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蝴蝶住宅楼奥地利布尔根兰

世界建筑导报 2018年第3期33卷 90-93页

作者： christina moder borsic christian münster onur arisan j.dith scheiber dorian zapp j.rgen kunz j.n morten loes teresa kohler zuzanna cichocka simon groihofer matthias nemestothy matthias raiger 无不详 GERNER GERNER PLUS

＂蝴蝶屋＂位于Hohe Warte气象站附近,曾有数位奥地利总统隐居于此,五座住宅楼就像五只黄蝴蝶飘落在这块天堂般的园林中。正是＂GERNER GERNER PLUS＂铸就了这份飘逸。整片土地占地约1公顷左右,核心元素并非住宅楼,而是茂盛的树木,这也... 详细信息

＂蝴蝶屋＂位于Hohe Warte气象站附近,曾有数位奥地利总统隐居于此,五座住宅楼就像五只黄蝴蝶飘落在这块天堂般的园林中。正是＂GERNER GERNER PLUS＂铸就了这份飘逸。整片土地占地约1公顷左右,核心元素并非住宅楼,而是茂盛的树木,这也是从设计之初就确定下来的。设计师并没有把五座住宅楼连成一片,反而在各个住宅楼间设置绿色景观。＂闭上眼睛,想象一只美丽的黄蝴蝶刚刚落在院子里,如此轻盈。＂这就是设计师对＂蝴蝶屋＂的外形描述。

关键词：住宅楼奥地利蝴蝶设计师 PLUS 绿色景观气象站园林

肥胖患者罗库溴铵的给药剂量应按理想体重还是校正体重计算

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麻醉与镇痛 2011年第4期7卷 62-67页

作者： Christian S. Meyhoff, MD, PhD j.rgen Lund, MD Morten T. j.nstrup, MD Casper Claudius, MD, PhD Anne M. Scrensen, MD, PhD j.rgen Viby-Mogensen, MD, DMSc Lars S. rasmussen, MD, PhD, DMSc 肖洁(译) 王祥瑞(校) Department of Anaesthesia Centre of Head and Orthopaedics Copenhagen University Hospital Rigshospitalet Copenhagen Department of Anaesthesia Hamlet Hospital Frederiksberg Denmark 不详

背景对于肥胖患者，药代动力学参数显示，应按照患者的理想体重计算罗库溴铵给药剂量，但此方生却可能延长罗库溴铵起效时间或不能满足插管条件。本研究按不同的校正体重将患者分成3组，并分别按照校正体重计算罗库溴铵给药剂量，比较3... 详细信息

背景对于肥胖患者，药代动力学参数显示，应按照患者的理想体重计算罗库溴铵给药剂量，但此方生却可能延长罗库溴铵起效时间或不能满足插管条件。本研究按不同的校正体重将患者分成3组，并分别按照校正体重计算罗库溴铵给药剂量，比较3组中罗库溴铵的起效时间、插管条件和药物持续时间。方法将51例择期行腹腔镜胃束带减容术和胃转流术的肥胖患者随机分成3组，平均体重指数为44（34-72）kg／m^2，分别按照理想体重（IBW组，n=17）、理想体重加超标体重的20％[校正体重（CBW）20％组，n=17]、理想阵重加起标体重的40％（CBW40％组，n=17）计算罗库溴铵给药剂量（0．6mg／kg）．所有患者都采用丙泊酚-瑞芬太尼复合麻醉。一次静注丙泊酚200mg并以5mg·kg^-1·h^-1泵注维持麻醉，瑞芬太尼则以1．0μg·kg^-1·min^-1的速度维持输注，2种药物均采用CBW40％组的校正体重计算给药量。采用TOF（4个成串刺激）监测神经肌肉功能，首要观察指标为罗库溴铵持续时间，即4个成串神经刺激中第4个肌颤搐的恢复时间。结果IBW组、CBW20％组和CBW40％组罗车溴铵持续时间分别为32（18～49）分钟、38（25～66）分钟和42（24—66）分钟，IBW组和CBW40%组间差异有统计学差异（P=0．001）：而在各组罗库溴铵的起效时间（分别为85、84和80秒）和注药后90秒内的插管条件差异无统计学意义。结论对于行胃束带减容术和胃转流术的肥胖患者，按照理想体重给予罗库溴铵后其持续时间短，不会明显延长药物的起效时间，也不会影响插管条件。

关键词：理想体重罗库溴铵肥胖患者给药剂量校正芬太尼复合麻醉统计学差异插管条件

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108Tc的赝自旋带研究

108Tc的赝自旋带研究

Toxicological studies of Caesalpinia sappan wood derived dye in Wister albino rats

二〇〇九全国核反应会暨生物物理与核物理交叉前沿研讨会

作者：朱胜江徐强 j.H.Hamilton A.V.Ramayya j.K.Hwang j.O.rasmussen Y.X.Luo S.H.Liu K.Li 亓斌孟杰彭婧王建国车兴来丁怀博顾龙清华大学物理系 Department of Physics Vanderbilt UniversityNashville Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Berkeley 北京大学物理学院北京师范大学物理系

在原子核结构的研究中,赝自旋的研究为人们非常感兴趣的课题之一。所谓赝自旋是指当原子核的一对角动量分别为j.l+1/2与j.(l+2)-1/2的单粒子轨道的能量非常接近时,这一对轨道的量子数可用所谓赝自旋量子数(?)=N-1,(?)=l-1,(?)=s=1/2来...

在原子核结构的研究中,赝自旋的研究为人们非常感兴趣的课题之一。所谓赝自旋是指当原子核的一对角动量分别为j.l+1/2与j.(l+2)-1/2的单粒子轨道的能量非常接近时,这一对轨道的量子数可用所谓赝自旋量子数(?)=N-1,(?)=l-1,(?)=s=1/2来表征。而在形变核的情况下,单粒子轨道用Nilsson

关键词：

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Food Science and Human Wellness 2017年第1期6卷 34-38页

作者： G.Athinarayanana A.j.A.Ranj.tsingh A.Usha Raj. Nanthini C.Padmalatha Department of Zoology Sri Paramakalyani CollegeAlwarkurichiMS UniversityTamil NaduIndia j. College of Arts and Science TenkasiMS UniversityTamil NaduIndia Department of Biotechnology Mother Teresa UniversityKodaikanalTamil NaduIndia UGC New DelhiIndia

Natural dyes taken from the barks of the tree Caesalpinia sappan has been used in many consumer *** it is imperative to test the toxicity of this *** the present study an investigation was conducted to find out the toxic effect of aqueous extract of the dye *** in test animal Wister albino *** oral toxicity showed no clinical signs of toxicity and no mortality even at a dose level of 100–2000 mg/kg in 14 days observation *** a dose level above 2500 mg/kg was given for 28 days,no death was noticed up to the dose level 5000 mg/kg body *** weight of the tested rats was not significantly reduced,when compared with the control *** organ-body weight ratio of kidney,liver and abdomen did not change when compared to the control group in the observation *** less toxicity of the dyes of ***.

关键词： C.sappan Natural dye Dye toxicity Food grade dye Consumer products

ASTM国际标准组织E60可持续发展技术委员会及其E60.02服务分委会重要工作进展

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中国标准化 2009年第8期 84-84页

作者： teresa j.Cendrowska Steve Mawn ASTM国际标准组织

可持续发展是当今社会一个普遍性的话题，影响到私营和公共领域的诸多方面，同样也广泛地为监管机构和企业所谈论。标准将在可持续发展的众多方面扮演主要角色：定义、技术解决方法的传播以及操作规程和法规的执行。以下介绍ASTM国际标... 详细信息

可持续发展是当今社会一个普遍性的话题，影响到私营和公共领域的诸多方面，同样也广泛地为监管机构和企业所谈论。标准将在可持续发展的众多方面扮演主要角色：定义、技术解决方法的传播以及操作规程和法规的执行。以下介绍ASTM国际标准组织新近成立的E60可持续发展技术委员会的工作概况，其中特别介绍了E60．02服务业分委会的工作。

关键词：国际标准组织可持续发展技术委员会 ASTM E60 分委会服务业监管机构

High Resolution Synchrotron Diffraction Study on Charge Density Distribution of Ampicillin Trihydrate

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Chinese j.urnal of Chemical Physics 2017年第1期30卷 50-62,I0001页

作者： C. Anzline S. lsrael R. Niranj.na Devi R. A. j. R.Sheeba P. Richard Raj.umar Research and Postgraduate Department of Physics The American college Madurai 625002 Tamil Nadu India Mother teresa Women＇s University Kodaikanal 624102 Tamil Nadu India Research and Postgraduate Department of Physics Madura College Madurai 625001 Tamil IVadu India

Charge density distribution in ampicillin trihydrate was investigated experimentally. Results were compared with the quantum calculations using density functional theory. The charge derived properties including Mulliken atomic charges, dipole moment, and molecular electrostatic potential were calculated. The multipole analysis was done for the refinement of experimental population parameters. The structure factors obtained from multipole treat- ment were used for the construction of Fourier maps. Topological properties of the charge distribution were discussed and the characteristics of （3, -1） critical points were analyzed.

关键词： Charge density Multipole analysis Density functional theory Electrophilicity index

Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma

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Frontiers of Medicine 2021年第2期15卷 275-291页

作者： Na Qin Yuancheng Li Cheng Wang Meng Zhu j.ncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBoj.sen Maria teresa Landi Mattias j.hansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan j.hn KField Sanj.y Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayj.an j.ung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kj.ll Grankvist Mikael j.hansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu j.n David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Center for Global HealthNanjing Medical UniversityNanjing 211166China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjing 211166China j.angsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China China International Cooperation Center for Environment and Human Health School of Public HealthNanjing Medical UniversityNanjing 211166China Division of Cancer Epidemiology and Genetics National Cancer InstituteBethesdaMD 20892-9304USA Department of Integrative Oncology British Columbia Cancer AgencyVancouverBC V5Z 1L3Canada Faculty of Medicine University of Oviedo and CIBERESPOviedo 33006Spain Program in Epidemiology Public Health Sciences DivisionFred Hutchinson Cancer Research CenterSeattleWA 98109-1024USA Public Health Sciences Division Swedish Cancer InstituteSeattleWA 98026USA Department of Clinical Biochemistry Copenhagen University HospitalCopenhagen DK-1017Denmark National Cancer Institute BethesdaMD 20892-9304USA Genetic Epidemiology Group International Agency for Research on CancerLyon 69372France Cancer Center Cluster Salzburg at PLUS Department of Molecular BiologyUniversity of SalzburgHeidelberg 5020Austria Institute of Medical Informatics Biometry and EpidemiologyChair of EpidemiologyLudwig Maximilians UniversityMunichBavaria 80539Germany Department of Genetic Epidemiology University Medical Center GoettingenGoettingen 37075Germany Technion Faculty of Medicine Carmel Medical CenterHaifa 3448516Israel Markey Cancer Center University of KentuckyLexingtonKY 40506-0054USA Department of Molecular and Clinical Cancer Medicine Roy Castle Lung Cancer Research ProgrammeThe University of Liverpool Institute of Translational MedicineLiverpool L697Z

Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely *** integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility *** identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive *** factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was *** annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency *** results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.

关键词： lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity

心电图预激表现与心血管病和死亡风险的关系:哥本哈根心电图研究结果

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中华高血压杂志 2017年第10期25卷 989-989页

作者：刘莉叶鹏 Skov MW rasmussen PV Ghouse j.Hansen SM Graff C Olesen MS Pietersen A Torp-Pedersen C HaunsS Kφber L Svendsen j. Holst AG Nielsen j.

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患... 详细信息

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患者的电子心电图数据，确定了310例心电图显示预激（年龄8～85岁）的个体。并从丹麦全国注册管理机构获取关于患者药物、合并症和临床结局的资料。随访中位数为7．4（四分位间距4．6～10．3）年。

关键词：心电图数据心室预激哥本哈根死亡风险心血管病三级医疗中心临床发病过程初级保健

Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina

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World j.urnal of Gastroenterology 2013年第35期19卷 5813-5827页

作者： Noemí del Pino j.sé Raúl Oubia Francisco Rodríguez-Frías j.an Ignacio Esteban María Buti teresa Otero j.sep Gregori Damir García-Cehic Silvia Camos María Cubero Rosario Casillas j.ume Guàrdia Rafael Esteban j.sep Quer Apunlab Laboratories Institute of Medical Microbiology and Parasitology (IMPAM) UBA-CONICET Department of MicrobiologyParasitology and Immunology Faculty of Medicine University of Buenos Aires CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos Ⅲ and Biochemistry Department Hospital Universitari Vall d’Hebrón (HUVH) CIBERehd del Instituto de Salud Carlos Ⅲ Autonomous University of Barcelona and Liver Unit Internal Medicine Lab. Malalties Hepatiques Vall d’Hebron Institut de Recerca (VHIR) Hospital Universitari Vall d’Hebrón (HUVH) Unitat de Diagnostic Molecular HUVH Liver Unit Internal Medicine Lab Malalties Hepatiques VHIR-HUVH Roche Diagnostics SL CIBERehd del Instituto de Salud Carlos Ⅲ Liver Unit Internal Medicine Lab MalaltiesHepatiques VHIR-HUVH Liver Unit and Biochemistry Department HUVH

AIM:To study the subtype prevalence and the phylogenetic relatedness of hepatitis C virus(HCV)sequences obtained from the Argentine general population,a large cohort of individuals was ***:Healthy Argentinian volunteers(n=6251)from 12 provinces representing all geographical regions of the country were *** parents or legal guardians of individuals younger than 18 years provided informed written consent for *** corresponding written permission from all municipal authorities was obtained from each city or town where subj.cts were to be *** RNA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically *** 5’untranslated region(5’UTR)was used for RNA detection and initial genotype *** NS5B polymerase region,encompassing nt 8262-8610,was used for ***:An unexpectedly low prevalence of HCV infection in the general population(0.32%)was *** data contrasted with previous studies that reported rates ranging from 1.5%to 2.5%,mainly performed in selected populations of blood donors or vulnerable *** latter values are in keeping with the prevalence reported by the 2007 Argentinian HCV Consensus(approximately 2%).HCV subtypes weredistributed as follows:1a(25%),1b(25%),2c(25%),3a(5%),and 2j.5%).Two isolates ascribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic analysis could not be *** 1a sequences comprised a highly homogeneous population and clustered with United States ***1b sequences represented a heterogeneous population,suggesting that this genotype might have been introduced from different *** subtype 2c sequences clustered close to the 2c reported from Italy and Southern ***:HCV has a low prevalence of 0.32%in the studied general population of *** pattern of HCV introduction and transmission in Argentina appears to be a consequence of multiple events and different

关键词： Hepatitis C virus NS5B subtyping Molecular epidemiology Hepatitis C virus Argentina Hepatitis C virus 5’ untranslated region