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Impacts of timing,length,and intensity of behavioral interventions to COVID-19 dynamics:North Carolina countylevel examples

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Infectious Disease Modelling 2022年第3期7卷 535-544页

作者： Claire Quiner Kasey jones Georgiy Bobashev RTI International 3040 E.Cornwallis RoadPO Box 12194Research Triangle ParkNC27709USA

We sought to examine how the impact of revocable behavioral interventions,e.g.,shelterin-place,varies throughout an epidemic,as well as the role that the proportion of susceptible individuals had on an intervention's *** estimated the theoretical impacts of start day,length,and intensity of interventions on disease transmission and illustrated them on COVID-19 dynamics inWake County,North Carolina,to inform how interventions can be most *** used a susceptible,Exposed,Infectious,and Recovered(sEIR)model to estimate epidemic curves with modifications to the disease transmission parameter(β).We designed modifications to simulate events likely to increase transmission(e.g.,long weekends,holiday seasons)or behavioral interventions likely to decrease it(e.g.,shelter-in-place,masking).We compared the resultant curves'shape,timing,and cumulative case count to baseline and across other modified *** led to changes in COVID-19 dynamics,including moving the peak's location,height,and *** proportion susceptible,at the start day,strongly influenced their *** interventions shifted the curve,while interventions near the peak modified shape and case *** some scenarios,in which the transmission parameter was decreased,the final cumulative count increased over *** showed that the timing of revocable interventions has a strong impact on their *** same intervention applied at different time points,corresponding to different proportions of susceptibility,resulted in qualitatively differential *** estimation of the proportion susceptible is critical for understanding an intervention's *** findings presented here provide evidence of the importance of estimating the proportion of the population that is susceptible when predicting the impact of behavioral infection control *** emphasis should be placed on the estimation of this epidemic component in intervention design and decision-makin

关键词： sars-cov-2 Public health decision-making Infection control policies

A review of conditions altering the permanent appearance of the vulva

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 382-384页

作者： Ian s. C. jones Women’s and Newborn services Royal Brisbane and Women’s Hospital Herston Australia

This article is aimed at providing information on variations in the clinical appearance of the vulva. The appearance of the vulva can be altered by reversible or permanent conditions both of which may result in minor or major changes. Reversible conditions include those associated with infections or acute trauma which results in distortion of the vulva. some permanent changes are caused by life threatening conditions which are present at birth whereas others develop more slowly or as the result of a deliberate act either traditional female surgery or surgery performed by a registered medical practitioner. To the inexperienced practitioner changes from the normal vulvar appearance can be confusing. The aim of this article is to highlight and categorise changes that can affect the appearance of the vulva. Whatever the presentation the importance of obtaining a detailed history and performing an appropriate, sensitive and thorough examination can not be over emphasised.

关键词： Vulvar Appearance Congenital Traumatic Cultural Iatrogenic

Feasibility Limits for a Hybrid system with Ocean Wave and Ocean Current Power Plants in southern Coast of Brazil

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Computational Water, Energy, and Environmental Engineering 2021年第1期10卷 1-17页

作者： Andrea Fischer jones s. silva Alexandre Beluco Instituto Federal sul Riograndense (IFsUL) Pelotas Brazil Universidade Federal do Rio Grande do sul (UFRGs) Porto Alegre Brazil

some types of renewable energy have been experiencing rapid evolution in recent decades, notably among the energies associated with the oceans, such as wave and current energies. The development of new energy conversion technologies for these two forms of energy has been offering a large number of equipment configurations and plant geometries for energy conversion. This process can be implemented aiming at the result of feasibility studies in places with energy potentials, establishing minimum feasibility limits to be reached. This work aims to contribute in this sense with a feasibility study of a system with ocean wave power plants and with socio-current power plants to be operated on the southern coast of Brazil. This study evaluates a hybrid system with contributions from energy supplies obtained from wave plants and current plants, connected to the grid and supplying the demand of the municipalities in the North Coast region of the state of Rio Grande do sul, the southernmost state of Brazil. The study was carried out with simulations with the Homer Legacy software, with some adaptations for the simulation of ocean wave plants and ocean current plants. The results indicate that the ocean wave power plants were viable in the vast majority of simulated scenarios, while the ocean current power plants were viable in the scenarios with more intense average ocean current speeds and with more expensive energy acquired from the interconnected system.

关键词： Hybrid Energy systems Ocean Wave Power Plants Ocean Current Power Plants Feasibility Limits New Technologies software Homer

Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy

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World Journal of Gastroenterology 2016年第30期22卷 6944-6954页

作者： Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza Cristina Granetto teresa Fabozzi Emanuela Miraglio Marco C Merlano Department of Oncology S. Croce and Carle Teaching Hospital Department of Oncology San Raffaele Institute

AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers (mCRCs) addicted to epidermal growth factor receptor (EGFR) ***: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting mCRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of PubMed, Medline and Web of science to identify eligible papers until March 21sup>stsup>, 2016 using these following terms: ‘‘colorectal cancer’’, “predictive biomarkers’’, “anti-EGFR therapy”, “KRAs”, “NRAs’’, “PIK3CA”, “TP53”, “PTEN”, ‘‘EGFR”, “MET”, “HER2”, “epiregulin”, “amphiregulin”, “prognostic biomarkers”, “BRAF”, “miRNA” and “antibody-dependent cell-mediated cytotoxicity (ADCC) activity”. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and ***: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mCRCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAs mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAs-wild type colorectal cancers. so far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mRNA levels of EGFR ligands, of activating mutations in other genes such as NRAs and PIK3CA. The pr

关键词： Metastatic colorectal cancer Anti-epidermal growth factor receptor therapy KRAs Biomarkers Antibody-dependent cell-mediated cytotoxicity

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Pond Water （II）

考试与评价（英语高一专刊） 2018年第8期 44-45,38页

作者： teresa Bateman

Influences on the study of Vulvar Anatomy and Disease

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 223-226页

作者： Ian s. C. jones Women’s and Newborn services Royal Brisbane and Women’s Hospital Brisbane and University of Queensland Herston Australia

The study of Gynaecology over the years has been influenced by the culture and social attitudes of society to the body as a whole and to the genital organs in particular. Variations in these attitudes between different cultures and at different times have influenced the subsequent rate of progress in the study of the vulva and its diseases.

关键词： Vulvar Cancer Attitudes Communication scientific Developments

DIsCOMYCETEs: the apothecial representatives of the phylum Ascomycota

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Fungal Diversity 2017年第6期87卷 237-298页

作者： A.H.Ekanayaka H.A.Ariyawansa K.D.Hyde E.B.G.jones D.A.Daranagama A.J.L.Phillips s.Hongsanan s.C.Jayasiri Qi Zhao Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Pathology and Microbiology College of Bio-resources and AgricultureNational Taiwan UniversityNo.1Sec.4Roosevelt RoadTaipei 106TaiwanROC Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Faculty of sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Biotechnology and Germplasm Resources Institute Yunnan Academy of Agricultural ScienceKunming 650221YunnanPeople’s Republic of China

Discomycetes are an artificial grouping of apothecia-producing fungi in the phylum ***-based studies have revealed that the discomycetes can be found among ten classes of *** classification of discomycetes has been a major challenge due to the lack of a clear understanding of the important morphological characters,as well as a lack of reference *** this review,we provide a historical perspective of discomycetes,notes on their morphology(including both asexual and sexual morphs),ecology and importance,an outline of discomycete families and a synoptical cladogram of currently accepted families in Ascomycota showing their systematic *** also calculated evolutionary divergence times for major discomycetous taxa based on phylogenetic relationships using a combined LsU,ssU and RPB2 data set from 175 strains and fossil *** results confirm that discomycetes are found in two major subphyla of the Ascomycota:Taphrinomycotina and *** taxonomic placement of major discomycete taxa is briefly *** most basal group of discomycetes is the class Neolectomycetes,which diverged from other Taphrinomycotina around 417 MYA(216–572),and the most derived group of discomycetes,the class Lecanoromycetes,diverged from Eurotiomycetes around 340 MYA(282–414).Further clarifications based on type specimens,designation of epitypes or reference specimens from fresh collections,and multi-gene analyses are needed to determine the taxonomic arrangement of many discomycetes.

关键词： Asci amyloidity Lichenized discomycetes Non-operculate discomycetes Operculate discomycetes

Detailed bed topography and sediment load measurements for two stepdown flows in a laboratory flume

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International Journal of sediment Research 2022年第3期37卷 287-298页

作者： Daniel Wren Roger Kuhnle Tate Mc Alpin David Abraham Keaton jones United states Department of Agriculture Agricultural Research Service National Sedimentation Laboratory U.s.Army Research and Development Center Coastal and Hydraulics Laboratory

streams and rivers, particularly smaller ones, often do not maintain steady flow rates for long enough to reach equilibrium conditions for sediment transport and bed topography. In particular, streams in small watersheds may be subject to rapidly changing hydrographs, and relict bedforms from previous high flows can cause further disequilibrium that complicates the prediction of sediment transport rates. In order to advance the understanding of how bedforms respond to rapid changes in flow rate, a series of flume experiments were performed where the flow was reduced rapidly from equilibrium *** transport rates and bed elevation data across the flume and over a 15-meter-long test section were collected during the experiments to allow detailed examination of evolving bedform dynamics. It was found that relict bedforms stopped moving completely after flow reductions, and the mode of sediment transport was shifted to small bedforms that arose rapidly over dune stoss sections throughout the test section. The changes in sediment transport with time as the sand bed adjusted to the new flow rate was found to agree with predictions based on the relations proposed in Wren et al.(2020). Wavelet analysis is used to visualize changes in length and amplitude scales during the bed transition process.

关键词： sediment transport Bedforms Dunes Wavelets

Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1614-1616页

作者： Daniel Monsálvez-Romín Antonio Del águila-Carrasco teresa Ferrer-Blasco José J.Esteve-Taboada Robert Montés-Micó Optics and Optometry and Vision sciences Department University of Valencia

The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence *** right eyes were included in the *** device used for the measurement was the Visante？omni *** stimuli were set up at different vergences（0.0 D,-1.5 D,and-3.0 D）.The angle opening distance 500 and 750,the trabecular iris space area 500 and 750,and the scleral spur angle parameters were assessed at the nasal and temporal *** results in the iridotrabecular angle comparing the three accommodative states of the eye did not yield any statistically significant difference at nasal or temporal angle *** light of our results and in the conditions of our study,the structures of the iridocorneal angle are not significantly changed with accommodation.

关键词： iridocorneal angle accommodation optical coherence tomography anterior segment