发动脉瘤则远期进一步手术治疗。结果25例患者均通过手术证实破裂动脉瘤的确切部位，其中术中确认的责任破裂动脉瘤与术前诊断一致者20例（80％）；而术前判断错误者4例（16％），且术后均发生再出血，其中2例因再出血死亡；还有1例诊断不明确。结论约80％左右的责任动脉瘤可通过术前CT、脑血管造影检查明确诊断，有疑议时应增加检查手段，如CTA或MRI等；术中需对责任动脉瘤进行确认；即使已经发现了责任动脉瘤，也要对其他部位的动脉瘤进行术中确认。

关键词：自发性蛛网膜下腔出血颅内多发性动脉瘤脑血管造影

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of Angle Resolved HXPS Instrument for Laboratory Use

Development of Angle Resolved HXPS Instrument for Laboratory...

引用

第18届国际真空大会

作者： H. Iwai M. kobata I. Pí H. Yoshikawa S. Tanuma H. Yamazui H. Takahashi M. Kodama A. Tanaka M. Suzuki E. Ikenaga H. Matsuda H. Daimon K. Kobayashi Materials Analysis Station National Institute for Materials ScienceTsukuba 305-0047Japan NIMS Beamline Station at Spring-8 National Institute for Materials ScienceSayo 679-5148Japan Department of Surface and Plasma Science Charles University in Prague 18000Czech Republic

We have developed high throughput angle resolved hard X-ray photoelectron spectroscopy （HXPS） instrument for laboratory use [1], which are composed by combining a monochromatic Cr Kα focused X-ray source and a wide acceptance objective for a spectrometer. The Cr Kα X-rays （5.4 keV） excited by micro focused electron beam are monochromatized and focused on to a sample surface by an ellipsoidal bent crystal monochromater with 300 mm Roland circle. The X-ray spot size is variable from 10 μm （1.25 W） to 200 μm （50 W） in diameter. In front of a VG Scienta R4000 10 kV spectrometer, a wide acceptance objective lens is integrated as a hybrid lens to collect photoelectrons emitted from a sample in the range of ±35 degrees for high sensitivity and angle resolved XPS spectra without tilting the sample. The total energy resolution of 0.53 eV was verified by Au Fermi edge measurement. A typical acquisition time for angle resolved Si 1s spectra of a SiO2（4 nm）/Si（001） overlayered thin film sample is around 1 hour in the emission angle of 10 to 80 degrees with 0.5 degrees angler resolution without tilting the sample. The Si 1s peak from the substrate at kinetic energy of 3569 eV is observed through the 25 nm thickness overlayered SiO2 on Si（001）.

关键词： HAXPES ARXPS nondestructive depth profiling

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：